ABCD3 Protein


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Official Full Name ATP-binding cassette, sub-family D (ALD), member 3
Background The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the ALD subfamily, which is involved in peroxisomal import of fatty acids and/or fatty acyl-CoAs in the organelle. All known peroxisomal ABC transporters are half transporters which require a partner half transporter molecule to form a functional homodimeric or heterodimeric transporter. This peroxisomal membrane protein likely plays an important role in peroxisome biogenesis. Mutations have been associated with some forms of Zellweger syndrome, a heterogeneous group of peroxisome assembly disorders. Alternative splicing results in multiple transcript variants encoding distinct isoforms.
Synonyms ABCD3; ATP-binding cassette, sub-family D (ALD), member 3; PXMP1; ATP-binding cassette sub-family D member 3; PMP70; ZWS2; 70 kDa peroxisomal membrane protein; ABC 43; ABC D3; ABC43; ABCD 3; ABCD3 protein; ABCD3_HUMAN; ATP binding cassette sub family D (ALD) member 3; ATP binding cassette sub family D member 3; Peroxisomal membrane protein 1; PMP 70; PXMP 1; Peroxisomal membrane protein-1 (70kD); peroxisomal membrane protein 1 (70kD, Zellweger syndrome); dJ824O18.1 (ATP-binding cassette, sub-family D (ALD), member 3 (PMP70, PXMP1))
    • Species :
    • Chicken
    • Human
    • Mouse
    • Rat
    • Source :
    • E.coli
    • E.Coli or Yeast
    • Mammalian Cell
    • Wheat Germ
    • Tag :
    • GST
    • His
    • N/A
    • N-His
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human ABCD3-13H Recombinant Human ABCD3 Protein, His-tagged E.coli N-His
    Human ABCD3-2699H Recombinant Human ABCD3 protein, His-tagged E.coli His
    Human ABCD3-055H Recombinant Human ABCD3 Protein, GST-Tagged Wheat Germ GST
    Human ABCD3-056H Recombinant Human ABCD3 Protein, GST-Tagged Wheat Germ GST
    Human ABCD3-30011TH Recombinant Human ABCD3 Wheat Germ N/A
    Mouse ABCD3-1109M Recombinant Mouse ABCD3 Protein Mammalian Cell His
    Rat Abcd3-3737R Recombinant Rat Abcd3, His-tagged E.Coli or Yeast His
    Rat ABCD3-411R Recombinant Rat ABCD3 Protein Mammalian Cell His
    Chicken ABCD3-1967C Recombinant Chicken ABCD3 Mammalian Cell His

    ABCD3 involved in several pathways and played different roles in them. We selected most pathways ABCD3 participated on our site, such as ABC transporters, Peroxisome, which may be useful for your reference. Also, other proteins which involved in the same pathway with ABCD3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    ABC transporters ABCG8; ABCA6; ABCG3; ABCB10; ABCC10; ABCG2; ABCB8; ABCB6A; ABCA4; ABCB1A
    Peroxisome DAO.1; ACSL4B; CRATA; PRDX1; PMVK; SLC25A17; NUDT19; ACSL3B; PEX5L; CROT

    ABCD3 has several biochemical functions, for example, ATP binding, ATPase activity, ATPase activity, coupled to transmembrane movement of substances. Some of the functions are cooperated with other proteins, some of the functions could acted by ABCD3 itself. We selected most functions ABCD3 had, and list some proteins which have the same functions with ABCD3. You can find most of the proteins on our site.

    Function Related Protein
    ATP binding MST1R; NAIP7; EPHB4; UBA6; SLFNL1; KIF5C; MAP4K3; AK5L; TLK2; ACTR2A
    ATPase activity CLPB; HLTF; PEX6; HSPA1B; ABCA6; RALBP1; HSPD1; KIF6; VPS4A; KIFC3
    ATPase activity, coupled to transmembrane movement of substances TAP1; ABCA13; ABCB7; ABCA3; ABCA1; ABCG5; ABCC12; ABCD3A; ABCA8; ABCB4
    long-chain fatty acid transporter activity ABCD3; ABCD3A; FABP1; ABCD3B; FABP3
    nucleotide binding DCKL1B; ATP2B1A; PRKG1A; SEPT8B; RBM15; UBE2IB; RAB25B; ACTB2; RAB18B; OASL2
    protein binding DACT2; CSRNP1; KCTD9; LAT2; PKN1; PIK3C2B; CLSTN1; MEIS1B; NMB; MRPL48
    protein homodimerization activity ZFP365; KIAA1804; GSTM4; TREX1; TG; GRIK2; RPL7; AMBP; STUB1; FLNA
    protein self-association TRP53; TRIM32; ZSWIM2; SHANK3; TMEM190; ZKSCAN17; PABPN1; MDH2; TNFAIP3; S100A7A

    ABCD3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ABCD3 here. Most of them are supplied by our site. Hope this information will be useful for your research of ABCD3.

    ABCD1; Abcd2; Tmem173; Ywhab

    Liu, XX; Liu, JJ; et al. ABCD2 identifies a subclass of peroxisomes in mouse adipose tissue. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 456:129-134(2015).
    Grant, P; Ahlemeyer, B; et al. The biogenesis protein PEX14 is an optimal marker for the identification and localization of peroxisomes in different cell types, tissues, and species in morphological studies. HISTOCHEMISTRY AND CELL BIOLOGY 140:423-442(2013).
    Wiesinger, C; Kunze, M; et al. Impaired Very Long-chain Acyl-CoA beta-Oxidation in Human X-linked Adrenoleukodystrophy Fibroblasts Is a Direct Consequence of ABCD1 Transporter Dysfunction. JOURNAL OF BIOLOGICAL CHEMISTRY 288:19269-19279(2013).
    Dunster, K; Lai, FPL; et al. Limkain b1, a novel human autoantigen localized to a subset of ABCD3 and PXF marked peroxisomes. CLINICAL AND EXPERIMENTAL IMMUNOLOGY 140:556-563(2005).

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