bcl2 Protein, B-Cell CLL/Lymphoma 2

bcl2

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bcl2

Official Full Name B-Cell CLL/Lymphoma 2
Background This gene encodes an integral outer mitochondrial membrane protein that blocks the apoptotic death of some cells such as lymphocytes. Constitutive expression of BCL2, such as in the case of translocation of BCL2 to Ig heavy chain locus, is thought to be the cause of follicular lymphoma. Two transcript variants, produced by alternate splicing, differ in their C-terminal ends.
Synonyms BCL2; B-cell CLL/lymphoma 2; Bcl-2; apoptosis regulator Bcl-2; PPP1R50
    • Species :
    • Chicken
    • Human
    • Mouse
    • Rat
    • Source :
    • E.coli
    • E.Coli or Yeast
    • HEK293
    • HEK293T
    • Human (minus BH1 domain)
    • Human (minus BH3 domain)
    • Human (minus NWGR domain)
    • Mammalian Cell
    • Wheat Germ
    • Tag :
    • GST
    • His
    • T7
    • MYC/DDK
    • Myc
    • DDK
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Mouse Bcl2-697M Recombinant Mouse Bcl2 Protein, MYC/DDK-tagged HEK293T MYC/DDK
    Human BCL2-76H Recombinant Human BCL2 protein E.coli N/A
    Human BCL2-1346H Recombinant Human BCL2, BH2 domain, His-tagged E.coli His
    Human BCL2-143H Recombinant Human BCL2 Protein, GST-tagged Wheat Germ GST
    Human BCL2-147H Recombinant Human Bcl-2 BH4 [1-218, BH4(10-30)] E.coli GST
    Human BCL2-2469H Recombinant Human BCL2 Protein, MYC/DDK-tagged HEK293 Myc/DDK
    Human BCL2-264H Recombinant Human BCL2 Mammalian Cell His
    Human BCL2-26613TH Recombinant Human BCL2, His-tagged E.coli His
    Human BCL2-266H Recombinant Human BCL2 protein, His-tagged E.coli His
    Human BCL2-26734TH Recombinant Human BCL2 protein, GST-tagged E.coli GST
    Human BCL2-27441TH Recombinant Human BCL2, His-tagged E.coli His
    Human BCL2-322H Recombinant Human B-Cell CLL/Lymphoma 2, GST-tagged E.coli GST
    Human BCL2-4221H Recombinant Human (minus BH1 domain) B-Cell CLL/Lymphoma 2, His-tagged Human (minus BH1 domain) His
    Human BCL2-4222H Recombinant Human (minus BH3 domain) B-Cell CLL/Lymphoma 2, His-tagged Human (minus BH3 domain) His
    Human BCL2-4225H Recombinant Human (minus NWGR domain) B-Cell CLL/Lymphoma 2, His-tagged Human (minus NWGR domain) His
    Human BCL2-5289H Recombinant Human B-Cell CLL/Lymphoma 2, His-tagged E.coli His
    Human BCL2-5296H Recombinant Human B-Cell CLL/Lymphoma 2, His-tagged E.coli His
    Human BCL2-5298H Recombinant Human B-cell CLL/lymphoma 2, GST-tagged Wheat Germ GST
    Human BCL2-5361H Recombinant Human B-cell CLL/lymphoma 2, His-tagged E.coli His
    Mouse BCL2-2337M Recombinant Mouse BCL2 Protein Mammalian Cell His
    Mouse Bcl2-3582M Recombinant Mouse Bcl2, His-tagged E.Coli or Yeast His
    Mouse Bcl2-7661M Recombinant Mouse Bcl2 protein, His & T7-tagged E.coli His/T7
    Rat BCL2-957R Recombinant Rat BCL2 Protein Mammalian Cell His
    Chicken BCL2-6891C Recombinant Chicken BCL2 Mammalian Cell His
    Kit-1686 BCL-2 TR-FRET Assay Kit N/A

