ALDH2

  • Official Full Name

    aldehyde dehydrogenase 2 family (mitochondrial)
  • Overview

    This protein belongs to the aldehyde dehydrogenase family of proteins. Aldehyde dehydrogenase is the second enzyme of the major oxidative pathway of alcohol metabolism. Two major liver isoforms of this enzyme, cytosolic and mitochondrial, can be distinguished by their electrophoretic mobilities, kinetic properties, and subcellular localizations. Most Caucasians have two major isozymes, while ~50% of Asians have only the cytosolic isozyme, missing the mitochondrial isozyme. A remarkably higher frequency of acute alcohol intoxication among Asians than among Caucasians could be related to the absence of the mitochondrial isozyme. This gene encodes a mitochondrial isoform, which has a low Km for acetaldehydes, and is localized in mitochondrial matrix.
  • Synonyms

    ALDH2;aldehyde dehydrogenase 2 family (mitochondrial);aldehyde dehydrogenase, mitochondrial;ALDH class 2;liver mitochondrial ALDH;acetaldehyde dehydrogenase 2;nucleus-encoded mitochondrial aldehyde dehydrogenase 2;ALDM;ALDHI;ALDH-E2;MGC1806

Recombinant Proteins

  • Human
  • Mouse
  • Rat
  • E.coli
  • HEK293
  • Mammalian Cells
  • E.Coli/Yeast
  • Wheat Germ
  • In Vitro Cell Free System
  • Non
  • DDK
  • Myc
  • His
  • S
  • GST
  • Avi
  • Fc
Cat.# Product name Source (Host) Species Tag Protein Length Price
ALDH2-139H Active Recombinant Human ALDH2 protein E.coli Human Non 18-517 a.a.
ALDH2-130H Recombinant Human ALDH2 protein, MYC/DDK-tagged HEK293 Human DDK&Myc
ALDH2-1525M Recombinant Mouse ALDH2 Protein Mammalian Cells Mouse His
ALDH2-2122H Recombinant Human ALDH2 protein, His & S-tagged E.coli Human His&S Pro59~Ala150
ALDH2-27037TH Recombinant Human ALDH2 E.coli Human Non Full L. 18-517 a.a.
ALDH2-27039TH Recombinant Human ALDH2, His-tagged E.coli Human His 153-509 a.a.
Aldh2-3264R Recombinant Rat Aldh2, His-tagged E.Coli/Yeast Rat His 519
ALDH2-444H Recombinant Human ALDH2 Protein, GST-tagged Wheat Germ Human GST
ALDH2-620R Recombinant Rat ALDH2 Protein Mammalian Cells Rat His
Aldh2-83M Recombinant Mouse Aldh2, His-tagged E.coli Mouse His
ALDH2-8918HCL Recombinant Human ALDH2 293 Cell Lysate HEK293 Human Non
ALDH2-0564H Recombinant Human ALDH2 Protein (Full Length), N-His-tagged E.coli Human His Full L. Full Length
ALDH2-0566H Recombinant Human ALDH2 Protein (Pro59-Ala150), N-His-tagged E.coli Human His Pro59-Ala150
Aldh2-2422R Recombinant Rat Aldh2 protein, His&Myc-tagged E.coli Rat His&Myc 20-519aa
ALDH2-276R Recombinant Rat ALDH2 Protein, His (Fc)-Avi-tagged HEK293 Rat Avi&Fc&His
ALDH2-276R-B Recombinant Rat ALDH2 Protein Pre-coupled Magnetic Beads HEK293 Rat
ALDH2-4336H Recombinant Human ALDH2 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293 Human DDK&Myc
ALDH2-454M Recombinant Mouse ALDH2 Protein, His (Fc)-Avi-tagged HEK293 Mouse Avi&Fc&His
ALDH2-454M-B Recombinant Mouse ALDH2 Protein Pre-coupled Magnetic Beads HEK293 Mouse
ALDH2-4612H Recombinant Human ALDH2 protein, His-tagged E.coli Human His
Aldh2-5673R Recombinant Rat Aldh2 protein, His-tagged E.coli Rat His 20-519aa
Aldh2-570M Recombinant Mouse Aldh2 Protein, MYC/DDK-tagged HEK293 Mouse DDK&Myc
ALDH2-671HF Recombinant Full Length Human ALDH2 Protein, GST-tagged In Vitro Cell Free System Human GST Full L. 517 amino acids
ALDH2-6755H Recombinant Human ALDH2 protein, His-tagged E.coli Human His 165-517 aa
Kit-0076 Mitochondrial Aldehyde Dehydrogenase (ALDH2) Activity Assay Kit Non

