AGO1
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Official Full Name
argonaute RISC catalytic component 1 -
Overview
This gene encodes a member of the Argonaute family of proteins which play a role in RNA interference. The encoded protein is highly basic, and contains a PAZ domain and a PIWI domain. It may interact with dicer1 and play a role in short-interfering-RNA-mediated gene silencing. This gene is located on chromosome 1 in a cluster of closely related family members including argonaute 3, and argonaute 4. [provided by RefSeq, Jul 2008] -
Synonyms
AGO1;argonaute RISC catalytic component 1;Q99;EIF2C;EIF2C1;GERP95;protein argonaute-1;hAgo1;eIF2C 1;eIF-2C 1;argonaute1;argonaute 1;putative RNA-binding protein Q99;Golgi Endoplasmic Reticulum protein 95 kDa;eukaryotic translation initiation factor 2C, 1
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| AGO1-1393H | Recombinant Human AGO1 protein, His & T7-tagged | E.coli | Human | His&T7 | Cys689~Ala857 |
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| AGO1-693HCL | Recombinant Human AGO1 cell lysate | Insect Cells | Human | Non |
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| AGO1-4569HF | Recombinant Full Length Human AGO1 Protein, GST-tagged | In Vitro Cell Free System | Human | GST | Full L. 857 amino acids |
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Involved Pathway
AGO1 involved in several pathways and played different roles in them. We selected most pathways AGO1 participated on our site, such as Adaptive Immune System,Beta-catenin independent WNT signaling,Ca2+ pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with AGO1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Cellular responses to stress | RNF2,LC3,RB1CC1,CDKN2D,GABARAP,HTATIP,CEBPB,HMGA1-RS1,AMBRA1B,GABARAPL2 |
| Ca2+ pathway | AGO2,GNB5,MOV10,AGO3 |
| Cellular Senescence | MOV10,RAD50,HIST1H1E,TNIK,CDKN2A,SCMH1,POT1,HIST1H1B,TXN,CDK6 |
| DAP12 signaling | JAK3,PAQR3A,MOV10,LCP2A,DUSP4,DUSP9,RASGRP4,AGO2,CSF2RA,HBEGF |
| DAP12 interactions | KBTBD7,LAMTOR2,AHCYL1,AGO2,CD300LB,PRKAR1AA,FGFR1B,AGO3,NRG4,SPRED2 |
| Downstream signal transduction | MOV10,SPTB,AGO2,FRS2A,SPTBN1,DUSP9,FGFR1B,FGF18B,RASGRP4,PAQR3B |
| Beta-catenin independent WNT signaling | AGO2,PRICKLE1B,AGO3,AP2A2,CTNNB2,ROR2,DVL1,ITPR2,CLTA,DVL2 |
| Adaptive Immune System | LCP2A,NA,SIGLEC6,TREML4,RNF14,CREB1B,CTLA4,KIF15,DCTN6,UBE2V1 |
Protein Function
AGO1 has several biochemical functions, for example, RNA binding,RNA polymerase II core binding,RNA polymerase II core promoter proximal region sequence-specific DNA binding. Some of the functions are cooperated with other proteins, some of the functions could acted by AGO1 itself. We selected most functions AGO1 had, and list some proteins which have the same functions with AGO1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| core promoter binding | FOXO3,SAFB,PSPC1,INSM1B,ELK1,MYBBP1A,RB1,NONO,NPAS2,MED1 |
| single-stranded RNA binding | CBX6,HMGB1,LUZP4,IFIT5,CBX8,ENDOV,HNRNPF,LONP1,IFIH1,POLR2GL |
| double-stranded RNA binding | IFIH1,DROSHA,AGO2,MSN,BARHL1,OAS2,YRDC,MBNL1,CLTC,STAU2 |
| miRNA binding | SOX2,MEF2C,PNPT1,POU5F1,DICER1,RBM4,AGO3,AGO2,AGO4,TRIM71 |
| RNA polymerase II core promoter proximal region sequence-specific DNA binding | TCF7L2,KLF16,CC2D1A,FUBP3,BATF3,TFAM,SOX10,FIGLA,HNRNPC,GLI3 |
| poly(A) RNA binding | RBM12B2,ZCCHC7,WDR36,TIA1,SKIV2L2,GSPT2,GRN,PWP2,DHX38,KCTD12 |
| RNA binding | PUS10,DPPA5A,NABP1,PCBP2,CELF6,HNRPKL,HBP1,RNMTL1A,GTF3A,SPI1 |
| protein binding | RPS18,CD5,FMO4,DCDC2,SIP1,TTC19,NIF3L1,KCNJ10,PTPRE,GTF2I |
| RNA polymerase II core binding | ZFP326,SMYD2B,GTF2E1,SMYD2A,RECQL5,WAC,C14orf166,KIAA1530,KIAA1967,CDC73 |
Interacting Protein
AGO1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with AGO1 here. Most of them are supplied by our site. Hope this information will be useful for your research of AGO1.
DICER1;TNRC6A;HSP90AB1;PABPC1;TARBP2;IPO8
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References
- Laneve, P; Delaporte, C; et al. The Gcm/Glide molecular and cellular pathway: New actors and new lineages. DEVELOPMENTAL BIOLOGY 375:65-78(2013).
- Dallas, A; Ilves, H; et al. Right- and left-loop short shRNAs have distinct and unusual mechanisms of gene silencing. NUCLEIC ACIDS RESEARCH 40:9255-9271(2012).
