AHR
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Official Full Name
aryl hydrocarbon receptor
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Overview
This gene encodes a ligand-activated transcription factor involved in the regulation of biological responses to planar aromatic hydrocarbons. This receptor has been shown to regulate xenobiotic-metabolizing enzymes such as cytochrome P450. Its ligands included a variety of aromatic hydrocarbons. -
Synonyms
AHR; aryl hydrocarbon receptor; bHLHe76; AH-receptor; ah receptor; aromatic hydrocarbon receptor; class E basic helix-loop-helix protein 76;
- Recombinant Proteins
- Cell & Tissue Lysates
- Antibody
- Protein Pre-coupled Magnetic Beads
- Chicken
- Human
- Mouse
- Rat
- E.coli
- E.Coli or Yeast
- HEK293
- In Vitro Cell Free System
- Mammalian Cell
- Sf9 Insect Cell
- Wheat Germ
- GST
- His
- Fc
- Avi
- Non
- Involved Pathway
- Protein Function
- Interacting Protein
- Other Resource
AHR involved in several pathways and played different roles in them. We selected most pathways AHR participated on our site, such as Adipogenesis, AhR pathway, Integrated Breast Cancer Pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with AHR were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Adipogenesis | STIL;NR2F1A;DLK1;NRIP1;EGR2;AGPAT2;AHR;GATA2A;HMGA1 |
| AhR pathway | FLG;NQO1;CYP1B1;AHRR;PTGES3;AHR;EGFR;JUND;CYP1A1 |
| Integrated Breast Cancer Pathway | JAKMIP1;ALKBH1;USP38;GDI1;MYT1;ANXA1;CCNB1IP1;GRN;NAB1 |
AHR has several biochemical functions, for example, DNA binding, E-box binding, Hsp90 protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by AHR itself. We selected most functions AHR had, and list some proteins which have the same functions with AHR. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| DNA binding | SYCP3;BACH1A;RPS15;POLE3;ZBTB37;NR1H3;MCM3AP;HIST1H2BL;POU5F2 |
| E-box binding | ASCL2;TWIST1;TAL1;MYOG;TCF4;SREBF2;GATA3;ZEB1;NEUROG1 |
| Hsp90 protein binding | TELO2;PPEF2;USP19;CDC37;HIF1A;ARNTL;ERBB2;UNC45A;HDAC6 |
| RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding | NR2F1B;PPARA;HNF4G;RXRB;AHR;RORCA;RORAA;NR2F2;NR0B1 |
| enhancer binding | TIPARP;SOX9;FOXH1;TCF12;SP1;ARNT;AHR;RAI1;MESP1 |
| protein binding | TAF7;STATH;PLRG1;SLX4IP;NOX5;TLR6;POLE4;LDLR;GSTM5 |
| protein dimerization activity | ZBED1;ASCL2;PDCD6;NEUROG3;HEY1;PIP;POLR1C;STX2;HER3 |
| protein heterodimerization activity | KCNH1;PPARD;CENPW;MID1;HOMER2;BOKA;CEBPB;HIST3H2BB;NEFH |
| sequence-specific DNA binding | FOXF2A;HIVEP2A;BCL11B;LHX3;NKX2-8;NFE2L2A;HOXA11A;GTF2E1;HOXB1A |
| transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding | GATA5;OLIG2;SOX10;RELA;SPI1;SRF;SRY;POU3F1;PTH |
| transcription factor activity, sequence-specific DNA binding | ZNF79;RORAA;ZNF71;FOXQ1A;GATA2A;DBPB;ZNF274;ZNF518A;PKNOX1 |
| transcription factor binding | NKX2-5;TCF12;ENPP2;FOXF2;IRF4;AHR;SIRT1;HDAC5;IFI16 |
| transcription regulatory region DNA binding | ZFP513;CREB3L1;GABPB1;DLX5;AHR;TRP53;ETV5;HDAC1;GLI1 |
AHR has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with AHR here. Most of them are supplied by our site. Hope this information will be useful for your research of AHR.
EBNA3; ARNT; NCOA7; NCOR2; AIP; MAF; RB1
Research Area
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Q&As (10)
Ask a questionThe expression and function of AHR can be influenced by genetic polymorphisms, DNA methylation patterns, and histone modifications, which may have implications in individual susceptibility to environmental toxins.
AHR is expressed in skin cells and plays a role in the response to environmental toxins, UV radiation, and the regulation of skin barrier function.
AHR is essential for normal embryonic development and organogenesis. It participates in the patterning and differentiation of various organs, including the heart and vasculature.
Yes, AHR activation can interfere with hormonal signaling pathways, leading to cross-talk with estrogen receptor signaling, and affecting hormonal homeostasis.
AHR can impact cell cycle progression and apoptosis by modulating the expression of genes involved in these processes, which can have implications in cancer biology.
AHR is involved in the regulation of immune responses and inflammation by affecting the differentiation and function of immune cells, such as T cells and dendritic cells.
AHR activation induces the expression of cytochrome P450 enzymes, particularly CYP1A1 and CYP1B1, which metabolize and detoxify various environmental pollutants and xenobiotics.
AHR forms a complex with co-activators or co-repressors upon ligand binding, leading to the modulation of gene expression. Downstream targets include cytochrome P450 enzymes (CYP1A1, CYP1B1), phase II detoxification enzymes, and cytokines.
AHR activation occurs upon binding to specific ligands, including polycyclic aromatic hydrocarbons (PAHs), halogenated aromatic hydrocarbons (HAHs), and tryptophan derivatives, such as indole-3-carbinol. Endogenous ligands are derived from cellular metabolism and the diet.
AHR activity can be regulated through various post-translational modifications, including phosphorylation and ubiquitination. Protein-protein interactions with chaperones and co-regulators also influence AHR function.
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