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APOH

  • Official Full Name

    apolipoprotein H (beta-2-glycoprotein I)

  • Overview

    Apolipoprotein H has been implicated in a variety of physiologic pathways including lipoprotein metabolism, coagulation, and the production of antiphospholipid autoantibodies. APOH may be a required cofactor for anionic phospholipid binding by the antiphospholipid autoantibodies found in sera of many patients with lupus and primary antiphospholipid syndrome, but it does not seem to be required for the reactivity of antiphospholipid autoantibodies associated with infections.
  • Synonyms

    APOH; apolipoprotein H (beta-2-glycoprotein I); B2G1; beta-2-glycoprotein 1; beta 2 glycoprotein I; BG; Activated protein C binding protein; Activated protein C-binding protein; Anticardiolipin cofactor; APC inhibitor; Apo-H; APOH; APOH_HUMAN; Apolipoprotein H; B2G1; B2GPI; beta 2 glycoprotein I; beta 2 glycoprotein I precursor; BetaGPI; Beta-2-glycoprotein 1; Beta-2-glycoprotein I; BG; OTTMUSP00000003033; B2GPI; apo-H; betaGPI; APC inhibitor; anticardiolipin cofactor; activated protein C-binding protein; B2GP1;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Native Proteins
  • Protein Pre-coupled Magnetic Beads
  • Cattle
  • Chicken
  • Dog
  • Human
  • Mouse
  • Rat
  • E.coli
  • HEK293
  • HEK293T
  • Human Cell
  • Human plasma
  • Human Plasma
  • In Vitro Cell Free System
  • Insect Cell
  • Mammalian Cell
  • Mammalian cells
  • Sf9 Insect Cell
  • Wheat Germ
  • C
  • His
  • FITC
  • GST
  • His (Fc)
  • Avi
  • Myc
  • DDK
  • Myc|DDK
  • N/A
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human APOH-308H Active Recombinant Human APOH Protein, His-tagged HEK293 His
Human APOH-9765H Recombinant Human APOH, GST-tagged E.coli GST 20-345a.a.
Human APOH-101H Recombinant Human APOH, FITC-tagged FITC
Human APOH-710H Recombinant Human APOH protein, GST-tagged Wheat Germ GST
Human APOH-80H Recombinant Human APOH, His-tagged Sf9 Insect Cell His
Human APOH-439H Recombinant Human APOH Protein, His-tagged E.coli His Thr22~Cys345
Human APOH-393H Recombinant Human apolipoprotein H (beta-2-glycoprotein I), His-tagged E.coli His
Human APOH-2543HCL Recombinant Human APOH cell lysate Human Cell N/A
Human APOH-2473H Recombinant Human APOH Protein, MYC/DDK-tagged HEK293 Myc/DDK
Human APOH-4217H Native Human APOH protein Human Plasma N/A
Human APOH-0634H Recombinant Human APOH Protein (Thr22-Cys345), His-tagged E.coli His Thr22-Cys345
Human APOH-5365H Native Human Apolipoprotein H (beta-2-glycoprotein I) Human plasma N/A
Human APOH-506H Recombinant Human APOH Protein (Met1-Cys345), His-tagged Insect Cell His Met1-Cys345
Human APOH-1152HF Recombinant Full Length Human APOH Protein, GST-tagged In Vitro Cell Free System GST 345 amino acids
Human APOH-0633H Recombinant Human APOH Protein (Gly20-Ser345), C-His-tagged Mammalian cells C-His Gly20-Ser345
Mouse APOH-1794M Recombinant Mouse APOH Protein Mammalian Cell His
Mouse Apoh-440M Recombinant Mouse Apoh Protein, His-tagged E.coli His Arg21~Cys345
Mouse APOH-640M Recombinant Mouse APOH Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mouse Apoh-1663M Recombinant Mouse Apoh Protein, Myc/DDK-tagged HEK293T Myc/DDK
Mouse APOH-640M-B Recombinant Mouse APOH Protein Pre-coupled Magnetic Beads HEK293
Rat Apoh-1133R Recombinant Rat Apoh Protein, His-tagged HEK293 His
Rat Apoh-441R Recombinant Rat Apoh Protein, His-tagged E.coli His Gly20~Cys297
Dog APOH-438D Recombinant Dog APOH Protein, His-tagged E.coli His Arg21~Cys345
Cattle APOH-437C, 1 Recombinant Cattle APOH Protein, His-tagged E.coli His Arg21~Cys345
Chicken APOH-5278C Recombinant Chicken APOH Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • APOH Related Articles
  • APOH Related Research Area

APOH involved in several pathways and played different roles in them. We selected most pathways APOH participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with APOH were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein

APOH has several biochemical functions, for example, glycoprotein binding, heparin binding, identical protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by APOH itself. We selected most functions APOH had, and list some proteins which have the same functions with APOH. You can find most of the proteins on our site.

Function Related Protein
glycoprotein bindingSerpina1c;CD4;AZGP1;RGMA;HSPA5;VLDLR;FOXRED2;LDLR;PLAT
heparin bindingSFRP1;SELL;PCSK6;UBE4A;HRG;CCL5;LIPG;THBS3;CCL8
identical protein bindingPPPDE2;FRS3;GOT2B;TPCN1;ALCAMB;PSME3;ACTG1;SDCBP;DDX58
lipid bindingAPOA5;APOA4B.2;BPIFA5;STARD7;FAM123A;MARK2;HSP12;FABP7B;CYP21A1
lipoprotein lipase activator activityAPOA5;APOH;APOC2
phospholipid bindingDAPP1;GRK5;PON1;ARHGAP44;ANXA9;APOC3;PAFAH2;NOXO1;SEC14L2
protein bindingPELP1;SULT1B1;TRPV4;TRP53;TK1;Unc5b;H1F0;HIST1H2AM;MTMR9

APOH has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with APOH here. Most of them are supplied by our site. Hope this information will be useful for your research of APOH.

