ADCYAP1R1

  • Official Full Name

    adenylate cyclase activating polypeptide 1 (pituitary) receptor type I

  • Overview

    This gene encodes type I adenylate cyclase activating polypeptide receptor, which is a membrane-associated protein and shares significant homology with members of the secretin receptor family. This receptor mediates diverse biological actions of adenylate cyclase activating polypeptide 1 and is positively coupled to adenylate cyclase. Multiple alternatively spliced transcript variants encoding distinct isoforms have been identified. [provided by RefSeq, Dec 2010]
  • Synonyms

    ADCYAP1R1; adenylate cyclase activating polypeptide 1 (pituitary) receptor type I; PAC1; PAC1R; PACAPR; PACAPRI; pituitary adenylate cyclase-activating polypeptide type I receptor; PACAP-R1; PACAP receptor 1; PACAP type I receptor; pituitary adenylate cyclase activating polypeptide 1 receptor type I Hiphop;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Antibody
  • Protein Pre-coupled Magnetic Beads
  • Assay Kits
  • Bos taurus (Bovine)
  • Chicken
  • Homo sapiens (Human)
  • Human
  • Mus musculus (Mouse)
  • Rat
  • Rattus norvegicus (Rat)
  • E.coli expression system
  • HEK293
  • Human Cell
  • Mammalian Cell
  • Wheat Germ
  • Fc
  • GST
  • His
  • His (Fc)
  • Avi
  • N/A
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human ADCYAP1R1-510H Recombinant Human ADCYAP1R1 Protein, Fc-tagged HEK293 Fc
Human ADCYAP1R1-335H Recombinant Human ADCYAP1R1 Protein, GST-tagged Wheat Germ GST
Human ADCYAP1R1-1642HCL Recombinant Human ADCYAP1R1 cell lysate Human Cell N/A
Human ADCYAP1R1-28657TH Recombinant Human ADCYAP1R1 Wheat Germ N/A 100 amino acids
Rat ADCYAP1R1-521R Recombinant Rat ADCYAP1R1 Protein Mammalian Cell His
Rat ADCYAP1R1-177R Recombinant Rat ADCYAP1R1 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rat ADCYAP1R1-177R-B Recombinant Rat ADCYAP1R1 Protein Pre-coupled Magnetic Beads HEK293
Bos taurus (Bovine) RFL12979BF Recombinant Full Length Bovine Pituitary Adenylate Cyclase-Activating Polypeptide Type I Receptor(Adcyap1R1) Protein, His-Tagged E.coli expression system His Full Length of Mature Protein (38-513)
Homo sapiens (Human) RFL-34483HF Recombinant Full Length Human Pituitary Adenylate Cyclase-Activating Polypeptide Type I Receptor(Adcyap1R1) Protein, His-Tagged E.coli expression system His Full Length (21-468)
Mus musculus (Mouse) RFL-15503MF Recombinant Full Length Mouse Pituitary Adenylate Cyclase-Activating Polypeptide Type I Receptor(Adcyap1R1) Protein, His-Tagged E.coli expression system His Full Length (21-496)
Rattus norvegicus (Rat) RFL-6534RF Recombinant Full Length Rat Pituitary Adenylate Cyclase-Activating Polypeptide Type Ia Receptor(Adcyap1R1) Protein, His-Tagged E.coli expression system His Full Length of Mature Protein (20-523)
Chicken ADCYAP1R1-3708C Recombinant Chicken ADCYAP1R1 Mammalian Cell His
Kit-2175 ADCYAP1R1 CHO-K1 β-Arrestin GPCR Assay Kit N/A
Kit-0908 CYP2C19 Blue Screening Kit N/A
Kit-1047 Collagenase (Collagen Degradation/Zymography) Assay Kit (Fluorometric) N/A
Kit-1103 Peroxidase Activity Colorimetric/Fluorometric Assay Kit N/A
Kit-1104 Maltose and Glucose Colorimetric/Fluorometric Assay Kit N/A
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • Other Resource

