• Official Full Name

    CD74 molecule, major histocompatibility complex, class II invariant chain

  • Overview

    The protein encoded by this gene associates with class II major histocompatibility complex (MHC) and is an important chaperone that regulates antigen presentation for immune response. It also serves as cell surface receptor for the cytokine macrophage migration inhibitory factor (MIF) which, when bound to the encoded protein, initiates survival pathways and cell proliferation. This protein also interacts with amyloid precursor protein (APP) and suppresses the production of amyloid beta (Abeta). Multiple alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Aug 2011]
  • Synonyms

    CD74; CD74 molecule, major histocompatibility complex, class II invariant chain; II; DHLAG; HLADG; Ia-GAMMA; HLA class II histocompatibility antigen gamma chain; p33; HLA-DR-gamma; MHC HLA-DR gamma chain; Ia-associated invariant chain; gamma chain of class II antigens; HLA-DR antigens-associated invariant chain; CD74 antigen (invariant polypeptide of major histocompatibility complex, class II antigen-associated);

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Chicken
  • Homo sapiens (Human)
  • Human
  • Mouse
  • Mus musculus (Mouse)
  • Rat
  • Rattus norvegicus (Rat)
  • CHO
  • E.coli
  • E.coli expression system
  • HEK293
  • HEK293F
  • HEK293T
  • Human Cell
  • Human cells
  • Insect Cell
  • Mammalian Cell
  • Mammalian cells
  • Wheat Germ
  • C
  • His
  • Flag
  • GST
  • HA
  • His (Fc)
  • Avi
  • His|GST
  • His|T7
  • Myc
  • DDK
  • MYC
  • Myc|DDK
  • N/A
  • N
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human CD74-546H Active Recombinant Human CD74 Protein, HA-tagged CHO HA
Human CD74-2232H Active Recombinant Human CD74, HA-tagged CHO HA
Human CD74-2231H Active Recombinant Human CD74, Hemagglutinin-tagged CHO N/A
Human CD74-2230H Recombinant Human CD74, GST-Tagged Wheat Germ GST
Human CD74-2229H Recombinant Human CD74 Wheat Germ N/A
Human CD74-2227H Active Recombinant Human CD74 protein, His-tagged HEK293 His
Human CD74-589H Recombinant Human CD74 molecule, major histocompatibility complex, class II invariant chain, His-tagged E.coli His
Human CD74-114H Recombinant Human CD74, His-tagged Insect Cell His
Human CD74-2228H Recombinant Human CD74, Myc-DDK-Tagged HEK293 Myc/DDK
Human CD74-2603HCL Recombinant Human CD74 cell lysate Human Cell N/A
Human CD74-698H Recombinant Human CD74 Protein, His-tagged HEK293F N-His
Human CD74-1184H Recombinant Human CD74 Protein (Leu78-Lys208), N-His tagged E.coli N-His
Human CD74-546H-B Recombinant Human CD74 Protein Pre-coupled Magnetic Beads HEK293
Human CD74-1892H Recombinant Human CD74 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Human CD74-170H Recombinant Human CD74 Protein, His-tagged HEK293 His
Human CD74-151H Recombinant Human CD74 Protein, DYKDDDDK-tagged Human cells DYKDDDDK
Human CD74-5369H Recombinant Human CD74 Protein (Gln73-Met296), N-His tagged Mammalian cells N-His
Human CD74-1283HFL Recombinant Full Length Human CD74 Protein, C-Flag-tagged Mammalian cells Flag
Human CD74-5370H Recombinant Human CD74 Protein (Gln73-Met232), C-His tagged Mammalian cells C-His
Mouse Cd74-641M Active Recombinant Mouse Cd74 Protein, HA-tagged CHO HA
Mouse Cd74-6871M Recombinant Mouse Cd74 protein, His & T7-tagged E.coli His/T7
Mouse CD74-9493M Recombinant Mouse CD74, His-tagged HEK293 His
Mouse Cd74-1157M Recombinant Mouse Cd74 Protein, His-tagged E.coli His
Mouse Cd74-1231M Recombinant Mouse Cd74 Protein, MYC/DDK-tagged HEK293T MYC/DDK
Rat Cd74-6872R Recombinant Rat Cd74 protein, His & GST-tagged E.coli His/GST
Rat CD74-1262R Recombinant Rat CD74 Protein Mammalian Cell His
Rat CD74-920R-B Recombinant Rat CD74 Protein Pre-coupled Magnetic Beads HEK293
Rat Cd74-2672R Recombinant Rat Cd74 protein, His-tagged E.coli His
Rat CD74-920R Recombinant Rat CD74 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Homo sapiens (Human) RFL21480HF Recombinant Full Length Human Hla Class Ii Histocompatibility Antigen Gamma Chain(Cd74) Protein, His-Tagged E.coli expression system His
Mus musculus (Mouse) RFL27310MF Recombinant Full Length Mouse H-2 Class Ii Histocompatibility Antigen Gamma Chain(Cd74) Protein, His-Tagged E.coli expression system His
Rattus norvegicus (Rat) RFL12540RF Recombinant Full Length Rat H-2 Class Ii Histocompatibility Antigen Gamma Chain(Cd74) Protein, His-Tagged E.coli expression system His
Chicken CD74-1132C Recombinant Chicken CD74 Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • CD74 Related Articles
  • CD74 Related Research Area

