Alcam

  • Official Full Name

    activated leukocyte cell adhesion molecule

  • Overview

    This gene encodes activated leukocyte cell adhesion molecule (ALCAM), also known as CD166 (cluster of differentiation 166), which is a member of a subfamily of immunoglobulin receptors with five immunoglobulin-like domains (VVC2C2C2) in the extracellular domain. This protein binds to T-cell differentiation antigene CD6, and is implicated in the processes of cell adhesion and migration. Multiple alternatively spliced transcript variants encoding different isoforms have been found.
  • Synonyms

    ALCAM; activated leukocyte cell adhesion molecule; MEMD; CD166; CD166 antigen; FLJ3851; FLJ38514; MGC71733;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Antibody
  • Protein Pre-coupled Magnetic Beads
  • Canis lupus familiaris (Dog) (Canis familiaris)
  • Cattle
  • Chicken
  • Cynomolgus
  • Cynomolgus Monkey
  • Dog
  • Gallus gallus (Chicken)
  • Human
  • Mouse
  • Oryctolagus cuniculus (Rabbit)
  • Rabbit
  • Rat
  • Rattus norvegicus (Rat)
  • Rhesus Macaque
  • E.coli
  • E.coli expression system
  • HEK293
  • Human Cell
  • In Vitro Cell Free System
  • Insect Cell
  • Mammalian Cell
  • Mammalian cells
  • Wheat Germ
  • C
  • Fc
  • hFc
  • His
  • Fc Chimera
  • Fc|His
  • GST
  • hIgG
  • His (Fc)
  • Avi
  • His|T7
  • SUMO
  • human|IgG1|Fc
  • N/A
  • T7|His
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human ALCAM-214H Active Recombinant Human ALCAM, Fc Chimera HEK293 Fc Chimera
Human ALCAM-213H Active Recombinant Human ALCAM, Fc Chimera Mammalian cells Fc Chimera
Human ALCAM-112H Recombinant Human ALCAM protein, T7/His-tagged E.coli T7/His
Human ALCAM-3241H Recombinant Human ALCAM, Fc-His tagged Human Cell Fc/His
Human ALCAM-505H Recombinant Human ALCAM protein, His-tagged E.coli His
Human ALCAM-3140H Active Recombinant Human ALCAM protein, His-tagged HEK293 His
Human ALCAM-433H Recombinant Human ALCAM Protein, GST-tagged Wheat Germ GST
Human ALCAM-2294HCL Recombinant Human ALCAM cell lysate Human Cell N/A
Human ALCAM-27218TH Recombinant Human ALCAM Wheat Germ N/A
Human ALCAM-1396HF Recombinant Full Length Human ALCAM Protein, GST-tagged In Vitro Cell Free System GST
Human ALCAM-4382H Recombinant Human ALCAM protein, His-SUMO-tagged E.coli His-SUMO
Human ALCAM-166H Recombinant Human ALCAM Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Human ALCAM-2650H Active Recombinant Human ALCAM protein, hFc&His-tagged HEK293 hFc&His
Human ALCAM-088H Recombinant Human ALCAM Protein, His-tagged HEK293 His
Human ALCAM-0349H Recombinant Human ALCAM Protein (Trp28-Ala526), C-Fc-tagged Mammalian cells C-Fc
Human ALCAM-089H Recombinant Human ALCAM Protein, Fc-tagged HEK293 Fc
Human ALCAM-4094H Recombinant Human ALCAM Protein (Met1-Ala526), C-His tagged Mammalian cells C-His
Human ALCAM-166H-B Recombinant Human ALCAM Protein Pre-coupled Magnetic Beads HEK293
Human ALCAM-398H Recombinant Human ALCAM protein, Fc-tagged HEK293 human/IgG1/Fc
