CCL27
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Official Full Name
chemokine (C-C motif) ligand 27 -
Overview
CTACK is a keratinocyte-derived CC chemokine which signals through the CCR10 receptor. Both CTACK and CCR10 are expressed in normal and irritated epithelial cells. CTACK selectively attracts CLA+ T-cells and directs them into the skin. CTACK contains the -
Synonyms
CCL27;chemokine (C-C motif) ligand 27;SCYA27, small inducible cytokine subfamily A (Cys Cys), member 27;C-C motif chemokine 27;ALP;CC chemokine ILC;CTACK;CTAK;cutaneous T cell attracting chemokine;ESkine;IL 11 Ralpha locus chemokine;ILC;PESKY
Recombinant Proteins
- Rat
- Human
- Rhesus macaque
- E.coli
- Wheat Germ
- Mammalian Cells
- Human Cells
- In Vitro Cell Free System
- HEK293
- Non
- GST
- His
- S
- Fc
- Flag
- Avi
Involved Pathway
CCL27 involved in several pathways and played different roles in them. We selected most pathways CCL27 participated on our site, such as Chemokine receptors bind chemokines,Chemokine signaling pathway,Class A/1 (Rhodopsin-like receptors), which may be useful for your reference. Also, other proteins which involved in the same pathway with CCL27 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| GPCR ligand binding | PNOCB,TAS2R16,TAS2R7,NMS,PTH,EDNRB,CXCR7B,GCGA,CRHB,UTS2 |
| Class A/1 (Rhodopsin-like receptors) | OPN1LW1,CYSLTR1,S1PR3,TAC2,GPR55,CCL35.1,PROKR2,XK,S1PR5B,CHRM3 |
| GPCR downstream signaling | KALRN,FGD4,PROK2,CHRM2,RGS18,DGKA,EDN2,FFAR3,CNR2,MGLL |
| Chemokine signaling pathway | CXCL3,CXCL1,GNB2,CCL22,GNG10,CXCL12,PLCB4,CCL17,PIK3R3,CXCR5 |
| Peptide ligand-binding receptors | CXCL11.8,PYY,UTS2D,EDNRAB,QRFPR,UTS2,QRFP,TAC3,PROKR2,CX3CR1 |
| Chemokine receptors bind chemokines | CCR9,CXCL13,CCR6,CCRL2,CCR8,CXCR7B,CCL35.1,CCL35.2,CCR1,CCR5 |
| G alpha (i) signalling events | ANXA1C,OPN1SW1,RGR,ANXA1B,RLN3,S1PR5B,ADORA3,LPAR2B,AGT,ADORA1 |
| Cytokine-cytokine receptor interaction | IL17RA,IL22,Ccl12,GM2506,CCL5,IFNA6,EDAR,CSF2,GHR,CXCL16 |
Protein Function
CCL27 has several biochemical functions, for example, chemokine activity. Some of the functions are cooperated with other proteins, some of the functions could acted by CCL27 itself. We selected most functions CCL27 had, and list some proteins which have the same functions with CCL27. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| chemokine activity | CCL11,CXCL11.8,CXCL12,Ccl21a,CXCL19,CCL34B.9,CCL22,CCL13,CCL14,CX3CL1 |
Interacting Protein
CCL27 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CCL27 here. Most of them are supplied by our site. Hope this information will be useful for your research of CCL27.
Resources
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References
- Xiong, N; Fu, YY; et al. CCR10 and its ligands in regulation of epithelial immunity and diseases. PROTEIN & CELL 3:571-580(2012).
- Ye, ZJ; Zhou, Q; et al. Differentiation and Recruitment of IL-22-Producing Helper T Cells Stimulated by Pleural Mesothelial Cells in Tuberculous Pleurisy. AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE 185:660-669(2012).
