CD74 Protein

September 27-30, 2022

Boston Convention and Exhibition Center

Booth #336

Learn More

  • 00


  • 00


  • 00


  • 00



Home / Products / CD74


Official Full Name CD74 molecule, major histocompatibility complex, class II invariant chain
Background The protein encoded by this gene associates with class II major histocompatibility complex (MHC) and is an important chaperone that regulates antigen presentation for immune response. It also serves as cell surface receptor for the cytokine macrophage migration inhibitory factor (MIF) which, when bound to the encoded protein, initiates survival pathways and cell proliferation. This protein also interacts with amyloid precursor protein (APP) and suppresses the production of amyloid beta (Abeta). Multiple alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Aug 2011]
Synonyms CD74; CD74 molecule, major histocompatibility complex, class II invariant chain; II; DHLAG; HLADG; Ia-GAMMA; HLA class II histocompatibility antigen gamma chain; p33; HLA-DR-gamma; MHC HLA-DR gamma chain; Ia-associated invariant chain; gamma chain of class II antigens; HLA-DR antigens-associated invariant chain; CD74 antigen (invariant polypeptide of major histocompatibility complex, class II antigen-associated);
    • Species :
    • Chicken
    • Homo sapiens (Human)
    • Human
    • Mouse
    • Mus musculus (Mouse)
    • Rat
    • Rattus norvegicus (Rat)
    • Source :
    • CHO
    • E.coli
    • E.coli expression system
    • HEK293
    • HEK293F
    • HEK293T
    • Human Cell
    • Human cells
    • Insect Cell
    • Mammalian Cell
    • Wheat Germ
    • Tag :
    • GST
    • HA
    • His
    • T7
    • MYC/DDK
    • Myc
    • DDK
    • N/A
    • N-His
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human CD74-114H Recombinant Human CD74, His-tagged Insect Cell His
    human CD74-2227H Recombinant human CD74 protein, His-tagged HEK293 His
    Human CD74-2228H Recombinant Human CD74, Myc-DDK-Tagged HEK293 Myc/DDK
    Human CD74-2229H Recombinant Human CD74 Wheat Germ N/A
    Human CD74-2230H Recombinant Human CD74, GST-Tagged Wheat Germ GST
    Human CD74-2231H Recombinant Human CD74, Hemagglutinin-tagged CHO N/A
    Human CD74-2232H Recombinant Human CD74, HA-tagged CHO HA
    Human CD74-546H Recombinant Human CD74 Protein, HA-tagged CHO HA
    Human CD74-589H Recombinant Human CD74 molecule, major histocompatibility complex, class II invariant chain, His-tagged E.coli His
    Mouse Cd74-1157M Recombinant Mouse Cd74 Protein, His-tagged E.coli His
    Mouse Cd74-641M Recombinant Mouse Cd74 Protein, HA-tagged CHO HA
    Mouse Cd74-6871M Recombinant Mouse Cd74 protein, His & T7-tagged E.coli His/T7
    Mouse CD74-9493M Recombinant Mouse CD74, His-tagged HEK293 His
    Rat CD74-1262R Recombinant Rat CD74 Protein Mammalian Cell His
    Rat Cd74-6872R Recombinant Rat Cd74 protein, His & GST-tagged E.coli His/GST
    Chicken CD74-1132C Recombinant Chicken CD74 Mammalian Cell His
    Human CD74-2603HCL Recombinant Human CD74 cell lysate Human Cell N/A
    Human CD74-151H Recombinant Human CD74 Protein, DYKDDDDK-tagged Human cells DYKDDDDK
    Rat Cd74-2672R Recombinant Rat Cd74 protein, His-tagged E.coli His
    Human CD74-698H Recombinant Human CD74 Protein, His-tagged HEK293F N-His
    Rattus norvegicus (Rat) RFL12540RF Recombinant Full Length Rat H-2 Class Ii Histocompatibility Antigen Gamma Chain(Cd74) Protein, His-Tagged E.coli expression system His
    Homo sapiens (Human) RFL21480HF Recombinant Full Length Human Hla Class Ii Histocompatibility Antigen Gamma Chain(Cd74) Protein, His-Tagged E.coli expression system His
    Mus musculus (Mouse) RFL27310MF Recombinant Full Length Mouse H-2 Class Ii Histocompatibility Antigen Gamma Chain(Cd74) Protein, His-Tagged E.coli expression system His
    Human CD74-1892H Recombinant Human CD74 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
    Mouse Cd74-1231M Recombinant Mouse Cd74 Protein, MYC/DDK-tagged HEK293T MYC/DDK

