CD5
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Official Full Name
CD5 molecule
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Overview
CD5 is a 67kDa single-chain transmembrane glycoprotein expressed on mature T lymphocytes, most thymocytes and B lymphocytes subset (B-1a lymphocytes) and on many T-cell leukemias and lymphomas. It is a type I membrane glycoprotein whose extracellular region contains three scavenger receptor cysteine-rich (SRCR) domains. The CD5 is a signal transducing molecule whose cytoplasmic tail is devoid of any intrinsic catalytic activity. CD5 modulates signaling through the antigen-specific receptor complex (TCR and BCR). CD5 may serve as a dual receptor, giving either stimulatory or inhibitory signals depending both on the cell type and development stage. In thymocytes and B1a cells seems to provide inhibitory signals, in peripheral mature T lymhocytes it acts as a costimulatory signal receptor. CD19 is a member of the immunoglobulin superfamily and has two Ig like domains. The CD19 molecule is expressed on 100% of the peripheral B cells as defined by expression of kappa or lamda light chains. It is expressed on approximately 10% of normal human peripheral blood cells and approximately 60% of splenic lymphocytes. It is not expressed on granulocytes, monocytes or T cells as defined by CD3 expression. CD19 defines a pan B antigen which is expressed from the earliest stages of B progenitor development, but is lost on terminal differentiation to plasma cells. It may also be present on some early myeloid progenitors, particularly those of the monoblastic type. The CD19 antigen is expressed on approximately 12% of peripheral blood lymphocytes. It appears to be expressed on myeloid leukemia cells, particularly those of monocytic lineage. Leukemia phenotype studies have demonstrated that the earliest and broadest B cell restricted antigen is the CD19 antigen. -
Synonyms
CD5; CD5 molecule; CD5 antigen (p56 62) , LEU1; T-cell surface glycoprotein CD5; T1; CD5 antigen (p56-62); lymphocyte antigen T1/Leu-1; LEU1;
- Recombinant Proteins
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- Arg25-Asn371
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- Involved Pathway
- Protein Function
- Interacting Protein
- Other Resource
CD5 involved in several pathways and played different roles in them. We selected most pathways CD5 participated on our site, such as Hematopoietic cell lineage, which may be useful for your reference. Also, other proteins which involved in the same pathway with CD5 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Hematopoietic cell lineage | CD37;CD1E, B2M;IL3;Itgam&Itgb2;IL4R;IL11RA2;ITGA1;HLA-DRB5;CD2 |
CD5 has several biochemical functions, for example, protein binding, receptor activity, scavenger receptor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by CD5 itself. We selected most functions CD5 had, and list some proteins which have the same functions with CD5. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| protein binding | CAMTA2;USF1;TFF3;TTC25;CEP72;GEMIN4;SLC14A2;DDX20;LDLRAD1 |
| receptor activity | FPR3;TRAM1;SLC20A2;ANTXR2A;DARC;VMN1R41;OGFRL1;GRIA3A;GRIN1B |
| scavenger receptor activity | PRG4B;TMPRSS4;PRSS12;GM106;ENPP2;COLEC12;LOXL3;CD163;LOXL3A |
| transmembrane signaling receptor activity | GPR124;TLR9;NPC1;LGR6;LEPR;KIR2DS2;GHRHRL;KLRC2;FZD7A |
CD5 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CD5 here. Most of them are supplied by our site. Hope this information will be useful for your research of CD5.
PIK3R1; CD72; RASA1
Research Area
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Customer Reviews (3)
Write a reviewThe stability of CD5 is very good, and even if it is stored for a long time, it will not affect its performance.
I have recommended it to other students, the price is affordable, the operation is convenient, and the effect is good.
I'm very happy with the results, the stability is strong.
Q&As (6)
Ask a questionThere are interactions between CD5 and other biomolecules. For example, it binds to antigens and antibodies and participates in the activation and differentiation of immune cells, and also binds to other signal transduction molecules and participates in cell signal transduction.
Certain biomolecules can be used as molecular markers of CD5, including CD5 antigens detected on the surface of lymphocytes, as well as related proteins and genes that interact with CD5. These markers can be used for early diagnosis of diseases, prognosis judgment, or monitoring the effectiveness of treatment.
Assessing the efficacy and safety of treatments targeting CD5 requires clinical trials and drug monitoring. The effectiveness of the treatment was evaluated by designing a rigorous clinical trial protocol that compared the disease remission rate, symptom improvement, and quality of life improvement between the treatment and control groups. At the same time, drug monitoring is used to monitor the safety and efficacy of drugs in actual use, adjust treatment regimens in a timely manner, maximize the efficacy of drugs and reduce the risk of side effects.
CD5 has a typical immunoglobulin superfamily domain, which is a single-stranded transmembrane glycoprotein that is distributed in an asymmetrical manner across the cell membrane. This structure allows it to bind to antigens and antibodies and participate in the immune response.
CD5 has been linked to a number of immune system-related diseases. For example, certain autoimmune diseases, allergic reactions, transplant rejection, etc. In addition, CD5 has been implicated in the development and progression of certain tumors.
Treatment strategies for CD5 include inhibition of its activity, regulation of its expression, and gene therapy. For example, the development of antibody drugs or small molecule inhibitors against CD5 to inhibit its overactivation in the immune response, or the regulation of CD5 expression through gene knockout or overexpression techniques.
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