ARRB1
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Official Full Name
arrestin, beta 1
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Overview
Members of arrestin/beta-arrestin protein family are thought to participate in agonist-mediated desensitization of G-protein-coupled receptors and cause specific dampening of cellular responses to stimuli such as hormones, neurotransmitters, or sensory signals. Arrestin beta 1 is a cytosolic protein and acts as a cofactor in the beta-adrenergic receptor kinase (BARK) mediated desensitization of beta-adrenergic receptors. Besides the central nervous system, it is expressed at high levels in peripheral blood leukocytes, and thus the BARK/beta-arrestin system is believed to play a major role in regulating receptor-mediated immune functions. Alternatively spliced transcripts encoding different isoforms of arrestin beta 1 have been described. [provided by RefSeq, Jan 2011] -
Synonyms
ARRB1; arrestin, beta 1; ARB1; ARR1; beta-arrestin-1; arrestin 2;
- Recombinant Proteins
- Cell & Tissue Lysates
- Protein Pre-coupled Magnetic Beads
- Human
- Mouse
- Rat
- Zebrafish
- E.coli
- HEK293
- HEK293T
- In Vitro Cell Free System
- Mamanlian cells
- Mammalian Cell
- Wheat Germ
- C
- His
- Flag
- GST
- His (Fc)
- Avi
- Myc
- DDK
- MYC
- Myc|DDK
- N/A
- N
- Involved Pathway
- Protein Function
- Interacting Protein
- ARRB1 Related Articles
- ARRB1 Related Research Area
- ARRB1 Related Signal Pathway
ARRB1 involved in several pathways and played different roles in them. We selected most pathways ARRB1 participated on our site, such as MAPK signaling pathway, Chemokine signaling pathway, Endocytosis, which may be useful for your reference. Also, other proteins which involved in the same pathway with ARRB1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| MAPK signaling pathway | TRAF2;CACNA2D4;MAPK4;FGFR4;MAX;PPP3CCB;RPS6KA1;HSC70;PTPN7 |
| Chemokine signaling pathway | IKBKB;GNB4;CCL15;GNG7;CRK;STAT1;RELA;CXCL9;CCL7 |
| Endocytosis | CXCR1;ARF5;FAM125B;GRK6;TGFB2;LDLRAP1A;ACAP3B;LDLRAP1;ADRB3B |
| Olfactory transduction | OR6Q1;OR52B6;GNG13;OLFR473;OR6B2;CALM4;PRKG1;OR13A1;ADRBK2 |
ARRB1 has several biochemical functions, for example, AP-2 adaptor complex binding, GTPase activator activity, alpha-1A adrenergic receptor binding. Some of the functions are cooperated with other proteins, some of the functions could acted by ARRB1 itself. We selected most functions ARRB1 had, and list some proteins which have the same functions with ARRB1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| AP-2 adaptor complex binding | ARRB1;TBC1D5;OTOF;AAK1;FCHO1;LDLRAP1 |
| GTPase activator activity | RGS20;PLCB1;RANBP1;LRRK2;PTPLAD1;GARNL3;TBC1D1;ARHGAP11A;STARD13 |
| alpha-1A adrenergic receptor binding | ARRB1;ARRB2 |
| alpha-1B adrenergic receptor binding | ARRB1;ADRA2A;ARRB2 |
| angiotensin receptor binding | ARRB2;DRD1;DRD1A;ARRB1 |
| clathrin adaptor activity | DAB2;PICALM;LDLRAP1;ARRB1 |
| cysteine-type endopeptidase inhibitor activity involved in apoptotic process | BIRC7;BIRC5;SERPINB1A;ARRB1;AVP;RPS6KA1;GAS6;NOL3;IGF1RB |
| enzyme inhibitor activity | HSPBP1;NOTCH1;PRPSAP1;ATPIF1;DGKZ;TAE1;PDE6G;TXNIP;GCHFR |
| estrogen receptor binding | CNOT1;MMS19;DDX54;PPARGC1A;MED1;CCDC62;DDX17;PHB2;PPARGC1B |
| follicle-stimulating hormone receptor binding | ARRB1;ARRB2 |
| NOT histone acetyltransferase activity | ARRB1;BRCA2;BAZ1A;EDF1 |
| insulin-like growth factor receptor binding | INSL4;SOCS2;YWHAH;YWHAG;IGF1;REN;INS2;IGF2;IGF2B |
| ion channel binding | ACTN2;PANX1;USP10;SCN3B;PACS1A;CAV1;KCNE2;PKD1;KCND3 |
| mitogen-activated protein kinase kinase binding | TRIB1;MAP3K11;TAOK2;ACE;BRAF;TRIB3;PIN1;DLG1;TRIB2 |
| protein binding | ARPC4;TRIM10;EID3;ZBTB44;GEMIN6;LMNA;SOCS5;NUP37;ETV7 |
| protein phosphorylated amino acid binding | CRK;BTRC;ARRB1 |
| transcription factor binding | TCF12;CREG1;CCND1;THRA;KLF5;APBB2;STK36;EGR1;HMGA1 |
| transcription regulatory region DNA binding | KLF4;FOXM1;SALL4;TOMM20A;ZNF831;MEF2C;TCF7;FOXC2;TCF7L1B |
| ubiquitin protein ligase binding | SLC22A18;TNFRSF14;AMBRA1;UBE2T;CCT2;CDC34;BECN1;FZD8;TRAF3 |
ARRB1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ARRB1 here. Most of them are supplied by our site. Hope this information will be useful for your research of ARRB1.
MAPK9; GNMT; ARRB2; ZRANB2
- Q&As
- Reviews
Q&As (7)
Ask a questionTargeting ARRB1 or its associated signaling pathways holds potential therapeutic implications for various diseases. Since ARRB1 is involved in regulating GPCR signaling, modulating its activity may provide a means to selectively enhance or reduce the signaling of specific GPCRs. This could be relevant in the treatment of diseases where dysregulated GPCR signaling is implicated, such as certain types of cancer, neurodegenerative disorders, and cardiovascular diseases.
Dysregulation of ARRB1 can lead to altered GPCR signaling and contribute to various diseases, including cardiovascular disorders, cancer, and neurological disorders.
ARRB1 is expressed in a wide range of tissues and organs, including the brain, heart, liver, kidneys, lungs, and immune cells.
ARRB1 binds to phosphorylated GPCRs, which occurs when GPCRs are activated by ligand binding. This binding helps recruit other proteins involved in the desensitization and internalization of the receptor.
ARRB1 has emerged as a potential target for drug development due to its involvement in various diseases. Modulating ARRB1 activity could offer opportunities for developing novel therapeutics aiming to fine-tune GPCR signaling and related pathways.
ARRB1 interacts with various other proteins, including clathrin, which facilitates receptor endocytosis, and signaling molecules such as kinases and phosphatases, which mediate downstream signaling events.
In addition to its role in GPCR regulation, ARRB1 has been implicated in intracellular signaling pathways, including mitogen-activated protein kinase (MAPK) signaling, cell migration, and regulation of gene transcription.
Customer Reviews (3)
Write a reviewIt demonstrates excellent performance in ELISA, consistently delivering accurate and reliable results.
I highly recommend the ARRB1 protein for a variety of research applications.
Great performance in ELISA.
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