CD5

  • Official Full Name

    CD5 molecule

  • Overview

    CD5 is a 67kDa single-chain transmembrane glycoprotein expressed on mature T lymphocytes, most thymocytes and B lymphocytes subset (B-1a lymphocytes) and on many T-cell leukemias and lymphomas. It is a type I membrane glycoprotein whose extracellular region contains three scavenger receptor cysteine-rich (SRCR) domains. The CD5 is a signal transducing molecule whose cytoplasmic tail is devoid of any intrinsic catalytic activity. CD5 modulates signaling through the antigen-specific receptor complex (TCR and BCR). CD5 may serve as a dual receptor, giving either stimulatory or inhibitory signals depending both on the cell type and development stage. In thymocytes and B1a cells seems to provide inhibitory signals, in peripheral mature T lymhocytes it acts as a costimulatory signal receptor. CD19 is a member of the immunoglobulin superfamily and has two Ig like domains. The CD19 molecule is expressed on 100% of the peripheral B cells as defined by expression of kappa or lamda light chains. It is expressed on approximately 10% of normal human peripheral blood cells and approximately 60% of splenic lymphocytes. It is not expressed on granulocytes, monocytes or T cells as defined by CD3 expression. CD19 defines a pan B antigen which is expressed from the earliest stages of B progenitor development, but is lost on terminal differentiation to plasma cells. It may also be present on some early myeloid progenitors, particularly those of the monoblastic type. The CD19 antigen is expressed on approximately 12% of peripheral blood lymphocytes. It appears to be expressed on myeloid leukemia cells, particularly those of monocytic lineage. Leukemia phenotype studies have demonstrated that the earliest and broadest B cell restricted antigen is the CD19 antigen.
  • Synonyms

