APOH
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Official Full Name
apolipoprotein H (beta-2-glycoprotein I)
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Overview
Apolipoprotein H has been implicated in a variety of physiologic pathways including lipoprotein metabolism, coagulation, and the production of antiphospholipid autoantibodies. APOH may be a required cofactor for anionic phospholipid binding by the antiphospholipid autoantibodies found in sera of many patients with lupus and primary antiphospholipid syndrome, but it does not seem to be required for the reactivity of antiphospholipid autoantibodies associated with infections. -
Synonyms
APOH; apolipoprotein H (beta-2-glycoprotein I); B2G1; beta-2-glycoprotein 1; beta 2 glycoprotein I; BG; Activated protein C binding protein; Activated protein C-binding protein; Anticardiolipin cofactor; APC inhibitor; Apo-H; APOH; APOH_HUMAN; Apolipoprotein H; B2G1; B2GPI; beta 2 glycoprotein I; beta 2 glycoprotein I precursor; BetaGPI; Beta-2-glycoprotein 1; Beta-2-glycoprotein I; BG; OTTMUSP00000003033; B2GPI; apo-H; betaGPI; APC inhibitor; anticardiolipin cofactor; activated protein C-binding protein; B2GP1;
- Recombinant Proteins
- Cell & Tissue Lysates
- Native Proteins
- Protein Pre-coupled Magnetic Beads
- Cattle
- Chicken
- Dog
- Human
- Mouse
- Rat
- E.coli
- HEK293
- HEK293T
- Human Cell
- Human plasma
- Human Plasma
- In Vitro Cell Free System
- Insect Cell
- Mammalian Cell
- Mammalian cells
- Sf9 Insect Cell
- Wheat Germ
- C
- His
- FITC
- GST
- His (Fc)
- Avi
- Myc
- DDK
- Myc|DDK
- N/A
- Involved Pathway
- Protein Function
- Interacting Protein
- APOH Related Articles
- APOH Related Research Area
APOH involved in several pathways and played different roles in them. We selected most pathways APOH participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with APOH were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name | Pathway Related Protein |
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APOH has several biochemical functions, for example, glycoprotein binding, heparin binding, identical protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by APOH itself. We selected most functions APOH had, and list some proteins which have the same functions with APOH. You can find most of the proteins on our site.
Function | Related Protein |
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glycoprotein binding | Serpina1c;CD4;AZGP1;RGMA;HSPA5;VLDLR;FOXRED2;LDLR;PLAT |
heparin binding | SFRP1;SELL;PCSK6;UBE4A;HRG;CCL5;LIPG;THBS3;CCL8 |
identical protein binding | PPPDE2;FRS3;GOT2B;TPCN1;ALCAMB;PSME3;ACTG1;SDCBP;DDX58 |
lipid binding | APOA5;APOA4B.2;BPIFA5;STARD7;FAM123A;MARK2;HSP12;FABP7B;CYP21A1 |
lipoprotein lipase activator activity | APOA5;APOH;APOC2 |
phospholipid binding | DAPP1;GRK5;PON1;ARHGAP44;ANXA9;APOC3;PAFAH2;NOXO1;SEC14L2 |
protein binding | PELP1;SULT1B1;TRPV4;TRP53;TK1;Unc5b;H1F0;HIST1H2AM;MTMR9 |
APOH has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with APOH here. Most of them are supplied by our site. Hope this information will be useful for your research of APOH.
LPA; PLG; TP53; AKT1; GEM; CDC42; GRB2; CLEC4G; RBBP6; q99ib8-pro_0000045596
- Q&As
- Reviews
Q&As (16)
Ask a questionYes, the APOH protein has anticoagulant properties. It inhibits the formation of blood clots by interacting with several components involved in the coagulation cascade, such as phospholipids and negatively charged surfaces.
Yes, alterations in APOH protein levels and function have been observed in cardiovascular diseases, including atherosclerosis and coronary artery disease. Dysregulated lipid metabolism and impaired clotting control contribute to these associations.
Certain antibodies against the APOH protein are associated with the development of antiphospholipid syndrome (APS), an autoimmune disorder characterized by an increased risk of blood clot formation. These antibodies can disrupt the balance of normal blood coagulation.
Targeting the APOH protein is a potential therapeutic strategy, especially for conditions like thrombosis, autoimmune diseases, and dyslipidemia. Developing drugs or interventions that modulate its function or expression may offer benefits in managing these diseases.
Yes, ongoing research studies are examining the role of APOH protein in various diseases, exploring its mechanisms of action, and investigating its potential as a therapeutic target. These studies aim to better understand its significance and explore new treatment avenues.
The APOH protein interacts with lipoproteins, such as high-density lipoprotein (HDL), to facilitate the transport and clearance of cholesterol from peripheral tissues. It helps in maintaining the balance of lipids in the bloodstream.
Yes, elevated levels of APOH protein have been detected in various pathological conditions, including autoimmune diseases and certain cancers. Therefore, it could serve as a potential biomarker for disease diagnosis or prognosis.
APOH protein deficiency can lead to an increased risk of developing thrombotic disorders, such as deep vein thrombosis (DVT) and recurrent miscarriages in women. It can also contribute to autoimmune diseases and cardiovascular complications.
The APOH protein is primarily produced in the liver, but it is also synthesized and secreted by other tissues, such as the endothelial cells and the placenta.
The expression of the APOH gene is regulated by various factors, including transcription factors, hormones, and inflammatory mediators. Specific DNA sequences within the gene promoter region interact with these regulators to control gene expression.
Due to its involvement in lipid metabolism, coagulation, and immune regulation, targeting the APOH protein may hold therapeutic potential for treating disorders such as dyslipidemia, thrombosis, and autoimmune diseases. Further research is necessary to explore its therapeutic applications.
The APOH protein has been implicated in the pathogenesis of autoimmune diseases, such as systemic lupus erythematosus (SLE). Some antibodies against APOH have been observed in individuals with SLE and may contribute to disease development.
The APOH protein has multiple functions, including regulating lipid metabolism, inhibiting blood clotting, and modulating immune responses. It also functions as a cofactor for various molecular interactions.
Yes, dietary factors, such as omega-3 fatty acids, have been shown to modulate the expression and function of the APOH protein. Consumption of certain nutrients can influence lipid metabolism and potentially impact APOH protein levels.
Yes, the APOH protein interacts with various proteins, including clotting factors, lipoproteins, receptors, and immune molecules. These interactions are essential for its functional roles in lipid metabolism, coagulation, and immune regulation.
Yes, certain genetic mutations in the APOH gene have been associated with an increased risk of developing autoimmune diseases, thrombosis-related disorders, and cardiovascular diseases.
Customer Reviews (4)
Write a reviewthe manufacturer's commitment to scientific collaboration and knowledge sharing greatly enhances my research experience.
They actively engage with the scientific community, staying up-to-date with the latest advancements related to APOH protein and sharing this valuable information.
This reliable supply chain management guarantees uninterrupted access to the protein, allowing me to plan and conduct my experiments with confidence and without concern for availability issues.
To summarize, the APOH protein provided by the manufacturer is of exceptional quality and perfectly aligns with my experimental requirements.
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