BCL2

  • Official Full Name

    B-Cell CLL/Lymphoma 2

  • Overview

    This gene encodes an integral outer mitochondrial membrane protein that blocks the apoptotic death of some cells such as lymphocytes. Constitutive expression of BCL2, such as in the case of translocation of BCL2 to Ig heavy chain locus, is thought to be the cause of follicular lymphoma. Two transcript variants, produced by alternate splicing, differ in their C-terminal ends.
  • Synonyms

    BCL2; B-cell CLL/lymphoma 2; Bcl-2; apoptosis regulator Bcl-2; PPP1R50;

  • Recombinant Proteins
  • Protein Pre-coupled Magnetic Beads
  • Assay Kits
  • Bos taurus (Bovine)
  • Canis lupus familiaris (Dog) (Canis familiaris)
  • Chicken
  • Cricetulus griseus (Chinese hamster) (Cricetulus barabensis griseus)
  • Gallus gallus (Chicken)
  • Homo sapiens (Human)
  • Human
  • Mouse
  • Mus musculus (Mouse)
  • Rat
  • Rattus norvegicus (Rat)
  • E.coli
  • E.coli expression system
  • E.Coli or Yeast
  • HEK293
  • HEK293T
  • Human (minus BH1 domain)
  • Human (minus BH3 domain)
  • Human (minus NWGR domain)
  • In Vitro Cell Free System
  • In vitro E. coli expression system
  • Mammalian Cell
  • Mammalian cells
  • Wheat Germ
  • C
  • His
  • Flag
  • GST
  • His (Fc)
  • Avi
  • His|T7
  • Myc
  • DDK
  • MYC
  • Myc|DDK
  • N/A
  • N
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human BCL2-267H Active Recombinant Human BCL2 protein (Met 1-Asp 211), His-tagged E.coli His
Human BCL2-5289H Recombinant Human B-Cell CLL/Lymphoma 2, His-tagged E.coli His
Human BCL2-26734TH Recombinant Human BCL2 protein, GST-tagged E.coli GST
Human BCL2-4221H Recombinant Human (minus BH1 domain) B-Cell CLL/Lymphoma 2, His-tagged Human (minus BH1 domain) His
Human BCL2-4222H Recombinant Human (minus BH3 domain) B-Cell CLL/Lymphoma 2, His-tagged Human (minus BH3 domain) His
Human BCL2-5361H Recombinant Human B-cell CLL/lymphoma 2, His-tagged E.coli His
Human BCL2-264H Recombinant Human BCL2 Mammalian Cell His
Human BCL2-4225H Recombinant Human (minus NWGR domain) B-Cell CLL/Lymphoma 2, His-tagged Human (minus NWGR domain) His
Human BCL2-322H Recombinant Human B-Cell CLL/Lymphoma 2, GST-tagged E.coli GST
Human BCL2-26613TH Recombinant Human BCL2, His-tagged E.coli His
Human BCL2-147H Recombinant Human Bcl-2 BH4 [1-218, BH4(10-30)] E.coli GST
Human BCL2-5298H Recombinant Human B-cell CLL/lymphoma 2, GST-tagged Wheat Germ GST
Human BCL2-5296H Recombinant Human B-Cell CLL/Lymphoma 2, His-tagged E.coli His
Human BCL2-27441TH Recombinant Human BCL2, His-tagged E.coli His
Human BCL2-266H Recombinant Human BCL2 protein, His-tagged E.coli His
Human BCL2-1346H Recombinant Human BCL2 Protein, His-tagged E.coli His
Human BCL2-143H Recombinant Human BCL2 Protein, GST-tagged Wheat Germ GST
Human BCL2-2469H Recombinant Human BCL2 Protein, MYC/DDK-tagged HEK293 Myc/DDK
Human BCL2-76H Recombinant Human BCL2 protein E.coli N/A
Human BCL2-4343H Recombinant Human BCL2 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Human BCL2-775HFL Recombinant Full Length Human BCL2 Protein, C-Flag-tagged Mammalian cells Flag
Human BCL2-438H Recombinant Human BCL2 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Human BCL2-1588HF Recombinant Full Length Human BCL2 Protein, GST-tagged In Vitro Cell Free System GST
Human BCL2-2608H Active Recombinant Human BCL2 protein E.coli N/A
Human Bcl2-2607H Recombinant Human Bcl2 protein E.coli N/A
Human BCL2-22H Recombinant Human BCL2 Protein E.coli
Human BCL2-438H-B Recombinant Human BCL2 Protein Pre-coupled Magnetic Beads HEK293
Human BCL2-0580H Recombinant Human BCL2 Protein (Met1-Asp211), C-His-tagged E.coli C-His
Mouse BCL2-2337M Recombinant Mouse BCL2 Protein Mammalian Cell His
Mouse Bcl2-3582M Recombinant Mouse Bcl2, His-tagged E.Coli or Yeast His
Mouse Bcl2-7661M Recombinant Mouse Bcl2 protein, His & T7-tagged E.coli His/T7
Mouse Bcl2-2580M Recombinant Mouse Bcl2 protein, His-tagged E.coli His
Mouse BCL2-988M Recombinant Mouse BCL2 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mouse Bcl2-697M Recombinant Mouse Bcl2 Protein, MYC/DDK-tagged HEK293T MYC/DDK
Mouse BCL2-988M-B Recombinant Mouse BCL2 Protein Pre-coupled Magnetic Beads HEK293
Rat BCL2-957R Recombinant Rat BCL2 Protein Mammalian Cell His
Rat Bcl2-304R Recombinant Rat Bcl2 Protein, His-tagged E.coli N-His
Rat BCL2-615R-B Recombinant Rat BCL2 Protein Pre-coupled Magnetic Beads HEK293
Rat BCL2-615R Recombinant Rat BCL2 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rat Bcl2-1213R Recombinant Rat Bcl2 Full Length Transmembrane protein, His-tagged In vitro E. coli expression system His
Bos taurus (Bovine) RFL25430BF Recombinant Full Length Bovine Apoptosis Regulator Bcl-2(Bcl2) Protein, His-Tagged E.coli expression system His
Canis lupus familiaris (Dog) (Canis familiaris) RFL12012CF Recombinant Full Length Dog Apoptosis Regulator Bcl-2(Bcl2) Protein, His-Tagged E.coli expression system His
Cricetulus griseus (Chinese hamster) (Cricetulus barabensis griseus) RFL10353CF Recombinant Full Length Cricetulus Griseus Apoptosis Regulator Bcl-2(Bcl2) Protein, His-Tagged E.coli expression system His
Gallus gallus (Chicken) RFL26317GF Recombinant Full Length Chicken Apoptosis Regulator Bcl-2(Bcl2) Protein, His-Tagged E.coli expression system His
Homo sapiens (Human) RFL23045HF Recombinant Full Length Human Apoptosis Regulator Bcl-2(Bcl2) Protein, His-Tagged E.coli expression system His
Mus musculus (Mouse) RFL20057MF Recombinant Full Length Mouse Apoptosis Regulator Bcl-2(Bcl2) Protein, His-Tagged E.coli expression system His
Rattus norvegicus (Rat) RFL26870RF Recombinant Full Length Rat Apoptosis Regulator Bcl-2(Bcl2) Protein, His-Tagged E.coli expression system His
Chicken BCL2-6891C Recombinant Chicken BCL2 Mammalian Cell His
Kit-1686 BCL-2 TR-FRET Assay Kit N/A
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • BCL2 Related Articles
  • BCL2 Related Gene Family
  • BCL2 Related Signal Pathway

