atg5
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  • Official Full Name
  • autophagy related 5
  • Background
  • Required for autophagy. Conjugates to ATG12 and associates with isolation membrane to form cup-shaped isolation membrane and autophagosome. The conjugate detaches from the membrane immediately before or after autophagosome formation is completed.
    May play an important role in the apoptotic process, possibly within the modified cytoskeleton. Its expression is a relatively late event in the apoptotic process, occurring downstream of caspase activity.
  • Synonyms
  • ATG5; autophagy related 5; ASP; APG5; APG5L; hAPG5; APG5-LIKE; autophagy protein 5; apoptosis-specific protein; ATG5 autophagy related 5 homolog;
Cat.#:APG5L-679HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human APG5L protein, GST-tagged
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Cat.#:ATG5-174HTag:T7
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human ATG5 protein, T7-tagged
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Cat.#:ATG5-26988THTag:T7
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human ATG5, T7 -tagged
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Cat.#:ATG5-3425HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human ATG5, His-tagged
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Cat.#:ATG5-543HTag:
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human ATG5 Protein
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Cat.#:ATG5-73HTag:T7
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human ATG5 Autophagy Related 5 Homolog, T7-tagged
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Cat.#:ATG5-951HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human ATG5 protein, GST-tagged
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Cat.#:ATG5-2085MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse ATG5 Protein
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Cat.#:ATG5-1551CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken ATG5
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Cat.#:ATG5-1983ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish ATG5
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Cat.#:ATG5-5279HTag:T7
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human ATG5 Autophagy Related 5 Homolog (S. cerevisiae), T7-tagged
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Cat.#:ATG5-8622HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human ATG5 293 Cell Lysate
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Involved Pathway

ATG5 involved in several pathways and played different roles in them. We selected most pathways ATG5 participated on our site, such as Regulation of autophagy, RIG-I-like receptor signaling pathway, Shigellosis, which may be useful for your reference. Also, other proteins which involved in the same pathway with ATG5 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Regulation of autophagy
ULK3; ATG4B; PRKAA1; IFNA6; IFNPHI3; IFNA5; INS2; IFNA12; IFNA16; IFNA1
RIG-I-like receptor signaling pathway
NLRX1; MAPK12; TBKBP1; IL12B; MAPK13; TRADD; CXCL8B.3; Ifna11; IFNK; Ifna15
Shigellosis
IKBKG; WASL; ROCK1; MAPK12; VCL; MAPK9; MAPK1; BTRC; NFKB1; ABL1

Protein Function

ATG5 has several biochemical functions, for example, contributes_to Atg8 ligase activity, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by ATG5 itself. We selected most functions ATG5 had, and list some proteins which have the same functions with ATG5. You can find most of the proteins on our site.
Function
Related Protein
Function contributes_to Atg8 ligase activity
Related Protein ATG5
Function protein binding
Related Protein KCTD9; CLOCKA; KCNMB4; GAK; RIPK1L; RPA2; BST2; NTM; MICALL2; ARSA

Interacting Protein

ATG5 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ATG5 here. Most of them are supplied by our site. Hope this information will be useful for your research of ATG5.
ATG12; WDFY3; ATG16L1; GABARAP; MAP1LC3B

ATG5 Related Articles

Cai, PP; Wang, HX; et al. Variants of autophagy-related gene 5 are associated with neuromyelitis optica in the Southern Han Chinese population. AUTOIMMUNITY 47:563-566(2014).
Cenci, S; et al. Autophagy, a new determinant of plasma cell differentiation and antibody responses. MOLECULAR IMMUNOLOGY 62:289-295(2014).