ADCYAP1R1 involved in several pathways and played different roles in them. We selected most pathways ADCYAP1R1 participated on our site, such as Activation of TRKA receptors, Circadian entrainment, Class B/2 (Secretin family receptors), which may be useful for your reference. Also, other proteins which involved in the same pathway with ADCYAP1R1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Activation of TRKA receptorsNTF7;ADORA2A;ADCYAP1;ADCYAP1R1
Circadian entrainmentPER3;ADCYAP1R1;PRKCB;CALM4;AKR1C1;CACNA1H;GRIN2D;CAMK2B;PLCB4
Class B/2 (Secretin family receptors)CD97;CRHR2;GHRH;RAMP2;EMR2;CALCB;GCGA;ADM2;PTHRP2
G alpha (s) signalling eventsRAMP3;NPSR1;ADORA2A;GPBAR1;GHRH;RAMP2;ADM2A;ADM;RLN3A
GPCR downstream signalingGPBAR1;RGS7;UTS2;RGS12;NMBA;QRFP;CNR2;ADRA2B;PROKR1A
GPCR ligand bindingCGA;CALCA;CCR8;S1PR3;NMBB;OPN1LW;GPR37L1;EDN2;RCA2.1
GPCRs, Class B Secretin-likeADCYAP1R1;CRHR2;CD97;EMR2;CRHR1;LPHN1;ELTD1;CALCRL;EMR1

ADCYAP1R1 has several biochemical functions, for example, ADP-ribosylation factor binding, adenylate cyclase binding, neuropeptide binding. Some of the functions are cooperated with other proteins, some of the functions could acted by ADCYAP1R1 itself. We selected most functions ADCYAP1R1 had, and list some proteins which have the same functions with ADCYAP1R1. You can find most of the proteins on our site.

Function Related Protein
ADP-ribosylation factor bindingSORL1;RAB11FIP4A;GRASP;RAB11FIP4B;RAB11FIP4;RAB11FIP3;GGA3;GGA2;ADCYAP1R1
adenylate cyclase bindingADRB2;AKAP5;AKAP12;CALM3;ADCYAP1R1;CALM2;CALM1;CHRNA7;AKAP6
neuropeptide bindingPTGDR2;OPRM1;SSTR2;MC3R;OPRL1;NPY8BR;SSTR1;ADCYAP1R1;NPBWR2
protein bindingKCTD15;ATP1B2;CCDC170;TMEM64;HIP1;FLI1;ZFPL1;EIF2B5;PPP2CB
receptor activityCHRM3;THBD;EPHB6;PVR;EIF2D;VMN1R47;TLR1;TNFRSF17;PVRL1B
vasoactive intestinal polypeptide receptor activityADCYAP1R1;VIPR1;ADCYAP1R1A;VIPR2;GHRHRL;VIPR1B

ADCYAP1R1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ADCYAP1R1 here. Most of them are supplied by our site. Hope this information will be useful for your research of ADCYAP1R1.

CALM1

Gene Family

GPCRs

Research Area

Related articles

Anderson, ST; Kusters, DHL; et al. Expression of pituitary adenylate cyclase activating polypeptide type 1 receptor (PAC1R) in the ewe hypothalamus: Distribution and colocalization with tyrosine hydroxylase-immunoreactive neurones. JOURNAL OF NEUROENDOCRINOLOGY 17:298-305(2005).
Joo, KM; Chung, YH; et al. Distribution of vasoactive intestinal peptide and pituitary adenylate cyclase-activating polypeptide receptors (VPAC(1), VPAC(2), and PAC(1) receptor) in the rat brain. JOURNAL OF COMPARATIVE NEUROLOGY 476:388-413(2004).
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Is ADCYAP1R1 protein therapy currently approved for use in the treatment of mental health disorders? 10/28/2021

ADCYAP1R1 protein therapy is not currently approved by the FDA for the treatment of mental health disorders. It is still in the experimental stages of development and clinical trials.

