Recombinant Human AHR protein, GST-tagged
Cat.No. : | AHR-26267TH |
Product Overview : | Recombinant Human AHR(1 a.a. - 848 a.a.) fused with GST tag at N-terminal was expressed in Wheat Germ. |
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Source : | Wheat Germ |
Species : | Human |
Tag : | GST |
Form : | 50 mM Tris-HCI, 10 mM reduced Glutathione, pH=8.0 in the elution buffer. |
Molecular Mass : | 122.5 kDa |
Protein length : | 1 a.a. - 848 a.a. |
AA Sequence : | MNSSSANITYASRKRRKPVQKTVKP IPAEGIKSNPSKRHRDRLNTELDRL ASLLPFPQDVINKLDKLSVLRLSVS YLRAKSFFDVALKSSPTERNGGQDN CRAANFREGLNLQEGEFLLQALNGF VLVVTTDALVFYASSTIQDYLGFQQ SDVIHQSVYELIHTEDRAEFQRQLH WALNPSQCTESGQGIEEATGLPQTV VCYNPDQIPPENSPLMERCFICRLR CLLDNSSGFLAMNFQGKLKYLHGQK KKGKDGSILPPQLALFAIATPLQPP SILEIRTKNFIFRTKHKLDFTPIGC DAKGRIVLGYTEAELCTRGSGYQFI HAADMLYCAESHIRMIKTGESGMIV FRLLTKNNRWTWVQSNARLLYKNGR PDYIIVTQRPLTDEEGTEHLRKRNT KLPFMFTTGEAVLYEATNPFPAIMD PLPLRTKNGTSGKDSATTSTLSKDS LNPSSLLAAMMQQDESIYLYPASST SSTAPFENNFFNESMNECRNWQDNT APMGNDTILKHEQIDQPQDVNSFAG GHPGLFQDSKNSDLYSIMKNLGIDF EDIRHMQNEKFFRNDFSGEVDFRDI DLTDEILTYVQDSLSKSPFIPSDYQ QQQSLALNSSCMVQEHLHLEQQQQH HQKQVVVEPQQQLCQKMKHMQVNGM FENWNSNQFVPFNCPQQDPQQYNVF TDLHGISQEFPYKSEMDSMPYTQNF ISCNQPVLPQHSKCTELDYPMGSFE PSPYPTTSSLEDFVTCLQLPENQKH GLNPQSAIITPQTCYAGAVSMYQCQ PEPQHTHVGQMQYNPVLPGQQAFLN KFQNGVLNETYPAELNNINNTQTTT HLQPLHHPSEARPFPDLTSSGFL |
Applications : | Enzyme-linked Immunoabsorbent Assay; Western Blot (Recombinant protein); Antibody Production; Protein Array |
Notes : | Best use within three months from the date of receipt of this protein. |
Storage : | Store at -80 centigrade. Aliquot to avoid repeated freezing and thawing. |
Gene Name : | AHR aryl hydrocarbon receptor [ Homo sapiens ] |
Official Symbol : | AHR |
Synonyms : | AHR; aryl hydrocarbon receptor; bHLHe76; AH-receptor; ah receptor; aromatic hydrocarbon receptor; class E basic helix-loop-helix protein 76; |
Gene ID : | 196 |
mRNA Refseq : | NM_001621 |
Protein Refseq : | NP_001612 |
MIM : | 600253 |
UniProt ID : | P35869 |
Chromosome Location : | 7p15 |
Pathway : | Adipogenesis, organism-specific biosystem; |
Function : | DNA binding; DNA binding; Hsp90 protein binding; ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity; protein binding; protein dimerization activity; protein heterodimerization activity; receptor activity; sequence-specific DNA binding; sequence-specific DNA binding transcription factor activity; sequence-specific distal enhancer binding RNA polymerase II transcription factor activity; signal transducer activity; transcription factor binding; transcription regulatory region DNA binding; |
Products Types
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AHR-228R | Recombinant Rat AHR Protein, His (Fc)-Avi-tagged | +Inquiry |
AHR-9497H | Recombinant Human AHR, His-tagged | +Inquiry |
AHR-572R | Recombinant Rat AHR Protein | +Inquiry |
◆ Lysates | ||
AHR-8962HCL | Recombinant Human AHR 293 Cell Lysate | +Inquiry |
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For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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Customer Reviews (5)
Write a reviewThumbs up for this lab protein – it's top-notch!
I'm loving this lab protein – it's a research game-changer.
Five stars for this incredible lab protein – highly recommend.
The lab protein's performance has exceeded our expectations, and its versatility has enabled diverse applications within our research scope.
We've seen remarkable results with this lab protein.
Q&As (10)
Ask a questionThe expression and function of AHR can be influenced by genetic polymorphisms, DNA methylation patterns, and histone modifications, which may have implications in individual susceptibility to environmental toxins.
AHR is expressed in skin cells and plays a role in the response to environmental toxins, UV radiation, and the regulation of skin barrier function.
AHR is essential for normal embryonic development and organogenesis. It participates in the patterning and differentiation of various organs, including the heart and vasculature.
Yes, AHR activation can interfere with hormonal signaling pathways, leading to cross-talk with estrogen receptor signaling, and affecting hormonal homeostasis.
AHR can impact cell cycle progression and apoptosis by modulating the expression of genes involved in these processes, which can have implications in cancer biology.
AHR is involved in the regulation of immune responses and inflammation by affecting the differentiation and function of immune cells, such as T cells and dendritic cells.
AHR activation induces the expression of cytochrome P450 enzymes, particularly CYP1A1 and CYP1B1, which metabolize and detoxify various environmental pollutants and xenobiotics.
AHR forms a complex with co-activators or co-repressors upon ligand binding, leading to the modulation of gene expression. Downstream targets include cytochrome P450 enzymes (CYP1A1, CYP1B1), phase II detoxification enzymes, and cytokines.
AHR activation occurs upon binding to specific ligands, including polycyclic aromatic hydrocarbons (PAHs), halogenated aromatic hydrocarbons (HAHs), and tryptophan derivatives, such as indole-3-carbinol. Endogenous ligands are derived from cellular metabolism and the diet.
AHR activity can be regulated through various post-translational modifications, including phosphorylation and ubiquitination. Protein-protein interactions with chaperones and co-regulators also influence AHR function.
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