Recombinant Human BRAP Protein (S2-K592), His tagged

• Cat.No.: BRAP-0724H
• Product Overview: Recombinant Human 6His-TEV-(GG)-BRAP(S2-K592 end) Protein was expressed in E. coli.

Specification

• Description: Negatively regulates MAP kinase activation by limiting the formation of Raf/MEK complexes probably by inactivation of the KSR1 scaffold protein. Also acts as a Ras responsive E3 ubiquitin ligase that, on activation of Ras, is modified by auto-polyubiquitination resulting in the release of inhibition of Raf/MEK complex formation. May also act as a cytoplasmic retention protein with a role in regulating nuclear transport.
• Source: E. coli
• Species: Human
• Tag: His
• Form: Liquid
• Protein Length: S2-K592
• Endotoxin: < 0.01 EU per μg of the protein
• Purity: 85%
• Stability: Samples are stable for up to twelve months from date of receipt at -20 to -80 centigrade.
• Storage: Store it under sterile conditions at -20 to -80 centigrade. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
• Storage Buffer: Supplied as sterile 50 mM Tris-HCl (pH7.5), 200 mM NaCl, 5% glycerol, 1 mM DTT.
• Shipping: It is shipped out with blue ice.

Gene Information

• Gene Name: BRAP BRCA1 associated protein [ Homo sapiens (human) ]
• Official Symbol: BRAP
• Synonyms: BRAP; BRCA1 associated protein; BRCA1-associated protein; BRAP2; galectin 2 binding protein; IMP; impedes mitogenic signal propagation; RNF52; RING finger protein 52; galectin-2-binding protein; renal carcinoma antigen NY-REN-63
• Gene ID: 8315
• mRNA Refseq: NM_006768
• Protein Refseq: NP_006759
• MIM: 604986
• UniProt ID: Q7Z569