Creative BioMart to Present at
                        BIO-Europe Spring Creative BioMart to Present at AACR Annual Meeting|Apr. 5-10, 2024|Booth #2953

Recombinant Mouse Ambp Protein, His-tagged

Cat.No. : Ambp-223M
Product Overview : Recombinant Mouse Ambp(Arg18~Ala202) fused with His tag at N-terminal was expressed in E. coli.
  • Specification
  • Gene Information
  • Related Products
Description : This gene encodes a fusion protein that undergoes proteolytic processing to generate two mature proteins: alpha-1-microglobulin (A1m) is a heme-binding plasma glycoprotein of the lipocalin superfamily of proteins that bind to hydrophobic molecules, whereas bikunin belongs to the superfamily of Kunitz-type protease inhibitors. The transgenic mice specifically lacking bikunin, but not A1m, exhibit female infertility and an increased sensitivity to lung metastasis.
Source : E. coli
Species : Mouse
Tag : His
Form : PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
Molecular Mass : 22.5kDa
Identity : Reconstitute in PBS or others
Protein length : Arg18~Ala202
Endotoxin : <1.0EU per 1µg (determined by the LAL method)
Purity : > 95%
Applications : Positive Control; Immunogen; SDS-PAGE; WB.
If bio-activity of the protein is needed, please check active protein
Stability : The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37 centigrade for 48h, and no obvious degradation and precipitation were observed. The loss rate is less than 5% within the expiration date under appropriate storage condition.
Storage : Avoid repeated freeze/thaw cycles. Store at 2-8 centigrade for one month. Aliquot and store at -80 centigrade for 12 months.
Reconstitution : Reconstitute in PBS or others
Gene Name : Ambp alpha 1 microglobulin/bikunin [ Mus musculus ]
Official Symbol : Ambp
Synonyms : AMBP; alpha 1 microglobulin/bikunin; protein AMBP; polyprotein; ulinastatin; Urinary Trypsin Inhibitor; UTI; ASPI; Itil; HI-30; Intin4; AI194774;
Gene ID : 11699
mRNA Refseq : NM_007443
Protein Refseq : NP_031469
UniProt ID : Q07456

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

Inquiry

  • Q&As
  • Reviews

Q&As (10)

Ask a question
Can AMBP serve as a diagnostic biomarker for inflammatory diseases or immune dysregulation, and what are the clinical implications of its expression levels or isoform variations? 12/01/2021

AMBP expression levels and isoform variations can serve as diagnostic biomarkers for inflammatory diseases, immune dysregulation, or infection, aiding in disease diagnosis, monitoring, and prognostication.

What are the genetic and epigenetic factors that regulate AMBP expression, and how do they contribute to its physiological and pathological roles in the immune system? 03/15/2021

AMBP expression is regulated by genetic and epigenetic factors, including transcription factors, DNA methylation, and histone modifications, which influence its expression patterns in different cell types and disease contexts.

How does AMBP modulate the activity and function of immune cells, such as neutrophils, macrophages, or lymphocytes, and what signaling pathways are involved? 12/21/2020

AMBP modulates immune cell activities by regulating cellular adhesion, migration, phagocytosis, cytokine production, and immune cell differentiation through intracellular signaling pathways, such as MAPK and NF-魏B pathways.

How does AMBP participate in the regulation of complement activation and the modulation of the inflammatory response? 12/20/2019

AMBP participates in the regulation of complement activation by interacting with complement components, controlling the formation of membrane attack complexes and modulating the inflammatory response.

Can AMBP be targeted for therapeutic interventions in immune-mediated disorders or inflammatory conditions, and what strategies can be employed to modulate its activity? 05/18/2019

Targeting AMBP for therapeutic interventions in immune-mediated disorders or inflammatory conditions can be achieved through approaches such as small molecule inhibitors, antibody-based therapies, or gene editing techniques.

What are the cellular and molecular functions of AMBP in the immune system and inflammation processes? 11/17/2018

AMBP plays important roles in the immune system, including regulating inflammatory responses, modulating complement activation, and contributing to host defense mechanisms.

What are the mechanisms of AMBP release or secretion from immune cells, and how can these processes be modulated for therapeutic purposes? 08/10/2018

AMBP is released or secreted by immune cells through various mechanisms, including vesicular trafficking, exosomes, or proteolytic cleavage, which can be exploited for therapeutic purposes or biomarker discovery.

How does AMBP contribute to tissue homeostasis and immune surveillance in different organs, and what are the consequences of its dysregulation in specific tissues or disease contexts? 11/05/2017

AMBP contributes to tissue homeostasis and immune surveillance in different organs, such as the kidney, lung, or reproductive system, and its dysregulation can have implications in tissue damage, autoimmune diseases, or infections in specific organ systems.

How does AMBP interact with other immune-related proteins, such as complement components or cytokines, and what are the functional consequences of these interactions? 10/29/2017

AMBP interacts with various immune-related proteins, such as complement components C3 and C5, cytokines, and cell surface receptors, influencing immune cell functions, immune signaling, and inflammation processes.

What are the structural features of AMBP and its domains that are essential for its immune-related functions? 10/09/2017

The structural features of AMBP, including its two domains (伪1-microglobulin and bikunin), are crucial for its immune-related functions, protein-protein interactions, and stability.

Customer Reviews (3)

Write a review
Reviews
08/27/2018

    Compatibility with various protein modification detection methods.

    08/05/2018

      Enhanced data reproducibility in protein quantification.

      03/20/2018

        Comprehensive profiling of protein expression patterns.

        Ask a Question for All Ambp Products

        Required fields are marked with *

        My Review for All Ambp Products

        Required fields are marked with *

        0

        Inquiry Basket

        cartIcon
        logo

        FOLLOW US

        Terms and Conditions        Privacy Policy

        Copyright © 2024 Creative BioMart. All Rights Reserved.

        Contact Us

        • /

        Stay Updated on the Latest Bioscience Trends