ADAM15
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Official Full Name
ADAM metallopeptidase domain 15
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Overview
The protein encoded by this gene is a member of the ADAM (a disintegrin and metalloproteinase) protein family. ADAM family members are type I transmembrane glycoproteins known to be involved in cell adhesion and proteolytic ectodomain processing of cytokines and adhesion molecules. This protein contains multiple functional domains including a zinc-binding metalloprotease domain, a disintegrin-like domain, as well as a EGF-like domain. Through its disintegrin-like domain, this protein specifically interacts with the integrin beta chain, beta 3. It also interacts with Src family protein-tyrosine kinases in a phosphorylation-dependent manner, suggesting that this protein may function in cell-cell adhesion as well as in cellular signaling. Multiple alternatively spliced transcript variants encoding distinct isoforms have been observed. [provided by RefSeq, Jul 2008] -
Synonyms
ADAM15; ADAM metallopeptidase domain 15; MDC15; disintegrin and metalloproteinase domain-containing protein 15; MDC-15; metalloprotease RGD disintegrin protein; a disintegrin and metalloproteinase domain 15 (metargidin); metalloproteinase-like, disintegrin-like, and cysteine-rich protein 15;
- Recombinant Proteins
- Cell & Tissue Lysates
- Human
- Mouse
- Mus musculus (Mouse)
- CHO
- E.coli
- E.coli expression system
- HEK293
- Human Cell
- In Vitro Cell Free System
- Wheat Germ
- GST
- His
- N/A
- Involved Pathway
- Protein Function
- Interacting Protein
- ADAM15 Related Articles
- ADAM15 Related Research Area
ADAM15 involved in several pathways and played different roles in them. We selected most pathways ADAM15 participated on our site, such as Degradation of the extracellular matrix, Extracellular matrix organization, which may be useful for your reference. Also, other proteins which involved in the same pathway with ADAM15 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name | Pathway Related Protein |
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Degradation of the extracellular matrix | ADAM9;MMP19;CTSL2;ADAMTS18;MMP12;ELANE;MMP20;CTSL1;FURINA |
Extracellular matrix organization | PRP;SERPINH1A;SERPINH1B;MGC174857;LOC100686744;MFAP3;LTBP4;COL8A2;MMP12 |
ADAM15 has several biochemical functions, for example, SH3 domain binding, integrin binding, metalloendopeptidase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by ADAM15 itself. We selected most functions ADAM15 had, and list some proteins which have the same functions with ADAM15. You can find most of the proteins on our site.
Function | Related Protein |
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SH3 domain binding | PLSCR3;SGIP1;PDCD6IP;SH3BP2;MAPK15;KHDRBS3;ENKUR;INPP5D;QK |
integrin binding | VCAM1;Npnt;CD226;EGFL6;TSPAN4;ITGA5;CD151;ICAM2;S1PR3 |
metalloendopeptidase activity | NLN;YME1L1B;ECEL1;ADAM10A;ADAM17;MMP3;ADAM1B;ADAM10B;MMP26 |
metallopeptidase activity | MMP13A;ADAMTS5;ADAMTSL1;PAPPA;ADAM23;ADAM9;HE2;MMP2;CHMP1A |
protein binding | CDYL2;NUBP1;DIXDC1;RPLP1;CARF;PTGES3;CLC;ICAM4;SGOL2 |
zinc ion binding | ALPI;ADAM15;MME;MATR3;WHSC1L1;PHF17;KPNB1;JADE3;RAI1 |
ADAM15 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ADAM15 here. Most of them are supplied by our site. Hope this information will be useful for your research of ADAM15.
SRC; PACSIN3; FYN; HCK; GRB2; SNX9; NUP62; SP4
- Q&As
- Reviews
Q&As (4)
Ask a questionADAM15 used in studies of liver and bladder cancers.
We offer MMP9 and MMP2 proteins in addition to ADAM15 proteins.
ADAM15 affects the proliferation of H460 cells by regulating PI3K-AKT and MAPK-ERK signaling pathways.
Addition of GST tags can accelerate the solubilization of certain insoluble proteins.
Customer Reviews (2)
Write a reviewThe purchased protein is suitable for WB experiments and I am satisfied with the results.
The technical expert communicated with me in time to understand the progress of my experiment and gave me suggestions for improvement.
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