    CD5; CD5 molecule; CD5 antigen (p56 62) , LEU1; T-cell surface glycoprotein CD5; T1; CD5 antigen (p56-62); lymphocyte antigen T1/Leu-1; LEU1;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Bos taurus (Bovine)
  • Chicken
  • Homo sapiens (Human)
  • Human
  • Mouse
  • Mus musculus (Mouse)
  • Rat
  • Rattus norvegicus (Rat)
  • E.coli
  • E.coli expression system
  • HEK293
  • HEK293F
  • HEK293T
  • Human Cell
  • Human Cells
  • In Vitro Cell Free System
  • Insect Cell
  • Mammalian Cell
  • Mammalian cells
  • Wheat Germ
  • C
  • 6×His
  • hFc
  • His
  • Myc
  • DDK
  • DDK|His
  • Fc
  • Avi
  • Flag
  • GST
  • His (Fc)
  • HlgG1 Fc
  • MYC
  • Myc|DDK
  • N/A
  • N
  • Strep II
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human CD5-2222H Recombinant Human CD5, His tagged Human Cell His
Human CD5-0830H Recombinant Human CD5 Protein, GST-Tagged Wheat Germ GST
Human CD5-135H Recombinant Human CD5 protein, His-tagged Insect Cell His
Human CD5-26633TH Recombinant Human CD5 Wheat Germ N/A
Human CD5-146H Recombinant Human CD5, His-tagged E.coli His
Human CD5-235H Recombinant Human CD5, StrepII-tagged Human Cell Strep II
Human CD5-175H Recombinant Human CD5 protein, His-tagged HEK293 His
Human CD5-830H Recombinant Human CD5 Protein, DDK/His-tagged HEK293 DDK/His
Human CD5-2572HCL Recombinant Human CD5 cell lysate Human Cell N/A
Human CD5-151H Recombinant Human CD5 Protein, His-tagged Human Cells His
Human CD5-542H Recombinant Human CD5 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Human CD5-3098H Recombinant Human CD5 Protein, MYC/DDK-tagged HEK293 Myc/DDK
Human CD5-697H Active Recombinant Human CD5 Protein, His-tagged HEK293 His
Human CD5-687H Recombinant Human CD5 Protein, His-tagged HEK293F N-His
Human CD5-2679H Recombinant Human CD5 protein, His-tagged HEK293 His
Human CD5-60HF Recombinant Full Length Human CD5 Protein In Vitro Cell Free System
Human CD5-491H Recombinant Human CD5 Protein (Arg25-Pro372), C-6×His-tagged HEK293 C-6×His
Human CD5-173H Recombinant Human CD5 Protein, C-His-tagged E.coli C-His
Human CD5-401H Recombinant Human CD5 Protein, MYC/DDK-tagged, C13 and N15-labeled HEK293 C-Myc/DDK
Human CD5-2999HF Recombinant Full Length Human CD5 Protein, GST-tagged In Vitro Cell Free System GST
Human CD5-4687H Active Recombinant Human CD5 Protein, His-tagged, PE-Labeled HEK293 His
Human CD5-1438HFL Recombinant Full Length Human CD5 Protein, C-Flag-tagged Mammalian cells Flag
Human CD5-5297H Recombinant Human CD5 Protein (Met1-Pro371), C-His tagged Mammalian cells C-His
Human CD5-133H Active Recombinant Human CD5 Protein, Fc-tagged HEK293 Fc
Human CD5-127HB Recombinant Human CD5 Protein, Fc-Avi-tagged, Biotinylated HEK293 Fc-Avi
Human CD5-1093H Recombinant Human CD5 Protein (Met1-Pro372), HlgG1 Fc-tagged HEK293 HlgG1 Fc
Human CD5-103H Recombinant Human CD5 protein, His& Avi-tagged, Biotinylated HEK293 His& Avi
Human CD5-163H Recombinant Human CD5 Protein, His-tagged HEK293 His
Human CD5-542H-B Recombinant Human CD5 Protein Pre-coupled Magnetic Beads HEK293
Human CD5-5296H Recombinant Human CD5 Protein (Met1-Pro372), C-His tagged Mammalian cells C-His
Mouse Cd5-2277M Recombinant Mouse Cd5 protein, His-tagged HEK293 His
Mouse CD5-2498MCL Recombinant Mouse CD5 cell lysate Human Cell N/A
Mouse Cd5-843M Recombinant Mouse Cd5 Protein, MYC/DDK-tagged HEK293T MYC/DDK
Rat Cd5-8796R Active Recombinant Rat Cd5 protein, His-tagged HEK293 His
Rat Cd5-8797R Recombinant Rat Cd5, Fc-tagged Human Cell Fc
Rat Cd5-8795R Recombinant Rat Cd5 protein(Met1-Pro368), hFc-tagged HEK293 C-hFc
Rat CD5-1257R Recombinant Rat CD5 Protein Mammalian Cell His
Rat CD5-1293RCL Recombinant Rat CD5 cell lysate Human Cell N/A
Rat CD5-915R Recombinant Rat CD5 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rat CD5-915R-B Recombinant Rat CD5 Protein Pre-coupled Magnetic Beads HEK293
Rat Cd5-688R Recombinant Rat Cd5 Protein, His-tagged E.coli N-His
Bos taurus (Bovine) RFL14307BF Recombinant Full Length Bovine T-Cell Surface Glycoprotein Cd5(Cd5) Protein, His-Tagged E.coli expression system His
Homo sapiens (Human) RFL20875HF Recombinant Full Length Human T-Cell Surface Glycoprotein Cd5(Cd5) Protein, His-Tagged E.coli expression system His
Mus musculus (Mouse) RFL32650MF Recombinant Full Length Mouse T-Cell Surface Glycoprotein Cd5(Cd5) Protein, His-Tagged E.coli expression system His
Rattus norvegicus (Rat) RFL636RF Recombinant Full Length Rat T-Cell Surface Glycoprotein Cd5(Cd5) Protein, His-Tagged E.coli expression system His
Chicken CD5-6483C Recombinant Chicken CD5 Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • CD5 Related Articles
  • CD5 Related Research Area

CD5 involved in several pathways and played different roles in them. We selected most pathways CD5 participated on our site, such as Hematopoietic cell lineage, which may be useful for your reference. Also, other proteins which involved in the same pathway with CD5 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Hematopoietic cell lineageHLA-DRB1;IL9R;MS4A1;IL6R;GYPA;CD8A;EPO;MME;GM13305

CD5 has several biochemical functions, for example, protein binding, receptor activity, scavenger receptor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by CD5 itself. We selected most functions CD5 had, and list some proteins which have the same functions with CD5. You can find most of the proteins on our site.