Human ALCAM-2864H Recombinant Human ALCAM protein, Fc-tagged HEK293 Fc
Mouse Alcam-232M Active Recombinant Mouse Alcam, Fc Chimera Mammalian cells Fc Chimera
Mouse Alcam-624M Active Recombinant Mouse Alcam protein(Met1-Lys527), His&hFc-tagged HEK293 C-His&hFc
Mouse Alcam-3267M Active Recombinant Mouse Alcam protein, His-tagged HEK293 His
Mouse Alcam-1703M Recombinant Mouse Alcam, Fc-tagged Mammalian cells Fc
Mouse Alcam-506M Recombinant Mouse Alcam protein, His & T7-tagged E.coli His/T7
Mouse ALCAM-2644MCL Recombinant Mouse ALCAM cell lysate Human Cell N/A
Mouse Alcam-5606M Recombinant Mouse Alcam Protein (Trp28-Lys527), C-Fc tagged Mammalian cells C-Fc
Mouse Alcam-124M-B Recombinant Mouse Alcam Protein Pre-coupled Magnetic Beads HEK293
Mouse Alcam-124M Recombinant Mouse Alcam Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mouse Alcam-01M Active Recombinant Mouse Alcam Protein, hIgG/His-tagged Insect Cell hIgG/His
Rat ALCAM-1355R Acitve Recombinant Rat ALCAM protein(Met1-Lys527), hFc-tagged HEK293 C-hFc
Rat Alcam-18R Recombinant Rat Alcam, Fc tagged Human Cell Fc/His
Rat Alcam-507R Recombinant Rat Alcam protein, His-tagged E.coli His
Rat Alcam-7465R Active Recombinant Rat Alcam protein(Met1-Lys527), His-tagged HEK293 C-His
Rat ALCAM-828RCL Recombinant Rat ALCAM cell lysate Human Cell N/A
Rabbit ALCAM-508R Recombinant Rabbit ALCAM protein, His-tagged E.coli His
Dog ALCAM-504D Recombinant Dog ALCAM protein, His-tagged E.coli His
Canis lupus familiaris (Dog) (Canis familiaris) RFL-36899CF Recombinant Full Length Dog Cd166 Antigen(Alcam) Protein, His-Tagged E.coli expression system His
Cattle ALCAM-503C Recombinant Cattle ALCAM protein, His-tagged E.coli His
Cynomolgus ALCAM-3387C Active Recombinant Cynomolgus ALCAM protein(Met1-Ala526), His-tagged HEK293 C-His
Cynomolgus Monkey ALCAM-118C Recombinant Cynomolgus ALCAM, His tagged Human Cell N/A
Cynomolgus Monkey ALCAM-1211C Recombinant Cynomolgus ALCAM Protein, Fc-tagged HEK293 Fc
Cynomolgus Monkey ALCAM-1098CCL Recombinant Cynomolgus ALCAM cell lysate Human Cell N/A
Gallus gallus (Chicken) RFL-13210GF Recombinant Full Length Chicken Cd166 Antigen(Alcam) Protein, His-Tagged E.coli expression system His
Oryctolagus cuniculus (Rabbit) RFL-3406OF Recombinant Full Length Rabbit Cd166 Antigen(Alcam) Protein, His-Tagged E.coli expression system His
Rattus norvegicus (Rat) RFL-36418RF Recombinant Full Length Rat Cd166 Antigen(Alcam) Protein, His-Tagged E.coli expression system His
Rhesus Macaque ALCAM-300R Recombinant Rhesus monkey ALCAM Protein, His-tagged Mammalian Cell His
Rhesus Macaque ALCAM-128R-B Recombinant Rhesus Macaque ALCAM Protein Pre-coupled Magnetic Beads HEK293
Rhesus Macaque ALCAM-128R Recombinant Rhesus Macaque ALCAM Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Chicken ALCAM-6734C Recombinant Chicken ALCAM Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • Alcam Related Articles
  • Alcam Related Research Area

