BRAP

  • Official Full Name

    BRCA1 associated protein

  • Overview

    The protein encoded by this gene was identified by its ability to bind to the nuclear localization signal of BRCA1 and other proteins. It is a cytoplasmic protein which may regulate nuclear targeting by retaining proteins with a nuclear localization signal in the cytoplasm. [provided by RefSeq, Jul 2008]

  • Synonyms

    BRAP;BRCA1 associated protein;IMP;BRAP2;RNF52;BRCA1-associated protein;RING finger protein 52;galectin-2-binding protein;renal carcinoma antigen NY-REN-63;impedes mitogenic signal propagation

Recombinant Proteins

  • Mouse
  • Chicken
  • Rhesus macaque
  • Zebrafish
  • Human
  • Mammalian Cells
  • E.coli
  • HEK293
  • Yeast
  • E. coli
  • His
  • Non
  • Avi
  • Fc
  • GST

    Involved Pathway

    BRAP involved in several pathways and played different roles in them. We selected most pathways BRAP participated on our site, such as Ras signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with BRAP were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Ras signaling pathway PAK7,ABL1,FGFR4,PLD2,RASSF1,FGF16,CALM2,GNG10,FGF4,FASLG

    Protein Function

    BRAP has several biochemical functions, for example, identical protein binding,ligase activity,nuclear localization sequence binding. Some of the functions are cooperated with other proteins, some of the functions could acted by BRAP itself. We selected most functions BRAP had, and list some proteins which have the same functions with BRAP. You can find most of the proteins on our site.

    Function Related Protein
    ubiquitin-protein transferase activity RNF144B,NSMCE1,ZER1,UBE2S,RNF125,PARK2,SHPRH,UHRF1,MIB2,MUL1A
    protein binding NFKB1,RGS1,SPC24,VAMP7,COLGALT2,ELANE,TXNL4B,EHMT1,CD2,NSMCE4A
    nuclear localization sequence binding KPNA3,KPNA5,NUP214,KPNA2,KPNB3,KPNA4,KPNA6,KPNA1,IPO4,NFKBIA
    nucleotide binding IMPDH2,MAPK12B,PDPK1A,DNM1B,SEPT9A,AGAP2,SYNJ1,RAD51L3,NELFE,EPHB3A
    ligase activity RNF123,LTN1,NAPRT1,RNF212,WWP2,MARCH8,RNF168,HECTD2,NSMCE2,ZNRF2
    ubiquitin protein ligase activity MED21,RNF115,UBE2O,TRIM32,UBE2NA,UBE2B,RAD18,ZNRF1,RNF122,UBR5
    identical protein binding PLN,PCBD1,TFRC,SLIT2,FAS,MLL1,HSD17B10,CNTN2,CHMP4B,CHEK2
    zinc ion binding ADAM7,DNMT5,ING5B,CPZ,RAG1,L3MBTL2,RARGB,USP3,RECQL4,TRIM35-21
    ubiquitin binding UBR5,BCL10,TNFAIP3,HSPB1,C36E6.2,KCNS1,SHRPRBCK1R,C6orf106,MARK4,USP13

    Interacting Protein

    BRAP has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with BRAP here. Most of them are supplied by our site. Hope this information will be useful for your research of BRAP.

    HRAS;AKAP3;BRCA1;PHLPP1;PHLPP1;PHLPP1;Dnmt1;KSR1;ATMIN;APOA1;UBB;UBC

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