Species : |
Rat |
Source : |
Human Cells |
Tag : |
Fc |
Protein Length : |
1-181 a.a. |
Description : |
FZD4, also known as CD344, belongs to the the frizzle family. Members of this family encode seven-transmembrane domain proteins that are receptors for the Wingless type MMTV integration site family of signaling proteins. Most of frizzled receptors are coupled to the beta-catenin (CTNNB1) canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin (CTNNB1) and activation of Wnt target genes. FZD4 is the receptor for Wnt proteins. In retina, it can be both activated by Wnt protein-binding, but also by a Wnt-independent signaling via binding of norrin, promoting in both cases beta-catenin (CTNNB1) accumulation and stimulation of LEF/TCF-mediated transcriptional programs. FZD4 plays a critical role in retinal vascularization by acting as a receptor for Wnt proteins and norrin. |
Predicted N Terminal : |
Phe 38 |
Form : |
Lyophilized from sterile PBS, pH 7.4. Normally 5 % - 8 % trehalose and mannitol are added as protectants before lyophilization. |
Molecular Mass : |
The recombinant rat FZD4 is a disulfide-linked homodimer. The reduced monomer comprises 385 amino acids and has a predicted molecular mass of 43.2 kDa. The apparent molecular mass of the protein is approximately 113, 58 and 36 kDa in SDS-PAGE under reducing conditions. |
Endotoxin : |
1.0 eu/μg of the protein as determined by the lal |
Purity : |
>(13.3+78.9+5.2 )% as determined by SDS-PAGE |
Stability : |
Samples are stable for up to twelve months from date of receipt at -70℃ |
Storage : |
Store it under sterile conditions at -70℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles. |