ACTL6A
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Official Full Name
actin-like 6A
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Overview
This gene encodes a family member of actin-related proteins (ARPs), which share significant amino acid sequence identity to conventional actins. Both actins and ARPs have an actin fold, which is an ATP-binding cleft, as a common feature. The ARPs are involved in diverse cellular processes, including vesicular transport, spindle orientation, nuclear migration and chromatin remodeling. This gene encodes a 53 kDa subunit protein of the BAF (BRG1/brm-associated factor) complex in mammals, which is functionally related to SWI/SNF complex in S. cerevisiae and Drosophila; the latter is thought to facilitate transcriptional activation of specific genes by antagonizing chromatin-mediated transcriptional repression. Together with beta-actin, it is required for maximal ATPase activity of BRG1, and for the association of the BAF complex with chromatin/matrix. Three transcript variants that encode two different protein isoforms have been described. [provided by RefSeq, Jul 2008] -
Synonyms
ACTL6A; actin-like 6A; Arp4; ACTL6; BAF53A; INO80K; ARPN-BETA; actin-like protein 6A; BAF53; arpNbeta; hArpN beta; INO80 complex subunit K; actin-related protein 4; BAF complex 53 kDa subunit; BRG1-associated factor 53A; actin-related protein Baf53a; 53 kDa BRG1-associated factor A;
- Recombinant Proteins
- Cell & Tissue Lysates
- Protein Pre-coupled Magnetic Beads
- Human
- Mouse
- Rhesus Macaque
- Zebrafish
- E.coli
- HEK293
- HEK293T
- In Vitro Cell Free System
- Mammalian Cell
- Wheat Germ
- GST
- His
- His (Fc)
- Avi
- Myc
- DDK
- N/A
- T7
- Involved Pathway
- Protein Function
- Interacting Protein
- ACTL6A Related Research Area
ACTL6A involved in several pathways and played different roles in them. We selected most pathways ACTL6A participated on our site, such as C-MYC pathway, Chromatin modifying enzymes, Chromatin organization, which may be useful for your reference. Also, other proteins which involved in the same pathway with ACTL6A were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name | Pathway Related Protein |
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C-MYC pathway | HBP1;KAT5;RUVBL2;ACTL6A;MYC |
Chromatin modifying enzymes | KDM5D;PADI6;SMARCA2;KDM1A;PADI2;CAPNS2;SMARCC1;KDM7AB;SMYD2 |
Chromatin organization | MBD3B;ING5A;JHDM1D;RBBP5;BRD8;SMARCB1B;ARID1A;JMJD6;PHF8 |
DNA Damage Recognition in GG-NER | CETN2;INO80C;MCRS1;ACTR5;INO80B;COPS4;COPS7A;YY1;DDB2 |
DNA Repair | ALKBH2;RAD9A;ELL;DDB1;RTEL1;ACTR5;KIAA1530;APITD1;BRE |
Gastric cancer network 1 | TPX2;RNF216;ECT2;GATS;ESM1;S100P;LIN9;C21orf33;ACTL6A |
Global Genome Nucleotide Excision Repair (GG-NER) | GPS1;COPS7A;COPS4;NFRKB;CHD1L;INO80B;COPS7B;TFPT;DDB2 |
HATs acetylate histones | KANSL3;DR1;BRPF3;MSL1;KAT7;KAT8;KAT7A;KIAA1267;BRD8 |
ACTL6A has several biochemical functions, for example, contributes_to RNA polymerase II core promoter proximal region sequence-specific DNA binding, contributes_to RNA polymerase II distal enhancer sequence-specific DNA binding, chromatin binding. Some of the functions are cooperated with other proteins, some of the functions could acted by ACTL6A itself. We selected most functions ACTL6A had, and list some proteins which have the same functions with ACTL6A. You can find most of the proteins on our site.
Function | Related Protein |
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contributes_to RNA polymerase II core promoter proximal region sequence-specific DNA binding | HDAC1;SMARCC1;ACTL6A;HDAC2;GATAD2B;ACTB;SMARCE1;RBBP4;SMARCA4 |
contributes_to RNA polymerase II distal enhancer sequence-specific DNA binding | MTA2;HDAC1;ACTL6A;HDAC2;SMARCB1;SMARCC2;ACTB;CHD4;SMARCC1 |
chromatin binding | NFATC2;ACTL6A;AJUBA;HCFC1;SMC1A;NKAP;GATA1A;HIST2H3C1;SP100 |
contributes_to nucleosomal DNA binding | SMARCA4;GATAD2B;MBD3;SMARCB1;MTA2;ACTL6A;HDAC1;RBBP4;CHD4 |
protein binding | SFPI1;LGR5;ARID5A;KIF13B;DPY30;NME7;PPM1A;VPS26A;SV2B |
transcription coactivator activity | MYOCD;DYRK1B;RFXAP;BCL10;NPM1;NEUROG3;MTA1;MKL1B;TFAP2B |
ACTL6A has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ACTL6A here. Most of them are supplied by our site. Hope this information will be useful for your research of ACTL6A.
