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Official Full Name cyclin-dependent kinase inhibitor 1B (p27, Kip1)
Background Cyclin-dependent kinase inhibitor 1B is an enzyme that in humans is encoded by the CDKN1B gene. It encodes a protein which belongs to the Cip/Kip family of cyclin dependent kinase (Cdk) inhibitor proteins. The encoded protein binds to and prevents the activation of cyclin E-CDK2 or cyclin D-CDK4 complexes, and thus controls the cell cycle progression at G1. It is often referred to as a cell cycle inhibitor protein because its major function is to stop or slow down the cell division cycle.
Synonyms CDKN1B; cyclin-dependent kinase inhibitor 1B (p27, Kip1); KIP1; MEN4; CDKN4; MEN1B; P27KIP1; cyclin-dependent kinase inhibitor 1B; Cyclin-dependent kinase inhibitor p27; p27Kip1; OTTHUMP00000195098; OTTHUMP00000195099; kinase inhibitory protein (Kip1)
    • Species :
    • Chicken
    • Human
    • Mouse
    • Rhesus Macaque
    • Source :
    • E.coli
    • HEK293
    • Human
    • Insect Cell
    • Mammalian Cell
    • Wheat Germ
    • Tag :
    • DDK
    • GST
    • His
    • MBP
    • T7
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human CDKN1B-006H Recombinant Human CDKN1B Protein, DDK-tagged Insect Cell DDK
    Human CDKN1B-1056H Recombinant Human CDKN1B Protein, GST-Tagged Wheat Germ GST
    Human CDKN1B-1478H Recombinant Human CDKN1B, GST-tagged E.coli GST
    Human CDKN1B-2499H Recombinant Human Cyclin-Dependent Kinase Inhibitor 1B (p27, Kip1), His-tagged E.coli His
    Human CDKN1B-313H Recombinant Human CDKN1B protein, His/MBP-tagged E.coli His/MBP
    Human CDKN1B-33H Recombinant Human CDKN1B protein, GST-tagged E.coli GST
    Human CDKN1B-4729H Recombinant Human CDKN1B, His-tagged Human His
    Human CDKN1B-7617HCL Recombinant Human CDKN1B 293 Cell Lysate HEK293 N/A
    Mouse Cdkn1b-1252M Recombinant Mouse Cdkn1b protein, His & T7-tagged E.coli His/T7
    Mouse CDKN1B-3221M Recombinant Mouse CDKN1B Protein Mammalian Cell His
    Rhesus Macaque CDKN1B-794R Recombinant Rhesus monkey CDKN1B Protein, His-tagged Mammalian Cell His
    Chicken CDKN1B-5829C Recombinant Chicken CDKN1B Mammalian Cell His

    cdkn1b involved in several pathways and played different roles in them. We selected most pathways cdkn1b participated on our site, such as AKT phosphorylates targets in the cytosol, Adaptive Immune System, AhR pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with cdkn1b were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    AKT phosphorylates targets in the cytosol CHUK; AKT3; CDKN1B; CDKN1A
    Adaptive Immune System ATG7; SEC24A; CD300LH; LAIR1; RNF220; TPP2; AP1S1; LILRB5; RAP1GAP2B; SPSB1
    AhR pathway CYP1B1; CDC37; AHR; EGFR; NQO1; CYP1A1; CDKN1B; FLG; CYP1A2; JUN
    C-MYB transcription factor network ELANE; GATA1; CEBPB; PRTN3; MYF6; CBX4; YEATS4; CREBBP; LECT2; CLTA
    Cell Cycle DIDO1; HAUS2; MAU2; TUBGCP2; CEP152; TBC1D8; NPM1; CDC23; NSL1; CTDNEP1A
    Cell Cycle Checkpoints BARD1; HIST4H4; RAD9A; RAD50; RAD9B; BRCC3; UIMC1; BRE; KAT5; YWHAQ
    Cell Cycle, Mitotic STIL; KIF2A; TUBGCP4; PDS5B; CENPA; KIF18A; CSNK1D; TUBG1; SMC2; DYNC1I2

    cdkn1b has several biochemical functions, for example, Hsp70 protein binding, chaperone binding, cyclin-dependent protein serine/threonine kinase inhibitor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by cdkn1b itself. We selected most functions cdkn1b had, and list some proteins which have the same functions with cdkn1b. You can find most of the proteins on our site.

    Function Related Protein
    Hsp70 protein binding GPR37; TFRC; CDK1; PPID; L7RN6; STIP1; ST13; TSACC; MVD; DNAJB2
    chaperone binding UBL4A; ERP29; DNAJA4; PIH1D3; ST13; DNLZ; DNAJB7; HSPA5; BAG5; FGB
    cyclin-dependent protein serine/threonine kinase inhibitor activity CDKN1D; Casp3; HEXIM1; CDKN1BB; CDKN1C; CDKN2A; CDKN2C; CDKN2B; HEXIM2; CDKN1BA
    contributes_to cysteine-type endopeptidase activator activity involved in apoptotic process CDKN1B; NKX3-1; NKX3
    protein binding HDDC3; CSTF1; COL18A1; RIBC2; RPH3A; CYFIP1; ERCC6; SET; TMEM147; SEC14L4
    protein complex binding HSPD1; CDK2; BAG3; PLK2; MYSM1; NCKAP1; IST1; RAP1B; GNB1; NDUFA4
    protein phosphatase binding MAP3K5; PPP1R3C; PPP1R3G; EGFR; LCK; CDH5; STAT3; ITPR1; NEK2; VRK3
    transforming growth factor beta receptor, cytoplasmic mediator activity ENG; CDKN1B

    cdkn1b has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with cdkn1b here. Most of them are supplied by our site. Hope this information will be useful for your research of cdkn1b.


    Atsaves, V; Lekakis, L; et al. The oncogenic JUNB/CD30 axis contributes to cell cycle deregulation in ALK plus anaplastic large cell lymphoma. BRITISH JOURNAL OF HAEMATOLOGY 167:514-523(2014).
    Cattoretti, G; et al. MYC expression and distribution in normal mature lymphoid cells. JOURNAL OF PATHOLOGY 229:430-440(2013).

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