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Official Full Name ADAM metallopeptidase domain 22
Background This gene encodes a member of the ADAM (a disintegrin and metalloprotease domain) family. Members of this family are membrane-anchored proteins structurally related to snake venom disintegrins, and have been implicated in a variety of biological processes involving cell-cell and cell-matrix interactions, including fertilization, muscle development, and neurogenesis. Unlike other members of the ADAM protein family, the protein encoded by this gene lacks metalloprotease activity since it has no zinc-binding motif. This gene is highly expressed in the brain and may function as an integrin ligand in the brain. In mice, it has been shown to be essential for correct myelination in the peripheral nervous system. Alternative splicing results in several transcript variants.
Synonyms ADAM22; ADAM metallopeptidase domain 22; a disintegrin and metalloproteinase domain 22; disintegrin and metalloproteinase domain-containing protein 22; MDC2; metalloproteinase like; disintegrin like; and cysteine rich protein 2; and cysteine-rich protein 2; disintegrin-like; ADA22_HUMAN; ADAM 22; MDC 2; Metalloproteinase disintegrin ADAM22 3; Metalloproteinase like disintegrin like and cysteine rich protein 2; Metalloproteinase-disintegrin ADAM22-3; Metalloproteinase-like; MGC149832; OTTHUMP00000174585; OTTHUMP00000174587; OTTHUMP00000174588; OTTHUMP00000207170; OTTHUMP00000207298; metalloproteinase-like, disintegrin-like, and cysteine-rich protein 2
    • Species :
    • Chicken
    • Human
    • Mouse
    • Source :
    • E.coli
    • Mammalian Cell
    • Wheat Germ
    • Tag :
    • GST
    • His
    • T7
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human ADAM22-1750H Recombinant Human ADAM22 protein, His & T7-tagged E.coli His/T7
    Human ADAM22-24HCL Recombinant Human ADAM22 cell lysate N/A
    Human ADAM22-283H Recombinant Human ADAM22 Protein, GST-tagged Wheat Germ GST
    Mouse ADAM22-1286M Recombinant Mouse ADAM22 Protein Mammalian Cell His
    Chicken ADAM22-3914C Recombinant Chicken ADAM22 Mammalian Cell His

    ADAM22 involved in several pathways and played different roles in them. We selected most pathways ADAM22 participated on our site, such as Developmental Biology, LGI-ADAM interactions, which may be useful for your reference. Also, other proteins which involved in the same pathway with ADAM22 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Developmental Biology EFNB2; ANK2B; ARHGEF28; TCF3B; COL6A1; MED10; MED19; ITGB3A; PEA15; ITSN1
    LGI-ADAM interactions LGI1A; LGI2; STX1B; LGI1; LGI1B; LGI2B; CACNG2B; LGI2A; ADAM22; ADAM23

    ADAM22 has several biochemical functions, for example, integrin binding, metalloendopeptidase activity, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by ADAM22 itself. We selected most functions ADAM22 had, and list some proteins which have the same functions with ADAM22. You can find most of the proteins on our site.

    Function Related Protein
    integrin binding ICAM1; CD226; ADAM25; CD151; LAMA5; ESM1; TLN1; THBS4; ECM2; P4HB
    metalloendopeptidase activity ADAM17A; PMPCB; ECE2; Adamts19; ADAMTSL5; ADAM22; Adam6; MMP14A; MME; MMP23BB
    protein binding FKBP6; SEMG1; PRKAG1; DCLRE1B; ZNF207; YIPF2; BCL2A1; BTG1; GLYAT; PPM1A
    zinc ion binding SP140L; CXXC5; LIMCH1; AGBL3; TRIM35-27; NR1D2; ALAD; CSRP3; CPE; CA8

    ADAM22 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ADAM22 here. Most of them are supplied by our site. Hope this information will be useful for your research of ADAM22.


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