What are the potential side effects of ADCYAP1R1 protein therapy for anxiety disorders? 09/28/2021

Side effects of ADCYAP1R1 protein therapy may include injection site reactions, fatigue, and dizziness. However, side effects are generally mild and resolve quickly.

In which specific populations might ADCYAP1R1 protein therapy be particularly effective in treating mental health disorders? 08/27/2020

ADCYAP1R1 protein therapy may be particularly effective in treating mental health disorders in individuals who have not responded to or cannot tolerate standard treatments such as psychotherapy or medication. Additionally, it may be effective in individuals with PTSD or depression who have elevated levels of stress hormones. Further research is needed to identify specific patient populations who may benefit from this treatment.

What are some of the challenges associated with developing and using ADCYAP1R1 protein therapy in the treatment of mental health disorders? 08/20/2020

One of the main challenges associated with the development and use of ADCYAP1R1 protein therapy is the need for further research to determine its therapeutic potential and safety. Additionally, there may be issues related to cost and access to this type of treatment.

How is ADCYAP1R1 protein therapy administered? 06/29/2020

ADCYAP1R1 protein therapy is administered through intravenous injection, nasal spray, or subcutaneous injection.

Are there any alternative treatments for mental health disorders that work similarly to ADCYAP1R1 protein therapy? 06/26/2020

Currently, there are no alternative treatments that work similarly to ADCYAP1R1 protein therapy. However, there are other treatments such as medication, therapy, and lifestyle changes that have been shown to be effective in the treatment of mental health disorders.

Is ADCYAP1R1 protein therapy a cure for mental health disorders? 12/14/2019

ADCYAP1R1 protein therapy is not a cure for mental health disorders. It is a potential treatment option that may provide relief from symptoms and improve quality of life for individuals with certain conditions. Regular and ongoing treatment may be necessary for long-term management of mental health disorders.

How long does it take for ADCYAP1R1 protein therapy to start working in the treatment of mental health disorders? 08/06/2019

The time it takes for ADCYAP1R1 protein therapy to start working can vary among individuals, and studies examining its efficacy are ongoing. However, some studies have shown that improvements in symptoms may be seen within the first weeks of treatment.

Is ADCYAP1R1 protein therapy effective for all types of anxiety disorders? 04/12/2019

ADCYAP1R1 protein therapy has shown promising results in the treatment of generalized anxiety disorder. However, more research is needed to determine its effectiveness for other types of anxiety disorders, such as panic disorder or social anxiety disorder.

What conditions can ADCYAP1R1 protein therapy potentially treat? 01/09/2019

ADCYAP1R1 protein therapy has shown potential for treating mental health conditions such as anxiety, post-traumatic stress disorder (PTSD), and depression. It has also been studied for its potential use in the treatment of Parkinson's disease and chronic pain.

How does ADCYAP1R1 protein therapy work? 12/07/2018

ADCYAP1R1 protein therapy works by targeting a specific receptor in the brain called the pituitary adenylate cyclase-activating polypeptide type 1 receptor (PAC1R). This receptor is involved in many important brain processes, including stress response, mood regulation, and memory formation.

Is ADCYAP1R1 protein therapy a first-line treatment for anxiety disorders? 11/13/2018

ADCYAP1R1 protein therapy is not currently a first-line treatment for anxiety disorders. It is considered a second-line or adjunct treatment option for patients who have not responded to or cannot tolerate standard treatments such as antidepressants or benzodiazepines.

What are the potential benefits of ADCYAP1R1 protein therapy? 09/10/2017

The potential benefits of ADCYAP1R1 protein therapy include the reduction of anxiety symptoms, such as excessive worry, restlessness, and difficulty sleeping.

What are the side effects of ADCYAP1R1 protein therapy? 02/20/2015

The side effects of ADCYAP1R1 protein therapy are not well-known because it is still in the experimental stages of development. However, potential side effects could include headache, fatigue, nausea, and allergic reactions.

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