bcl2
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  • Official Full Name
  • B-Cell CLL/Lymphoma 2
  • Background
  • This gene encodes an integral outer mitochondrial membrane protein that blocks the apoptotic death of some cells such as lymphocytes. Constitutive expression of BCL2, such as in the case of translocation of BCL2 to Ig heavy chain locus, is thought to be the cause of follicular lymphoma. Two transcript variants, produced by alternate splicing, differ in their C-terminal ends.
  • Synonyms
  • BCL2; B-cell CLL/lymphoma 2; Bcl-2; apoptosis regulator Bcl-2; PPP1R50
Cat.#:BCL2-2469HTag:MYC/DDK
Source (Host):HEK293Species:Human
Product nameRecombinant Human BCL2 Protein, MYC/DDK-tagged
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Cat.#:BCL2-143HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human BCL2 Protein, GST-tagged
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Cat.#:BCL2-264HTag:His
Source (Host):Mammalian CellsSpecies:Human
Product nameRecombinant Human BCL2
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Cat.#:BCL2-26613THTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human BCL2, His-tagged
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Cat.#:BCL2-266HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human BCL2 protein, His-tagged
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Cat.#:BCL2-26734THTag:GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human BCL2 protein, GST-tagged
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Cat.#:BCL2-27441THTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human BCL2, His-tagged
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Cat.#:BCL2-4221HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human (minus BH1 domain) B-Cell CLL/Lymphoma 2, His-tagged
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Cat.#:BCL2-4222HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human (minus BH3 domain) B-Cell CLL/Lymphoma 2, His-tagged
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Cat.#:BCL2-4225HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human (minus NWGR domain) B-Cell CLL/Lymphoma 2, His-tagged
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Cat.#:BCL2-2337MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse BCL2 Protein
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Cat.#:Bcl2-3582MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse Bcl2, His-tagged
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Cat.#:Bcl2-7661MTag:His/T7
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse Bcl2 protein, His & T7-tagged
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Cat.#:BCL2-957RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat BCL2 Protein
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Cat.#:BCL2-6891CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken BCL2
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Cat.#:BCL2-5289HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human B-Cell CLL/Lymphoma 2, His-tagged
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Cat.#:BCL2-5296HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human B-Cell CLL/Lymphoma 2, His-tagged
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Cat.#:BCL2-5298HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human B-cell CLL/lymphoma 2, GST-tagged
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Cat.#:BCL2-5361HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human B-cell CLL/lymphoma 2, His-tagged
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Cat.#:BCL2-322HTag:GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human B-Cell CLL/Lymphoma 2, GST-tagged
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Cat.#:BCL2-1346HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human BCL2, BH2 domain, His-tagged
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Cat.#:BCL2-147HTag:GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human Bcl-2 BH4 [1-218, BH4(10-30)]
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Cat.#:Kit-1686Tag:
Source (Host):Species:
Product nameBCL-2 TR-FRET Assay Kit
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Involved Pathway

BCL2 involved in several pathways and played different roles in them. We selected most pathways BCL2 participated on our site, such as NF-kappa B signaling pathway, HIF- signaling pathway, Sphingolipid signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with BCL2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
NF-kappa B signaling pathway
LBP; MYD88; BCL2; CCL4L1; PLCG2; XIAP; TNFSF11; TNFRSF13C; CCL13; ICAM1
HIF- signaling pathway
Trf; PRKCB; HKDC1; PRKCG; IFNG; EGLN1; IGF1; MAP2K1; PDHA2; ERBB2
Sphingolipid signaling pathway
PRKCB; SMPD2; PRKCA; NFKB1; NOS3; PLCB4; S1PR5; CERS2; PPP2CA; PPP2CB
Protein processing in endoplasmic reticulum
SEC24B; DNAJC5G; MBTPS2; UGGT1; CAPN1A; MAN1A; RPN2; MAP2K7; UBE2D1B; ERO1L
PIK-Akt signaling pathway
Pdgfa&Pdgfb; NGF; CREB3L2; HRAS; RXRA; LPAR6; PDGFRB; ITGA5; ITGA2B; IL3
Apoptosis
GAS2; H1F0; TNFRSF10D; TRADD; MAP3K14; IRAK4; ADD1; PLEC; XIAP; PPP3CCB
Adrenergic signaling in cardiomyocytes
MYH15; CALM1; CALM3; TPMA; CREB5; PLN; SLC9A1; RYR2; GNAI2; ADRB2
Focal adhesion
ITGA3; COL27A1B; LAMA1; ITGB1B.2; RAF1; PIK3CB; ACTN2; STYK1; VEGFAB; MYL9A
Jak-STAT signaling pathway
SOCS6; IFNE; MYCB; IL5; IFNW1; IL27RA; IL15; AOX2P; IL11RA2; CSF3
Neurotrophin signaling pathway
CALM2; FOXO3; PIK3CD; NTF3; RAP1B; RAPGEF1; BAD; SHC1; PIK3CA; PSEN2
Cholinergic synapse
CHRNA6; CAMK2D; MAPK1; KCNQ4; CHRNA7; CREB5; GNAI3; PIK3CG; CREB3L2; PIK3CB
Amyotrophic lateral sclerosis (ALS)
MAP3K5; CCS; TNF; DAXX; CASP12; APAF1; TP53; MAPK11; PPP3CB; PRPH
Toxoplasmosis
LAMA4; HLA-DMB; MAPK11; LAMB3; MAP2K3; Toxoplasma Gondii Profilin Family Protein; IL12B; HLA-DRB3; BIRC8; PIK3CA
Tuberculosis
ATP6V0A2; RIPK2; SPHK1; FCGR1; PIK3C3; IL1B; IFNA16; HLA-DRB5; HLA-DOB; IFNA13
Hepatitis B
PIK3R2; IFNA10; EP300; RELA; CCNE1; DDX58; ATF4; IFIH1; NFKBIA; FADD
Epstein-Barr virus infection
HSPA1A; POLR2A; EIF2AK1; YWHAE; HSPB2; TAB1; PSMD1; POLR2D; TRADD; PSMC2
Pathways in cancer
SPI1; GLI1; KRAS; VHL; Flt3l; STAT5A; TGFB3; GNAI2; PML; PTCH2
MicroRNAs in cancer
ZFPM2; PDGFA; MET; PRKCE; EZH2; MCL1; PRKCB; IRS1; TNXB; SLC7A1
Colorectal cancer
APC2; PIK3CA; FOS; SMAD2; APPL1; Casp3; AXIN1; PIK3CB; RAC2; RAC1
Prostate cancer
MAPK3; AKT2; RAF1; NKX3; MAPK1; NOXA1; CREB5; NRAS; HSP90AA1; CCND1
Small cell lung cancer
FN1; CCNE1; SKP2; BIRC7; ITGA2B; LAMA4; LAMB1; LAMA1; PIK3R5; PTGS2

