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Recombinant Human ACTL6A Protein, GST-tagged

Cat.No. : ACTL6A-220H
Product Overview : Human ACTL6A full-length ORF ( AAH00949, 1 a.a. - 387 a.a.) recombinant protein with GST-tag at N-terminal.
  • Specification
  • Gene Information
  • Related Products
Description : This gene encodes a family member of actin-related proteins (ARPs), which share significant amino acid sequence identity to conventional actins. Both actins and ARPs have an actin fold, which is an ATP-binding cleft, as a common feature. The ARPs are involved in diverse cellular processes, including vesicular transport, spindle orientation, nuclear migration and chromatin remodeling. This gene encodes a 53 kDa subunit protein of the BAF (BRG1/brm-associated factor) complex in mammals, which is functionally related to SWI/SNF complex in S. cerevisiae and Drosophila; the latter is thought to facilitate transcriptional activation of specific genes by antagonizing chromatin-mediated transcriptional repression. Together with beta-actin, it is required for maximal ATPase activity of BRG1, and for the association of the BAF complex with chromatin/matrix. Three transcript variants that encode two different protein isoforms have been described. [provided by RefSeq, Jul 2008]
Source : Wheat Germ
Species : Human
Tag : GST
Molecular Mass : 68.31 kDa
AA Sequence : MVVERDDGSTLMEIDGDKGKQGGPT YYIDTNALRVPRENMEAISPLKNGM VEDWDSFQAILDHTYKMHVKSEASL HPVLMSEAPWNTRAKREKLTELMFE HYNIPAFFLCKTAVLTAFANGRSTG LILDSGATHTTAIPVHDGYVLQQGI VKSPLAGDFITMQCRELFQEMNIEL VPPYMIASKEAVREGSPANWKRKEK LPQVTRSWHNYMCNCVIQDFQASVL QVSDSTYDEQVAAQMPTVHYEFPNG YNCDFGAERLKIPEGLFDPSNVKGL SGNTMLGVSHVVTTSVGMCDIDIRP GLYGSVIVAGGNTLIQSFTDRLNRE LSQKTPPSMRLKLIANNTTVERRFS SWIGGSILASLGTFQQMWISKQEYE EGGKQCVERKCP
Applications : Enzyme-linked Immunoabsorbent Assay
Western Blot (Recombinant protein)
Antibody Production
Protein Array
Notes : Best use within three months from the date of receipt of this protein.
Storage : Store at -80 centigrade. Aliquot to avoid repeated freezing and thawing.
Storage Buffer : 50 mM Tris-HCI, 10 mM reduced Glutathione, pH=8.0 in the elution buffer.
Gene Name : ACTL6A actin-like 6A [ Homo sapiens ]
Official Symbol : ACTL6A
Synonyms : ACTL6A; actin-like 6A; actin-like protein 6A; actin related protein 4; Actl6; Arp4; BAF complex 53 kDa subunit; BAF53A; Baf53a; BRG1 associated factor; INO80 complex subunit K; INO80K; BAF53; arpNbeta; hArpN beta; actin-related protein 4; BRG1-associated factor 53A; actin-related protein Baf53a; 53 kDa BRG1-associated factor A; ACTL6; ARPN-BETA;
Gene ID : 86
mRNA Refseq : NM_004301
Protein Refseq : NP_004292
MIM : 604958
UniProt ID : O96019

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (21)

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How is ACTL6A involved in metastasis and EMT in hepatocellular carcinoma? 08/26/2022

CTL6A plays a critical role in promoting metastasis and epithelial-to-mesenchymal transition (EMT) in hepatocellular carcinoma, processes associated with cancer progression and invasion.

Can ACTL6A be a potential therapeutic target for colon cancer? 04/20/2022

Yes, based on its pro-tumor function and role as an EMT activator in colon cancer, ACTL6A may serve as a potential therapeutic target for developing novel treatment strategies.

Are there any specific molecular pathways or mechanisms associated with ACTL6A's pro-tumor function and EMT activation? 12/10/2021

The specific molecular pathways and mechanisms through which ACTL6A promotes tumor progression and activates EMT in hepatocellular carcinoma and colon cancer are still under investigation.

What is the significance of elevated ACTL6A levels in cancer cells? 07/06/2020

Elevated ACTL6A levels in cancer cells suggest its potential role as a driver in promoting cancer cell survival and tumor formation.

What is the significance of Actl6a acting as a gatekeeper in mESCs? 06/22/2020

Actl6a's role as a gatekeeper in mESCs is to prevent the cells from differentiating into the PrE lineage, ensuring the maintenance of their pluripotency and self-renewal capabilities.

What is the significance of ACTL6A acting as an EMT activator in colon cancer? 03/17/2020

 In colon cancer, ACTL6A functions as an activator of epithelial-to-mesenchymal transition (EMT), a process that contributes to cancer cell invasion, metastasis, and drug resistance.