BCL2 involved in several pathways and played different roles in them. We selected most pathways BCL2 participated on our site, such as NF-kappa B signaling pathway, HIF- signaling pathway, Sphingolipid signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with BCL2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
NF-kappa B signaling pathwayLTBR;IKBKG;LAT;CD40LG;LRDD;CXCL2;GM1987;IL1B;PRKCQ
HIF- signaling pathwayNPPA;MTOR;LTBR;RPS6;PGK1;ANGPT4;HMOX1;NOS3;TFRC
Sphingolipid signaling pathwayPLCB2;PIK3R2;GAB2;PPP2CA;PPP2R1A;ACER1;NOS3;MAP2K1;TRAF2
Protein processing in endoplasmic reticulumATF4;BAX;EIF2AK1;CAPN1;BAK1;BCL2A;CALR;CKAP4;SEC63
PIK-Akt signaling pathwayAKT1;PIK3CD;RXRA;THBS3;TCL1B;INS2;IFNAR1;GNG10;LPAR6
ApoptosisTICAM1;CLSPN;IL1RAP;IKBKB;PRKAR1A;NTRK1;PIK3R5;PPP3CC;BCL2
Adrenergic signaling in cardiomyocytesADCY1B;ATP1A2A;RAPGEF3;ATP2B3B;CREB3;MYL3;SCN1BA;ATP2B2;PRKACA
Focal adhesionMYLK2;BADB;ITGA10;SOS1;DIAPH1;MAP2K1;Itga10&Itgb1;COL1A1A;PIK3CD
Jak-STAT signaling pathwayRAF1A;IL7;IL6;CNTFR;IFNG;IL28RA;CCND3;STAT5B;SOS1
Neurotrophin signaling pathwayZNF274;IRS1;CDC42;PDPK1;IKBKB;YWHAE;PIK3R2;AKT1;ARHGDIG
Cholinergic synapsePRKACG;GNB2;PIK3R2;CREB3L2;NRAS;PIK3R1;ATF4;AKT1;JAK2
Amyotrophic lateral sclerosis (ALS)TP53;MAP3K5;PPP3CC;GRIN2A;TRP53;GRIN2B;APAF1;CASP1;GRIN1
ToxoplasmosisBIRC2;GNAI1;PIK3R5;TAB2;H2-AA;TYK2;ITGA6;NFKBIA;TNFRSF1A
TuberculosisATP6V0D1;LSP1;HLA-DRB1;Ifna11;RAF1;SRC;MAPK8;TLR2;LAMP2
Hepatitis BCASP9;NRAS;IKBKE;IL-8;STAT6;PRKCB;IL6;PIK3R5;RELA
Epstein-Barr virus infectionIKBKG;POLR2G;POLR3G;TRAF5;TBPL1;PSMD7;SND1;HLA-DRB1;PIK3R3
Pathways in cancerCXCL12;MMP1A;GNB2;HIF1A;GNA12;BCL2;EGLN1;PIK3CG;PTGER3
MicroRNAs in cancerST14;ABCB1A;RASSF1;IGF2BP1;IRS2;MAP2K2;CCND1;Pdgfa&Pdgfb;STAT3
Colorectal cancerCYCS;AXIN1;PIK3CG;BIRC5;FOS;PIK3R2;PIK3CD;MAPK9;BAX
Prostate cancerHRAS;CPN1;CREB5;RELA;PDGFD;SPRY1;GRB2;NFKB1;MAP4K1
Small cell lung cancerPIK3R2;CYCS;XIAP;TRAF6;LAMA1;PIK3CD;PTK2;RXRG;ITGA2B