CD74 involved in several pathways and played different roles in them. We selected most pathways CD74 participated on our site, such as Antigen processing and presentation, Tuberculosis, Herpes simplex infection, which may be useful for your reference. Also, other proteins which involved in the same pathway with CD74 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Antigen processing and presentationIFI30;HLA-DQA1;HLA-DRB3;KLRC4;HLA-DRB1;PDIA3;KIR2DL1;KLRC1;KIR2DS3
Herpes simplex infectionEIF2S1B;IFNA8;HLA-DMB;SRSF6A;PER3;MAPK8;CD74;GTF2I;Casp3

CD74 has several biochemical functions, for example, MHC class II protein binding, MHC class II protein binding, via antigen binding groove, MHC class II protein complex binding. Some of the functions are cooperated with other proteins, some of the functions could acted by CD74 itself. We selected most functions CD74 had, and list some proteins which have the same functions with CD74. You can find most of the proteins on our site.

Function Related Protein
MHC class II protein bindingLAG3;CD74B;CD4;CD74;CD74A;KRT17;MARCH8
MHC class II protein binding, via antigen binding groove
MHC class II protein complex bindingHSP90AA1;YWHAE;HLA-DMA;HSPA8;ATP1B1;HSP90AB1;ANXA11;CD81;CD74
beta-amyloid bindingAPOEA;ARMCX5-GPRASP2;APBA2;LDLRAP1;CHRNA7;TM2D1;HSD17B10;APOA1;Apba1
cytokine receptor activityCRFB2;IL17RB;IL1RL1;IL12B;CSF3R;PRLRA;FLT3;CRFB6;GHRA
identical protein bindingMUL1;KCTD13;FTL;IK;CLDN9;LEPR;PIK3AP1;SOD1;PYDC3
macrophage migration inhibitory factor binding
nitric-oxide synthase bindingCD74;ACTB;NOS1AP;ATP2B4;SLC6A4;CALM3;CALM2;CAV1;SLC14A2
protein binding involved in protein foldingCLGN;HSPA1B;RIC3;PFDN1;CALR;PDCL3;CD74;HSPA1A;DNAJB8

CD74 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CD74 here. Most of them are supplied by our site. Hope this information will be useful for your research of CD74.

HLA-DQA1; CXCR4; UBA1; UBE2N; UBE2V1; Map3k1; HLA-DRA; HLA-DPA1; yopM; HADHA; ltp_ebvg; yegQ; q5nem9_fratt; q5nes9_fratt; dnaJ2; hemL

Zou, HLY; Li, QH; et al. PF-06463922 is a potent and selective next-generation ROS1/ALK inhibitor capable of blocking crizotinib-resistant ROS1 mutations. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 112:3493-3498(2015).
Setti, SE; Littlefield, AM; et al. Diet-induced obesity attenuates endotoxin-induced cognitive deficits. PHYSIOLOGY & BEHAVIOR 141:1-8(2015).
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