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AHR

  • Official Full Name

    aryl hydrocarbon receptor

  • Overview

    This gene encodes a ligand-activated transcription factor involved in the regulation of biological responses to planar aromatic hydrocarbons. This receptor has been shown to regulate xenobiotic-metabolizing enzymes such as cytochrome P450. Its ligands included a variety of aromatic hydrocarbons.
  • Synonyms

    AHR; aryl hydrocarbon receptor; bHLHe76; AH-receptor; ah receptor; aromatic hydrocarbon receptor; class E basic helix-loop-helix protein 76;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Antibody
  • Protein Pre-coupled Magnetic Beads
  • Chicken
  • Human
  • Mouse
  • Rat
  • E.coli
  • E.Coli or Yeast
  • HEK293
  • In Vitro Cell Free System
  • Mammalian Cell
  • Sf9 Insect Cell
  • Wheat Germ
  • GST
  • His
  • His (Fc)
  • Avi
  • His|GST
  • N/A
  • N
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human AHR-109H Recombinant Human Aryl hydrocarbon receptor LBD/Hsp90 complex, GST-tagged Sf9 Insect Cell GST
Human AHR-9497H Recombinant Human AHR, His-tagged E.coli His 1-387a.a.
Human AHR-26267TH Recombinant Human AHR protein, GST-tagged Wheat Germ GST 1 a.a. - 848 a.a.
Human AhR-3644H Recombinant Human AhR, His-tagged E.coli His 848
Human AHR-120H Recombinant Human AHR protein, His-tagged E.coli His Val128~Asn399
Human AHR-8962HCL Recombinant Human AHR 293 Cell Lysate HEK293 N/A
Human AHR-26266TH Recombinant Human AHR Wheat Germ N/A 100 amino acids
Human AHR-3256H Recombinant Human AHR protein, His-tagged E.coli His 25-300 aa
Human AHR-603HF Recombinant Full Length Human AHR Protein, GST-tagged In Vitro Cell Free System GST 848 amino acids
Human AHR-0316H Recombinant Human AHR Protein (Val23-Gln273), N-His-tagged E.coli N-His Val23-Gln273
Mouse Ahr-3645M Recombinant Mouse Ahr, His-tagged E.Coli or Yeast His 805
Mouse Ahr-145M Recombinant Mouse Ahr protein, His/GST-tagged E.coli His/GST Val126~Gly385
Mouse AHR-1443M Recombinant Mouse AHR Protein Mammalian Cell His
Mouse AHR-405M Recombinant Mouse AHR Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mouse AHR-405M-B Recombinant Mouse AHR Protein Pre-coupled Magnetic Beads HEK293
Rat AHR-572R Recombinant Rat AHR Protein Mammalian Cell His
Rat Ahr-6846R Recombinant Rat Ahr protein, His-tagged E.coli His Val311~Thr579 (Accession # P41738)
Rat AHR-228R-B Recombinant Rat AHR Protein Pre-coupled Magnetic Beads HEK293
Rat AHR-228R Recombinant Rat AHR Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Chicken AHR-5694C Recombinant Chicken AHR Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • Other Resource

AHR involved in several pathways and played different roles in them. We selected most pathways AHR participated on our site, such as Adipogenesis, AhR pathway, Integrated Breast Cancer Pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with AHR were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
AdipogenesisEGR2B;FRZB;NAMPT;CFD;HMGA1-RS1;BSCL2;EPAS1B;GDF10;NCOA2
AhR pathwayCYP1A2;FLG;AHR;CDKN1B;NQO1;AHRR;JUN;CYP1B1;CDKN1A
Integrated Breast Cancer PathwayBACH1;ANXA1;SELK;RPP38;USP38;USP16;PLK3;EDAR;SMARCA4

AHR has several biochemical functions, for example, DNA binding, E-box binding, Hsp90 protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by AHR itself. We selected most functions AHR had, and list some proteins which have the same functions with AHR. You can find most of the proteins on our site.