LPA; PLG; TP53; AKT1; GEM; CDC42; GRB2; CLEC4G; RBBP6; q99ib8-pro_0000045596

Kolyada, A; Karageorgos, I; et al. An A1-A1 mutant with improved binding and inhibition of beta 2GPI/antibody complexes in antiphospholipid syndrome. FEBS JOURNAL 282:864-873(2015).
Thammasri, K; Rauhamaki, S; et al. Human Parvovirus B19 Induced Apoptotic Bodies Contain Altered Self-Antigens that are Phagocytosed by Antigen Presenting Cells. PLOS ONE 8:-(2013).
  • Q&As
  • Reviews

Q&As (16)

Ask a question
Can the APOH protein influence blood clotting? 02/12/2023

Yes, the APOH protein has anticoagulant properties. It inhibits the formation of blood clots by interacting with several components involved in the coagulation cascade, such as phospholipids and negatively charged surfaces.

Is there any association between APOH protein and cardiovascular diseases? 06/23/2022

Yes, alterations in APOH protein levels and function have been observed in cardiovascular diseases, including atherosclerosis and coronary artery disease. Dysregulated lipid metabolism and impaired clotting control contribute to these associations.

How is the APOH protein linked to thrombosis? 05/16/2022

Certain antibodies against the APOH protein are associated with the development of antiphospholipid syndrome (APS), an autoimmune disorder characterized by an increased risk of blood clot formation. These antibodies can disrupt the balance of normal blood coagulation.

Can the APOH protein be targeted for therapeutic interventions? 04/20/2022

Targeting the APOH protein is a potential therapeutic strategy, especially for conditions like thrombosis, autoimmune diseases, and dyslipidemia. Developing drugs or interventions that modulate its function or expression may offer benefits in managing these diseases.

Are there any ongoing research studies investigating the APOH protein? 12/19/2020

Yes, ongoing research studies are examining the role of APOH protein in various diseases, exploring its mechanisms of action, and investigating its potential as a therapeutic target. These studies aim to better understand its significance and explore new treatment avenues.

How does the APOH protein regulate lipid metabolism? 08/25/2020

The APOH protein interacts with lipoproteins, such as high-density lipoprotein (HDL), to facilitate the transport and clearance of cholesterol from peripheral tissues. It helps in maintaining the balance of lipids in the bloodstream.

Can the APOH protein be used as a biomarker for certain diseases? 05/05/2020

Yes, elevated levels of APOH protein have been detected in various pathological conditions, including autoimmune diseases and certain cancers. Therefore, it could serve as a potential biomarker for disease diagnosis or prognosis.

What are the consequences of APOH protein deficiency in the body? 03/20/2019

APOH protein deficiency can lead to an increased risk of developing thrombotic disorders, such as deep vein thrombosis (DVT) and recurrent miscarriages in women. It can also contribute to autoimmune diseases and cardiovascular complications.

Where is the APOH protein produced in the body? 01/07/2019

The APOH protein is primarily produced in the liver, but it is also synthesized and secreted by other tissues, such as the endothelial cells and the placenta.

How is the APOH gene regulated in the body? 09/08/2017

The expression of the APOH gene is regulated by various factors, including transcription factors, hormones, and inflammatory mediators. Specific DNA sequences within the gene promoter region interact with these regulators to control gene expression.

Are there any therapeutic implications of targeting the APOH protein? 07/02/2017

Due to its involvement in lipid metabolism, coagulation, and immune regulation, targeting the APOH protein may hold therapeutic potential for treating disorders such as dyslipidemia, thrombosis, and autoimmune diseases. Further research is necessary to explore its therapeutic applications.

Does the APOH protein have any role in autoimmune diseases? 03/18/2017

The APOH protein has been implicated in the pathogenesis of autoimmune diseases, such as systemic lupus erythematosus (SLE). Some antibodies against APOH have been observed in individuals with SLE and may contribute to disease development.

What are the functions of the APOH protein? 08/19/2016

The APOH protein has multiple functions, including regulating lipid metabolism, inhibiting blood clotting, and modulating immune responses. It also functions as a cofactor for various molecular interactions.

Can dietary factors affect the APOH protein levels? 08/17/2016

Yes, dietary factors, such as omega-3 fatty acids, have been shown to modulate the expression and function of the APOH protein. Consumption of certain nutrients can influence lipid metabolism and potentially impact APOH protein levels.

Does the APOH protein have any interactions with other proteins in the body? 07/03/2016

Yes, the APOH protein interacts with various proteins, including clotting factors, lipoproteins, receptors, and immune molecules. These interactions are essential for its functional roles in lipid metabolism, coagulation, and immune regulation.

Can genetic mutations in the APOH gene lead to diseases? 02/19/2016

Yes, certain genetic mutations in the APOH gene have been associated with an increased risk of developing autoimmune diseases, thrombosis-related disorders, and cardiovascular diseases.

Customer Reviews (4)

Write a review
Reviews
08/03/2021

    the manufacturer's commitment to scientific collaboration and knowledge sharing greatly enhances my research experience.

    08/27/2018

      They actively engage with the scientific community, staying up-to-date with the latest advancements related to APOH protein and sharing this valuable information.

      12/14/2016

        This reliable supply chain management guarantees uninterrupted access to the protein, allowing me to plan and conduct my experiments with confidence and without concern for availability issues.

        05/15/2016

          To summarize, the APOH protein provided by the manufacturer is of exceptional quality and perfectly aligns with my experimental requirements.

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