Recombinant Human ARRB1 Protein, His-tagged

• Cat.No.: ARRB1-026H
• Product Overview: Recombinant protein of human arrestin, beta 1 (ARRB1), transcript variant 1. was expressed in E. coli.

Specification

• Description: Members of arrestin/beta-arrestin protein family are thought to participate in agonist-mediated desensitization of G-protein-coupled receptors and cause specific dampening of cellular responses to stimuli such as hormones, neurotransmitters, or sensory signals. Arrestin beta 1 is a cytosolic protein and acts as a cofactor in the beta-adrenergic receptor kinase (BARK) mediated desensitization of beta-adrenergic receptors. Besides the central nervous system, it is expressed at high levels in peripheral blood leukocytes, and thus the BARK/beta-arrestin system is believed to play a major role in regulating receptor-mediated immune functions. Alternatively spliced transcripts encoding different isoforms of arrestin beta 1 have been described. [provided by RefSeq, Jan 2011]
  GeneCards Summary for ARRB1 Gene
• Source: E. coli
• Species: Human
• Tag: His
• Molecular Mass: 48.1 kDa
• Endotoxin: < 0.1 EU per µg protein as determined by LAL test.
• Purity: > 95% as determined by SDS-PAGE and Coomassie blue staining
• Stability: Stable for at least 6 months from date of receipt under proper storage and handling conditions.
• Concentration: Resuspend the protein to the desired concentration in proper buffer.
• Storage Buffer: Lyophilized from a 0.2 µM filtered solution of 20mM Phosphate buffer, 150mM NaCl, pH 7.2.

Gene Information

• Gene Name: ARRB1 arrestin, beta 1 [ Homo sapiens ]
• Official Symbol: ARRB1
• Synonyms: ARRB1; arrestin, beta 1; ARR1; beta-arrestin-1; arrestin 2; ARB1
• Gene ID: 408
• mRNA Refseq: NM_004041
• Protein Refseq: NP_004032
• MIM: 107940
• UniProt ID: P49407