MRGBP; RUVBL2; RUVBL1
- Q&As
- Reviews
Q&As (21)
Ask a questionCTL6A plays a critical role in promoting metastasis and epithelial-to-mesenchymal transition (EMT) in hepatocellular carcinoma, processes associated with cancer progression and invasion.
Yes, based on its pro-tumor function and role as an EMT activator in colon cancer, ACTL6A may serve as a potential therapeutic target for developing novel treatment strategies.
The specific molecular pathways and mechanisms through which ACTL6A promotes tumor progression and activates EMT in hepatocellular carcinoma and colon cancer are still under investigation.
Elevated ACTL6A levels in cancer cells suggest its potential role as a driver in promoting cancer cell survival and tumor formation.
Actl6a's role as a gatekeeper in mESCs is to prevent the cells from differentiating into the PrE lineage, ensuring the maintenance of their pluripotency and self-renewal capabilities.
In colon cancer, ACTL6A functions as an activator of epithelial-to-mesenchymal transition (EMT), a process that contributes to cancer cell invasion, metastasis, and drug resistance.
In hepatocellular carcinoma, ACTL6A is involved in metastasis and epithelial-to-mesenchymal transition (EMT). In colon cancer, ACTL6A acts as an EMT activator, exhibiting pro-tumor function.
ACTL6A is vital for embryogenesis and differentiation processes, playing crucial roles in the development of various tissues and organs during embryonic development.
The discovery of Actl6a's role as a gatekeeper in preventing mESCs from entering the PrE lineage expands our understanding of the regulatory mechanisms underlying cell fate decisions in embryonic stem cells.
ACTL6A has been identified as a central oncogenic driver in various tumor types beyond esophageal squamous cell carcinoma, suggesting its broad significance in cancer development and progression.
By identifying ACTL6A as a potential therapeutic target, it suggests the possibility of developing alternative treatment strategies specifically for ESCC, potentially leading to improved therapeutic outcomes.
ACTL6A's functional roles beyond its involvement in chromatin remodeling and tumor development are still under investigation.
ACTL6A suppresses p21Cip1 promoter activity, leading to reduced p21Cip1 protein levels in aggressive mesothelioma cells.
Actl6a demonstrates a Yin/Yang regulating pattern by repressing the expression of PrE regulators while maintaining the expression of pluripotency-related genes, maintaining a balance between differentiation and pluripotency in mESCs.
ACTL6A and p63 collaborate as oncogenic drivers in HNSCC, suggesting their combined role in promoting the development and progression of this type of cancer.
The SWI/SNF complexes are involved in regulating gene expression by remodeling chromatin structure. ACTL6A acts as a regulatory subunit within these complexes, contributing to their activity and function.
Actl6a is a subunit of complexes such as esBAF, INO80, and Tip60-p400, which play crucial roles in maintaining the pluripotency and self-renewal of embryonic stem cells.
Actl6a's presence in complexes such as esBAF, INO80, and Tip60-p400 suggests its multifaceted involvement in chromatin remodeling and gene regulation, which are crucial for the maintenance of embryonic stem cells.
Actl6a targets the promoters of key PrE regulators, such as Sall4 and Fgf4, and represses their expression, thereby inhibiting PrE differentiation in embryonic stem cells.
The crucial role of ACTL6A in DNA replication and the ATR-Chk1 pathway in glioblastoma, indicating that it could serve as a potential therapeutic target for intervention in this type of cancer.
ACTL6A expression influences ESCC cell cycle redistribution by activating the S6K1/pS6 pathway, which plays a role in regulating cell cycle progression and proliferation.
Customer Reviews (5)
Write a reviewExtensive quality control measures, including rigorous testing for activity, stability, and functionality, ensure that the protein product meets the highest standards of quality.
Stringent quality control protocols are followed during the production process, ensuring the protein's consistent performance and characteristics.
The company's customer support team is highly responsive and knowledgeable, promptly addressing any inquiries or concerns we have regarding the protein product.
We have observed significant improvements in experimental outcomes
We have consistently received our orders on time, with efficient shipping and reliable tracking information provided by the company.
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