ABCD3
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Official Full Name
ATP-binding cassette, sub-family D (ALD), member 3
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Overview
The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the ALD subfamily, which is involved in peroxisomal import of fatty acids and/or fatty acyl-CoAs in the organelle. All known peroxisomal ABC transporters are half transporters which require a partner half transporter molecule to form a functional homodimeric or heterodimeric transporter. This peroxisomal membrane protein likely plays an important role in peroxisome biogenesis. Mutations have been associated with some forms of Zellweger syndrome, a heterogeneous group of peroxisome assembly disorders. Alternative splicing results in multiple transcript variants encoding distinct isoforms. -
Synonyms
ABCD3; ATP-binding cassette, sub-family D (ALD), member 3; PXMP1; ATP-binding cassette sub-family D member 3; PMP70; ZWS2; 70 kDa peroxisomal membrane protein; ABC 43; ABC D3; ABC43; ABCD 3; ABCD3 protein; ABCD3_HUMAN; ATP binding cassette sub family D (ALD) member 3; ATP binding cassette sub family D member 3; Peroxisomal membrane protein 1; PMP 70; PXMP 1; Peroxisomal membrane protein-1 (70kD); peroxisomal membrane protein 1 (70kD, Zellweger syndrome); dJ824O18.1 (ATP-binding cassette, sub-family D (ALD), member 3 (PMP70, PXMP1));
- Recombinant Proteins
- Antibody
- Protein Pre-coupled Magnetic Beads
- Chicken
- Dictyostelium discoideum (Slime mold)
- Homo sapiens (Human)
- Human
- Mouse
- Mus musculus (Mouse)
- Rat
- Rattus norvegicus (Rat)
- E.coli
- E.coli expression system
- E.Coli or Yeast
- HEK293
- In Vitro Cell Free System
- In vitro E. coli expression system
- Mammalian Cell
- Wheat Germ
- GST
- His
- His (Fc)
- Avi
- N/A
- N
- Involved Pathway
- Protein Function
- Interacting Protein
- ABCD3 Related Articles
ABCD3 involved in several pathways and played different roles in them. We selected most pathways ABCD3 participated on our site, such as ABC transporters, Peroxisome, which may be useful for your reference. Also, other proteins which involved in the same pathway with ABCD3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| ABC transporters | ABCD2;SUR2A;CFTR;ABCA9;ABCC3;ABCC10;TAP1;ABCC2;ABCB4 |
| Peroxisome | AGXTA;PMVK;ACSL1;GSTK1;AGPS;HACL1;GNPAT;PEX3;HAO1 |
ABCD3 has several biochemical functions, for example, ATP binding, ATPase activity, ATPase activity, coupled to transmembrane movement of substances. Some of the functions are cooperated with other proteins, some of the functions could acted by ABCD3 itself. We selected most functions ABCD3 had, and list some proteins which have the same functions with ABCD3. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| ATP binding | NDUFA13;NPR1;SMARCAD1;PTK7A;EPHA6;KDR;TPX2;PIK3R4;STK35L |
| ATPase activity | ERCC3;ATAD2B;NSFB;ATAD1A;ABCC5;TOR1B;PMS1;EIF4A2;MLH3 |
| ATPase activity, coupled to transmembrane movement of substances | ABCC8;ABCA6;ABCD1;ABCC9;ABCA8;ABCB3L1;Abca2;ABCC12;ABCA3 |
| long-chain fatty acid transporter activity | ABCD3B;FABP3;ABCD3;ABCD3A;FABP1 |
| nucleotide binding | VDAC2;SNRPA;RBM39;ORC4;ACTG2;PTK2AB;EEF2B;MAGI1;RBFOX3 |
| protein binding | EFTUD2;ATP6V1E2;KATNAL1;CST3;THAP6;KDM5B;DDAH2;CST7;PMAIP1 |
| protein homodimerization activity | APOBEC3G;SLC22A1;HES1;TLR13;BHLHE40;RABEP1;FGFR1OP2;BCL2A;UGT1A2 |
| protein self-association | SVIP;ACVR2A;ADAM8;PABPN1;CTSC;NKX3-1;AXIN1;PROSAPIP1;DYRK1A |
ABCD3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ABCD3 here. Most of them are supplied by our site. Hope this information will be useful for your research of ABCD3.
ABCD1; Abcd2; Tmem173; Ywhab
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