Recombinant Human ADAM22 Protein, GST-tagged

• Cat.No.: ADAM22-283H
• Product Overview: Human ADAM22 full-length ORF ( AAH36029.1, 1 a.a. - 342 a.a.) recombinant protein with GST-tag at N-terminal.

Specification

• Description: This gene encodes a member of the ADAM (a disintegrin and metalloprotease domain) family. Members of this family are membrane-anchored proteins structurally related to snake venom disintegrins, and have been implicated in a variety of biological processes involving cell-cell and cell-matrix interactions, including fertilization, muscle development, and neurogenesis. Unlike other members of the ADAM protein family, the protein encoded by this gene lacks metalloprotease activity since it has no zinc-binding motif. This gene is highly expressed in the brain and may function as an integrin ligand in the brain. In mice, it has been shown to be essential for correct myelination in the peripheral nervous system. Alternative splicing results in several transcript variants.[provided by RefSeq, Dec 2010]
• Source: Wheat Germ
• Species: Human
• Tag: GST
• Molecular Mass: 65.9 kDa
• AA Sequence: MQAAVAVSVPFLLLCVLGTCPPARC GQAGDASLMELEKRKENRFVERQSI VPLRLIYRSGGEDESRHDALDTRVR GDVGGPQLTHVDQASFQVDAFGTSF ILDVVLNHDLLSSEYIERHIEHGGK TVEVKGGEHCYYQGHIRGNPDSFVA LSTCHGLHGMFYDGNHTYLIEPEEN DTTQEDFHFHSVYKSRLFEFSLDDL PSEFQQVNITPSKFILKPRPKRSKR QLRRYPRNVEEETKYIELMIVNDHL MFKKHRLSVVHTNTYAKSVVNMADL IYKDQLKTRIVLVAMETWATDNKFA ISENPLITLREFMKYRRDFIKEKSD AVHLFSYVTSVMMYYFF
• Applications: Enzyme-linked Immunoabsorbent Assay
  Western Blot (Recombinant protein)
  Antibody Production
  Protein Array
• Notes: Best use within three months from the date of receipt of this protein.
• Storage: Store at -80 centigrade. Aliquot to avoid repeated freezing and thawing.
• Storage Buffer: 50 mM Tris-HCI, 10 mM reduced Glutathione, pH=8.0 in the elution buffer.

Gene Information

• Gene Name: ADAM22 ADAM metallopeptidase domain 22 [ Homo sapiens ]
• Official Symbol: ADAM22
• Synonyms: ADAM22; ADAM metallopeptidase domain 22; a disintegrin and metalloproteinase domain 22; disintegrin and metalloproteinase domain-containing protein 22; MDC2; metalloproteinase like; disintegrin like; and cysteine rich protein 2; metalloproteinase-disintegrin ADAM22-3; metalloproteinase-like, disintegrin-like, and cysteine-rich protein 2; ADAM 22; MGC149832
• Gene ID: 53616
• mRNA Refseq: NM_004194
• Protein Refseq: NP_004185
• MIM: 603709
• UniProt ID: Q9P0K1