Function Related Protein
protein bindingSLC9A3R1;MRAP2;SGTB;HMOX2;LTA4H;FSTL1;GNE;PNMA1;Arid4b
receptor activityNLGN4X;EXTL3;BTN1A1;P2RY1;NLGN2;ERBB3B;TNFRSF11B;CMKLR1;OGFRL1
scavenger receptor activityDMBT1;CD6;CXCR7;SCART1;PRSS12;PRSS7;ENDOU;HHIPL1;SUSD2
transmembrane signaling receptor activityOR4C13;TNFRSF10C;FCGR2C;MPL;NPC1;KLRC1;AGER;GPR113;P2RX5

CD5 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CD5 here. Most of them are supplied by our site. Hope this information will be useful for your research of CD5.

PIK3R1; CD72; RASA1

Kostopoulos, IV; Paterakis, G; et al. Immunophenotypic Analysis Reveals Heterogeneity and Common Biologic Aspects in Monoclonal B-Cell Lymphocytosis. GENES CHROMOSOMES & CANCER 54:210-221(2015).
Antosz, H; Wojciechowska, K; et al. IL-6, IL-10, c-Jun and STAT3 expression in B-CLL. BLOOD CELLS MOLECULES AND DISEASES 54:258-265(2015).
  • Q&As
  • Reviews

Q&As (6)

Ask a question
What is the interaction between CD5 and other biomolecules? 05/11/2023

There are interactions between CD5 and other biomolecules. For example, it binds to antigens and antibodies and participates in the activation and differentiation of immune cells, and also binds to other signal transduction molecules and participates in cell signal transduction.

Which biomolecules can be used as molecular markers for CD5? 02/21/2022

Certain biomolecules can be used as molecular markers of CD5, including CD5 antigens detected on the surface of lymphocytes, as well as related proteins and genes that interact with CD5. These markers can be used for early diagnosis of diseases, prognosis judgment, or monitoring the effectiveness of treatment.

How can the efficacy and safety of treatments for CD5 be assessed? 09/12/2021

Assessing the efficacy and safety of treatments targeting CD5 requires clinical trials and drug monitoring. The effectiveness of the treatment was evaluated by designing a rigorous clinical trial protocol that compared the disease remission rate, symptom improvement, and quality of life improvement between the treatment and control groups. At the same time, drug monitoring is used to monitor the safety and efficacy of drugs in actual use, adjust treatment regimens in a timely manner, maximize the efficacy of drugs and reduce the risk of side effects.

What is the structure of CD5? 07/14/2021

CD5 has a typical immunoglobulin superfamily domain, which is a single-stranded transmembrane glycoprotein that is distributed in an asymmetrical manner across the cell membrane. This structure allows it to bind to antigens and antibodies and participate in the immune response.

What diseases are CD5 associated with? 11/19/2020

CD5 has been linked to a number of immune system-related diseases. For example, certain autoimmune diseases, allergic reactions, transplant rejection, etc. In addition, CD5 has been implicated in the development and progression of certain tumors.

How is the therapeutic strategy of CD5 evaluated? 11/06/2020

Treatment strategies for CD5 include inhibition of its activity, regulation of its expression, and gene therapy. For example, the development of antibody drugs or small molecule inhibitors against CD5 to inhibit its overactivation in the immune response, or the regulation of CD5 expression through gene knockout or overexpression techniques.

Customer Reviews (3)

Write a review
Reviews
08/18/2022

    The stability of CD5 is very good, and even if it is stored for a long time, it will not affect its performance.

    12/20/2021

      I have recommended it to other students, the price is affordable, the operation is convenient, and the effect is good.

      11/28/2020

        I'm very happy with the results, the stability is strong.

        Ask a Question for All CD5 Products

        Required fields are marked with *

        My Review for All CD5 Products

        Required fields are marked with *

        logo

        FOLLOW US

        Terms and Conditions        Privacy Policy

        Copyright © 2024 Creative BioMart. All Rights Reserved.

        Contact Us

        • /

        Stay Updated on the Latest Bioscience Trends