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CDKN1B

  • Official Full Name

    cyclin-dependent kinase inhibitor 1B (p27, Kip1)

  • Overview

    Cyclin-dependent kinase inhibitor 1B is an enzyme that in humans is encoded by the CDKN1B gene. It encodes a protein which belongs to the Cip/Kip family of cyclin dependent kinase (Cdk) inhibitor proteins. The encoded protein binds to and prevents the activation of cyclin E-CDK2 or cyclin D-CDK4 complexes, and thus controls the cell cycle progression at G1. It is often referred to as a cell cycle inhibitor protein because its major function is to stop or slow down the cell division cycle.
  • Synonyms

    CDKN1B; cyclin-dependent kinase inhibitor 1B (p27, Kip1); KIP1; MEN4; CDKN4; MEN1B; P27KIP1; cyclin-dependent kinase inhibitor 1B; Cyclin-dependent kinase inhibitor p27; p27Kip1; OTTHUMP00000195098; OTTHUMP00000195099; kinase inhibitory protein (Kip1);

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Chicken
  • Human
  • Mouse
  • Rhesus Macaque
  • E.coli
  • HEK293
  • HEK293T
  • Human
  • In Vitro Cell Free System
  • Insect Cell
  • Mammalian Cell
  • Mammalian cells
  • Wheat Germ
  • DDK
  • Flag
  • GST
  • His
  • His (Fc)
  • Avi
  • His|MBP
  • His|T7
  • Myc
  • MYC
  • N/A
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human CDKN1B-006H Recombinant Human CDKN1B Protein, DDK-tagged Insect Cell DDK
Human CDKN1B-1478H Recombinant Human CDKN1B, GST-tagged E.coli GST
Human CDKN1B-313H Recombinant Human CDKN1B protein, His/MBP-tagged E.coli His/MBP 123-198 aa
Human CDKN1B-33H Recombinant Human CDKN1B protein, GST-tagged E.coli GST
Human CDKN1B-1056H Recombinant Human CDKN1B Protein, GST-Tagged Wheat Germ GST
Human CDKN1B-4729H Recombinant Human CDKN1B, His-tagged Human His
Human CDKN1B-2499H Recombinant Human Cyclin-Dependent Kinase Inhibitor 1B (p27, Kip1), His-tagged E.coli His 1-198aa
Human CDKN1B-7617HCL Recombinant Human CDKN1B 293 Cell Lysate HEK293 N/A
Human CDKN1B-2041HFL Recombinant Full Length Human CDKN1B Protein, C-Flag-tagged Mammalian cells Flag
Human CDKN1B-3192HF Recombinant Full Length Human CDKN1B Protein, GST-tagged In Vitro Cell Free System GST 198 amino acids
Human CDKN1B-4158H Recombinant Human CDKN1B Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Human CDKN1B-3259H Recombinant Human CDKN1B protein, His-tagged HEK293 His Met1~Thr198
Human CDKN1B-568H Recombinant Human CDKN1B Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Human CDKN1B-568H-B Recombinant Human CDKN1B Protein Pre-coupled Magnetic Beads HEK293
Human CDKN1B-2704H Recombinant Human CDKN1B protein, His-tagged E.coli His 44-198 aa
Human CDKN1B-1076H Recombinant Human CDKN1B Protein (Met1-Thr198), His tagged E.coli His Met1-Thr198
Mouse Cdkn1b-1252M Recombinant Mouse Cdkn1b protein, His & T7-tagged E.coli His/T7 Ser2~Thr197 (Accession # P46414)
Mouse CDKN1B-3221M Recombinant Mouse CDKN1B Protein Mammalian Cell His
Mouse CDKN1B-1535M Recombinant Mouse CDKN1B Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mouse CDKN1B-1535M-B Recombinant Mouse CDKN1B Protein Pre-coupled Magnetic Beads HEK293
Mouse Cdkn1b-870M Recombinant Mouse Cdkn1b Protein, MYC/DDK-tagged HEK293T MYC/DDK
Rhesus Macaque CDKN1B-794R Recombinant Rhesus monkey CDKN1B Protein, His-tagged Mammalian Cell His
Rhesus Macaque CDKN1B-620R-B Recombinant Rhesus Macaque CDKN1B Protein Pre-coupled Magnetic Beads HEK293
Rhesus Macaque CDKN1B-620R Recombinant Rhesus Macaque CDKN1B Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Chicken CDKN1B-5829C Recombinant Chicken CDKN1B Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • CDKN1B Related Articles

