BCL2

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BCL2

Official Full Name B-Cell CLL/Lymphoma 2
Background This gene encodes an integral outer mitochondrial membrane protein that blocks the apoptotic death of some cells such as lymphocytes. Constitutive expression of BCL2, such as in the case of translocation of BCL2 to Ig heavy chain locus, is thought to be the cause of follicular lymphoma. Two transcript variants, produced by alternate splicing, differ in their C-terminal ends.
Synonyms BCL2; B-cell CLL/lymphoma 2; Bcl-2; apoptosis regulator Bcl-2; PPP1R50
    • Species :
    • Chicken
    • Human
    • Mouse
    • Rat
    • Source :
    • E. coli
    • E.coli
    • E.Coli or Yeast
    • HEK293
    • HEK293T
    • Human (minus BH1 domain)
    • Human (minus BH3 domain)
    • Human (minus NWGR domain)
    • Mammalian Cell
    • Wheat Germ
    • Tag :
    • GST
    • His
    • T7
    • MYC/DDK
    • Myc
    • DDK
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Mouse Bcl2-2580M Recombinant Mouse Bcl2 protein, His-tagged E.coli His
    Human BCL2-1346H Recombinant Human BCL2, BH2 domain, His-tagged E.coli His
    Human BCL2-143H Recombinant Human BCL2 Protein, GST-tagged Wheat Germ GST
    Human BCL2-147H Recombinant Human Bcl-2 BH4 [1-218, BH4(10-30)] E.coli GST
    Human BCL2-2469H Recombinant Human BCL2 Protein, MYC/DDK-tagged HEK293 Myc/DDK
    Human BCL2-264H Recombinant Human BCL2 Mammalian Cell His
    Human BCL2-26613TH Recombinant Human BCL2, His-tagged E.coli His
    Human BCL2-266H Recombinant Human BCL2 protein, His-tagged E.coli His
    Human BCL2-26734TH Recombinant Human BCL2 protein, GST-tagged E.coli GST
    Human BCL2-267H Recombinant Human BCL2 protein (Met 1-Asp 211), His-tagged E. coli His
    Human BCL2-27441TH Recombinant Human BCL2, His-tagged E.coli His
    Human BCL2-322H Recombinant Human B-Cell CLL/Lymphoma 2, GST-tagged E.coli GST
    Human BCL2-4221H Recombinant Human (minus BH1 domain) B-Cell CLL/Lymphoma 2, His-tagged Human (minus BH1 domain) His
    Human BCL2-4222H Recombinant Human (minus BH3 domain) B-Cell CLL/Lymphoma 2, His-tagged Human (minus BH3 domain) His
    Human BCL2-4225H Recombinant Human (minus NWGR domain) B-Cell CLL/Lymphoma 2, His-tagged Human (minus NWGR domain) His
    Human BCL2-4343H Recombinant Human BCL2 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
    Human BCL2-5289H Recombinant Human B-Cell CLL/Lymphoma 2, His-tagged E.coli His
    Human BCL2-5296H Recombinant Human B-Cell CLL/Lymphoma 2, His-tagged E.coli His
    Human BCL2-5298H Recombinant Human B-cell CLL/lymphoma 2, GST-tagged Wheat Germ GST
    Human BCL2-5361H Recombinant Human B-cell CLL/lymphoma 2, His-tagged E.coli His
    Human BCL2-76H Recombinant Human BCL2 protein E.coli N/A
    Mouse BCL2-2337M Recombinant Mouse BCL2 Protein Mammalian Cell His
    Mouse Bcl2-3582M Recombinant Mouse Bcl2, His-tagged E.Coli or Yeast His
    Mouse Bcl2-697M Recombinant Mouse Bcl2 Protein, MYC/DDK-tagged HEK293T MYC/DDK
    Mouse Bcl2-7661M Recombinant Mouse Bcl2 protein, His & T7-tagged E.coli His/T7
    Rat BCL2-957R Recombinant Rat BCL2 Protein Mammalian Cell His
    Chicken BCL2-6891C Recombinant Chicken BCL2 Mammalian Cell His
    Kit-1686 BCL-2 TR-FRET Assay Kit N/A

