BCL2

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BCL2

Official Full Name B-Cell CLL/Lymphoma 2
Background This gene encodes an integral outer mitochondrial membrane protein that blocks the apoptotic death of some cells such as lymphocytes. Constitutive expression of BCL2, such as in the case of translocation of BCL2 to Ig heavy chain locus, is thought to be the cause of follicular lymphoma. Two transcript variants, produced by alternate splicing, differ in their C-terminal ends.
Synonyms BCL2; B-cell CLL/lymphoma 2; Bcl-2; apoptosis regulator Bcl-2; PPP1R50
    • Species :
    • Chicken
    • Human
    • Mouse
    • Rat
    • Source :
    • E. coli
    • E.coli
    • E.Coli or Yeast
    • HEK293
    • HEK293T
    • Human (minus BH1 domain)
    • Human (minus BH3 domain)
    • Human (minus NWGR domain)
    • Mammalian Cell
    • Wheat Germ
    • Tag :
    • GST
    • His
    • T7
    • MYC/DDK
    • Myc
    • DDK
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human BCL2-1346H Recombinant Human BCL2, BH2 domain, His-tagged E.coli His
    Human BCL2-143H Recombinant Human BCL2 Protein, GST-tagged Wheat Germ GST
    Human BCL2-147H Recombinant Human Bcl-2 BH4 [1-218, BH4(10-30)] E.coli GST
    Human BCL2-2469H Recombinant Human BCL2 Protein, MYC/DDK-tagged HEK293 Myc/DDK
    Human BCL2-264H Recombinant Human BCL2 Mammalian Cell His
    Human BCL2-26613TH Recombinant Human BCL2, His-tagged E.coli His
    Human BCL2-266H Recombinant Human BCL2 protein, His-tagged E.coli His
    Human BCL2-26734TH Recombinant Human BCL2 protein, GST-tagged E.coli GST
    Human BCL2-267H Recombinant Human BCL2 protein (Met 1-Asp 211), His-tagged E. coli His
    Human BCL2-27441TH Recombinant Human BCL2, His-tagged E.coli His
    Human BCL2-322H Recombinant Human B-Cell CLL/Lymphoma 2, GST-tagged E.coli GST
    Human BCL2-4221H Recombinant Human (minus BH1 domain) B-Cell CLL/Lymphoma 2, His-tagged Human (minus BH1 domain) His
    Human BCL2-4222H Recombinant Human (minus BH3 domain) B-Cell CLL/Lymphoma 2, His-tagged Human (minus BH3 domain) His
    Human BCL2-4225H Recombinant Human (minus NWGR domain) B-Cell CLL/Lymphoma 2, His-tagged Human (minus NWGR domain) His
    Human BCL2-4343H Recombinant Human BCL2 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
    Human BCL2-5289H Recombinant Human B-Cell CLL/Lymphoma 2, His-tagged E.coli His
    Human BCL2-5296H Recombinant Human B-Cell CLL/Lymphoma 2, His-tagged E.coli His
    Human BCL2-5298H Recombinant Human B-cell CLL/lymphoma 2, GST-tagged Wheat Germ GST
    Human BCL2-5361H Recombinant Human B-cell CLL/lymphoma 2, His-tagged E.coli His
    Human BCL2-76H Recombinant Human BCL2 protein E.coli N/A
    Mouse BCL2-2337M Recombinant Mouse BCL2 Protein Mammalian Cell His
    Mouse Bcl2-3582M Recombinant Mouse Bcl2, His-tagged E.Coli or Yeast His
    Mouse Bcl2-697M Recombinant Mouse Bcl2 Protein, MYC/DDK-tagged HEK293T MYC/DDK
    Mouse Bcl2-7661M Recombinant Mouse Bcl2 protein, His & T7-tagged E.coli His/T7
    Rat BCL2-957R Recombinant Rat BCL2 Protein Mammalian Cell His
    Chicken BCL2-6891C Recombinant Chicken BCL2 Mammalian Cell His
    Kit-1686 BCL-2 TR-FRET Assay Kit N/A