CDKN1B involved in several pathways and played different roles in them. We selected most pathways CDKN1B participated on our site, such as AKT phosphorylates targets in the cytosol, Adaptive Immune System, AhR pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with CDKN1B were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
AKT phosphorylates targets in the cytosolCHUK;AKT3;CDKN1B;CDKN1A
Adaptive Immune SystemKIF3B;HUWE1;ASB7;RAP1GAP2;ITPR2;IGKC;KIF5A;KLRF1;DYNC1LI2
AhR pathwayPTGES3;CDKN1B;AHR;AHRR;JUN;CYP1A1;FLG;CDKN1A;CYP1A2
C-MYB transcription factor networkMYOD1;CDKN1B;YEATS4;ADORA2B;ADA;PRTN3;TOM1;CLTA;LECT2
Cell CycleCENPJ;INCENP;MSH4;CDKN1C;TUBGCP3;USO1;GADD45AA;CCNA2;CSNK2B
Cell Cycle CheckpointsHTATIP;RAD9B;RAD9A;CHEK1;RAD17;KAT5;CDK2;HIST3H2BB;BABAM1
Cell Cycle, MitoticTUBB4B;DCTN3;ARPP19;ACTR1A;MIS12;AURKB;ESCO2;CTDNEP1;ENSA

CDKN1B has several biochemical functions, for example, Hsp70 protein binding, chaperone binding, cyclin-dependent protein serine/threonine kinase inhibitor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by CDKN1B itself. We selected most functions CDKN1B had, and list some proteins which have the same functions with CDKN1B. You can find most of the proteins on our site.

Function Related Protein
Hsp70 protein bindingCDKN1B;C11orf73;FAM119A;BAG6;ERN1;RNF207;STIP1;PACRG;L7RN6
chaperone bindingCP;BIRC5;TBCE;ST13;GNB5;HSPE1;CTSC;AMFR;FGB
cyclin-dependent protein serine/threonine kinase inhibitor activityCDKN2C;CDKN1C;CDKN2B;HEXIM1;HEXIM2;CDKN2D;Casp3;CDKN1BA;CDKN1D
contributes_to cysteine-type endopeptidase activator activity involved in apoptotic processCDKN1B;NKX3-1;NKX3
protein bindingPSMF1;CDK5R2;PEX3;HIST1H2BB;C2orf28;DPYSL5;2610109H07Rik;PSMB4;RASSF2
protein complex bindingPROS1;SKAP1;ST13;PEX26;RAD18;RIPK3;NCKAP1L;YWHAB;ERCC6
protein phosphatase bindingTP53;PPP1R3G;IRS2;ANAPC7;JAK3;ITPR1;GNB2L1;Itga10&Itgb1;ITGA1
transforming growth factor beta receptor, cytoplasmic mediator activityCDKN1B;ENG

CDKN1B has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CDKN1B here. Most of them are supplied by our site. Hope this information will be useful for your research of CDKN1B.

CDK2

Atsaves, V; Lekakis, L; et al. The oncogenic JUNB/CD30 axis contributes to cell cycle deregulation in ALK plus anaplastic large cell lymphoma. BRITISH JOURNAL OF HAEMATOLOGY 167:514-523(2014).
Cattoretti, G; et al. MYC expression and distribution in normal mature lymphoid cells. JOURNAL OF PATHOLOGY 229:430-440(2013).
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