Function Related Protein
DNA bindingNUPR1;THAP2;MECP2;POLDIP2;HMGN5;HER6;POLG2;PAX2B;LHX1B
E-box bindingNEUROD2;TFAP4;NEUROG1;C1orf51;PER1;CLOCK;ASCL1;ASCL2;ARNTL2
Hsp90 protein bindingSTUB1;PPID;AHR;TELO2;EIF2AK3;PPEF2;NPAS2;GBP1;CHORDC1
RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA bindingPPARAA;RORAB;RORAA;PPARDB;NR4A1;HNF4G;NR1I2;NR5A5;NR1H4
enhancer bindingLEF1;ARNT;SMAD3;TCF3;AHR;TIPARP;SP1;SMAD2;SOX9
protein bindingNAGK;DEFB121;ECSIT;RAB39A;MPPE1;NAT2;LATS1;TCOF1;EIF2S2
protein dimerization activityTCF21;ARNTL1B;PTF1A;PRDX5;TXLNB;TCF23;MYCN;STAT5B;HER4.3
protein heterodimerization activityBRAF;ARNT;YWHAH;UGT1A6B;HIST1H47;HIST4H4;NTSR1;PVRL1;UGT1A2
sequence-specific DNA bindingHOXB6B;SPI1B;NKX2.5;HNF1B;ZKSCAN14;HOXA9;GRHL1;NFIL3-6;ZNF263
transcription factor activity, RNA polymerase II distal enhancer sequence-specific bindingPROX1;PDX1;OLIG2;TFAP4;FOXC2;FOXP3;NFATC1;NKX2-1;FOXC1
transcription factor activity, sequence-specific DNA bindingTAF5L;MECP2;POU3F3;ZNF239;HOXA2B;FOXC1B;ZXDC;NR1D4B;TBX5A
transcription factor bindingJUN;ENPP2;PPP1R13BA;TCF7L2;GTF2A1;ERCC3;UBN1;HMGB2;PPARG
transcription regulatory region DNA bindingHNRNPL;FOXM1;ARRB1;SMAD4;SALL1A;ATF4;HDAC1;SALL3;KLF4

AHR has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with AHR here. Most of them are supplied by our site. Hope this information will be useful for your research of AHR.

EBNA3; ARNT; NCOA7; NCOR2; AIP; MAF; RB1

Research Area

Related articles

Kim, JY; Sohn, JH; et al. Obesity Increases Airway Hyperresponsiveness via the TNF-alpha Pathway and Treating Obesity Induces Recovery. PLOS ONE 10:-(2015).
  • Q&As
  • Reviews

Q&As (10)

Ask a question
What are the genetic and epigenetic factors that regulate AHR expression and function? 12/19/2022

The expression and function of AHR can be influenced by genetic polymorphisms, DNA methylation patterns, and histone modifications, which may have implications in individual susceptibility to environmental toxins.

How is AHR involved in skin biology and the response to environmental toxins? 09/28/2022

AHR is expressed in skin cells and plays a role in the response to environmental toxins, UV radiation, and the regulation of skin barrier function.

What is the role of AHR in embryonic development and organogenesis? 06/07/2022

AHR is essential for normal embryonic development and organogenesis. It participates in the patterning and differentiation of various organs, including the heart and vasculature.

Can AHR activation affect hormonal signaling pathways? 03/15/2022

Yes, AHR activation can interfere with hormonal signaling pathways, leading to cross-talk with estrogen receptor signaling, and affecting hormonal homeostasis.

How does AHR influence cellular proliferation and apoptosis? 12/06/2021

AHR can impact cell cycle progression and apoptosis by modulating the expression of genes involved in these processes, which can have implications in cancer biology.

What role does AHR play in the immune system and inflammation? 09/09/2021

AHR is involved in the regulation of immune responses and inflammation by affecting the differentiation and function of immune cells, such as T cells and dendritic cells.

How does AHR contribute to xenobiotic metabolism and detoxification? 06/25/2021

AHR activation induces the expression of cytochrome P450 enzymes, particularly CYP1A1 and CYP1B1, which metabolize and detoxify various environmental pollutants and xenobiotics.

What are the downstream targets of AHR signaling, and how is gene expression regulated by AHR? 03/04/2021

AHR forms a complex with co-activators or co-repressors upon ligand binding, leading to the modulation of gene expression. Downstream targets include cytochrome P450 enzymes (CYP1A1, CYP1B1), phase II detoxification enzymes, and cytokines.

How does AHR activation occur, and what are its endogenous ligands? 12/13/2020

AHR activation occurs upon binding to specific ligands, including polycyclic aromatic hydrocarbons (PAHs), halogenated aromatic hydrocarbons (HAHs), and tryptophan derivatives, such as indole-3-carbinol. Endogenous ligands are derived from cellular metabolism and the diet.

How is AHR activity regulated post-translationally, and what are the protein-protein interactions that modulate its function? 04/18/2018

AHR activity can be regulated through various post-translational modifications, including phosphorylation and ubiquitination. Protein-protein interactions with chaperones and co-regulators also influence AHR function.

Customer Reviews (5)

Write a review
Reviews
09/01/2022

    Thumbs up for this lab protein – it's top-notch!

    02/13/2022

      I'm loving this lab protein – it's a research game-changer.

      07/14/2021

        Five stars for this incredible lab protein – highly recommend.

        08/07/2018

          The lab protein's performance has exceeded our expectations, and its versatility has enabled diverse applications within our research scope.

          06/13/2018

            We've seen remarkable results with this lab protein.

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