    BCL2 involved in several pathways and played different roles in them. We selected most pathways BCL2 participated on our site, such as NF-kappa B signaling pathway, HIF- signaling pathway, Sphingolipid signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with BCL2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    NF-kappa B signaling pathway CCL4; RIPK1; LTBR; CCL13; CCL19; IL1R1; TRAF1; Bcl2a1b; LTA; GM13304
    HIF- signaling pathway RELA; PFKFB3; NOX3; ENO1; TCEB1; FLT1; ANGPT1; STAT3; PRKCG; ENO3
    Sphingolipid signaling pathway SGMS2; KRAS; PLCB1; CERS4; LASS5; NFKB1; PDPK1; GNAI3; PPP2R5E; HRAS
    Protein processing in endoplasmic reticulum CAPN2B; HNF4B; MAP3K5; HSP90AA1.1; VCP; UFD1L; SEC23B; SEC24B; SEC31B; HERPUD1
    PIK-Akt signaling pathway HSP90AB1; NR4A1; TEK; IL6R; FGF4; MAPK1; MLST8; FGF3; PHLPP1; GNG3
    Apoptosis NFKBIAB; PPP3R1; CSF2RB; BCL2A; BAXB; PKP1; CASP9; IRF2; PPP3R2; STK24A
    Adrenergic signaling in cardiomyocytes ATF4B1; PLCB4; MAPK12; BCL2A; VMHC; ATF2; PIK3CB; CALM1; ADCY2B; ADCY1A
    Focal adhesion ELK1; ITGA7; ARHGAP35; MYL9B; ITGA8; ITGA6; GRB2; PPP1R12B; RHOAB; ITGA3B
    Jak-STAT signaling pathway IFNA2; PIK3CA; PRP2; Ifnl2; RAF1B; AOX3; EPOR; CSF3; AOX4; CNTF
    Neurotrophin signaling pathway ARHGDIB; SH2B2; PIK3R1; MAPKAPK2; PSEN2; GSK3B; YWHAE; RAP1B; NTRK3; PLCG2
    Cholinergic synapse PRKCG; GNG5; KCNJ4; PIK3CB; GNAI2; CHRNA6; JAK2; CHRM2; KRAS; ITPR3
    Amyotrophic lateral sclerosis (ALS) CCS; SOD1; TNFRSF1A; PPP3CC; CYCS; GPX1; MAPK13; GRIN2C; RAC1; MAPK14
    Toxoplasmosis CASP9; LAMA3; SOCS1; MYD88; GNAI2; TGFB1; TRAF6; HLA-DQB1; TNF; PIK3R3
    Tuberculosis RAB5C; FCER1G; NOS2; ATP6V1H; CAP18; TGFB1; CLEC4E; IFNA21; RFX5; IFNB1
    Hepatitis B RELA; BAD; IFNA21; FOS; CASP8; Ifna11; CCNE1; ELK1; IFNA7; PIK3CA
    Epstein-Barr virus infection MAP2K3; POLR2G; CSNK2B; TRAF6; RAN; HSPA2; TRAF3; CD38; NUP214; PSMC5
    Pathways in cancer F2RL3; SMO; LAMB4; PTCH2; FGF12; GSK3B; GLI1; Shh; NCOA4; FGF20
    MicroRNAs in cancer PTGS2; SLC7A1; SHC4; PDGFRA; MTOR; PDCD4; RAF1; NFKB1; WNT3A; THBS1
    Colorectal cancer MAPK8; MAPK10; APC; PIK3CG; TCF7L2; TGFBR2; AXIN1; CYCS; TGFB2; SMAD3
    Prostate cancer SMARCA4; NKX3-1; IKBKB; FOXO1; HSP90AA1; CCNE1; AKT1; FGFR2; PDGFRA; NDRG1
    Small cell lung cancer SKP2; TRAF1; LAMC2; TRAF2; MAX; ITGA2; XIAP; LAMB2; RB1; PIK3CD

    BCL2 has several biochemical functions, for example, BH3 domain binding, channel activity, channel inhibitor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by BCL2 itself. We selected most functions BCL2 had, and list some proteins which have the same functions with BCL2. You can find most of the proteins on our site.

    Function Related Protein
    BH3 domain binding MCL1; BCL2; BAX; BCL2L1
    channel activity BAXA; TRPA1; STEAP1; PANX1B; P2RX6; BAXB; PANX1A; BCL2; GJA8; MAL
    channel inhibitor activity BCL2
    identical protein binding CNTN2; IMPA1; SERPINB1A; BNIP3L; CCDC155; GPR50; HSPB8; MUL1; SMAD6; ACTN2
    protease binding OS9; CSTA; SERPINB4; BRCA2; ANXA2; TIMP2A; CCBE1; NFRKB; C10orf2; ITGB3
    protein binding ING4; EVLA; TMED10; DYRK1A; VAT1L; GLS2; PTH1R; RPL23A; ICAM5; RELA
    protein heterodimerization activity PPP3CB; ITGB1B; SLC51A; BOKB; PDGFB; CABYR; BNIP3L; CYBA; AXL; HIST1H3A
    protein homodimerization activity RAB11FIP3; ACTN3; PRKG2; IKBKG; DMRT2; HRSP12; ATF3; CARS; ADD1; TBX18
    protein phosphatase 2A binding IGBP1; CPD; SMG5; ANKLE2; CTTNBP2NL; STRN; TP53; RPS6KB1; ENSA; TRP53
    sequence-specific DNA binding OTX1A; KDM6B; RX1; HNF1B; NFIL3-6; SPI1B; FOXB1; LHX3; HIVEP2A; ATF4B1
    transcription factor binding POU5F1; IGHMBP2; KAT6B; FLNA; PARP1; NR0B2; TRP53; FOXA3; PIAS2; TP73
    ubiquitin protein ligase binding ERLIN2; SMAD3; PRKAR1A; MAGEC2; CUL5A; CD40; GABARAPL2; PRKACB; SMAD5; GLMN

    BCL2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with BCL2 here. Most of them are supplied by our site. Hope this information will be useful for your research of BCL2.

    BECN1; BAX

    Marguet, F; Bergogne, L; et al. Fetal presentation of congenital fibrosarcoma of the meninges: case report and literature review. CLINICAL NEUROPATHOLOGY 34:70-75(2015).
    Abdel-Latif, M; Sakran, T; et al. Immunomodulatory effect of diethylcarbamazine citrate plus filarial excretory-secretory product on rat hepatocarcinogenesis. INTERNATIONAL IMMUNOPHARMACOLOGY 24:173-181(2015).

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