ARHGAP24
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Official Full Name
Rho GTPase activating protein 24
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Overview
ARHGAPs, such as ARHGAP24, encode negative regulators of Rho GTPases (see ARHA; MIM 165390), which are implicated in actin remodeling, cell polarity, and cell migration (Katoh and Katoh, 2004 [PubMed 15254788]).[supplied by OMIM, Mar 2008] -
Synonyms
ARHGAP24; Rho GTPase activating protein 24; p73; FILGAP; RCGAP72; RC-GAP72; p73RhoGAP; rho GTPase-activating protein 24; rhoGAP of 73 kDa; sarcoma antigen NY-SAR-88; filamin-A-associated RhoGAP; rho-type GTPase-activating protein 24; RAC1- and CDC42-specific GTPase-activating protein of 72 kDa;
- Recombinant Proteins
- Cell & Tissue Lysates
- Protein Pre-coupled Magnetic Beads
- Human
- Mouse
- Rat
- E.coli
- HEK293
- HEK293T
- In Vitro Cell Free System
- Mammalian Cell
- Wheat Germ
- GST
- His
- His (Fc)
- Avi
- Myc
- DDK
- Myc|DDK
- N/A
| Species | Cat.# | Product name | Source (Host) | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| Human | ARHGAP24-765H | Recombinant Human ARHGAP24 protein, GST-tagged | Wheat Germ | GST |
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| Human | ARHGAP24-110HCL | Recombinant Human ARHGAP24 cell lysate | N/A |
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| Human | ARHGAP24-1460HF | Recombinant Full Length Human ARHGAP24 Protein, GST-tagged | In Vitro Cell Free System | GST | 653 amino acids |
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| Human | ARHGAP24-2579H | Recombinant Human ARHGAP24 Protein, MYC/DDK-tagged | HEK293 | Myc/DDK |
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| Human | ARHGAP24-3271H | Recombinant Human ARHGAP24 Protein, Myc/DDK-tagged, C13 and N15-labeled | HEK293T | Myc/DDK |
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| Human | ARHGAP24-2581H | Recombinant Human ARHGAP24 Protein, His-tagged | E.coli | His |
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| Mouse | Arhgap24-1682M | Recombinant Mouse Arhgap24 Protein, Myc/DDK-tagged | HEK293T | Myc/DDK |
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| Rat | ARHGAP24-765R | Recombinant Rat ARHGAP24 Protein | Mammalian Cell | His |
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| Rat | ARHGAP24-421R | Recombinant Rat ARHGAP24 Protein, His (Fc)-Avi-tagged | HEK293 | His (Fc)-Avi |
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| Rat | ARHGAP24-421R-B | Recombinant Rat ARHGAP24 Protein Pre-coupled Magnetic Beads | HEK293 |
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- Involved Pathway
- Protein Function
- Interacting Protein
ARHGAP24 involved in several pathways and played different roles in them. We selected most pathways ARHGAP24 participated on our site, such as Rho GTPase cycle, Signal Transduction, Signaling by Rho GTPases, which may be useful for your reference. Also, other proteins which involved in the same pathway with ARHGAP24 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Rho GTPase cycle | ARHGAP28;OPHN1;RHOJ;ARHGAP17A;GDI1;DCLRE1B;CHN1;ARHGAP19;ARHGAP6 |
| Signal Transduction | OXGR1A.3;ARHGAP28;OXER1;SOX6;WDR19;RXFP2B;RSPO3;RSPO4;NET1 |
| Signaling by Rho GTPases | RHOT1;TAGAPA;ARHGAP17B;ARHGEF16;TAGAPB;ARHGAP25;RHOT1A;RHPN2;FMNL2 |
ARHGAP24 has several biochemical functions, for example, GTPase activator activity, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by ARHGAP24 itself. We selected most functions ARHGAP24 had, and list some proteins which have the same functions with ARHGAP24. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| GTPase activator activity | ARHGAP29B;GNAQ;ARHGAP17;RGS19;ANKRD27;ADAP1;TBC1D10A;RANGAP1B;AGAP1 |
| protein binding | SYT11;DUSP15;GTF3C6;ZP3;TFAM;SULT2B1;MRPL1;MLC1;CCNB3 |
ARHGAP24 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ARHGAP24 here. Most of them are supplied by our site. Hope this information will be useful for your research of ARHGAP24.
FLNA; Rock1; gtp; CDC42; HTT
- Q&As
- Reviews
Q&As (11)
Ask a questionARHGAP24 is found in various species, indicating its conservation across evolution. It has been identified in mice, rats, and other mammalian species, suggesting its significance in cellular processes across different organisms.
The known interacting partners of ARHGAP24 are currently limited. However, it has been reported to interact with components of the actin cytoskeleton and other proteins involved in Rho GTPase signaling pathways. More studies are needed to identify and characterize the interacting partners of ARHGAP24.
Currently, there is limited research on ARHGAP24, and there are no well-documented knockout or knockdown studies available. More studies are needed to understand the functional consequences of ARHGAP24 loss or reduction.
There is currently no strong evidence linking ARHGAP24 to specific neurological disorders. However, since Rho GTPases are critical for neuronal development and function, further research may reveal potential implications of ARHGAP24 in neurological disorders.
The exact involvement of ARHGAP24 in signaling pathways is still being investigated. However, based on its structural characteristics, ARHGAP24 may have a role in modulating Rho GTPase signaling pathways, which are involved in various cellular processes.
Limited information is available regarding post-translational modifications of ARHGAP24. However, it is possible that ARHGAP24 undergoes modifications such as phosphorylation or acetylation, which can impact its function and activity.
Limited studies have explored the developmental role of ARHGAP24. However, it is speculated that ARHGAP24 may be involved in various developmental processes, considering the importance of Rho GTPases in cell migration, tissue morphogenesis, and neuronal development.
The therapeutic potential of targeting ARHGAP24 is yet to be explored. However, considering the involvement of Rho GTPases in various diseases, including cancer, it is plausible that modulating ARHGAP24 activity could have therapeutic benefits. Further research is needed to investigate this possibility.
Limited information is available on the genetic variations or mutations in the ARHGAP24 gene and their association with diseases. More studies are required to determine if any mutations in ARHGAP24 contribute to the onset or development of specific diseases.
Currently, there is minimal evidence linking ARHGAP24 to cancer. However, some studies suggest that alterations in Rho GTPase signaling, which can be influenced by ARHGAP24, have implications in cancer progression and metastasis. Further research is needed to determine the specific role of ARHGAP24 in cancer biology.
As of now, there is no evidence to suggest that ARHGAP24 can be used as a biomarker for any specific diseases. Further research is needed to determine its potential as a disease biomarker or therapeutic target.
Customer Reviews (8)
Write a reviewManufacturers can support researchers in developing assays to measure ARHGAP24 protein levels or activity specific to their clinical trial settings.
They can offer detailed characterization data, including purity, stability, and functional assessments, to support researchers' confidence in using the protein in their trials.
I am extremely satisfied with the high performance and the exceptional support associated with this protein, as it has greatly contributed to the success of my scientific endeavors.
Their expertise and prompt assistance have been instrumental in overcoming challenges and optimizing the use of the ARHGAP24 protein in my studies.
This may involve guidance in selecting appropriate detection methods, providing assay components, or optimizing protocols for optimal performance and sensitivity.
Such manufacturer support fosters a conducive environment for successful and impactful research outcomes.
The ARHGAP24 protein is of exceptional quality, making it an ideal candidate to fulfill my experimental requirements.
the manufacturer's commitment to delivering excellent technical support has proven to be invaluable in troubleshooting any issues that arose during my experiments.
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