Recombinant Full Length Human ARHGAP24 Protein, GST-tagged

• Cat.No.: ARHGAP24-1460HF
• Product Overview: Human ARHGAP24 full-length ORF ( NP_001036134.1, 1 a.a. - 653 a.a.) recombinant protein with GST-tag at N-terminal.

Specification

• Description: This gene encodes a Rho-GTPase activating protein, which is specific for the small GTPase family member Rac. Binding of the encoded protein by filamin A targets it to sites of membrane protrusion, where it antognizes Rac. This results in suppression of lamellae formation and promotion of retraction to regulate cell polarity. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2016]
• Source: In Vitro Cell Free System
• Species: Human
• Tag: GST
• Molecular Mass: 99.7 kDa
• Protein Length: 653 amino acids
• AA Sequence: MTANHESYLL MASTQNDMED WVKSIRRVIW GPFGGGIFGQ KLEDTVRYEK RYGNRLAPML VEQCVDFIRQ RGLKEEGLFR LPGQANLVKE LQDAFDCGEK PSFDSNTDVH TVASLLKLYL RELPEPVIPY AKYEDFLSCA KLLSKEEEAG VKELAKQVKS LPVVNYNLLK YICRFLDEVQ SYSGVNKMSV QNLATVFGPN ILRPKVEDPL TIMEGTVVVQ QLMSVMISKH DCLFPKDAEL QSKPQDGVSN NNEIQKKATM GQLQNKENNN TKDSPSRQCS WDKSESPQRS SMNNGSPTAL SGSKTNSPKN SVHKLDVSRS PPLMVKKNPA FNKGSGIVTN GSFSSSNAEG LEKTQTTPNG SLQARRSSSL KVSGTKMGTH SVQNGTVRMG ILNSDTLGNP TNVRNMSWLP NGYVTLRDNK QKEQAGELGQ HNRLSTYDNV HQQFSMMNLD DKQSIDSATW STSSCEISLP ENSNSCRSST TTCPEQDFFG GNFEDPVLDG PPQDDLSHPR DYESKSDHRS VGGRSSRATS SSDNSETFVG NSSSNHSALH SLVSSLKQEM TKQKIEYESR IKSLEQRNLT LETEMMSLHD ELDQERKKFT MIEIKMRNAE RAKEDAEKRN DMLQKEMEQF FSTFGELTVE PRRTERGNTI WIQ
• Applications: Enzyme-linked Immunoabsorbent Assay; Western Blot (Recombinant protein); Antibody Production; Protein Array
• Storage: Store at -80 centigrade. Aliquot to avoid repeated freezing and thawing.
• Storage Buffer: 50 mM Tris-HCl, 10 mM reduced Glutathione, pH=8.0 in the elution buffer.

Gene Information

• Gene Name: ARHGAP24 Rho GTPase activating protein 24 [ Homo sapiens ]
• Official Symbol: ARHGAP24
• Synonyms: ARHGAP24; Rho GTPase activating protein 24; rho GTPase-activating protein 24; DKFZP564B1162; FilGAP; FLJ33877; rhoGAP of 73 kDa; sarcoma antigen NY-SAR-88; filamin-A-associated RhoGAP; rho-type GTPase-activating protein 24; RAC1- and CDC42-specific GTPase-activating protein of 72 kDa; p73; FILGAP; RCGAP72; RC-GAP72; p73RhoGAP; DKFZp564B1162
• Gene ID: 83478
• mRNA Refseq: NM_001025616
• Protein Refseq: NP_001020787
• MIM: 610586
• UniProt ID: Q8N264