Active Human alpha 1-Microglobulin Reference Standard

• Cat.No.: AMBP-5H

Specification

• Description: This gene encodes a complex glycoprotein secreted in plasma. The precursor is proteolytically processed into distinct functioning proteins: alpha-1-microglobulin, which belongs to the superfamily of lipocalin transport proteins and may play a role in the regulation of inflammatory processes, and bikunin, which is a urinary trypsin inhibitor belonging to the superfamily of Kunitz-type protease inhibitors and plays an important role in many physiological and pathological processes. This gene is located on chromosome 9 in a cluster of lipocalin genes.
• Species: Human
• Form: Liquid
• Bio-activity: The level of alpha 1-Microglobulin in the serum was quantified using ELISA.
• Usage: For research use only, not for diagnostic or therapeutic use.
• Quality Control Test: Generated from a human serum pool. This lot has been tested by standard laboratory procedures and found to be negative for HIV 1, HIV 2, Hepatitis B and Hepatitis C.
• Storage: Stored at -20 °C, 4 °C for less than seven days, frozen for greater than seven days.
• Concentration: 12.09 ug/ml
• Preservative: 0.1% sodium azide
• Tag: Non

Gene Information

• Gene Name: AMBP alpha-1-microglobulin/bikunin precursor [ Homo sapiens ]
• Official Symbol: AMBP
• Synonyms: AMBP; alpha-1-microglobulin/bikunin precursor; ITI, ITIL; protein AMBP; bikunin; complex forming glycoprotein heterogeneous in charge; EDC1; growth inhibiting protein 19; HCP; HI30; IATIL; inter alpha trypsin inhibitor light chain; ITILC; protein HC; trypstatin; uristatin; uronic acid rich protein; UTI; uronic-acid-rich protein; growth-inhibiting protein 19; inter-alpha-trypsin inhibitor light chain; complex-forming glycoprotein heterogeneous in charge; A1M; ITI; ITIL
• Gene ID: 259
• mRNA Refseq: NM_001633
• Protein Refseq: NP_001624
• MIM: 176870
• UniProt ID: P02760
• Chromosome Location: 9q32-q33
• Function: IgA binding; calcium channel inhibitor activity; calcium oxalate binding; heme binding; peptidase inhibitor activity; protein homodimerization activity; serine-type endopeptidase inhibitor activity; transporter activity

Reviews

08/27/2018

Compatibility with various protein modification detection methods.

08/05/2018

Enhanced data reproducibility in protein quantification.

03/20/2018

Comprehensive profiling of protein expression patterns.

Q&As

Can AMBP serve as a diagnostic biomarker for inflammatory diseases or immune dysregulation, and what are the clinical implications of its expression levels or isoform variations?

AMBP expression levels and isoform variations can serve as diagnostic biomarkers for inflammatory diseases, immune dysregulation, or infection, aiding in disease diagnosis, monitoring, and prognostication.

What are the genetic and epigenetic factors that regulate AMBP expression, and how do they contribute to its physiological and pathological roles in the immune system?

AMBP expression is regulated by genetic and epigenetic factors, including transcription factors, DNA methylation, and histone modifications, which influence its expression patterns in different cell types and disease contexts.

How does AMBP modulate the activity and function of immune cells, such as neutrophils, macrophages, or lymphocytes, and what signaling pathways are involved?

AMBP modulates immune cell activities by regulating cellular adhesion, migration, phagocytosis, cytokine production, and immune cell differentiation through intracellular signaling pathways, such as MAPK and NF-魏B pathways.

How does AMBP participate in the regulation of complement activation and the modulation of the inflammatory response?

AMBP participates in the regulation of complement activation by interacting with complement components, controlling the formation of membrane attack complexes and modulating the inflammatory response.

Can AMBP be targeted for therapeutic interventions in immune-mediated disorders or inflammatory conditions, and what strategies can be employed to modulate its activity?

Targeting AMBP for therapeutic interventions in immune-mediated disorders or inflammatory conditions can be achieved through approaches such as small molecule inhibitors, antibody-based therapies, or gene editing techniques.

What are the cellular and molecular functions of AMBP in the immune system and inflammation processes?

AMBP plays important roles in the immune system, including regulating inflammatory responses, modulating complement activation, and contributing to host defense mechanisms.

What are the mechanisms of AMBP release or secretion from immune cells, and how can these processes be modulated for therapeutic purposes?

AMBP is released or secreted by immune cells through various mechanisms, including vesicular trafficking, exosomes, or proteolytic cleavage, which can be exploited for therapeutic purposes or biomarker discovery.

How does AMBP contribute to tissue homeostasis and immune surveillance in different organs, and what are the consequences of its dysregulation in specific tissues or disease contexts?

AMBP contributes to tissue homeostasis and immune surveillance in different organs, such as the kidney, lung, or reproductive system, and its dysregulation can have implications in tissue damage, autoimmune diseases, or infections in specific organ systems.

How does AMBP interact with other immune-related proteins, such as complement components or cytokines, and what are the functional consequences of these interactions?

AMBP interacts with various immune-related proteins, such as complement components C3 and C5, cytokines, and cell surface receptors, influencing immune cell functions, immune signaling, and inflammation processes.

What are the structural features of AMBP and its domains that are essential for its immune-related functions?

The structural features of AMBP, including its two domains (伪1-microglobulin and bikunin), are crucial for its immune-related functions, protein-protein interactions, and stability.