aldh2
Share
  • Official Full Name
  • aldehyde dehydrogenase 2 family (mitochondrial)
  • Background
  • This protein belongs to the aldehyde dehydrogenase family of proteins. Aldehyde dehydrogenase is the second enzyme of the major oxidative pathway of alcohol metabolism. Two major liver isoforms of this enzyme, cytosolic and mitochondrial, can be distinguished by their electrophoretic mobilities, kinetic properties, and subcellular localizations. Most Caucasians have two major isozymes, while ~50% of Asians have only the cytosolic isozyme, missing the mitochondrial isozyme. A remarkably higher frequency of acute alcohol intoxication among Asians than among Caucasians could be related to the absence of the mitochondrial isozyme. This gene encodes a mitochondrial isoform, which has a low Km for acetaldehydes, and is localized in mitochondrial matrix.
  • Synonyms
  • ALDH2; aldehyde dehydrogenase 2 family (mitochondrial); aldehyde dehydrogenase, mitochondrial; ALDH class 2; liver mitochondrial ALDH; acetaldehyde dehydrogenase 2; nucleus-encoded mitochondrial aldehyde dehydrogenase 2; ALDM; ALDHI; ALDH-E2; MGC1806
Cat.#:ALDH2-27037THTag:N/A
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human ALDH2
+Inquiry
Cat.#:ALDH2-27039THTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human ALDH2, His-tagged
+Inquiry
Cat.#:ALDH2-130HTag:MYC/DDK
Source (Host):HEK293Species:Human
Product nameRecombinant Human ALDH2 protein, MYC/DDK-tagged
+Inquiry
Cat.#:ALDH2-131HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human ALDH2 protein, GST-tagged
+Inquiry
Cat.#:ALDH2-139HTag:N/A
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human ALDH2 protein
+Inquiry
Cat.#:ALDH2-2122HTag:His/S
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human ALDH2 protein, His & S-tagged
+Inquiry
Cat.#:ALDH2-444HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human ALDH2 Protein, GST-tagged
+Inquiry
Cat.#:ALDH2-1525MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse ALDH2 Protein
+Inquiry
Cat.#:Aldh2-83MTag:His
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse Aldh2, His-tagged
+Inquiry
Cat.#:Aldh2-3264RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat Aldh2, His-tagged
+Inquiry
Cat.#:ALDH2-620RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat ALDH2 Protein
+Inquiry
Cat.#:ALDH2-8918HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human ALDH2 293 Cell Lysate
+Inquiry
Cat.#:Kit-0076Tag:
Source (Host):Species:
Product nameMitochondrial Aldehyde Dehydrogenase (ALDH2) Activity Assay Kit
+Inquiry

Involved Pathway

ALDH2 involved in several pathways and played different roles in them. We selected most pathways ALDH2 participated on our site, such as Glycolysis / Gluconeogenesis, Pentose and glucuronate interconversions, Ascorbate and aldarate metabolism, which may be useful for your reference. Also, other proteins which involved in the same pathway with ALDH2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Glycolysis / Gluconeogenesis
ALDOCB; ALDOA; ALDH3B1; ACSS2L; PFKMB; ENO1; HK3; LDHA; GPIA; PFKP
Pentose and glucuronate interconversions
UGT5G1; UGT2A2; UGT1A6A; GKUP; UGT1A6; AKR1B7; AKR1A1A; ALDH1B1; KL; UGP2
Ascorbate and aldarate metabolism
UGT1A6A; MIOX; UGT1A7; ALDH2; UGT2A2; UGT1AB; UGT2B15; UGT2A1; GULO; GKUP
Fatty acid degradation
ADH6; EHHADH; ACADVL; ACAA1; ACADL; ADH1A; ACSL4; ALDH1B1; ACADM; ADH5
Valine, leucine and isoleucine degradation
OXCT1B; AOX4; AUH; HMGCS2; HADHA; IVD; ALDH6A1; ALDH2; OXCT2; DLDH
Lysine degradation
MLL5; ACAT2; GLT25D2; KMT2A; SETD7; DLST; WBP7; HADH; PLOD2; ALDH2.2
Arginine and proline metabolism
PYCRL; DHDPSL; PYCR1B; ARG2; GOT2B; PYCR2; NOS2; ALDH2.1; CKM; SAT2
Histidine metabolism
ALDH2.2; AMDHD1; ALDH9A1B; ALDH2.1; UROC1; CNDP2; HNMT; AOC1; CARNS1; ALDH3B1
Tryptophan metabolism
ASMT; OGDHL; DHCR24; CYP4F12; ALDH2; TPH1A; AOX3L1; IDO1; MAOA; INMT
beta-Alanine metabolism
ALDH3B1; CNDP2; ALDH3A2A; ALDH7A1; SRM; SMS; UPB1; GAD2; ALDH6A1; ALDH3A2
Glycerolipid metabolism
AGPAT9L; AKR1B1L; AGK; ALDH2; DGKB; GK2; PNPLA3; DGKZ; ALDH9A1B; ALDH9A1A.1
Pyruvate metabolism
MDH1; ACSS2L; ALDH9A1B; PDHA2; ALDH7A1; ACACA; HAGHL; ACSS2; PDHA1A; ME1
Metabolic pathways
URAH; NT5C3B; KCNG4; PNAT3; HMGCS1; DCXR; DEGS1; ALG12; SPAM1; CYP3A65

Protein Function

ALDH2 has several biochemical functions, for example, aldehyde dehydrogenase (NAD) activity, aldehyde dehydrogenase [NAD(P)+] activity, electron carrier activity. Some of the functions are cooperated with other proteins, some of the functions could acted by ALDH2 itself. We selected most functions ALDH2 had, and list some proteins which have the same functions with ALDH2. You can find most of the proteins on our site.
Function
Related Protein
Function aldehyde dehydrogenase (NAD) activity
Related Protein ALDH5A1; ALDH4A1; Aldh1a7; ALDH1B1; ALDH3A2; ALDH7A1; ALDH9A1A.1; ALDH1L1; ALDH3B2; ALDH2
Function aldehyde dehydrogenase [NAD(P)+] activity
Related Protein ALDH3A1; ALDH3B1; ALDH2; ALDH3B2; ALDH1A3; ALDH3A2B; ALDH3A2; ALDH3A2A
Function electron carrier activity
Related Protein PTGESL; IDH3B; ACAD11; GSR; COX11; ACADVL; AOC2; ALDH4A1; HSD17B6; AOX3L1

Interacting Protein

ALDH2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ALDH2 here. Most of them are supplied by our site. Hope this information will be useful for your research of ALDH2.
ALDH1A1; FHIT; UBA5; SIRT3; RPL13A; ITGB3BP; UNC119; CRMP1; q7cgs8_yerpe; SLC35F6; FAM45A; IGSF21; C14orf1; 15-deoxy-delta(12,14; ICT1; GABARAPL1; SIRT4

ALDH2 Related Articles

Lai, CL; Yao, CT; et al. Dominance of the Inactive Asian Variant Over Activity and Protein Contents of Mitochondrial Aldehyde Dehydrogenase 2 in Human Liver. ALCOHOLISM-CLINICAL AND EXPERIMENTAL RESEARCH 38:44-50(2014).
Yokoyama, A; Mizukami, T; et al. Genetic Polymorphisms of Alcohol Dehydrogenase-1B and Aldehyde Dehydrogenase-2 and Liver Cirrhosis, Chronic Calcific Pancreatitis, Diabetes Mellitus, and Hypertension Among Japanese Alcoholic Men. ALCOHOLISM-CLINICAL AND EXPERIMENTAL RESEARCH 37:1391-1401(2013).