Alcam involved in several pathways and played different roles in them. We selected most pathways Alcam participated on our site, such as Cell adhesion molecules (CAMs), which may be useful for your reference. Also, other proteins which involved in the same pathway with Alcam were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Cell adhesion molecules (CAMs)OCLNA;MHC1UEA;HLA-B;BLB2;Itgam&Itgb2;CD276;HLA-DQB1;SELPLG;PTPRF

Alcam has several biochemical functions, for example, protein binding, receptor binding. Some of the functions are cooperated with other proteins, some of the functions could acted by Alcam itself. We selected most functions Alcam had, and list some proteins which have the same functions with Alcam. You can find most of the proteins on our site.

Function Related Protein
protein bindingIL6;SCFD1;UBC;TAF13;MIIP;SMNDC1;ZBTB1;EDDM3B;PYGM
receptor bindingHAND2;FGF11;MPV17L;FGF24;FZD8;ABCA1;ARPP19;TAC1;TNFSF13B

Alcam has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with Alcam here. Most of them are supplied by our site. Hope this information will be useful for your research of Alcam.

LGALS1; LGALS3; CD6; ART3; EGFR

Williams, DW; Anastos, K; et al. JAM-A and ALCAM are therapeutic targets to inhibit diapedesis across the BBB of CD14(+)CD16(+) monocytes in HIV-infected individuals. JOURNAL OF LEUKOCYTE BIOLOGY 97:401-412(2015).
Ding, V; Chin, A; et al. Generation of novel monoclonal antibodies for the enrichment and characterization of human corneal endothelial cells (hCENC) necessary for the treatment of corneal endothelial blindness. MABS 6:1439-1452(2014).
  • Q&As
  • Reviews

Q&As (30)

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Is ALCAM protein involved in any physiological processes other than immune response and cell adhesion? 11/18/2022

Yes, ALCAM protein is involved in various physiological processes, such as neurite outgrowth, axon guidance, synaptic plasticity, and wound healing. It also plays a role in embryonic development and tissue regeneration.

Can blocking ALCAM have therapeutic potential in autoimmune diseases? 11/11/2021

Some studies suggest that blocking ALCAM could have therapeutic potential in certain autoimmune diseases, as it impacts immune cell activation and migration.

Are there any known interactions between ALCAM protein and drugs or other proteins? 09/30/2021

ALCAM protein has been found to interact with various proteins and receptors, including CD6, CD166, CD58, integrins, and growth factor receptors. These interactions regulate cell signaling pathways and modulate cellular functions.

Can ALCAM protein be used as a diagnostic or prognostic marker for any diseases? 07/10/2021

ALCAM protein levels have been explored as potential diagnostic or prognostic markers in several diseases, including various types of cancer. However, further research is required to establish its clinical utility.

What are the implications of ALCAM overexpression in cancer? 02/26/2021

ALCAM overexpression has been associated with poor prognosis in various cancers. It enhances cancer cell migration and adhesion to endothelial cells, promoting tumor invasion and metastasis.

Are there any known genetic disorders associated with mutations in the ALCAM gene? 02/14/2021

Yes, mutations in the ALCAM gene have been identified in individuals with a rare genetic disorder called Basan syndrome. Basan syndrome is characterized by intellectual disability, developmental delay, distinctive facial features, and other associated abnormalities. These mutations affect the function of ALCAM protein and contribute to the development of the disorder.

Are there any clinical trials targeting ALCAM protein for therapeutic purposes? 09/24/2020

Currently, there are no known clinical trials specifically targeting ALCAM protein. However, preclinical studies and research in animal models are ongoing to explore the potential therapeutic applications of ALCAM inhibition or modulation in various diseases, including cancer and neurodevelopmental disorders.

Can ALCAM protein be used as a diagnostic marker for cancer? 08/12/2020

ALCAM protein has been proposed as a diagnostic marker for various cancer types. Increased expression of ALCAM has been detected in cancer tissues compared to normal tissues, and it has been associated with tumor aggressiveness and prognosis. However, more research is needed to validate its diagnostic potential and determine its specificity and sensitivity as a cancer biomarker.