BCL2 has several biochemical functions, for example, BH3 domain binding, channel activity, channel inhibitor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by BCL2 itself. We selected most functions BCL2 had, and list some proteins which have the same functions with BCL2. You can find most of the proteins on our site.

Function Related Protein
BH3 domain bindingBCL2L1;BAX;MCL1;BCL2
channel activitySTEAP1;PANX1B;APNL;P2RX6;GJA8;BAX;MAL;PANX2;CHRNB1
channel inhibitor activity
identical protein bindingSUN2;LYZ2;UBE2G2;RIPK1;HNRNPC;GSTM3;AKT1;EIF2AK3;DVL1
protease bindingADRM1;OS9;FAP;SERPINA1A;TP53;COMP;ANXA2;TRIP4;CST3
protein bindingWLS;PTPN13;RAB3B;KCNJ5;WIPF1;PTCRA;CHMP5;SOX15;DDR1
protein heterodimerization activityALX4;TGFB3;MEF2C;CEBPG;UGT1A7;NFE2L2A;HIST1H2BD;NOTCH1;TAS1R2
protein homodimerization activityDMRT3A;WRN;ADRB3;ENPP1;NETO2;TIMM10;CARD9;YARS2;SRGAP2A
protein phosphatase 2A bindingANKLE2;RPS6KB1;SMG7;GRIN3A;SHC1;SMG5;STRN4;IGBP1;MASTL
sequence-specific DNA bindingSHOX2;NFE2L1B;RXRA;HOXC3A;RORAB;LEF1;MEIS3;FOXP1A;EN2
transcription factor bindingSUFU;NAB1;LCOR;CREBBP;KEAP1B;Trl;MED12L;NAB2;KAT2B
ubiquitin protein ligase bindingUBE2Z;C10orf46;SCN5A;UQCRC1;TMEM189;UBE2A;GPI1;MAGEC2;CDKN1A

BCL2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with BCL2 here. Most of them are supplied by our site. Hope this information will be useful for your research of BCL2.

BECN1; BAX

Marguet, F; Bergogne, L; et al. Fetal presentation of congenital fibrosarcoma of the meninges: case report and literature review. CLINICAL NEUROPATHOLOGY 34:70-75(2015).
Abdel-Latif, M; Sakran, T; et al. Immunomodulatory effect of diethylcarbamazine citrate plus filarial excretory-secretory product on rat hepatocarcinogenesis. INTERNATIONAL IMMUNOPHARMACOLOGY 24:173-181(2015).
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