AVPR1B
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Official Full Name
arginine vasopressin receptor 1B
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Overview
The protein encoded by this gene acts as receptor for arginine vasopressin. This receptor belongs to the subfamily of G-protein coupled receptors which includes AVPR1A, V2R and OXT receptors. Its activity is mediated by G proteins which stimulate a phosphatidylinositol-calcium second messenger system. The receptor is primarily located in the anterior pituitary, where it stimulates ACTH release. It is expressed at high levels in ACTH-secreting pituitary adenomas as well as in bronchial carcinoids responsible for the ectopic ACTH syndrome. A spliced antisense transcript of this gene has been reported but its function is not known. -
Synonyms
AVPR1B; arginine vasopressin receptor 1B; AVPR3; vasopressin V1b receptor; Antidiuretic hormone receptor 1B; AVPR V1b; AVPR V3; V1bR; V1BR_HUMAN; Vasopressin V3 receptor; VPR3; arginine vasopressin receptor 3; pituitary vasopressin receptor 3;
- Recombinant Proteins
- Protein Pre-coupled Magnetic Beads
- Assay Kits
- Chicken
- Cynomolgus Monkey
- Human
- Mouse
- Mus musculus (Mouse)
- Rat
- Rattus norvegicus (Rat)
- Rhesus Macaque
- Zebrafish
- E.coli
- E.coli expression system
- HEK293
- In Vitro Cell Free System
- In vitro E. coli expression system
- Mammalian Cell
- Wheat Germ
- His
- His (Fc)
- Avi
- N/A
- Involved Pathway
- Protein Function
- Interacting Protein
AVPR1B involved in several pathways and played different roles in them. We selected most pathways AVPR1B participated on our site, such as Calcium signaling pathway, Phospholipase D signaling pathway, Neuroactive ligand-receptor interaction, which may be useful for your reference. Also, other proteins which involved in the same pathway with AVPR1B were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Calcium signaling pathway | ADRA1D;OXTR;TRHR2;PTGER3;CACNA1DA;ATP2B4;PLCD3;EDNRBA;TACR1 |
| Phospholipase D signaling pathway | DGKD;MAP2K1;MRAS;GRM7;PLA2G4F;PIK3R1;AKT1;LPAR4;GRM1 |
| Neuroactive ligand-receptor interaction | THRA;GRM6;GABRR1;VIPR2;NPY8AR;CHRNB3B;EDNRB2;ADCYAP1R1A;HTR1AA |
| Vascular smooth muscle contraction | GNA15.1;GNA11;PRKACB;PPP1CBL;PRKACBA;RHOA;PPP1R14AB;ROCK2;PRKCA |
AVPR1B has several biochemical functions, for example, peptide binding, protein kinase C binding. Some of the functions are cooperated with other proteins, some of the functions could acted by AVPR1B itself. We selected most functions AVPR1B had, and list some proteins which have the same functions with AVPR1B. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| peptide binding | NPFFR1L2;ANPEPA;CMA1;CCKAR;AVPR2;AVPR1A;NPFFR1;ANG;GPR37L1 |
| protein kinase C binding | TIRAP;TOP2B;GRK5;LDB3;HDAC9;HDAC5;SDC4;TRPV4;SDPR |
AVPR1B has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with AVPR1B here. Most of them are supplied by our site. Hope this information will be useful for your research of AVPR1B.
- Q&As
- Reviews
Q&As (6)
Ask a questionThe AVPR1B protein binds to arginine vasopressin and, through its binding to arginine vasopressin, triggers the activation of intracellular signal transduction pathways.
AVPR1B has been implicated in a variety of neuropsychiatric disorders, and it is considered as a potential drug development target. Researchers are exploring the development of drugs that interact with AVPR1B protein for the treatment of related diseases.
AVPR1B protein is associated with a variety of signal transduction pathways, including G protein-coupled receptor signal transduction, phosphatidylinositol signal transduction, protein kinase C signal transduction, etc.
The protein is mainly expressed in the central nervous system, including areas such as the anterior pituitary, hypothalamus, and hippocampus, and is also expressed at low levels in the adrenal gland and other tissues.
The AVPR1B protein is a seven-fold transmembrane receptor protein with an N-terminal external domain and a C-terminal internal domain. The N-terminal external domain contains the site for binding to arginine vasopressin.
The protein is involved in the regulation of stress response by increasing the release of corticotrophin from the anterior pituitary in the central nervous system and regulating the levels of stress hormones, thereby affecting the generation and regulation of stress response.
Customer Reviews (3)
Write a reviewThe solubility is very good and can be easily dissolved in various buffers.
Storage conditions are very simple and can be stored for a long time.
Anti-pollution ability is very strong, not easy to be contaminated.
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