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ADAM15

  • Official Full Name

    ADAM metallopeptidase domain 15

  • Overview

    The protein encoded by this gene is a member of the ADAM (a disintegrin and metalloproteinase) protein family. ADAM family members are type I transmembrane glycoproteins known to be involved in cell adhesion and proteolytic ectodomain processing of cytokines and adhesion molecules. This protein contains multiple functional domains including a zinc-binding metalloprotease domain, a disintegrin-like domain, as well as a EGF-like domain. Through its disintegrin-like domain, this protein specifically interacts with the integrin beta chain, beta 3. It also interacts with Src family protein-tyrosine kinases in a phosphorylation-dependent manner, suggesting that this protein may function in cell-cell adhesion as well as in cellular signaling. Multiple alternatively spliced transcript variants encoding distinct isoforms have been observed. [provided by RefSeq, Jul 2008]
  • Synonyms

    ADAM15; ADAM metallopeptidase domain 15; MDC15; disintegrin and metalloproteinase domain-containing protein 15; MDC-15; metalloprotease RGD disintegrin protein; a disintegrin and metalloproteinase domain 15 (metargidin); metalloproteinase-like, disintegrin-like, and cysteine-rich protein 15;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Human
  • Mouse
  • Mus musculus (Mouse)
  • CHO
  • E.coli
  • E.coli expression system
  • HEK293
  • Human Cell
  • In Vitro Cell Free System
  • Wheat Germ
  • GST
  • His
  • N/A
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human ADAM15-281H Active Recombinant Human ADAM15 protein, His-tagged CHO His
Human ADAM15-277H Recombinant Human ADAM15 Protein, GST-tagged Wheat Germ GST
Human ADAM15-276H Recombinant Human ADAM15 Protein, GST-tagged Wheat Germ GST
Human ADAM15-243H Recombinant Human ADAM15 protein, His-tagged HEK293 His Met1-Thr696
Human ADAM15-228H Recombinant Human ADAM15 Protein, His-tagged CHO His
Human ADAM15-2808HCL Recombinant Human ADAM15 cell lysate Human Cell N/A
Human ADAM15-001HCL Recombinant Human ADAM15 cell lysate CHO N/A
Human ADAM15-3697H Recombinant Human ADAM15 protein, His-tagged E.coli His 362-486 aa
Human ADAM15-1717H Recombinant Human ADAM15 protein, His-tagged E.coli His Ser505~Arg745
Human ADAM15-1186H Recombinant Human ADAM15 Protein (207-452 aa), GST-tagged E.coli GST 207-452 aa
Human ADAM15-863HF Recombinant Full Length Human ADAM15 Protein, GST-tagged In Vitro Cell Free System GST 772 amino acids
Mouse ADAM15-948M Active Recombinant Mouse ADAM15 Protein, His-tagged HEK293 His
Mouse ADAM15-1820MCL Recombinant Mouse ADAM15 cell lysate Human Cell N/A
Mus musculus (Mouse) RFL-8603MF Recombinant Full Length Mouse Disintegrin And Metalloproteinase Domain-Containing Protein 15(Adam15) Protein, His-Tagged E.coli expression system His Full Length of Mature Protein (208-864)
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • ADAM15 Related Articles
  • ADAM15 Related Research Area

ADAM15 involved in several pathways and played different roles in them. We selected most pathways ADAM15 participated on our site, such as Degradation of the extracellular matrix, Extracellular matrix organization, which may be useful for your reference. Also, other proteins which involved in the same pathway with ADAM15 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Degradation of the extracellular matrixADAM9;MMP19;CTSL2;ADAMTS18;MMP12;ELANE;MMP20;CTSL1;FURINA
Extracellular matrix organizationPRP;SERPINH1A;SERPINH1B;MGC174857;LOC100686744;MFAP3;LTBP4;COL8A2;MMP12

ADAM15 has several biochemical functions, for example, SH3 domain binding, integrin binding, metalloendopeptidase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by ADAM15 itself. We selected most functions ADAM15 had, and list some proteins which have the same functions with ADAM15. You can find most of the proteins on our site.

Function Related Protein
SH3 domain bindingPLSCR3;SGIP1;PDCD6IP;SH3BP2;MAPK15;KHDRBS3;ENKUR;INPP5D;QK
integrin bindingVCAM1;Npnt;CD226;EGFL6;TSPAN4;ITGA5;CD151;ICAM2;S1PR3
metalloendopeptidase activityNLN;YME1L1B;ECEL1;ADAM10A;ADAM17;MMP3;ADAM1B;ADAM10B;MMP26
metallopeptidase activityMMP13A;ADAMTS5;ADAMTSL1;PAPPA;ADAM23;ADAM9;HE2;MMP2;CHMP1A
protein bindingCDYL2;NUBP1;DIXDC1;RPLP1;CARF;PTGES3;CLC;ICAM4;SGOL2
zinc ion bindingALPI;ADAM15;MME;MATR3;WHSC1L1;PHF17;KPNB1;JADE3;RAI1

ADAM15 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ADAM15 here. Most of them are supplied by our site. Hope this information will be useful for your research of ADAM15.

SRC; PACSIN3; FYN; HCK; GRB2; SNX9; NUP62; SP4

Pasten, K; Bastian, Y; et al. ADAM15 participates in fertilization through a physical interaction with acrogranin. REPRODUCTION 148:623-634(2014).
Grabowska, MM; Sandhu, B; et al. EGF promotes the shedding of soluble E-cadherin in an ADAM10-dependent manner in prostate epithelial cells. CELLULAR SIGNALLING 24:532-538(2012).
  • Q&As
  • Reviews

Q&As (4)

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In addition to breast cancer research, what other diseases is ADAM15 currently used to study? 04/05/2022

ADAM15 used in studies of liver and bladder cancers.

I want to buy ADAM15-related proteins, do you provide other proteins? 10/09/2021

We offer MMP9 and MMP2 proteins in addition to ADAM15 proteins.

Does ADAM15 affect H460 expression? 06/26/2020

ADAM15 affects the proliferation of H460 cells by regulating PI3K-AKT and MAPK-ERK signaling pathways.

Does adding GST tag have any effect on protein? 12/13/2019

Addition of GST tags can accelerate the solubilization of certain insoluble proteins.

Customer Reviews (2)

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Reviews
09/04/2021

    The purchased protein is suitable for WB experiments and I am satisfied with the results.

    05/17/2020

      The technical expert communicated with me in time to understand the progress of my experiment and gave me suggestions for improvement.

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