What is the role of ACTL6A in hepatocellular carcinoma and colon cancer? 08/28/2019

In hepatocellular carcinoma, ACTL6A is involved in metastasis and epithelial-to-mesenchymal transition (EMT). In colon cancer, ACTL6A acts as an EMT activator, exhibiting pro-tumor function.

How does ACTL6A impact embryogenesis and differentiation? 02/22/2019

ACTL6A is vital for embryogenesis and differentiation processes, playing crucial roles in the development of various tissues and organs during embryonic development.

What are the implications of the novel function of Actl6a in mESCs? 10/25/2018

The discovery of Actl6a's role as a gatekeeper in preventing mESCs from entering the PrE lineage expands our understanding of the regulatory mechanisms underlying cell fate decisions in embryonic stem cells.

 In which other tumor types has ACTL6A been identified as a central oncogenic driver? 08/26/2018

ACTL6A has been identified as a central oncogenic driver in various tumor types beyond esophageal squamous cell carcinoma, suggesting its broad significance in cancer development and progression.

What is the potential therapeutic significance of targeting ACTL6A in esophageal squamous cell carcinoma (ESCC)? 07/20/2018

By identifying ACTL6A as a potential therapeutic target, it suggests the possibility of developing alternative treatment strategies specifically for ESCC, potentially leading to improved therapeutic outcomes.

Does ACTL6A have any known functional roles outside of its involvement in chromatin remodeling and tumor development? 07/03/2018

ACTL6A's functional roles beyond its involvement in chromatin remodeling and tumor development are still under investigation.

How does ACTL6A affect p21Cip1 protein levels in aggressive mesothelioma cells? 06/17/2018

ACTL6A suppresses p21Cip1 promoter activity, leading to reduced p21Cip1 protein levels in aggressive mesothelioma cells.

How does Actl6a exhibit a Yin/Yang regulating pattern in mESCs? 05/12/2018

Actl6a demonstrates a Yin/Yang regulating pattern by repressing the expression of PrE regulators while maintaining the expression of pluripotency-related genes, maintaining a balance between differentiation and pluripotency in mESCs.

How do ACTL6A and p63 collaborate as oncogenic drivers in HNSCC? 02/28/2018

ACTL6A and p63 collaborate as oncogenic drivers in HNSCC, suggesting their combined role in promoting the development and progression of this type of cancer.

What are the ATP-dependent chromatin-remodeling complexes SWI/SNF, and how does ACTL6A function within these complexes? 01/01/2018

The SWI/SNF complexes are involved in regulating gene expression by remodeling chromatin structure. ACTL6A acts as a regulatory subunit within these complexes, contributing to their activity and function.

What are the main complexes that Actl6a is a subunit of, and what are their roles in embryonic stem cells? 12/12/2017

Actl6a is a subunit of complexes such as esBAF, INO80, and Tip60-p400, which play crucial roles in maintaining the pluripotency and self-renewal of embryonic stem cells.

How does Actl6a's involvement in multiple complexes contribute to its role in maintaining embryonic stem cells? 11/18/2017

Actl6a's presence in complexes such as esBAF, INO80, and Tip60-p400 suggests its multifaceted involvement in chromatin remodeling and gene regulation, which are crucial for the maintenance of embryonic stem cells.

How does Actl6a impact the expression of key regulators in the primitive endoderm (PrE) lineage? 05/16/2017

Actl6a targets the promoters of key PrE regulators, such as Sall4 and Fgf4, and represses their expression, thereby inhibiting PrE differentiation in embryonic stem cells.

What is the role of ACTL6A in glioblastoma and its potential therapeutic implications? 02/17/2017

The crucial role of ACTL6A in DNA replication and the ATR-Chk1 pathway in glioblastoma, indicating that it could serve as a potential therapeutic target for intervention in this type of cancer.

How does ACTL6A facilitate ESCC cell cycle redistribution through the S6K1/pS6 pathway? 01/16/2016

ACTL6A expression influences ESCC cell cycle redistribution by activating the S6K1/pS6 pathway, which plays a role in regulating cell cycle progression and proliferation.

Customer Reviews (5)

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Reviews
12/06/2021

    Extensive quality control measures, including rigorous testing for activity, stability, and functionality, ensure that the protein product meets the highest standards of quality.

    10/25/2021

      Stringent quality control protocols are followed during the production process, ensuring the protein's consistent performance and characteristics.

      12/19/2017

        The company's customer support team is highly responsive and knowledgeable, promptly addressing any inquiries or concerns we have regarding the protein product.

        09/18/2016

          We have observed significant improvements in experimental outcomes

          05/16/2016

            We have consistently received our orders on time, with efficient shipping and reliable tracking information provided by the company.

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