    BCL2 involved in several pathways and played different roles in them. We selected most pathways BCL2 participated on our site, such as NF-kappa B signaling pathway, HIF- signaling pathway, Sphingolipid signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with BCL2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    NF-kappa B signaling pathway MAP3K7; GM10591; CFLAR; CCL19; CXCL12; TRAF1; VCAM1; BLNK; BCL2A1A; PTGS2
    HIF- signaling pathway STAT3; Trf; PIK3R2; RBX1; PIK3CB; RPS6KB1; ENO3; ANGPT1; MAPK1; SERPINE1
    Sphingolipid signaling pathway OPRD1; ROCK2; PPP2R5E; PPP2R5C; NRAS; SGPL1; PIK3CD; BDKRB2; DEGS2; PPP2R2A
    Protein processing in endoplasmic reticulum UBE2D1B; RAD23B; ERN1; MAN1C1; RNF185; RAD23A; DNAJC1; CAPN1A; EIF2S1B; UBE2D1A
    PIK-Akt signaling pathway TLR4; THBS1; IRS1; ANGPT4; Ifna11; RAF1; HSP90AB1; LAMA4; SGK3; GSK3B
    Apoptosis IL1A; BOK; HIST1H1A; PIK3R5; GZMF; PRKACAB; BIRC5A; DNM1L; DIABLO; DFFB
    Adrenergic signaling in cardiomyocytes MAPK14B; ADRB2A; PPP2R5A; CACNB3A; RAPGEF4; ATP1B3A; PPP1CAB; CALM1B; CACNA1C; PPP2R5D
    Focal adhesion ROCK1; CCND3; ACTN3; Itga10&Itgb1; FYN; RAC1; MAPK4; MYLPFB; PPP1CB; LAMA4
    Jak-STAT signaling pathway IL12RB2; LEPA; IL2RGB; SOCS7; IL5RA; IL6; IL10RA; PRLR; TP-1; IL7R
    Neurotrophin signaling pathway PIK3R3; SH2B2; PLCG1; SH2B3; NGFR; RAPGEF1; MAP3K5; MAP2K5; IKBKB; TRAF6
    Cholinergic synapse PLCB3; GNG5; BCL2; CREB3L2; ITPR1; KCNJ4; JAK2; KCNQ5; CHRNB2; CHRNA7
    Amyotrophic lateral sclerosis (ALS) TRP53; NEFL; GRIA1; CASP12; GRIA2; NOS1; ALS2; NEFM; PPP3CA; PPP3CB
    Toxoplasmosis PDPK1; TGFB3; IRAK4; TLR4; HSPA1L; PIK3R1; HLA-DRB1; HSPA2; BCL2L1; H2-AB1
    Tuberculosis PPP3CB; CAMK2B; cgr2b; BAD; HLA-DQA1; ITGB2L; RELA; HLA-DPA1; IFNA4; IRAK2
    Hepatitis B ELK1; FAS; BAD; CASP8; MAPK1; STAT5A; PIK3R5; TLR4; IFNA1; NFATC3
    Epstein-Barr virus infection HLA-DRB5; PRKACB; AKT2; PSMD11; SPN; IKBKB; TRAF1; HDAC4; ICAM1; HLA-DQA2
    Pathways in cancer RBX1; LEF1; ITGA2B; MMP9; HRAS; AGTR1B; CDC42; CCND1; BIRC7; CBL
    MicroRNAs in cancer RPS6KA5; SOS1; DNMT3B; RDX; ROCK1; PTEN; NFKB1; ZEB2; MAPK7; CDC25B
    Colorectal cancer MLH1; AXIN1; MSH3; PIK3CA; MAPK10; PIK3CD; MSH2; PIK3CB; AKT1; MAPK1
    Prostate cancer Pdgfa&Pdgfb; MDM2; NRAS; KRAS; FGFR1; TGFA; PDGFRA; TCF7L2; TCF7; PDGFC
    Small cell lung cancer TRAF3; PIK3CA; PIK3CG; RB1; LAMA5; RARB; TRAF5; TRAF4; LAMA4; CCND1

    BCL2 has several biochemical functions, for example, BH3 domain binding, channel activity, channel inhibitor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by BCL2 itself. We selected most functions BCL2 had, and list some proteins which have the same functions with BCL2. You can find most of the proteins on our site.

    Function Related Protein
    BH3 domain binding BCL2L1; BCL2; MCL1; BAX
    channel activity TRPA1; PANX2; PANX1B; PANX1A; STEAP1; GJA8; BCL2; APNL; BAX; CHRNB1
    channel inhibitor activity BCL2
    identical protein binding ALAD; CLDN16; TTN; AKT1; SCAND1; UBQLN4; HGF; S100A4; TGFB3; GM5077
    protease binding TIMP2A; ADAMTSL4; SERPINA1D; C10orf2; MBP; CFLAR; FAP; Casp3; IL1R1; TNFRSF10A
    protein binding BRMS1; SRPK2; COX4I1; AGGF1; ADAMTS4; EFEMP1; RTN4RL1; RTN1; MASP2; EIF2B4
    protein heterodimerization activity TIRAP; MAFGB; SYT14; AXL; HIST1H3F; GABPB2; HEXA; IKZF4; SLC51A; HIST1H2AF
    protein homodimerization activity MID1; RAG1; S100B; BCL11A; KIAA1804; SYNE1; SFTPC; SLC9A7; GAMT; GRIK2
    protein phosphatase 2A binding STRN; CPD; CTTNBP2NL; FOXO1; PPP2R4; SMG7; EIF4EBP1; AKT1; IGBP1; TRP53
    sequence-specific DNA binding CDX1B; SALL4; NFE2L2B; FOXR2; IRX3; RARAB; NKX2-6; HOXA9A; ZBTB49; HMX2
    transcription factor binding RNF19A; GTF2B; ZFPM2; HTT; BCL10; UBN1; RNF222; HDAC1; PPP1R13BA; HYAL1
    ubiquitin protein ligase binding ATXN3; ANKRD32; TMEM173; PACRG; FZD6; TRIB1; PPARGC1A; UBE2S; MOAP1; USP13

    BCL2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with BCL2 here. Most of them are supplied by our site. Hope this information will be useful for your research of BCL2.

    BECN1; BAX

    Marguet, F; Bergogne, L; et al. Fetal presentation of congenital fibrosarcoma of the meninges: case report and literature review. CLINICAL NEUROPATHOLOGY 34:70-75(2015).
    Abdel-Latif, M; Sakran, T; et al. Immunomodulatory effect of diethylcarbamazine citrate plus filarial excretory-secretory product on rat hepatocarcinogenesis. INTERNATIONAL IMMUNOPHARMACOLOGY 24:173-181(2015).

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