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Official Full Name cyclin-dependent kinase inhibitor 2B (p15, inhibits CDK4)
Background This gene lies adjacent to the tumor suppressor gene CDKN2A in a region that is frequently mutated and deleted in a wide variety of tumors. This gene encodes a cyclin-dependent kinase inhibitor, which forms a complex with CDK4 or CDK6, and prevents the activation of the CDK kinases, thus the encoded protein functions as a cell growth regulator that controls cell cycle G1 progression. The expression of this gene was found to be dramatically induced by TGF beta, which suggested its role in the TGF beta induced growth inhibition. Two alternatively spliced transcript variants of this gene, which encode distinct proteins, have been reported. [provided by RefSeq, Jul 2008]
Synonyms CDKN2B; cyclin-dependent kinase inhibitor 2B (p15, inhibits CDK4); P15; MTS2; TP15; CDK4I; INK4B; p15INK4b; cyclin-dependent kinase 4 inhibitor B; MTS-2; p14-INK4b; p14_INK4B; p15-INK4b; p15_INK4B; CDK4B inhibitor; p14_CDK inhibitor; p15 CDK inhibitor; CDK inhibitory protein; multiple tumor suppressor 2; cyclin-dependent kinases 4 and 6 binding protein;
    • Species :
    • Chicken
    • Human
    • Mouse
    • Rat
    • Source :
    • E.coli
    • HEK293
    • HEK293T
    • Mammalian Cell
    • Wheat Germ
    • Tag :
    • GST
    • His
    • T7
    • Myc/DDK
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human CDKN2B-1064H Recombinant Human CDKN2B Protein, GST-Tagged Wheat Germ GST
    Human CDKN2B-11063H Recombinant Human CDKN2B, GST-tagged E.coli GST
    Human CDKN2B-134H Recombinant Human CDKN2B protein, His-tagged E.coli His
    Human CDKN2B-32H Recombinant Human CDKN2B protein E.coli N/A
    Human CDKN2B-4212H Recombinant Human CDKN2B Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
    Human CDKN2B-7613HCL Recombinant Human CDKN2B 293 Cell Lysate HEK293 N/A
    Mouse Cdkn2b-1253M Recombinant Mouse Cdkn2b protein, His & T7-tagged E.coli His/T7
    Mouse CDKN2B-3226M Recombinant Mouse CDKN2B Protein Mammalian Cell His
    Rat CDKN2B-1316R Recombinant Rat CDKN2B Protein Mammalian Cell His
    Chicken CDKN2B-6003C Recombinant Chicken CDKN2B Mammalian Cell His

    cdkn2b involved in several pathways and played different roles in them. We selected most pathways cdkn2b participated on our site, such as Cell Cycle, Cell Cycle, Mitotic, Cellular Senescence, which may be useful for your reference. Also, other proteins which involved in the same pathway with cdkn2b were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Cell Cycle, Mitotic CKAP5; PMF1; ODF2; AURKB; ARPP19B; ERCC6L; RANGAP1B; PDS5B; NCAPD3; H3F3D
    Cellular Senescence UBN1; TNIK; EP400; HMGA1; BMI1A; TXN; TERF2IP; PHC2; H1F0; HIST2H3C
    Cellular responses to stress EEF1A1; RNF2; PHC3; AMBRA1A; CBX6A; WIPI1; NUPL2; HSPA12B; HMGA1; CBX8B
    Cyclin D associated events in G1 CKS1B; CDK7; E2F4; CDKN2B; CDKN2C; PIANP; CDKN2D
    FoxO signaling pathway PIK3R3B; PCK2; SGK1; GRB2A; SGK2A; INSB; GADD45AB; MAPK1; MAPK10; MAP2K2A

    cdkn2b has several biochemical functions, for example, cyclin-dependent protein serine/threonine kinase inhibitor activity, protein binding, protein kinase binding. Some of the functions are cooperated with other proteins, some of the functions could acted by cdkn2b itself. We selected most functions cdkn2b had, and list some proteins which have the same functions with cdkn2b. You can find most of the proteins on our site.

    Function Related Protein
    cyclin-dependent protein serine/threonine kinase inhibitor activity CDKN2D; CDKN1C; HEXIM2; CDKN1A; CDKN2C; CDKN1B; KAT2B; CDKN1BB; CDKN2B; CDKN2A
    protein binding TAF1; GNB2; EXD1; UNC13A; C1R; GRN; LRP4; DPYSL5; PPP3CA; GBA
    protein kinase binding GRB7; AP2A1; PDGFRB; TMEM173; ADRA2A; ERRFI1; PRKCZ; LSM2; NIPAL1; KAT2B

    cdkn2b has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with cdkn2b here. Most of them are supplied by our site. Hope this information will be useful for your research of cdkn2b.

    CDK4; CDK6; 80125; TRAF1

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