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Recombinant Human ADAM15 protein, His-tagged

Cat.No. : ADAM15-1717H
Product Overview : Recombinant Human ADAM15 aa. (Ser505~Arg745) fused with N-terminal His tag was produced in E. coli cells.
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Description : The protein encoded by this gene is a member of the ADAM (a disintegrin and metalloproteinase) protein family. ADAM family members are type I transmembrane glycoproteins known to be involved in cell adhesion and proteolytic ectodomain processing of cytokines and adhesion molecules. This protein contains multiple functional domains including a zinc-binding metalloprotease domain, a disintegrin-like domain, as well as a EGF-like domain. Through its disintegrin-like domain, this protein specifically interacts with the integrin beta chain, beta 3. It also interacts with Src family protein-tyrosine kinases in a phosphorylation-dependent manner, suggesting that this protein may function in cell-cell adhesion as well as in cellular signaling. Multiple alternatively spliced transcript variants encoding distinct isoforms have been observed.
Source : E. coli
Species : Human
Tag : His
Form : Freeze-dried powder
Molecular Mass : 21kDa as determined by SDS-PAGE reducing conditions.
Protein length : Ser505~Arg745
Endotoxin : <1.0EU per 1ug (determined by the LAL method)
Purity : >95%
Applications : Positive Control; Immunogen; SDS-PAGE; WB.
Stability : The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37°C for 48h, and no obvious degradation and precipitation were observed. The loss rate is less than 5% within the expiration date under appropriate storage condition.
Storage : Avoid repeated freeze/thaw cycles. Store at 2-8°C for one month. Aliquot and store at -80°C for 12 months.
Concentration : 200μg/mL
Storage buffer : PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
Reconstitution : Reconstitute in 10mM PBS (pH7.4) to a concentration of 0.1-1.0 mg/mL. Do not vortex.
Isoelectric Point : 7.1
Gene Name : ADAM15 ADAM metallopeptidase domain 15 [ Homo sapiens (human) ]
Official Symbol : ADAM15
Synonyms : ADAM15; ADAM metallopeptidase domain 15; MDC15; disintegrin and metalloproteinase domain-containing protein 15; MDC-15; a disintegrin and metalloproteinase domain 15 (metargidin); metalloprotease RGD disintegrin protein; metalloproteinase-like, disintegrin-like, and cysteine-rich protein 15
Gene ID : 8751
mRNA Refseq : NM_001261464.1
Protein Refseq : NP_001248393.1
UniProt ID : Q13444

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (4)

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In addition to breast cancer research, what other diseases is ADAM15 currently used to study? 04/05/2022

ADAM15 used in studies of liver and bladder cancers.

I want to buy ADAM15-related proteins, do you provide other proteins? 10/09/2021

We offer MMP9 and MMP2 proteins in addition to ADAM15 proteins.

Does ADAM15 affect H460 expression? 06/26/2020

ADAM15 affects the proliferation of H460 cells by regulating PI3K-AKT and MAPK-ERK signaling pathways.

Does adding GST tag have any effect on protein? 12/13/2019

Addition of GST tags can accelerate the solubilization of certain insoluble proteins.

Customer Reviews (2)

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Reviews
09/04/2021

    The purchased protein is suitable for WB experiments and I am satisfied with the results.

    05/17/2020

      The technical expert communicated with me in time to understand the progress of my experiment and gave me suggestions for improvement.

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