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Official Full Name aldehyde dehydrogenase 2 family (mitochondrial)
Background This protein belongs to the aldehyde dehydrogenase family of proteins. Aldehyde dehydrogenase is the second enzyme of the major oxidative pathway of alcohol metabolism. Two major liver isoforms of this enzyme, cytosolic and mitochondrial, can be distinguished by their electrophoretic mobilities, kinetic properties, and subcellular localizations. Most Caucasians have two major isozymes, while ~50% of Asians have only the cytosolic isozyme, missing the mitochondrial isozyme. A remarkably higher frequency of acute alcohol intoxication among Asians than among Caucasians could be related to the absence of the mitochondrial isozyme. This gene encodes a mitochondrial isoform, which has a low Km for acetaldehydes, and is localized in mitochondrial matrix.
Synonyms ALDH2; aldehyde dehydrogenase 2 family (mitochondrial); aldehyde dehydrogenase, mitochondrial; ALDH class 2; liver mitochondrial ALDH; acetaldehyde dehydrogenase 2; nucleus-encoded mitochondrial aldehyde dehydrogenase 2; ALDM; ALDHI; ALDH-E2; MGC1806
    • Species :
    • Human
    • Mouse
    • Rat
    • Source :
    • E.coli
    • E.Coli or Yeast
    • HEK293
    • HEK293T
    • Mammalian Cell
    • Wheat Germ
    • Tag :
    • GST
    • His
    • S
    • MYC/DDK
    • Myc
    • DDK
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human ALDH2-130H Recombinant Human ALDH2 protein, MYC/DDK-tagged HEK293 Myc/DDK
    Human ALDH2-131H Recombinant Human ALDH2 protein, GST-tagged Wheat Germ GST
    Human ALDH2-139H Recombinant Human ALDH2 protein E.coli N/A
    Human ALDH2-2122H Recombinant Human ALDH2 protein, His & S-tagged E.coli His/S
    Human ALDH2-27037TH Recombinant Human ALDH2 E.coli N/A
    Human ALDH2-27039TH Recombinant Human ALDH2, His-tagged E.coli His
    Human ALDH2-4336H Recombinant Human ALDH2 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
    Human ALDH2-444H Recombinant Human ALDH2 Protein, GST-tagged Wheat Germ GST
    Human ALDH2-8918HCL Recombinant Human ALDH2 293 Cell Lysate HEK293 N/A
    Mouse ALDH2-1525M Recombinant Mouse ALDH2 Protein Mammalian Cell His
    Mouse Aldh2-570M Recombinant Mouse Aldh2 Protein, MYC/DDK-tagged HEK293T MYC/DDK
    Mouse Aldh2-7157M Recombinant Mouse Aldh2 Protein, His-tagged E.coli His
    Mouse Aldh2-83M Recombinant Mouse Aldh2, His-tagged E.coli His
    Rat Aldh2-3264R Recombinant Rat Aldh2, His-tagged E.Coli or Yeast His
    Rat ALDH2-620R Recombinant Rat ALDH2 Protein Mammalian Cell His
    Kit-0076 Mitochondrial Aldehyde Dehydrogenase (ALDH2) Activity Assay Kit N/A

