Recombinant Human ARRB1, GST-tagged

• Cat.No.: ARRB1-9892H
• Product Overview: Recombinant Human ARRB1 protein, fused to GST-tag, was expressed in E.coli and purified by GSH-sepharose.

Specification

• Species: Human
• Source: E.coli
• Tag: GST
• Protein Length: 69-418a.a.
• Description: Members of arrestin/beta-arrestin protein family are thought to participate in agonist-mediated desensitization of G-protein-coupled receptors and cause specific dampening of cellular responses to stimuli such as hormones, neurotransmitters, or sensory signals. Arrestin beta 1 is a cytosolic protein and acts as a cofactor in the beta-adrenergic receptor kinase (BARK) mediated desensitization of beta-adrenergic receptors. Besides the central nervous system, it is expressed at high levels in peripheral blood leukocytes, and thus the BARK/beta-arrestin system is believed to play a major role in regulating receptor-mediated immune functions. Alternatively spliced transcripts encoding different isoforms of arrestin beta 1 have been described.
• Storage: The protein is stored in PBS buffer at -20℃. Avoid repeated freezing and thawing cycles.
• Storage Buffer: 1M PBS (58mM Na2HPO4,17mM NaH2PO4, 68mM NaCl, pH8. ) added with 100mM GSH and 1% Triton X-100,15%glycerol.

Gene Information

• Gene Name: ARRB1 arrestin, beta 1 [ Homo sapiens ]
• Official Symbol: ARRB1
• Synonyms: ARRB1; arrestin, beta 1; ARR1; beta-arrestin-1; arrestin 2; ARB1
• Gene ID: 408
• mRNA Refseq: NM_004041
• Protein Refseq: NP_004032
• MIM: 107940
• UniProt ID: P49407
• Chromosome Location: 11q13
• Pathway: Activated NOTCH1 Transmits Signal to the Nucleus, organism-specific biosystem; CXCR3-mediated signaling events, organism-specific biosystem; Calcium Regulation in the Cardiac Cell, organism-specific biosystem; Chemokine signaling pathway, organism-specific biosystem; Chemokine signaling pathway, conserved biosystem; Clathrin derived vesicle budding, organism-specific biosystem; Endocytosis, organism-specific biosystem
• Function: GTPase activator activity; angiotensin receptor binding; enzyme inhibitor activity; NOT histone acetyltransferase activity; insulin-like growth factor receptor binding; protein binding; transcription factor binding; transcription regulatory region DNA bin