Creative BioMart to Present at
                        BIO-Europe Spring Creative BioMart to Present at AACR Annual Meeting|Apr. 5-10, 2024|Booth #2953

Recombinant Rat Ahr protein, His-tagged

Cat.No. : Ahr-6846R
Product Overview : Recombinant Rat Ahr aa. (Val311~Thr579 (Accession # P41738)) fused with N-terminal His tag was produced in E. coli cells.
  • Specification
  • Gene Information
  • Related Products
Source : E. coli
Species : Rat
Tag : His
Form : Freeze-dried powder
Molecular Mass : Predicted Molecular Mass: 32.1kDa.
Protein length : Val311~Thr579 (Accession # P41738)
Endotoxin : <1.0EU per 1ug (determined by the LAL method)
Purity : >95%
Characteristic : The isoelectric point is 5.6.
Applications : SDS-PAGE; WB; ELISA; IP.
Stability : The thermal stability is described by the loss rate of the target protein. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37°C for 48h, and no obvious degradation and precipitation were observed. (Referring from China Biological Products Standard, which was calculated by the Arrhenius equation.) The loss of this protein is less than 5% within the expiration date under appropriate storage condition.
Storage : Avoid repeated freeze/thaw cycles. Store at 2-8°C for one month. Aliquot and store at -80°C for 12 months.
Storage buffer : Supplied as lyophilized form in 20mM Tris, 500mM NaCl, pH8.0, containing 1mM EDTA, 1mM DTT, 0.01% sarcosyl, 5% trehalose, and preservative.
Reconstitution : Reconstitute in sterile PBS, pH7.2-pH7.4.
Gene Name : Ahr aryl hydrocarbon receptor [ Rattus norvegicus (Norway rat) ]
Official Symbol : Ahr
Synonyms : ah receptor; aryl hydrocarbon receptor
Gene ID : 25690
mRNA Refseq : NM_001308254.1
Protein Refseq : NP_001295183.1
UniProt ID : P41738

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

Inquiry

  • Q&As
  • Reviews

Q&As (10)

Ask a question
What are the genetic and epigenetic factors that regulate AHR expression and function? 12/19/2022

The expression and function of AHR can be influenced by genetic polymorphisms, DNA methylation patterns, and histone modifications, which may have implications in individual susceptibility to environmental toxins.

How is AHR involved in skin biology and the response to environmental toxins? 09/28/2022

AHR is expressed in skin cells and plays a role in the response to environmental toxins, UV radiation, and the regulation of skin barrier function.

What is the role of AHR in embryonic development and organogenesis? 06/07/2022

AHR is essential for normal embryonic development and organogenesis. It participates in the patterning and differentiation of various organs, including the heart and vasculature.

Can AHR activation affect hormonal signaling pathways? 03/15/2022

Yes, AHR activation can interfere with hormonal signaling pathways, leading to cross-talk with estrogen receptor signaling, and affecting hormonal homeostasis.

How does AHR influence cellular proliferation and apoptosis? 12/06/2021

AHR can impact cell cycle progression and apoptosis by modulating the expression of genes involved in these processes, which can have implications in cancer biology.

What role does AHR play in the immune system and inflammation? 09/09/2021

AHR is involved in the regulation of immune responses and inflammation by affecting the differentiation and function of immune cells, such as T cells and dendritic cells.

How does AHR contribute to xenobiotic metabolism and detoxification? 06/25/2021

AHR activation induces the expression of cytochrome P450 enzymes, particularly CYP1A1 and CYP1B1, which metabolize and detoxify various environmental pollutants and xenobiotics.

What are the downstream targets of AHR signaling, and how is gene expression regulated by AHR? 03/04/2021

AHR forms a complex with co-activators or co-repressors upon ligand binding, leading to the modulation of gene expression. Downstream targets include cytochrome P450 enzymes (CYP1A1, CYP1B1), phase II detoxification enzymes, and cytokines.

How does AHR activation occur, and what are its endogenous ligands? 12/13/2020

AHR activation occurs upon binding to specific ligands, including polycyclic aromatic hydrocarbons (PAHs), halogenated aromatic hydrocarbons (HAHs), and tryptophan derivatives, such as indole-3-carbinol. Endogenous ligands are derived from cellular metabolism and the diet.

How is AHR activity regulated post-translationally, and what are the protein-protein interactions that modulate its function? 04/18/2018

AHR activity can be regulated through various post-translational modifications, including phosphorylation and ubiquitination. Protein-protein interactions with chaperones and co-regulators also influence AHR function.

Customer Reviews (5)

Write a review
Reviews
09/01/2022

    Thumbs up for this lab protein – it's top-notch!

    02/13/2022

      I'm loving this lab protein – it's a research game-changer.

      07/14/2021

        Five stars for this incredible lab protein – highly recommend.

        08/07/2018

          The lab protein's performance has exceeded our expectations, and its versatility has enabled diverse applications within our research scope.

          06/13/2018

            We've seen remarkable results with this lab protein.

            Ask a Question for All Ahr Products

            Required fields are marked with *

            My Review for All Ahr Products

            Required fields are marked with *

            0

            Inquiry Basket

            cartIcon
            logo

            FOLLOW US

            Terms and Conditions        Privacy Policy

            Copyright © 2024 Creative BioMart. All Rights Reserved.

            Contact Us

            • /

            Stay Updated on the Latest Bioscience Trends