ADSL
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Official Full Name
adenylosuccinate lyase
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Overview
Adenylsuccinate lyase is involved in both de novo synthesis of purines and formation of adenosine monophosphate from inosine monophosphate. It catalyzes two reactions in AMP biosynthesis: the removal of a fumarate from succinylaminoimidazole carboxamide (SAICA) ribotide to give aminoimidazole carboxamide ribotide (AICA) and removal of fumarate from adenylosuccinate to give AMP. Adenylosuccinase deficiency results in succinylpurinemic autism, psychomotor retardation, and , in some cases, growth retardation associated with muscle wasting and epilepsy. Two transcript variants encoding different isoforms have been found for this gene. -
Synonyms
ADSL; adenylosuccinate lyase; Adenylosuccinase; AMPS; ASase; ASL; OTTHUMP00000199172; OTTHUMP00000199173; PUR8_HUMAN;
- Recombinant Proteins
- Cell & Tissue Lysates
- Protein Pre-coupled Magnetic Beads
- Chicken
- Human
- Mouse
- Zebrafish
- E.coli
- E.Coli or Yeast
- HEK293
- HEK293T
- Human
- In Vitro Cell Free System
- Mammalian Cell
- Wheat Germ
- GST
- His
- His (Fc)
- Avi
- Strep
- Myc
- DDK
- MYC
- N/A
- N
- No tag
- Involved Pathway
- Protein Function
- Interacting Protein
- ADSL Related Articles
ADSL involved in several pathways and played different roles in them. We selected most pathways ADSL participated on our site, such as Alanine, aspartate and glutamate metabolism, Biosynthesis of antibiotics, Metabolic pathways, which may be useful for your reference. Also, other proteins which involved in the same pathway with ADSL were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Alanine, aspartate and glutamate metabolism | ALDH4A1;GOT1;ADSSL1;ALDH5A1;GAD1B;GPT2;AGXTB;GPT;ybaS |
| Biosynthesis of antibiotics | DAO1;EHHADH;PAICS;ADH5;ACAA2;SDS;AGXT;ECHS1;DAO |
| Metabolic pathways | Nat3;LASS5;ATP6V1G3;GMDS;PYGMA;SPRA;GATM;MTAP;ADH2-1 |
| Metabolism | BSG;SLC25A20;OXSR1;CYP2N13;CHKA;TPTE;IVD;NOSIP;CYP8B2 |
| Metabolism of nucleotides | ADSSL1;PAICS;NUDT15;PNP5B;DGUOK;DUT;ADAL;DPYD;GRX2 |
| Nucleotide Metabolism | OAZ1;ADSL;MTHFD2;ADSS |
| Purine metabolism | ADCY1A;NPR2;ADSS;APRT;ENTPD4;PDE5AB;GMPR2;RRM2B;ADPRM |
| Purine ribonucleoside monophosphate biosynthesis | PAICS;ADSSL1;ADSL;ADSS |
ADSL has several biochemical functions, for example, (S)-2-(5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamido)succinate AMP-lyase (fumarate-forming) activity, N6-(1,2-dicarboxyethyl)AMP AMP-lyase (fumarate-forming) activity, NOT N6-(1,2-dicarboxyethyl)AMP AMP-lyase (fumarate-forming) activity. Some of the functions are cooperated with other proteins, some of the functions could acted by ADSL itself. We selected most functions ADSL had, and list some proteins which have the same functions with ADSL. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| (S)-2-(5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamido)succinate AMP-lyase (fumarate-forming) activity | |
| N6-(1,2-dicarboxyethyl)AMP AMP-lyase (fumarate-forming) activity | |
| NOT N6-(1,2-dicarboxyethyl)AMP AMP-lyase (fumarate-forming) activity |
ADSL has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ADSL here. Most of them are supplied by our site. Hope this information will be useful for your research of ADSL.
USP4; DDA1; USP15; NOV
- Q&As
- Reviews
Q&As (10)
Ask a questionGenetic variations or mutations in the Adsl gene can affect the stability or function of Adsl protein, leading to metabolic disorders like Adenylosuccinate Lyase Deficiency.
Adsl protein can interact with other proteins and form complexes, including the formation of multiprotein complexes involved in purine metabolism.
The enzymatic activity and substrate specificity of Adsl protein are attributed to its unique structural features, including conserved domains and active sites.
Experimental techniques such as enzymatic assays and substrate analysis have been used to characterize the enzymatic activity of Adsl protein.
Currently, there are no specific pharmacological agents targeting Adsl protein. However, understanding its regulation and functional implications may lead to the development of potential therapeutic approaches for related conditions.
Adsl protein is primarily involved in the de novo synthesis of purine nucleotides and participates in the purine salvage pathway.
The cellular localization of Adsl protein is primarily in the cytoplasm, but it can also be found in the nucleus under specific conditions.
Dysregulation or dysfunction of Adsl protein can disrupt purine metabolism, leading to metabolic disorders such as Adenylosuccinate Lyase Deficiency, which affects neurological and developmental processes.
The expression of Adsl protein is regulated at both the transcriptional and post-transcriptional levels by various factors, such as transcription factors and microRNAs.
Adsl protein activity can be modulated by cellular factors and cofactors, including magnesium ions and ATP.
Customer Reviews (3)
Write a reviewExploring protein-protein interactions involved in apoptosis signaling.
Characterizing protein-protein interactions involved in cancer progression.
Determining protein-protein interaction interfaces using X-ray crystallography.
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