ACTN1

  • Official Full Name

    actinin, alpha 1
  • Overview

    Alpha actinins belong to the spectrin gene superfamily which represents a diverse group of cytoskeletal proteins, including the alpha and beta spectrins and dystrophins. Alpha actinin is an actin-binding protein with multiple roles in different cell types. In nonmuscle cells, the cytoskeletal isoform is found along microfilament bundles and adherens-type junctions, where it is involved in binding actin to the membrane. In contrast, skeletal, cardiac, and smooth muscle isoforms are localized to the Z-disc and analogous dense bodies, where they help anchor the myofibrillar actin filaments. This gene encodes a nonmuscle, cytoskeletal, alpha actinin isoform and maps to the same site as the structurally similar erythroid beta spectrin gene. Three transcript variants encoding different isoforms have been found for this gene.
  • Synonyms

    ACTN1;actinin, alpha 1;BDPLT15;alpha-actinin-1;actinin 1 smooth muscle;non-muscle alpha-actinin-1;F-actin cross-linking protein;alpha-actinin cytoskeletal isoform

Recombinant Proteins

  • Human
  • Rat
  • Chicken
  • Zebrafish
  • Mouse
  • E.coli
  • Wheat Germ
  • Mammalian Cells
  • HEK293
  • Chicken Gizzard
  • GST
  • His
  • Non
  • Flag
  • Avi
  • Fc
  • DDK
  • Myc
Cat.# Product name Source (Host) Species Tag Protein Length Price
ACTN1-9339H Recombinant Human ACTN1, GST-tagged E.coli Human GST C-term-350a.a.
ACTN1-228H Recombinant Human ACTN1 Protein, GST-tagged Wheat Germ Human GST
ACTN1-229H Recombinant Human ACTN1 Protein, GST-tagged Wheat Germ Human GST
ACTN1-45H Recombinant Human ACTN1 protein, His-tagged E.coli Human His
ACTN1-486R Recombinant Rat ACTN1 Protein Mammalian Cells Rat His
ACTN1-5703C Recombinant Chicken ACTN1 Mammalian Cells Chicken His
ACTN1-7641Z Recombinant Zebrafish ACTN1 Mammalian Cells Zebrafish His
ACTN1-9056HCL Recombinant Human ACTN1 293 Cell Lysate HEK293 Human Non
ACTN1-1082HFL Recombinant Full Length Human ACTN1 Protein, C-Flag-tagged Mammalian Cells Human Flag Full L.
ACTN1-142R Recombinant Rat ACTN1 Protein, His (Fc)-Avi-tagged HEK293 Rat Avi&Fc&His
ACTN1-142R-B Recombinant Rat ACTN1 Protein Pre-coupled Magnetic Beads HEK293 Rat
ACTN1-162C Native chicken ACTN1 Chicken Gizzard Chicken Non
ACTN1-2411H Recombinant Human ACTN1 protein, GST-tagged E.coli Human GST 543-892 aa
ACTN1-270H Recombinant Human ACTN1 Protein, His (Fc)-Avi-tagged HEK293 Human Avi&Fc&His
ACTN1-270H-B Recombinant Human ACTN1 Protein Pre-coupled Magnetic Beads HEK293 Human
Actn1-432M Recombinant Mouse Actn1 Protein, MYC/DDK-tagged HEK293 Mouse DDK&Myc
ACTN1-435H Recombinant Human ACTN1 Protein, His-tagged E.coli Human His Ala28~Asn260

    Involved Pathway

    ACTN1 involved in several pathways and played different roles in them. We selected most pathways ACTN1 participated on our site, such as Focal adhesion,Adherens junction,Tight junction, which may be useful for your reference. Also, other proteins which involved in the same pathway with ACTN1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Amoebiasis TGFB2,MUC2,PLCB3,CD1d1,IL6,SERPINB2,NFKB1,COL1A1,CXCL1,SERPINB3
    Arrhythmogenic right ventricular cardiomyopathy (ARVC) CACNB3,CDH2,ITGA5,CACNG3,ITGB3,ACTN3,ACTB,EMD,SLC8A1,ITGB6
    Tight junction CLDN11B,CASKA,CLDN11A,SHROOM3,ACTG1,CLDN16,PRKCQ,CLDN20,RHOAD,EPB41L3B
    Focal adhesion MAPK10,ITGA2,ITGB1A,PIP5K1C,MYL7,ITGB5,RAP1A,MYLK4,MYLK,MYLPF
    Systemic lupus erythematosus HIST1H2AK,TROVE2,C8G,FCGR4,HLA-DQA1,C1QC,HIST3H2BB-PS,HIST1H2AL,FCGR2A,HIST1H4E
    Adherens junction PVRL2,SRC,PTPN1,PARD3,VCLA,Fert2,WASF3,NLK1,FYN,PTPN6
    Viral carcinogenesis MRPS18B,TBPL2,RHOA,PRKACA,STAT5A,GTF2H2C,LTBR,RELA,NFKB2,HIST1H4F
    Leukocyte transendothelial migration ITGAL,MAPK13,RAP1A,PIK3R2,RHOA,PIK3R3,CLDN18,MMP9,CLDN15,ITGB2L
    Regulation of Actin Cytoskeleton MAP2K2B,PIK3R3,ARPC5A,APC2,MYL12.2,FGF12,FGFR1A,RAC1,FGFR3,ITGB2L

    Protein Function

    ACTN1 has several biochemical functions, for example, actin filament binding,calcium ion binding,double-stranded RNA binding. Some of the functions are cooperated with other proteins, some of the functions could acted by ACTN1 itself. We selected most functions ACTN1 had, and list some proteins which have the same functions with ACTN1. You can find most of the proteins on our site.

    Function Related Protein
    ligand-dependent nuclear receptor transcription coactivator activity HELZ2,CARM1,THRAP3,SMARCD3,DCAF6,ZMIZ2,HMGA1,FGF2,ENY2,PPARG
    protein binding IL18R1,SERPINA5,MEN1,SNAP23,UGGT1,BMP10,SRM,SSBP1,MPDU1,CHGB
    integrin binding CD226,COL4A3,ADAMTS5,ITGB1,ILK,S1PR2,ICAM4,TLN1,ADAM25,LYN
    vinculin binding DMD,SORBS3,TLN1,SYNM,CTNNA1,DAG1,PXN,NRAP,C22orf28
    ion channel binding CAV1,SNTA1,FHL1,KCNJ11,SLC8A1,ACTN4,EPN1,NEDD4L,HTT,YWHAQ
    double-stranded RNA binding PRKRIP1,OASL,LRRFIP1,ADARB1,DHX36,DDX58,STAU2,TUBA1B,IFIH1,EIF4A1
    actin filament binding TAGLN3A,TMOD1,GAS2L2,ACTN4,MYO7A,CTNNA3,PANX1,ESPN,SSFA2,CORO1C
    protein homodimerization activity CREB3,DNTTIP1,OXCT1,RELA,ACHE,PSPH,E2F8,LRRK2,PARK7,PDCD6
    calcium ion binding PNLIPRP1,NUCB2B,EDIL3,PCDHGA1,PCDHGC4,TPM4,PPP3CB,ANXA11A,MMP11,PCLO

    Interacting Protein

    ACTN1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ACTN1 here. Most of them are supplied by our site. Hope this information will be useful for your research of ACTN1.

    p27958-pro_0000037577;CAMK2A;b2r8y4_human;OAS1;EPM2AIP1;MICALL2

    Resources

    References

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