ARID4B
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Official Full Name
AT rich interactive domain 4B (RBP1-like) -
Overview
This gene encodes a protein with sequence similarity to retinoblastoma-binding protein-1. The encoded protein is a subunit of the histone deacetylase-dependant SIN3A transcriptional corepressor complex, which functions in diverse cellular processes including proliferation, differentiation, apoptosis, oncogenesis, and cell fate determination. The gene product is recognized by IgG antibody isolated from a breast cancer patient and appears to be a molecular marker associated with a broad range of human malignancies. Alternate transcriptional splice variants encoding different isoforms have been characterized. This gene encodes a protein with sequence similarity to retinoblastoma-binding protein-1. The encoded protein is a subunit of the histone deacetylase-dependant SIN3A transcriptional corepressor complex, which functions in diverse cellular processes including proliferation, differentiation, apoptosis, oncogenesis, and cell fate determination. The gene product is recognized by IgG antibody isolated from a breast cancer patient and appears to be a molecular marker associated with a broad range of human malignancies. Alternate transcriptional splice variants encoding different isoforms have been characterized -
Synonyms
ARID4B;AT rich interactive domain 4B (RBP1-like);AT rich interactive domain 4B (RBP1 like) , RBP1L1, retinoblastoma binding protein 1 like 1;AT-rich interactive domain-containing protein 4B;BCAA;BRCAA1;SAP180;Rb-binding protein homolog;SIN3A-ass;SOLH;small optic lobes homolog (Drosophila);CAPN15;MGC131491;calpain-15;OTTHUMP00000147599;small optic lobes (Drosophila) homolog
Recombinant Proteins
- Human
- Mouse
- Rat
- E.coli
- Mammalian Cells
- E.Coli/Yeast
- Wheat Germ
- HEK293
- His
- GST
- Non
- Avi
- Fc
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| ARID4B-3550H | Recombinant Human ARID4B protein, His-tagged | E.coli | Human | His | 406-523 aa | |
| ARID4B-3658H | Recombinant Human ARID4B protein, GST-tagged | E.coli | Human | GST | 406-523 aa | |
| ARID4B-1915M | Recombinant Mouse ARID4B Protein | Mammalian Cells | Mouse | His |
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| Arid4b-3681M | Recombinant Mouse Arid4b, His-tagged | E.Coli/Yeast | Mouse | His | 1314 |
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| ARID4B-775R | Recombinant Rat ARID4B Protein | Mammalian Cells | Rat | His |
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| SOLH-15754M | Recombinant Mouse SOLH Protein | Mammalian Cells | Mouse | His |
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| SOLH-27401TH | Recombinant Human SOLH | Wheat Germ | Human | Non | 94 amino acids |
|
| ARID4B-431R | Recombinant Rat ARID4B Protein, His (Fc)-Avi-tagged | HEK293 | Rat | Avi&Fc&His |
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| ARID4B-431R-B | Recombinant Rat ARID4B Protein Pre-coupled Magnetic Beads | HEK293 | Rat |
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| ARID4B-4497H | Recombinant Human ARID4B protein, His-tagged | E.coli | Human | His | 167-415aa |
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| ARID4B-709M | Recombinant Mouse ARID4B Protein, His (Fc)-Avi-tagged | HEK293 | Mouse | Avi&Fc&His |
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| ARID4B-709M-B | Recombinant Mouse ARID4B Protein Pre-coupled Magnetic Beads | HEK293 | Mouse |
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Involved Pathway
ARID4B involved in several pathways and played different roles in them. We selected most pathways ARID4B participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with ARID4B were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|
Protein Function
ARID4B has several biochemical functions, for example, DNA binding,protein binding,transcription regulatory region DNA binding. Some of the functions are cooperated with other proteins, some of the functions could acted by ARID4B itself. We selected most functions ARID4B had, and list some proteins which have the same functions with ARID4B. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| transcription regulatory region DNA binding | GFI1,ARID4A,ZNF649,GABPB2,GLIS2,GLI1,TFAP2A,PAX8,NFE2L2,IKZF2 |
| protein binding | PSMD5,BRMS1,CTDP1,ATE1,CNIH2,TLE1,C21orf2,NRIP1,TSC22D1,NOL4 |
| DNA binding | MUS81,RAD54L,PCXB,ZSCAN10,THRB,ZNF189,KLF12,POLR2H,MXTX2,PMS2 |
Interacting Protein
ARID4B has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ARID4B here. Most of them are supplied by our site. Hope this information will be useful for your research of ARID4B.
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References
- Liangpunsakul, S; Lai, XY; et al. Novel Serum Biomarkers for Detection of Excessive Alcohol Use. ALCOHOLISM-CLINICAL AND EXPERIMENTAL RESEARCH 39:556-565(2015).
- Goldberger, N; Walker, RC; et al. Inherited Variation in miR-290 Expression Suppresses Breast Cancer Progression by Targeting the Metastasis Susceptibility Gene Arid4b. CANCER RESEARCH 73:2671-2681(2013).
