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Official Full Name aquaporin 4
Background This gene encodes a member of the aquaporin family of intrinsic membrane proteins that function as water-selective channels in the plasma membranes of many cells. The encoded protein is the predominant aquaporin found in brain. Two alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.
Synonyms AQP4; aquaporin 4; aquaporin-4; MIWC; WCH4; aquaporin type4; mercurial-insensitive water channel; HMIWC2; MGC22454
    • Species :
    • Chicken
    • Human
    • Mouse
    • Rat
    • Rhesus Macaque
    • Zebrafish
    • Source :
    • E.coli
    • E.Coli or Yeast
    • HEK293
    • Mammalian Cell
    • Wheat Germ
    • Yeast
    • Tag :
    • GST
    • His
    • SUMO
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human AQP4-1131H Recombinant Human AQP4 Protein, His-SUMO-tagged E.coli His/SUMO
    Human AQP4-32HCL Recombinant Human AQP4 lysate HEK293 N/A
    Human AQP4-734H Recombinant Human AQP4 protein, GST-tagged Wheat Germ GST
    Human AQP4-9731H Recombinant Human AQP4 protein, His-tagged Yeast His
    Human AQP4-9735H Recombinant Human AQP4 protein, His-tagged E.coli His
    Human AQP4-9782H Recombinant Human AQP4, GST-tagged E.coli GST
    Mouse AQP4-2226M Recombinant Mouse AQP4 Protein (253-323 aa), His-tagged Yeast His
    Mouse AQP4-3594M Recombinant Mouse Aqp4 protein, His-tagged E.coli His
    Mouse Aqp4-3600M Recombinant Mouse Aqp4, His-tagged E.Coli or Yeast His
    Rat Aqp4-2602R Recombinant Rat Aqp4 protein, His & GST-tagged E.coli His/GST
    Rat Aqp4-3532R Recombinant Rat Aqp4 protein, His-tagged E.coli His
    Rat AQP4-738R Recombinant Rat AQP4 Protein Mammalian Cell His
    Rhesus Macaque AQP4-374R Recombinant Rhesus monkey AQP4 Protein, His-tagged Mammalian Cell His
    Chicken AQP4-1236C Recombinant Chicken AQP4 Mammalian Cell His
    Zebrafish AQP4-1088Z Recombinant Zebrafish AQP4 Mammalian Cell His

    aqp4 involved in several pathways and played different roles in them. We selected most pathways aqp4 participated on our site, such as Bile secretion, which may be useful for your reference. Also, other proteins which involved in the same pathway with aqp4 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Bile secretion Adcy4; ADCY9; EPHX1; PRKACB; OSTB; ADCY7; PRKACG; ABCC3; AQP1; ATP1A2

    aqp4 has several biochemical functions, for example, glycerol channel activity, water channel activity, water transmembrane transporter activity. Some of the functions are cooperated with other proteins, some of the functions could acted by aqp4 itself. We selected most functions aqp4 had, and list some proteins which have the same functions with aqp4. You can find most of the proteins on our site.

    Function Related Protein
    glycerol channel activity AQP10B; AQP9B; AQP1; AQP8A.2; MIPA; AQP3B; AQP4; AQP8A.1; AQP8; MIPB
    water channel activity AQP8A.2; AQP4; MIP; AQP9; AQP10A; AQP8A.1; AQP8B; AQP1A.2; AQP9B; AQP8
    water transmembrane transporter activity AQP1A.2; SLC14A1; AQP3B; AQP1A.1; AQP8A.2; AQP1; AQP9; AQP8B; AQP10B; AQP8A.1

    aqp4 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with aqp4 here. Most of them are supplied by our site. Hope this information will be useful for your research of aqp4.


    Aboulenein-Djamshidian, F; Hoeftberger, R; et al. Reduction in Serum Aquaporin-4 Antibody Titers During Development of a Tumor-Like Brain Lesion in a Patient With Neuromyelitis Optica: A Serum Antibody-Consuming Effect?. JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY 74:194-197(2015).
    Chang, KH; Ro, LS; et al. Biomarkers for neuromyelitis optica. CLINICA CHIMICA ACTA 440:64-71(2015).

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