Protein Function

BCL2 has several biochemical functions, for example, BH3 domain binding, channel activity, channel inhibitor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by BCL2 itself. We selected most functions BCL2 had, and list some proteins which have the same functions with BCL2. You can find most of the proteins on our site.
Function
Related Protein
Function BH3 domain binding
Related Protein BCL2; BCL2L1; MCL1; BAX
Function channel activity
Related Protein TRPA1; PANX2; P2RX6; BCL2; PANX1A; BAXA; GJA8; CHRNB1; BAXB; STEAP1
Function channel inhibitor activity
Related Protein BCL2
Function identical protein binding
Related Protein FNBP1; BAG2; SQSTM1; SLC2A1; COMMD1; G6PD; MTPAP; ATXN10; RABAC1; TRA@
Function protease binding
Related Protein CST3; CSTA; F3; SERPINC1; SRI; NDUFS7; BCL2; SELL; POLG; CD70
Function protein binding
Related Protein NBR1; UBXN2B; RIBC2; CRTAC1; ADAM12; SNX6; ASB9; UBQLN4; EDA; KRTAP3-2
Function protein heterodimerization activity
Related Protein JDP2; YWHAH; Bcl2a1b; MYOD1; DMBX1; PDZD7; ALX4; CLCF1; SOX8; FZD9
Function protein homodimerization activity
Related Protein TPD52L1; GOLGA5; MID1; TIMM9; NACC2; ENO2; BNIP3L; DROSHA; GRPEL1; HRSP12
Function protein phosphatase 2A binding
Related Protein EIF4EBP1; SMG5; IGBP1; PTPN1; ANKLE2; SHC1; ENSA; HMGCR; STRN4; BCL2
Function sequence-specific DNA binding
Related Protein NR5A5; ZBTB4; TCF7L1A; FOXL1; FOXO3; OSR2; NR4A2A; RX3; ARGFX; THRA
Function transcription factor binding
Related Protein ARRB1; TFAP2A; TAF7L; MYOCD; DNAJA3; SOX10; MED25; PARD6A; NKX3-1; CEBPA
Function ubiquitin protein ligase binding
Related Protein LTBR; PRKAR2A; C10orf46; FAF2; VCP; ASB4; FAF1; HSPD1; SCN5A; PACRG

Interacting Protein

BCL2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with BCL2 here. Most of them are supplied by our site. Hope this information will be useful for your research of BCL2.
BECN1; BAX

BCL2 Related Articles

Marguet, F; Bergogne, L; et al. Fetal presentation of congenital fibrosarcoma of the meninges: case report and literature review. CLINICAL NEUROPATHOLOGY 34:70-75(2015).
Abdel-Latif, M; Sakran, T; et al. Immunomodulatory effect of diethylcarbamazine citrate plus filarial excretory-secretory product on rat hepatocarcinogenesis. INTERNATIONAL IMMUNOPHARMACOLOGY 24:173-181(2015).

BCL2 Related Gene Family

BCL2 Gene Family