What are the physiological functions of ALCAM protein in normal tissues? 08/12/2020

In normal tissues, ALCAM protein plays important roles in various biological processes. It is involved in immune cell adhesion and migration, neuronal development and connectivity, tissue morphogenesis and repair, and maintenance of epithelial integrity. ALCAM also contributes to the formation and function of the blood-brain barrier and plays a role in T cell activation and migration.

Are there any known mutations or genetic variations in ALCAM protein? 02/27/2020

Yes, several mutations and genetic variations in the ALCAM gene have been identified. These variations can lead to changes in ALCAM protein structure and function, and may be associated with certain diseases or conditions.

What are some diseases or conditions linked to ALCAM protein? 07/30/2019

ALCAM protein has been implicated in various diseases and conditions, including cancer, autoimmune diseases, neurodevelopmental disorders, and inflammatory disorders.

How is ALCAM protein regulated? 03/12/2019

The expression and activity of ALCAM protein can be regulated by various factors, including cytokines, growth factors, and signaling pathways. Transcriptional regulation, post-translational modifications, and protein-protein interactions also play a role in its regulation.

Is ALCAM protein expressed in normal tissues or is it mostly associated with diseases? 10/29/2018

ALCAM protein is expressed in various normal tissues, including immune cells, neurons, epithelial cells, and endothelial cells. It plays important roles in physiological processes, such as immune response, neuronal development, and tissue homeostasis. However, dysregulation or aberrant expression of ALCAM can be associated with diseases or conditions.

Can ALCAM protein be used as a therapeutic target for autoimmune diseases? 10/27/2018

ALCAM protein has been implicated in autoimmune diseases such as multiple sclerosis and rheumatoid arthritis. Modulating ALCAM expression or function may have potential therapeutic benefits in these conditions. However, clinical validation and further research are necessary before considering ALCAM as a specific therapeutic target for autoimmune diseases.

What other molecules does ALCAM protein bind to? 09/13/2018

ALCAM protein can bind to other molecules such as CD6 and CD166 (itself) to mediate homotypic and heterotypic interactions.

How was ALCAM protein initially discovered and characterized? 08/10/2018

ALCAM protein was initially identified and characterized through molecular cloning and sequencing techniques. It was first discovered as a cell adhesion molecule expressed in activated leukocytes, and further studies revealed its involvement in various cellular processes.

What signaling pathways are regulated by ALCAM protein? 07/01/2018

ALCAM protein has been shown to interact with various signaling pathways, including the Wnt/β-catenin pathway, the Notch pathway, the NF-κB pathway, and the PI3K/Akt pathway. The exact mechanisms by which ALCAM regulates these pathways are still being investigated, but it is believed to interact with signaling molecules and receptors, leading to downstream effects on cell adhesion, migration, proliferation, and survival.

Can ALCAM protein be targeted therapeutically? 05/14/2018

Targeting ALCAM protein is a potential therapeutic strategy, particularly in cancer treatment. Inhibitors or antibodies that block ALCAM-mediated interactions and signaling pathways could potentially limit tumor growth, invasion, and metastasis. However, more research is needed to validate the efficacy and safety of such therapeutic approaches.

Is ALCAM considered a therapeutic target for cancer treatment? 04/11/2018

Yes, ALCAM has been investigated as a potential therapeutic target for cancer therapy. Targeted therapies aimed at inhibiting ALCAM-mediated processes are being explored.

Can you provide more information on the role of ALCAM protein in cancer? 04/03/2018

ALCAM protein has been implicated in various aspects of cancer progression and metastasis. It is often overexpressed in several cancer types, including breast, colorectal, lung, and ovarian cancer. ALCAM overexpression can promote tumor cell invasion, migration, and adhesion, as well as contribute to the formation of metastases. ALCAM has also been linked to cancer stem cell properties and resistance to therapies.