    CD74 involved in several pathways and played different roles in them. We selected most pathways CD74 participated on our site, such as Antigen processing and presentation, Tuberculosis, Herpes simplex infection, which may be useful for your reference. Also, other proteins which involved in the same pathway with CD74 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Antigen processing and presentation HLA-G; KIR2DS3; HSPA5; HLA-DQB1; HLA-E; TAPBP; KIR2DS2; PSME2; HLA-DRA; NFYB
    Tuberculosis CALML3; MAPK12; CLEC4E; ARHGEF12; PLK3; NFYB; CAMK2A; CD74; MAPK11; MAPK9
    Herpes simplex infection CLOCK; OAS1A; BMA2; SRSF3; HNRNPK; Ccl12; PPP1CB; MHC1UEA; SFRS3B; EIF2AK3

    CD74 has several biochemical functions, for example, MHC class II protein binding, MHC class II protein binding, via antigen binding groove, MHC class II protein complex binding. Some of the functions are cooperated with other proteins, some of the functions could acted by CD74 itself. We selected most functions CD74 had, and list some proteins which have the same functions with CD74. You can find most of the proteins on our site.

    Function Related Protein
    MHC class II protein binding CD74A; CD4; LAG3; KRT17; CD74; MARCH8; CD74B
    MHC class II protein binding, via antigen binding groove CD74
    MHC class II protein complex binding HSP90AB1; PKM2; MS4A1; HSP90AA1; ATP1B1; HLA-DOB; HLA-DRB1; HLA-DRA; CD81; HSPA8
    beta-amyloid binding CHRNA7; IDE; LDLRAD3; APOE; LDLRAP1; TSSK1B; NGFR; OLFM1; CD74; APBA3
    cytokine binding ELANE; CRLF1; KITB; KIT; IFNGR1; Fzd4; IL31RA; NRP1; CD74; GBP1
    cytokine receptor activity IL21R.2; Il6ra; GHR; IL11RA; F3A; IL1RL1; CRFB2; LIFRB; CRFB6; CRFB17
    identical protein binding IFIT3; EWSR1; CLDN2; CD74; CLDN4; PLDN; JMJD6; DVL1; VIL1; SH3BP4
    macrophage migration inhibitory factor binding CD74
    nitric-oxide synthase binding SCN5A; DMD; CALM2; CAMK2D; CAV3; SNTA1; ATP2B4; SLC6A4; CALM1; DNM2
    protein binding RBM39; PCGF6; NGLY1; FCN2; IP6K2; NUDCD2; TCTEX1D1; TMEM31; TATDN1; PIP5K1C
    protein binding involved in protein folding HSPA1B; RIC3; CALR3; CLGN; CALR; PDCL3; CD74; DNAJB8; HSPA1A; PFDN2

    CD74 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CD74 here. Most of them are supplied by our site. Hope this information will be useful for your research of CD74.

    HLA-DQA1; CXCR4; UBA1; UBE2N; UBE2V1; Map3k1; HLA-DRA; HLA-DPA1; yopM; HADHA; ltp_ebvg; yegQ; q5nem9_fratt; q5nes9_fratt; dnaJ2; hemL

    Zou, HLY; Li, QH; et al. PF-06463922 is a potent and selective next-generation ROS1/ALK inhibitor capable of blocking crizotinib-resistant ROS1 mutations. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 112:3493-3498(2015).
    Setti, SE; Littlefield, AM; et al. Diet-induced obesity attenuates endotoxin-induced cognitive deficits. PHYSIOLOGY & BEHAVIOR 141:1-8(2015).

    Related Services & Products

    Apply For A Coupon

    $50 OFF Your First Purchase

    Apply For a Coupon

    Enter your email here to subscribe.

    creative biomart inc.

    Easy access to products and services you need from our library via powerful searching tools.

    Follow Us

    Copyright © 2022 Creative BioMart. All Rights Reserved. Terms and Conditions | Privacy Policy