Recombinant Human ADAM15 Protein (207-452 aa), GST-tagged

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Recombinant Human ADAM15 Protein (207-452 aa), GST-tagged

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Cat.No. : ADAM15-1186H
Product Overview : Recombinant Human ADAM15 Protein (207-452 aa) is produced by E. coli expression system. This protein is fused with a GST tag at the N-terminal. Research Area: Cancer. Protein Description: Partial.
Description : Active metalloproteinase with gelatinolytic and collagenolytic activity. Plays a role in the wound healing process. Mediates both heterotypic intraepithelial cell/T-cell interactions and homotypic T-cell aggregation. Inhibits beta-1 integrin-mediated cell adhesion and migration of airway smooth muscle cells. Suppresses cell motility on or towards fibronectin possibly by driving alpha-v/beta-1 integrin (ITAGV-ITGB1) cell surface expression via ERK1/2 inactivation. Cleaves E-cadherin in response to growth factor deprivation. Plays a role in glomerular cell migration. Plays a role in pathological neovascularization. May play a role in cartilage rodeling. May be proteolytically processed, during sperm epididymal maturation and the acrosome reaction. May play a role in sperm-egg binding through its disintegrin domain.
Source : E. coli
Species : Human
Tag : GST
Form : Tris-based buffer,50% glycerol
Molecular Mass : 53.6 kDa
Protein length : 207-452 aa
AA Sequence : DVVTETKTVE LVIVADHSEA QKYRDFQHLL NRTLEVALLL DTFFRPLNVR VALVGLEAWT QRDLVEISPN PAVTLENFLH WRRAHLLPRL PHDSAQLVTG TSFSGPTVGM AIQNSICSPD FSGGVNMDHS TSILGVASSI AHELGHSLGL DHDLPGNSCP CPGPAPAKTC IMEASTDFLP GLNFSNCSRR ALEKALLDGM GSCLFERLPS LPPMAAFCGN MFVEPGEQCD CGFLDDCVDP CCDSLT
Purity : > 90% as determined by SDS-PAGE.
Notes : Repeated freezing and thawing is not recommended. Store working aliquots at 4 centigrade for up to one week.
Storage : The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself. Generally, the shelf life of liquid form is 6 months at -20 centigrade/-80 centigrade. The shelf life of lyophilized form is 12 months at -20 centigrade/-80 centigrade.
Concentration : A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information.
Figure :

(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.

Gene Name : ADAM15 ADAM metallopeptidase domain 15 [ Homo sapiens ]
Official Symbol : ADAM15
Synonyms : ADAM15; MDC15; metargidin; MDC-15; ADAM 15;
Gene ID : 8751
mRNA Refseq : NM_003815
Protein Refseq : NP_003806
MIM : 605548
UniProt ID : Q13444

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