How does ALCAM protein contribute to wound healing? 03/16/2018

ALCAM protein is involved in wound healing processes, particularly in cell migration and tissue regeneration. It promotes the migration of cells involved in wound healing, such as immune cells and fibroblasts, and helps in the formation of new blood vessels (angiogenesis) necessary for tissue repair. ALCAM also participates in the re-epithelialization process, where new skin cells cover the wound.

Are there any known ALCAM protein inhibitors or antagonists? 03/13/2018

Some inhibitors or antagonists targeting ALCAM protein have been developed for research purposes. These inhibitors aim to block ALCAM-mediated processes and explore their potential therapeutic applications.

What are the different isoforms or splice variants of ALCAM protein? 02/18/2018

ALCAM protein has several splice variants that result from alternative splicing of the ALCAM gene. The most well-known isoforms of ALCAM are the full-length isoform (known as ALCAM-FL or ALCAM-L), which contains all the extracellular, transmembrane, and cytoplasmic domains, and a soluble isoform (known as ALCAM-s) lacking the transmembrane and cytoplasmic domains.

Does ALCAM protein have any known physiological roles in non-human organisms? 01/13/2018

Yes, ALCAM protein has been studied in various non-human organisms, including mice, rats, chickens, and zebrafish. It plays similar roles in mediating cell adhesion, immune responses, and developmental processes in these organisms.

Where is ALCAM protein expressed? 04/27/2017

ALCAM protein is primarily expressed on the surface of immune cells, endothelial cells, neural cells, and certain cancer cells.

Is there a connection between ALCAM protein and neurodevelopmental disorders? 11/15/2016

Yes, ALCAM has been studied in the context of neurodevelopmental disorders, such as autism spectrum disorders. Alterations in ALCAM expression and function may contribute to disrupted neuronal connectivity.

Can ALCAM protein be used as a therapeutic target for Alzheimer's disease? 07/05/2016

ALCAM protein has been implicated in Alzheimer's disease due to its involvement in neuronal function and synaptic plasticity. However, its potential as a therapeutic target for Alzheimer's disease is still being explored, and more research is needed to understand its precise role and potential therapeutic applications in this context.

How is ALCAM protein involved in neurodevelopmental disorders? 07/02/2016

ALCAM protein plays a role in neurodevelopmental disorders such as autism spectrum disorders (ASD) and schizophrenia. It is involved in neuronal migration, synaptogenesis, and dendritic spine formation. Dysregulation or mutations in ALCAM may disrupt these processes, contributing to the development of neurodevelopmental disorders.

Are there any known drugs or compounds that specifically target ALCAM protein? 06/06/2016

Currently, there are no known drugs or compounds specifically designed to target ALCAM protein. However, there are ongoing efforts to develop therapeutic agents, such as antibodies or small molecules, that can selectively modulate ALCAM function or interfere with its interactions. These efforts aim to explore the potential of targeting ALCAM in different disease contexts.

Are there any known ALCAM gene polymorphisms associated with disease susceptibility? 04/22/2016

There are limited studies on ALCAM gene polymorphisms and their association with disease susceptibility. However, some studies have reported potential associations between specific ALCAM gene variants and increased susceptibility to conditions such as rheumatoid arthritis and celiac disease. Further research is required to validate these associations and explore the functional consequences of ALCAM gene polymorphisms.

Customer Reviews (3)

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Reviews
05/26/2021

    Its remarkable performance in ELISA, protein electron microscopy structure analysis, and Western Blotting sets it apart as a top recommendation.

    10/03/2018

      With its consistent and outstanding results, the ALCAM protein is an indispensable tool that I highly recommend for researchers in need of reliable and precise protein analysis.

      02/17/2017

        The ALCAM protein has proven invaluable in protein electron microscopy structure analysis, allowing for detailed investigations and providing critical insights.

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