AMBP
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Official Full Name
alpha-1-microglobulin/bikunin precursor
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Overview
This gene encodes a complex glycoprotein secreted in plasma. The precursor is proteolytically processed into distinct functioning proteins: alpha-1-microglobulin, which belongs to the superfamily of lipocalin transport proteins and may play a role in the regulation of inflammatory processes, and bikunin, which is a urinary trypsin inhibitor belonging to the superfamily of Kunitz-type protease inhibitors and plays an important role in many physiological and pathological processes. This gene is located on chromosome 9 in a cluster of lipocalin genes. -
Synonyms
AMBP; alpha-1-microglobulin/bikunin precursor; A1M; HCP; ITI; UTI; EDC1; HI30; ITIL; IATIL; ITILC;
- Recombinant Proteins
- Cell & Tissue Lysates
- Transfected Stable Cell Lines
- Native Proteins
- Protein Pre-coupled Magnetic Beads
- Cattle
- Chicken
- Human
- Mouse
- Rat
- Zebrafish
- E.coli
- HEK293
- HEK293F
- HEK293T
- Human Cell
- Human Urine
- In Vitro Cell Free System
- Mammalian Cell
- Mammalian cells
- P.pastoris
- Wheat Germ
- Yeast
- Flag
- GST
- His
- His (Fc)
- Avi
- His|GST
- mFc
- Myc
- DDK
- MYC
- N/A
- N
- Involved Pathway
- Protein Function
- Interacting Protein
- AMBP Related Research Area
AMBP involved in several pathways and played different roles in them. We selected most pathways AMBP participated on our site, such as Binding and Uptake of Ligands by Scavenger Receptors, Scavenging of heme from plasma, Vesicle-mediated transport, which may be useful for your reference. Also, other proteins which involved in the same pathway with AMBP were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name | Pathway Related Protein |
---|---|
Binding and Uptake of Ligands by Scavenger Receptors | IGKV1-5;AMBP;COL3A1;CD163;COL1A2;APOBB.1;HP;SAA1;IGLC2 |
Scavenging of heme from plasma | CD163;HP;AMBP;NFX1;LOC479668;HPX |
Vesicle-mediated transport | CX30.3;HSPH1;STAB2;GJA5;TRAPPC6B;COPE;DTNBP1;GJB4;BLOC1S1 |
AMBP has several biochemical functions, for example, IgA binding, calcium channel inhibitor activity, calcium oxalate binding. Some of the functions are cooperated with other proteins, some of the functions could acted by AMBP itself. We selected most functions AMBP had, and list some proteins which have the same functions with AMBP. You can find most of the proteins on our site.
Function | Related Protein |
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IgA binding | IGJ;FCAR;FCAMR;AMBP |
calcium channel inhibitor activity | SLC30A1A;SLC30A1B;STX1A;AMBP;SLC30A1;FKBP1AA;PACSIN3;ITPR1;PHPT1 |
calcium oxalate binding | |
heme binding | CYP2D10;CYP8B1;CYP3A25;MPO;CYP4A12A;CYP2AD3;CYP11C1;CYP46A1.2;HBAA1 |
protein binding | CSTF2;VPREB1;MARCH10;HIST1H2AL;KLHL18;KLF15;MPZL2;ELMO2;PELI2 |
protein homodimerization activity | ALX1;ODC1;SYT10;SRM;ABCB9;PRMT8;SLK;KLRB1B;PVRL3 |
serine-type endopeptidase inhibitor activity | WFIKKN2;SERPINC1;MUG1;SERPINA3K;WFDC13;OVAL;SPINK4;PAPLNB;SERPINE3 |
small molecule binding | MUP17;LCN2;AMBP;LCN15;PTGDSB;PTGDSA;PAEP;MUP20;MUP3 |
AMBP has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with AMBP here. Most of them are supplied by our site. Hope this information will be useful for your research of AMBP.
CTSB; FHL3; orf3_hevbu; eno1; COX8A; STAT3; PIK3CA; GRB2; PIK3R3; DAAM1; d-mannose; q99xu0_strp1
- Q&As
- Reviews
Q&As (10)
Ask a questionAMBP expression levels and isoform variations can serve as diagnostic biomarkers for inflammatory diseases, immune dysregulation, or infection, aiding in disease diagnosis, monitoring, and prognostication.
AMBP expression is regulated by genetic and epigenetic factors, including transcription factors, DNA methylation, and histone modifications, which influence its expression patterns in different cell types and disease contexts.
AMBP modulates immune cell activities by regulating cellular adhesion, migration, phagocytosis, cytokine production, and immune cell differentiation through intracellular signaling pathways, such as MAPK and NF-魏B pathways.
AMBP participates in the regulation of complement activation by interacting with complement components, controlling the formation of membrane attack complexes and modulating the inflammatory response.
Targeting AMBP for therapeutic interventions in immune-mediated disorders or inflammatory conditions can be achieved through approaches such as small molecule inhibitors, antibody-based therapies, or gene editing techniques.
AMBP plays important roles in the immune system, including regulating inflammatory responses, modulating complement activation, and contributing to host defense mechanisms.
AMBP is released or secreted by immune cells through various mechanisms, including vesicular trafficking, exosomes, or proteolytic cleavage, which can be exploited for therapeutic purposes or biomarker discovery.
AMBP contributes to tissue homeostasis and immune surveillance in different organs, such as the kidney, lung, or reproductive system, and its dysregulation can have implications in tissue damage, autoimmune diseases, or infections in specific organ systems.
AMBP interacts with various immune-related proteins, such as complement components C3 and C5, cytokines, and cell surface receptors, influencing immune cell functions, immune signaling, and inflammation processes.
The structural features of AMBP, including its two domains (伪1-microglobulin and bikunin), are crucial for its immune-related functions, protein-protein interactions, and stability.
Customer Reviews (3)
Write a reviewCompatibility with various protein modification detection methods.
Enhanced data reproducibility in protein quantification.
Comprehensive profiling of protein expression patterns.
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