ARHGDIA
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Official Full Name
Rho GDP dissociation inhibitor (GDI) alpha
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Overview
Rho family small GTPases, including Rho, Rac and cdc42, act as molecular switches, regulating processes such as cell migration, adhesion, proliferation and differentiation. They are activated by guanine nucleotide exchange factors (GEFs), which catalyze t -
Synonyms
ARHGDIA; Rho GDP dissociation inhibitor (GDI) alpha; GDIA1; rho GDP-dissociation inhibitor 1; RHOGDI; rho GDI 1; rho-GDI alpha; RHOGDI-1; MGC117248;
- Recombinant Proteins
- Cell & Tissue Lysates
- Protein Pre-coupled Magnetic Beads
- Chicken
- Cynomolgus Monkey
- Human
- Mouse
- Rat
- Zebrafish
- E.coli
- HEK293
- HEK293T
- In Vitro Cell Free System
- Mammalian Cell
- Wheat Germ
- GST
- His
- His (Fc)
- Avi
- Myc
- DDK
- N/A
- Involved Pathway
- Protein Function
- Interacting Protein
ARHGDIA involved in several pathways and played different roles in them. We selected most pathways ARHGDIA participated on our site, such as Neurotrophin signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with ARHGDIA were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name | Pathway Related Protein |
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Neurotrophin signaling pathway | MAPK9;MAPKAPK2;ZNF274;ABL1;CALML5;ARHGDIG;BDNF;ZFP110;KIDINS220 |
ARHGDIA has several biochemical functions, for example, GTPase activator activity, Rho GDP-dissociation inhibitor activity, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by ARHGDIA itself. We selected most functions ARHGDIA had, and list some proteins which have the same functions with ARHGDIA. You can find most of the proteins on our site.
Function | Related Protein |
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GTPase activator activity | CHML;ADAP2;RANGAP1;ALDH1A2;ALS2CL;ARHGDIB;ASAP1A;ARAP2;TBC1D2 |
Rho GDP-dissociation inhibitor activity | ARHGDIG;ARHGDIA;ARHGDIB |
protein binding | MT1X;DNAJC28;TXNRD2;RAI2;NFKBIZ;UACA;ISOC1;ZBTB33;DOHH |
ARHGDIA has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ARHGDIA here. Most of them are supplied by our site. Hope this information will be useful for your research of ARHGDIA.
RAC1; RHOA; CDC42; RDX; TINF2
- Q&As
- Reviews
Q&As (9)
Ask a questionCurrent research on ARHGDIA focuses on elucidating its role in various cellular processes and disease mechanisms. Scientists are investigating its involvement in cancer progression, metastasis, and therapeutic targeting potential. Additionally, studies are exploring the molecular mechanisms of ARHGDIA regulation and its interactions with other proteins and signaling pathways.
Yes, alterations in ARHGDIA expression or mutations in the ARHGDIA gene have been linked to certain diseases. In addition to neutrophil-specific granule deficiency (SGD), mentioned earlier, dysregulation of ARHGDIA has been observed in certain cancers, such as breast cancer and colorectal cancer. Abnormal ARHGDIA expression has also been associated with blood disorders and cardiovascular diseases.
Yes, targeting ARHGDIA has been explored as a potential therapeutic strategy in different diseases. For example, in cancer, inhibitors of Rho GTPases or RhoGEFs that interact with ARHGDIA have been investigated as potential anti-cancer agents. By inhibiting the activation of Rho GTPases, these compounds aim to disrupt signaling pathways involved in cancer progression and metastasis. Additionally, gene therapy approaches to modulate ARHGDIA expression levels have been explored as potential therapeutic interventions, particularly in diseases like neutrophil-specific granule deficiency.
There is emerging evidence suggesting that ARHGDIA expression levels may have diagnostic or prognostic value in certain diseases, particularly cancer. Alterations in ARHGDIA expression have been associated with tumor grade, metastatic potential, and patient survival outcomes in some studies. However, further research and validation are required before it can be considered a reliable clinical marker.
There is limited evidence suggesting the involvement of ARHGDIA in neural development and neurological disorders. Recent studies have found that ARHGDIA is expressed in the nervous system and may play a role in neuronal migration and axon guidance. However, further research is needed to fully understand its specific contributions to neural development and its potential involvement in neurological disorders.
Yes, several animal models have been developed to study the function and roles of ARHGDIA. Knockout mouse models lacking ARHGDIA expression have been generated, allowing researchers to investigate the impact of ARHGDIA deficiency in various tissues and organs. These models have provided valuable insights into the physiological and pathological roles of ARHGDIA in different systems.
Yes, ARHGDIA interacts with several proteins and molecules. It binds to Rho GTPases, specifically to their active GTP-bound form, preventing their activation. ARHGDIA also interacts with other regulatory proteins, such as Rho guanine nucleotide exchange factors (RhoGEFs) and Rho GTPase activating proteins (RhoGAPs), to modulate Rho GTPase activity. Additionally, ARHGDIA has been reported to interact with cytoskeletal proteins and participate in the regulation of actin dynamics.
Yes, various mutations and genetic variations in the ARHGDIA gene have been identified. Some mutations can result in altered protein function, leading to diseases or developmental disorders. For example, a specific mutation in the ARHGDIA gene has been associated with a rare genetic disorder called neutrophil-specific granule deficiency (SGD), characterized by impaired neutrophil function.
The dysregulation of ARHGDIA in diseases, particularly cancer, suggests it could be a potential therapeutic target. Strategies to modulate ARHGDIA expression or activity may help regulate Rho GTPase signaling, leading to potential therapeutic benefits in cancer treatment. However, more research is needed to fully understand the therapeutic potential and feasibility of targeting ARHGDIA.
Customer Reviews (8)
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