    ALDH2 involved in several pathways and played different roles in them. We selected most pathways ALDH2 participated on our site, such as Glycolysis / Gluconeogenesis, Pentose and glucuronate interconversions, Ascorbate and aldarate metabolism, which may be useful for your reference. Also, other proteins which involved in the same pathway with ALDH2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Glycolysis / Gluconeogenesis ALDOA; ALDOCB; ADH1; PGM2; G6PC; PFKMA; BPGM; GM5506; ADH1B; ADH2-1
    Pentose and glucuronate interconversions AKR1A1A; AKR1B7; UGT2B7; UGT1A7; UGP2A; GKUP; AKR1B1; ALDH2.2; AKR1B1L; RPE
    Ascorbate and aldarate metabolism UGT1A1; ALDH9A1B; GKUP; UGT5G1; GULO; ALDH9A1A.1; ALDH7A1; ALDH3A2; ALDH3A2A; UGT2A3
    Fatty acid degradation EHHADH; ACADM; CPT1B; ALDH2; CPT1C; ACSL4; PECI; ADH5; HADHA; ADH6
    Valine, leucine and isoleucine degradation ACAA1; BCKDHA; HADHB; ACAD8; HMGCS2; ACAA1A; HADH; AACS; OXCT2B; AOX3
    Lysine degradation SUV39H2; KMT2E; SUV420H1; ALDH3A2; SETD2; ALDH9A1A.1; DLST; SUV39H1A; SETDB1B; GLT25D1
    Arginine and proline metabolism DAO.3; CKBB; GATM; SAT1A.1; CKB; SAT1A.2; NOS1; ODC1; DAO1; AZIN2
    Histidine metabolism ALDH3A2; MAOB; ALDH3B1; ALDH9A1A.1; ALDH2; ABP1; FTCD; UROC1; CNDP2; AMDHD1
    Tryptophan metabolism GCDHA; ALDH3A2; INMT; IL4I1; TPH1B; MAOA; TPH1A; ALDH7A1; TDO2; CYP1A
    beta-Alanine metabolism ALDH1A3; ALDH3A1; ALDH3B1; ALDH9A1B; ALDH2.1; ALDH6A1; GAD2; AOC3; CNDP2; ALDH1B1
    Glycerolipid metabolism MOGAT3A; PNLIPRP2; LPL; MOGAT3; AGPAT9L; AGPAT4; TAE1; LIPC; GK; AGPAT1
    Pyruvate metabolism SLC16A8; PDK3; PDP2; ACYP2; LDHA; hchA; SLC16A1; PDHA2; ACACA; ACOT12
    Metabolic pathways PDHA1A; GK; MTMR1; LPCAT2; MDH2; CDA; AGK; FDFT1; GUK1B; GALT

    ALDH2 has several biochemical functions, for example, aldehyde dehydrogenase (NAD) activity, aldehyde dehydrogenase [NAD(P)+] activity, electron carrier activity. Some of the functions are cooperated with other proteins, some of the functions could acted by ALDH2 itself. We selected most functions ALDH2 had, and list some proteins which have the same functions with ALDH2. You can find most of the proteins on our site.

    Function Related Protein
    aldehyde dehydrogenase (NAD) activity ALDH9A1B; ALDH1A1; ALDH4A1; ALDH8A1; ALDH6A1; ALDH1B1; ALDH16A1; ALDH3A2; ALDH1A3; ALDH3B2
    aldehyde dehydrogenase [NAD(P)+] activity ALDH3A2B; ALDH3A2; ALDH1A3; ALDH3A1; ALDH2; ALDH3A2A; ALDH3B2; ALDH3B1
    electron carrier activity GCDHB; ALDH4A1; DHRS3; SDHC; QDPR; DERL3; UGDH; AKR1B1; GRX2; COX5A

    ALDH2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ALDH2 here. Most of them are supplied by our site. Hope this information will be useful for your research of ALDH2.

    ALDH1A1; FHIT; UBA5; SIRT3; RPL13A; ITGB3BP; UNC119; CRMP1; q7cgs8_yerpe; SLC35F6; FAM45A; IGSF21; C14orf1; 15-deoxy-delta(12,14; ICT1; GABARAPL1; SIRT4

    Lai, CL; Yao, CT; et al. Dominance of the Inactive Asian Variant Over Activity and Protein Contents of Mitochondrial Aldehyde Dehydrogenase 2 in Human Liver. ALCOHOLISM-CLINICAL AND EXPERIMENTAL RESEARCH 38:44-50(2014).
    Yokoyama, A; Mizukami, T; et al. Genetic Polymorphisms of Alcohol Dehydrogenase-1B and Aldehyde Dehydrogenase-2 and Liver Cirrhosis, Chronic Calcific Pancreatitis, Diabetes Mellitus, and Hypertension Among Japanese Alcoholic Men. ALCOHOLISM-CLINICAL AND EXPERIMENTAL RESEARCH 37:1391-1401(2013).

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