    Involved Pathway

    ALDH2 involved in several pathways and played different roles in them. We selected most pathways ALDH2 participated on our site, such as Glycolysis / Gluconeogenesis,Pentose and glucuronate interconversions,Ascorbate and aldarate metabolism, which may be useful for your reference. Also, other proteins which involved in the same pathway with ALDH2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Histidine metabolism HNMT,ALDH1B1,ALDH2.2,ALDH9A1A.1,ALDH7A1,FTCD,MAOB,ALDH3B1,CNDP1,ALDH3A2A
    Glycerolipid metabolism DGKD,Cel,PPAP2D,GK2,DGAT2,AKR1B1L,ALDH2.2,AGPAT6,DGKQ,PPAP2B
    Arginine and proline metabolism GOT2B,ALDH3A2,CKM,P4HA3,ALDH9A1B,ALDH2.1,CARNS1,CKB,ODC1,GOT2
    beta-Alanine metabolism UPB1,HADHA,ALDH2.2,HADHAB,SMOX,ALDH9A1,ALDH2.1,ALDH3A1,MLYCD,ALDH3B1
    Lysine degradation BBOX1,SETD1BA,SETD8A,WBP7,PIPOX,HADHA,EHMT1B,HYKK,SETDB1,SUV39H2
    Metabolic pathways TPI1,SDHDB,ACSM2,ASAH1B,G6PC3,RIMKLB,AMPD2,HK2,MINPP1,NDUFS2
    Pyruvate metabolism LDHBA,ackA,ALDH7A1,LDHB,LDHAL6B,PDHA1,HAGH,LDHAL6A,ALDH9A1,GRHPRB
    Valine, leucine and isoleucine degradation BCAT2,ACAA1A,ACAD8,OXCT1A,ALDH9A1B,AACS,ACADM,HSD17B10,BCKDHB,BCKDHA
    Pentose and glucuronate interconversions UGT2B15,AKR1B10,AKR1B1L,UGT1A7,UGP2A,ALDH3A2,CRYL1,XYLB,UGP2B,SORD

    Protein Function

    ALDH2 has several biochemical functions, for example, aldehyde dehydrogenase (NAD) activity,aldehyde dehydrogenase [NAD(P)+] activity,electron carrier activity. Some of the functions are cooperated with other proteins, some of the functions could acted by ALDH2 itself. We selected most functions ALDH2 had, and list some proteins which have the same functions with ALDH2. You can find most of the proteins on our site.

    Function Related Protein
    electron carrier activity IDO1,FDX1L,PTGES2,MAOB,ETFB,NCF1,ETFA,ACADS,NDUFA12,NOX4
    aldehyde dehydrogenase [NAD(P)+] activity ALDH1A3,ALDH3B1,ALDH3A2,ALDH3A2A,ALDH3A1,ALDH3A2B,ALDH3B2
    aldehyde dehydrogenase (NAD) activity ALDH1A3,ALDH3B2,ALDH8A1,ALDH5A1,ALDH1B1,ALDH9A1A.1,ALDH3A1,ALDH1L1,ALDH1A1,ALDH16A1

    Interacting Protein

    ALDH2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ALDH2 here. Most of them are supplied by our site. Hope this information will be useful for your research of ALDH2.

    ALDH1A1;FHIT;UBA5;SIRT3;RPL13A;ITGB3BP;UNC119;CRMP1;q7cgs8_yerpe;SLC35F6;FAM45A;IGSF21;C14orf1;15-deoxy-delta(12,14;ICT1;GABARAPL1;SIRT4

    Resources

    References

    • Lai, CL; Yao, CT; et al. Dominance of the Inactive Asian Variant Over Activity and Protein Contents of Mitochondrial Aldehyde Dehydrogenase 2 in Human Liver. ALCOHOLISM-CLINICAL AND EXPERIMENTAL RESEARCH 38:44-50(2014).
    • Yokoyama, A; Mizukami, T; et al. Genetic Polymorphisms of Alcohol Dehydrogenase-1B and Aldehyde Dehydrogenase-2 and Liver Cirrhosis, Chronic Calcific Pancreatitis, Diabetes Mellitus, and Hypertension Among Japanese Alcoholic Men. ALCOHOLISM-CLINICAL AND EXPERIMENTAL RESEARCH 37:1391-1401(2013).

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