ASAH1
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Official Full Name
N-acylsphingosine amidohydrolase (acid ceramidase) 1
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Overview
This gene encodes a heterodimeric protein consisting of a nonglycosylated alpha subunit and a glycosylated beta subunit that is cleaved to the mature enzyme posttranslationally. The encoded protein catalyzes the synthesis and degradation of ceramide into sphingosine and fatty acid. Mutations in this gene have been associated with a lysosomal storage disorder known as Farber disease. Multiple transcript variants encoding several distinct isoforms have been identified for this gene. -
Synonyms
ASAH1; N-acylsphingosine amidohydrolase (acid ceramidase) 1; ASAH, N acylsphingosine amidohydrolase (acid ceramidase); acid ceramidase; AC; FLJ21558; PHP32; acid CDase; acylsphingosine deacylase; putative 32 kDa heart protein; PHP; ASAH; ACDase; FLJ22079;
- Recombinant Proteins
- Cell & Tissue Lysates
- Protein Pre-coupled Magnetic Beads
- Chicken
- Chimpanzee
- Cynomolgus Monkey
- Human
- Mouse
- Pan troglodytes (Chimpanzee)
- Rat
- E.coli
- E.Coli or Yeast
- HEK293
- HEK293T
- In Vitro Cell Free System
- Mamanlian cells
- Mammalian Cell
- Wheat Germ
- Flag
- GST
- His
- His (Fc)
- Avi
- Myc
- His|GST|Myc
- His|SUMO
- SUMO
- DDK
- MYC
- Myc|DDK
- N/A
- N
- Involved Pathway
- Protein Function
- Interacting Protein
ASAH1 involved in several pathways and played different roles in them. We selected most pathways ASAH1 participated on our site, such as Sphingolipid metabolism, Metabolic pathways, Sphingolipid signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with ASAH1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Sphingolipid metabolism | SMPD4;VAPB;SGMS1;SMPD2;GALCA;B4GALT6;SPHK1;ACER1;NEU1 |
| Metabolic pathways | POLG;CDO1;RDH10B;ATP6V1E1;GUK1B;NAT2;POLE3;PIP5K1AB;IPMKB |
| Sphingolipid signaling pathway | PRKCZ;SGMS2;MAPK13;OPRD1;MAPK9;PPP2R5C;PIK3CA;BAX;AKT1 |
| Lysosome | CTSK;ACP5A;ARSA;CTSO;ACP5B;SLC11A2;AP1S2;GNSA;ATP6AP1B |
ASAH1 has several biochemical functions, for example, catalytic activity, ceramidase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by ASAH1 itself. We selected most functions ASAH1 had, and list some proteins which have the same functions with ASAH1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| catalytic activity | ALPI.2;BLM;DIP2BA;ETNPPL;ISOC1;RTCD1;ACSL1;ALDH1L1;CKMT2A |
| ceramidase activity | ASAH1B;ASAH2;ASAH1;ACER1 |
ASAH1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ASAH1 here. Most of them are supplied by our site. Hope this information will be useful for your research of ASAH1.
SRPK1; Bub1b; SETDB1; TSC22D1; CAMK1D; pi3p; 1-phosphatidyl-1d-myo-inositol 4,5-bisphosphate; midostaurin; A2M; cona_canen
- Q&As
- Reviews
Q&As (8)
Ask a questionGiven the involvement of ASAH1 in various diseases, including cancer, modulating its activity or developing ASAH1 inhibitors holds promise as potential therapeutic strategies.
Yes, alterations in ASAH1 gene expression or activity can impact cellular differentiation processes, as ceramide metabolism is crucial for normal development and tissue homeostasis.
Yes, mutations or deficiencies in the ASAH1 gene are associated with Farber disease, a rare inherited disorder characterized by the accumulation of ceramide in tissues throughout the body.
ASAH1 deficiency, as seen in Farber disease, is a genetic disorder. Prevention involves genetic counseling for at-risk individuals and prenatal testing during pregnancy.
Currently, ASAH1 deficiency is not included in routine newborn screening panels. However, advancements in testing methods may lead to its inclusion in the future.
Besides its role in ceramide metabolism, the ASAH1 protein can affect immune response, inflammation, and cellular stress responses.
Dysfunction of the ASAH1 protein impairs the breakdown of ceramide, leading to its accumulation in various tissues and disrupting cellular homeostasis.
Yes, the ASAH1 protein can modulate signaling pathways like the sphingosine-1-phosphate pathway, which influences various cellular processes such as migration, inflammation, and angiogenesis.
Customer Reviews (3)
Write a reviewSuch dedicated support makes me feel confident in my choice of using the ASAH1 protein for my experiments.
The manufacturer's commitment to excellence is truly commendable, especially when it comes to their outstanding technical support.
The ASAH1 Protein is a protein of exceptional quality that surpasses my expectations and fulfills all my experimental requirements.
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