CEBPB
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Official Full Name
CCAAT/enhancer binding protein (C/EBP), beta
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Overview
The protein encoded by this intronless gene is a bZIP transcription factor which can bind as a homodimer to certain DNA regulatory regions. It can also form heterodimers with the related proteins CEBP-alpha, CEBP-delta, and CEBP-gamma. The encoded protein is important in the regulation of genes involved in immune and inflammatory responses and has been shown to bind to the IL-1 response element in the IL-6 gene, as well as to regulatory regions of several acute-phase and cytokine genes. In addition, the encoded protein can bind the promoter and upstream element and stimulate the expression of the collagen type I gene. -
Synonyms
CEBPB; CCAAT/enhancer binding protein (C/EBP), beta; TCF5; CCAAT/enhancer-binding protein beta; C/EBP beta; CRP2; IL6DBP; interleukin 6 dependent DNA binding protein; LAP; liver enriched transcriptional activator protein; NFIL6; nuclear factor of interleu;
- Recombinant Proteins
- Cell & Tissue Lysates
- Protein Pre-coupled Magnetic Beads
- Chicken
- Human
- Mouse
- Rat
- Zebrafish
- E.coli
- HEK293
- HEK293T
- In Vitro Cell Free System
- Mammalian Cell
- Mammalian cells
- Wheat Germ
- Flag
- GST
- His
- His (Fc)
- Avi
- Myc
- DDK
- MYC
- Myc|DDK
- N/A
- N
- Involved Pathway
- Protein Function
- Interacting Protein
CEBPB involved in several pathways and played different roles in them. We selected most pathways CEBPB participated on our site, such as Adipogenesis, C-MYB transcription factor network, Cellular Senescence, which may be useful for your reference. Also, other proteins which involved in the same pathway with CEBPB were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name | Pathway Related Protein |
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Adipogenesis | CREB1;MEF2B;CELF1;E2F4;CYP26A1;CEBPD;DLK1;CDKN1A;KCNA3 |
C-MYB transcription factor network | YEATS4;MYC;GATA1;ADA;TOM1;TRIM28;PIAS3;MYF6;CSF1R |
Cellular Senescence | PHC1;EED;BMI1B;ACD;PHC2;RBBP4;H3F3B.1;CBX4;TERF2 |
Cellular responses to stress | CBX6A;SUZ12;DYNLL2B;HTATIP;RAD50;ATG7;UVRAG;HMGA1B;EGLN3 |
Developmental Biology | PAQR3A;RASGRP1;CLTC;FRS2A;BOC;RNF8;MYF6;DOCK1;NADL1.1 |
Diurnally regulated genes with circadian orthologs | EIF4G2;CEBPB;PURA;SF3A3;CBX3;ERC2;G0S2;ITM2B;DAZAP2 |
EGFR1 Signaling Pathway | DNM1;KRT17;RALBB;TNK2;JUND;RALBP1;DOK2;CRKL;ZNF259 |
FOXA1 transcription factor network | AP1B1;FOXA1;NRIP1;NFIA;TFF1;CEBPB;NFIC;DSCAM;NFIB |
CEBPB has several biochemical functions, for example, DNA binding, RNA polymerase II core promoter proximal region sequence-specific DNA binding, RNA polymerase II regulatory region sequence-specific DNA binding. Some of the functions are cooperated with other proteins, some of the functions could acted by CEBPB itself. We selected most functions CEBPB had, and list some proteins which have the same functions with CEBPB. You can find most of the proteins on our site.
Function | Related Protein |
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DNA binding | ZFP322A;NKX2.4B;ZNF26;HOPX;FOXD5;ZNF285A;ERCC6L;PALB2;ZNF701 |
RNA polymerase II core promoter proximal region sequence-specific DNA binding | CTCFL;NACC2;BCL11A;TCF7L2;HOXA7;NKX6;ZNF680;MZF1;ETV4 |
RNA polymerase II regulatory region sequence-specific DNA binding | PLAGL1;BARX2;FOXF1;HOXD8;HES6;CREB3L3;RORA;ELF5;JARID2 |
chromatin binding | HMG20A;PHC1;FOXN4;MED12;NCOA3;PHF13;CBX4;GATA6;MBD1 |
glucocorticoid receptor binding | NRIP1;STAT5B;CEBPB;STAT3;NR4A2;FKBP4;YWHAH;ETS2;EP300 |
histone acetyltransferase binding | EGR1;CITED2;FOXP3;PCNA;EID1;TRIM68;HIF1A;MTF1;EPAS1 |
histone deacetylase binding | KLF4;GMNN;TOP2A;HES1;NCOR1;RAD9A;MEF2D;NKX3;BCOR |
kinase binding | HAP1;BARD1;PFKFB1;MIDN;CDC37;NTRK1;LDHA;PFKM;CAB39 |
protein binding | DDX21;C14orf118;C14orf166;CAMLG;KIF2C;TEF;CASP6;GTF3C5;NOC2L |
protein heterodimerization activity | TAF11;BAXB;RAF1;INHBA;SOX15;Pdgfa&Pdgfb;CEBPE;POLE3;P2RY1 |
protein homodimerization activity | BST2;S100A16;VPS4B;SERPINF2;ACTN1;STOM;SLC11A1;SMAD3;ACCS |
transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding | MEIS1;NKX2-5;POU3F3;NR1H4;NKX2;FOXF1;HNF1B;GATA5;TFAP4 |
transcription factor activity, sequence-specific DNA binding | CNOT8;HOXD3A;ZNF789;E4F1;HIF1AL;POU4F2;ZHX3;HOXB7;TFE3 |
transcription factor binding | MED6;SP1;NLK;HIF1A;TFDP1A;TRAPPC2;PAX2;HES3;FOXA1 |
transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding | NKX2-8;MYOG;SREBF1;TP73;TRP53;BCL11B;KLF15;FOXK2;E2F4 |
ubiquitin-like protein ligase binding | DDRGK1;USP13;VCP;CEBPB;CDK5RAP3;TRIP4 |
CEBPB has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CEBPB here. Most of them are supplied by our site. Hope this information will be useful for your research of CEBPB.
SMAD4; E2; TP53; E2; E2; E2; HMGA1
- Q&As
- Reviews
Q&As (5)
Ask a questionYes, targeting CEBPB may be a strategy for managing inflammatory diseases, as it regulates the expression of genes involved in the inflammatory response.
Targeting CEBPB in cancer treatment may have applications in controlling cell proliferation, promoting apoptosis, and modulating the tumor microenvironment to inhibit cancer progression.
CEBPB protein is implicated in the clinical context due to its involvement in the regulation of genes related to immune function, cell differentiation, and inflammatory responses.
CEBPB regulates the expression of immune-related genes, making it a potential target for modulating immune responses in clinical settings, such as autoimmune diseases or enhancing immune activity in cancer immunotherapy.
It's advisable to check current clinical trial databases for the latest information, as ongoing trials may be exploring the therapeutic potential of CEBPB modulation in various diseases.
Customer Reviews (3)
Write a reviewIt can be effectively employed in in vitro and in vivo studies, offering insights into the intricate mechanisms underlying angiogenesis, lipid metabolism, and cardiovascular diseases.
One of the primary advantages of the CEBPB protein is its versatility in various trial applications.
In addition to its scientific advantages, the manufacturer of the CEBPB protein stands out for their exceptional support and assistance.
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