    bcl2 involved in several pathways and played different roles in them. We selected most pathways bcl2 participated on our site, such as NF-kappa B signaling pathway, HIF- signaling pathway, Sphingolipid signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with bcl2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    NF-kappa B signaling pathway CCL4L2; CD40LG; TRAF2; CCL21; IRAK1; TNFRSF13C; LCK; MAP3K14; IKBKB; CXCL2
    HIF- signaling pathway TCEB1; PDHB; Trf; PIK3R3; ANGPT1; HK2; RPS6KB2; ANGPT2; IGF1R; PIK3R2
    Sphingolipid signaling pathway PLCB2; PPP2CA; PLCB4; PLD2; PLCB1; TNFRSF1A; PLD1; LASS2; SMPD2; SPTLC3
    Protein processing in endoplasmic reticulum EIF2AK2; PRKCSH; TXNDC5; HSPA1L; HSPA6; RRBP1B; UBE2D2; PDIP5; HSP26; UBE2D2A
    PIK-Akt signaling pathway ITGA3; Il2; LPAR2; CASP9; Reln; RXRA; IFNA1; CD19; TCL1A; ITGB4
    Apoptosis AIFM1; IRF1B; BOK; CAPN2; PRKAR1AB; CSF2RB; GZMF; PIK3CB; CASP7; YWHAQ
    Adrenergic signaling in cardiomyocytes PPP1CBL; MAPK14B; PRKACAB; MAPK14A; RPS6KA5; PIK3R3B; ATP2B4; ATP1B3B; CREB3L3; ATF4B1
    Focal adhesion ACTB1; ACTN3B; COL6A6; LAMC1; PIK3R3A; RAC1B; PRKCB; AKT2L; RAC1A; SHC1
    Jak-STAT signaling pathway IL10RB; CCND1; PIK3R5; IL20; GH1; IL7; IL-15RA; IL27RA; PTPN2; IL6
    Neurotrophin signaling pathway ZNF274; KIDINS220; MAPK7; Fasl; PIK3CG; GRB2; ARHGDIG; SH2B2; PSEN1; SORT1
    Cholinergic synapse PIK3CD; CREB3L1; GNAI3; CREB3L2; PIK3CB; GNG10; PIK3R1; PLCB4; GNG13; GNGT1
    Amyotrophic lateral sclerosis (ALS) BCL2; SOD1; CASP12; NEFL; BCL2L1; CASP1; PPP3CA; SLC1A2; TNFRSF1A; CAT
    Toxoplasmosis IKBKB; PIK3CG; GNAO1; MAPK1; HLA-DQB1; IL10RB; LAMA1; CYCS; HSPA6; IRGM1
    Tuberculosis TGFB2; BCL2; Ifna15; HLA-DOB; Cd209g; CAP18; HSPD1; IFNA2; CAMP; TNFRSF1A
    Hepatitis B MAP3K1; IFNA14; DDB2; IKBKE; ATF4; CASP10; MAVS; YWHAB; IL6; PCNA
    Epstein-Barr virus infection NEDD4; HSPA1L; HLA-DRB1; POLR3K; MDM2; SPN; AKT1; LYN; YWHAG; POLR3D
    Pathways in cancer ROCK2; PDGFRA; STK36; FGF7; SMO; RASGRP3; KRAS; GNAQ; HSP90B1; GNG13
    MicroRNAs in cancer PRKCE; CCNE1; CDC25B; STMN1; EZR; TRP53; BMI1; TGFB2; SOX4; FOXP1
    Colorectal cancer TCF7; MLH1; TP53; MAP2K1; APC2; PIK3CA; BIRC5; AKT2; BCL2; RAC1
    Prostate cancer KRAS; PIK3R3; IGF1R; BAD; CCND1; SMARCC2; CPN1; MAP2K1; AKT2; ARAF
    Small cell lung cancer CKS2; ITGA2; LAMC1; PIK3CA; TRAF4; RXRA; PIK3CD; NOS2; LAMC2; BIRC3

    bcl2 has several biochemical functions, for example, BH3 domain binding, channel activity, channel inhibitor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by bcl2 itself. We selected most functions bcl2 had, and list some proteins which have the same functions with bcl2. You can find most of the proteins on our site.

    Function Related Protein
    BH3 domain binding BCL2L1; BAX; MCL1; BCL2
    channel activity APNL; BAXA; P2RX6; CHRNB1; STEAP1; GJA8; PANX1B; MAL; PANX2; BAX
    channel inhibitor activity BCL2
    identical protein binding UHRF1; IL12B; RBM10; DVL2; KCTD13; ALCAMB; CLDN17; L3MBTL1; PSMA7; NUP153
    protease binding LCN2; ITGB1; SERPINB3; INS2; CHL1; INS; ECM1; ADAM8A; SERPINB6; TRIP4
    protein binding PRC1; RAP1GAP; CDH2; AGBL4; HLA-A; NOTCH3; TMEM149; FKBP8; PUM1; USP17L2
    protein heterodimerization activity F11R.1; MAPK6; SOX8; PVRL1; HNF1B; NEFH; IRAK1; TBX15; H2-AB1; STX1A
    protein homodimerization activity GABPB2; NOG; HSPB6; SNX6; KCNN2; CRYM; MID1; MYH7; IRAK3; CCBL2
    protein phosphatase 2A binding CTTNBP2NL; MASTL; FOXO1; EIF4EBP1; BCL2; MAPT; SHC1; TRP53; STRN4; SPHK1
    sequence-specific DNA binding MSXE; MSXC; E2F5; BACH1A; DLX1A; TAF1; VENTX; POU3F3; NKX1-2; POU2F2
    transcription factor binding PRICKLE1; GATA3; FOXA3; FOXA1; HMGA1; INSIG2; NCOA2; HES1; NR0B2A; MYBBP1A
    ubiquitin protein ligase binding NEDD8; UBE2T; CDC34A; CUL4B; ARRB1; RELA; USP25; TPI1; LYN; CBS

    bcl2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with bcl2 here. Most of them are supplied by our site. Hope this information will be useful for your research of bcl2.

    BECN1; BAX

    Marguet, F; Bergogne, L; et al. Fetal presentation of congenital fibrosarcoma of the meninges: case report and literature review. CLINICAL NEUROPATHOLOGY 34:70-75(2015).
    Abdel-Latif, M; Sakran, T; et al. Immunomodulatory effect of diethylcarbamazine citrate plus filarial excretory-secretory product on rat hepatocarcinogenesis. INTERNATIONAL IMMUNOPHARMACOLOGY 24:173-181(2015).

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