BCL2
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Official Full Name
B-Cell CLL/Lymphoma 2
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Overview
This gene encodes an integral outer mitochondrial membrane protein that blocks the apoptotic death of some cells such as lymphocytes. Constitutive expression of BCL2, such as in the case of translocation of BCL2 to Ig heavy chain locus, is thought to be the cause of follicular lymphoma. Two transcript variants, produced by alternate splicing, differ in their C-terminal ends. -
Synonyms
BCL2; B-cell CLL/lymphoma 2; Bcl-2; apoptosis regulator Bcl-2; PPP1R50;
- Recombinant Proteins
- Protein Pre-coupled Magnetic Beads
- Assay Kits
- Bos taurus (Bovine)
- Canis lupus familiaris (Dog) (Canis familiaris)
- Chicken
- Cricetulus griseus (Chinese hamster) (Cricetulus barabensis griseus)
- Dog
- Gallus gallus (Chicken)
- Homo sapiens (Human)
- Human
- Mouse
- Mus musculus (Mouse)
- Rat
- Rattus norvegicus (Rat)
- E.coli
- E.coli expression system
- E.Coli or Yeast
- HEK293
- HEK293T
- Human (minus BH1 domain)
- Human (minus BH3 domain)
- Human (minus NWGR domain)
- In Vitro Cell Free System
- In vitro E. coli expression system
- in vitro E.coli expression system
- Mammalian Cell
- Mammalian cells
- Wheat Germ
- Flag
- GST
- His
- Fc
- Avi
- T7
- Myc
- DDK
- N
- Non
- SUMO
- C
- Involved Pathway
- Protein Function
- Interacting Protein
- Other Resource
- BCL2 Related Signal Pathway
BCL2 involved in several pathways and played different roles in them. We selected most pathways BCL2 participated on our site, such as NF-kappa B signaling pathway, HIF- signaling pathway, Sphingolipid signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with BCL2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| NF-kappa B signaling pathway | CCL4L2;LRDD;PLCG1;ATM;CFLAR;TRIM25;LCK;CCL4L1;PLCG2 |
| HIF- signaling pathway | LDHA;MAPK1;TFRC;INS;PDHA2;PGK1;IFNGR1;NPPA;PLCG2 |
| Sphingolipid signaling pathway | RAC3;GNA12;SMPD2;PPP2CA;MAPK10;GAB2;MAPK1;SPHK2;PPP2R3C |
| Protein processing in endoplasmic reticulum | EIF2AK3;SEC61AL2;ATF6;HNF4B;HSPA4L;DNAJB11;UBE2G1B;EDEM2;CAPN1A |
| PIK-Akt signaling pathway | COL6A6;ITGA2B;CREB3L2;FGF8;TCL1B1;CCND2;TSC1;NR4A1;FGF13 |
| Apoptosis | NGF;PRKACA;DBNLB;IL1B2;NFKB1;PRKAR2B;BADB;IRAK2;TNF |
| Adrenergic signaling in cardiomyocytes | CALM2A;ATP1B2A;ATP1B1A;CREB3L3L;SLC8A1;PPP2R1B;AGTR1A;GNAQ;ACTC1 |
| Focal adhesion | STYK1;BCAR1;ROCK2A;RAC3B;Pdgfa&Pdgfb;LAMA3;COL5A1;ITGB4;PIK3R3B |
| Jak-STAT signaling pathway | GRB2B;PIAS4B;PIK3CB;FHL1;STAM;CSH;STAT5A;LEPR;AOX3 |
| Neurotrophin signaling pathway | RAP1A;MAPKAPK2;RPS6KA1;PIK3CD;ARHGDIA;SOS1;MAPK3;ARHGDIB;MAPK10 |
| Cholinergic synapse | CHRNA3;CREB3L1;KCNQ1;KCNQ3;ACHE;GNG2;CREB5;BCL2;NRAS |
| Amyotrophic lateral sclerosis (ALS) | PPP3R2;BAD;NEFM;MAP3K5;BID;SLC1A2;PRPH;GRIN2C;DAXX |
| Toxoplasmosis | TNFRSF1A;ALOX5;H2-AA;RELA;LAMA5;TLR4;HLA-DOA;TGFB2;MAPK13 |
| Tuberculosis | Casp3;IL6;RFX5;PPP3CB;HLA-DRB1;CALM4;PMAP-36;MAPK8;CALML5 |
| Hepatitis B | NFATC1;CXCL8;STAT6;APAF1;RELA;CCNE1;MAPK3;IFNA7;PIK3R2 |
| Epstein-Barr virus infection | NFKBIE;CSNK2B;HLA-B;HSPA1L;TRAF3;FGR;PIK3CG;AKT2;SNW1 |
| Pathways in cancer | MMP1;LAMC2;Fasl;GNG7;RUNX1T1;HHIP;PPARD;PLCG1;PLCB4 |
| MicroRNAs in cancer | DICER1;HDAC4;BMF;MMP16;RAF1;TRIM71;PLCG2;GLS2;NOTCH2 |
| Colorectal cancer | CCND1;PIK3R5;RHOA;AXIN2;KRAS;TCF7;LEF1;RAC1;APPL1 |
| Prostate cancer | HSP90AA1;IGF1R;PDGFRB;PIK3CB;NKX3-1;PDPK1;FOXA1;MTOR;CASP9 |
| Small cell lung cancer | ITGA6;NOS2;LAMC1;FN1;LAMA2;TP53;RARB;PIAS2;PIK3CG |
BCL2 has several biochemical functions, for example, BH3 domain binding, channel activity, channel inhibitor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by BCL2 itself. We selected most functions BCL2 had, and list some proteins which have the same functions with BCL2. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| BH3 domain binding | MCL1;BCL2;BCL2L1;BAX |
| channel activity | APNL;PANX2;PANX1A;MAL;TRPA1;P2RX6;CHRNB1;BAX;GJA8 |
| channel inhibitor activity | |
| identical protein binding | CLDN23;DRD2;CXADR;NLRC4;DYRK1A;MYOM1;SNRNP200;DCTPP1;CCDC91 |
| protease binding | NFRKB;SRI;VWF;ADAMTS4;PEO1;ADRM1;POLG;TNFAIP3;NDUFS7 |
| protein binding | PELI3;PLCE1;ARHGAP1;GRASP;GPR37L1;LRPPRC;FANCG;ZMAT4;THEMIS |
| protein heterodimerization activity | LIMK2;CD3G;USF1;ENO2;SYCP2;PDX1;H3F3B;PRMT8;DMRTA2 |
| protein homodimerization activity | C9orf142;CISD2;S100A1;ASMT;TERF1;GSTM3;SYT14;VIL1;EIF2AK1 |
| protein phosphatase 2A binding | ARPP19;SMG7;TP53;GRIN3A;CPD;FOXO1;SHC1;MASTL;PPME1 |
| sequence-specific DNA binding | DMRT2;ISL2B;ZKSCAN3;TBX5;JUNBB;ZNF193;SIX1B;GLI1;VDRA |
| transcription factor binding | BRD7;SMARCA4;KAT2A;ZBTB49;HEY2;DIP2C;HES2;NFKBIA;KAT8 |
| ubiquitin protein ligase binding | IKBKE;DTX1;CUL9;BAG5;CUL5;MFN2;ACVR1B;HIF1A;TOLLIP |
BCL2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with BCL2 here. Most of them are supplied by our site. Hope this information will be useful for your research of BCL2.
BECN1; BAX
Gene Family
Research Area
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