AGO1
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Official Full Name
argonaute RISC catalytic component 1
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Overview
This gene encodes a member of the Argonaute family of proteins which play a role in RNA interference. The encoded protein is highly basic, and contains a PAZ domain and a PIWI domain. It may interact with dicer1 and play a role in short-interfering-RNA-mediated gene silencing. This gene is located on chromosome 1 in a cluster of closely related family members including argonaute 3, and argonaute 4. [provided by RefSeq, Jul 2008] -
Synonyms
AGO1; argonaute RISC catalytic component 1; Q99; EIF2C; EIF2C1; GERP95; protein argonaute-1; hAgo1; eIF2C 1; eIF-2C 1; argonaute1; argonaute 1; putative RNA-binding protein Q99; Golgi Endoplasmic Reticulum protein 95 kDa; eukaryotic translation initiation factor 2C, 1;
| Species | Cat.# | Product name | Source (Host) | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| Human | AGO1-3161H | Recombinant Human AGO1 Protein, GST-tagged | Wheat Germ | GST |
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| Human | AGO1-1393H | Recombinant Human AGO1 protein, His & T7-tagged | E.coli | His/T7 | Cys689~Ala857 (Accession # Q9UL18) |
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| Human | AGO1-693HCL | Recombinant Human AGO1 cell lysate | Insect Cell | N/A |
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| Human | AGO1-4569HF | Recombinant Full Length Human AGO1 Protein, GST-tagged | In Vitro Cell Free System | GST | 857 amino acids |
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| Human | AGO1-1240H | Recombinant Human AGO1 protein, His-tagged | Insect Cells | His | Met1-Ala857 |
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- Involved Pathway
- Protein Function
- Interacting Protein
- AGO1 Related Articles
AGO1 involved in several pathways and played different roles in them. We selected most pathways AGO1 participated on our site, such as Adaptive Immune System, Beta-catenin independent WNT signaling, Ca2+ pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with AGO1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Adaptive Immune System | LAIR2;AGO2;KIF2B;FRS2A;IGKC;TRIM63;UBE2V2;RNF6;HBEGF |
| Beta-catenin independent WNT signaling | AP2S1;RYK;AGO1;ROR1;CLTC;AP2A2;CTNNB2;DVL1;DVL3 |
| Ca2+ pathway | MOV10;AGO2;AGO1;AGO3;GNB5 |
| Cellular Senescence | IGFBP7;CDKN2A;EHMT2;HIST1H1C;HIST1H1A;H1F0;CEBPB;HIST1H1B;RBBP7 |
| Cellular responses to stress | LC3;ACD;PRDX2;ATG7;CDKN2C;AMBRA1;HIST1H1E;SUZ12B;NUP50 |
| DAP12 interactions | DUSP5;SPTBN2;RASGRP4;CSF2RB;SPTBN1;AHCYL1;SPTB;FGF10B;NRG4 |
| DAP12 signaling | PEBP1;FRS3;IL17RD;FGF8B;JAK1;THEM4;DUSP10;DUSP5;LCP2A |
| Downstream signal transduction | THEM4;DAB2IPB;DUSP9;FGF20A;SPRED1;DUSP2;SPTA1;SPRED3;RASGRP4 |
AGO1 has several biochemical functions, for example, RNA binding, RNA polymerase II core binding, RNA polymerase II core promoter proximal region sequence-specific DNA binding. Some of the functions are cooperated with other proteins, some of the functions could acted by AGO1 itself. We selected most functions AGO1 had, and list some proteins which have the same functions with AGO1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| RNA binding | DZIP3;KHDC3;ADARB2;MCTS2;EIF2S2;PPARGC1A;ZNF638;HNRNPH2;ILF3B |
| RNA polymerase II core binding | SMYD3;ZNF326;SMYD2;PCF11;AGO1;CDC73;CTR9;WACA;KIAA1530 |
| RNA polymerase II core promoter proximal region sequence-specific DNA binding | ARID3B;TLX1;TFAP2A;POU1F1;SNAI3;HOXA10;RBPJA;AEBP2;ZNF217 |
| core promoter binding | SAFB;E2F2;HDAC4;MYOG;E2F8;FOXP3;E2F7;HDAC2;NKX3-1 |
| double-stranded RNA binding | DHX58;OAS1B;TLR8;OAS1;HMGB1;ZNF346;DHX15;BARHL1;HSP90AB1 |
| NOT endoribonuclease activity | |
| miRNA binding | AGO4;TARBP2;LIN28A;SOX2;MEF2C;AGO2;AGO3;EIF2C3;RBM4 |
| poly(A) RNA binding | DDX27;GSPT2;RPUSD4;RBM22;GTPBP4;RPL26;RBBP6;NKAP;EMG1 |
| protein binding | FAM72A;NLRC5;PEX2;U2AF2;MAPK9;KIF27;MESDC1;FZD5;NUDT22 |
| single-stranded RNA binding | CBX4;CBX8;JMJD6;NXF1;ENDOV;LSM14A;A1CF;DHX58;AGO1 |
AGO1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with AGO1 here. Most of them are supplied by our site. Hope this information will be useful for your research of AGO1.
DICER1; TNRC6A; HSP90AB1; PABPC1; TARBP2; IPO8
- Q&As
- Reviews
Q&As (21)
Ask a questionAGO1’s activity impacts neuronal development and synaptic plasticity.
AGO1 helps control gene expression by degrading or inhibiting mRNA translation.
AGO1 dysfunction is linked to disorders involving impaired gene regulation.
Research explores AGO1’s role in guiding small RNAs to their target sequences.
Yes, AGO1’s activity leads to the suppression or degradation of target mRNAs.
Yes, AGO1’s function is linked to post-transcriptional regulation of circadian genes.
Yes, AGO1 is part of the antiviral RNA interference pathway.
Yes, AGO1’s function is important for maintaining stem cell populations.
Yes, AGO1 is involved in suppressing transposable element activity.
AGO1 participates in RNA quality control mechanisms, preventing aberrant RNA transcripts.
Research explores AGO1’s contribution to targeting RNAs for exosome-mediated decay.
Research explores how AGO1 guides small RNAs to complementary target mRNA sequences.
Yes, AGO1 is involved in regulating immune responses through gene silencing.
Yes, AGO1’s activity can influence heterochromatin formation and genome stability.
Research investigates AGO1’s connection to chromatin remodeling complexes.
Yes, AGO1’s role extends to epigenetic regulation through RNA-directed DNA methylation.
AGO1’s activity leads to translational repression through mRNA cleavage or inhibition.
Yes, AGO1’s activity can be regulated in response to cellular stress.
Yes, AGO1 is essential for normal development and cellular processes.
Yes, AGO1’s role in gene regulation is relevant in cancer studies.
Research investigates AGO1’s role in regulating germline development and fertility.
Customer Reviews (5)
Write a reviewThe protein product consistently yielded the expected outcomes, bolstering our experimental results.
Notable improvements in cell proliferation were attributed to the protein product’s efficacy.
Minimal background noise in our assays indicated the protein product’s quality.
We observed a significant enhancement in enzyme activity using the protein product.
Reliable protein-protein interaction studies were enabled by the protein product’s pure composition.
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