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CEBPB

  • Official Full Name

    CCAAT/enhancer binding protein (C/EBP), beta

  • Overview

    The protein encoded by this intronless gene is a bZIP transcription factor which can bind as a homodimer to certain DNA regulatory regions. It can also form heterodimers with the related proteins CEBP-alpha, CEBP-delta, and CEBP-gamma. The encoded protein is important in the regulation of genes involved in immune and inflammatory responses and has been shown to bind to the IL-1 response element in the IL-6 gene, as well as to regulatory regions of several acute-phase and cytokine genes. In addition, the encoded protein can bind the promoter and upstream element and stimulate the expression of the collagen type I gene.
  • Synonyms

    CEBPB; CCAAT/enhancer binding protein (C/EBP), beta; TCF5; CCAAT/enhancer-binding protein beta; C/EBP beta; CRP2; IL6DBP; interleukin 6 dependent DNA binding protein; LAP; liver enriched transcriptional activator protein; NFIL6; nuclear factor of interleu;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Chicken
  • Human
  • Mouse
  • Rat
  • Zebrafish
  • E.coli
  • HEK293
  • HEK293T
  • In Vitro Cell Free System
  • Mammalian Cell
  • Mammalian cells
  • Wheat Germ
  • Flag
  • GST
  • His
  • His (Fc)
  • Avi
  • Myc
  • DDK
  • MYC
  • Myc|DDK
  • N/A
  • N
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human CEBPB-27010TH Recombinant Human CEBPB, His-tagged E.coli His
Human CEBPB-1101H Recombinant Human CEBPB Protein, GST-Tagged Wheat Germ GST
Human CEBPB-7598HCL Recombinant Human CEBPB 293 Cell Lysate HEK293 N/A
Human CEBPB-6222H Recombinant Human CEBPB Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Human CEBPB-1249H Recombinant Human CEBPB Protein (Met199-Cys345), N-His tagged E.coli N-His Met199-Cys345
Human CEBPB-3782H Recombinant Human CEBPB Protein, His-tagged E.coli His Gln2-Cys345
Human CEBPB-4893H Recombinant Human CEBPB Protein, MYC/DDK-tagged HEK293T Myc/DDK
Human CEBPB-3278HF Recombinant Full Length Human CEBPB Protein, GST-tagged In Vitro Cell Free System GST 345 amino acids
Human CEBPB-0892H Recombinant Human CEBPB Protein (Val259-Cys345), N-His tagged E.coli N-His Val259-Cys345
Human CEBPB-543HFL Recombinant Full Length Human CEBPB Protein, C-Flag-tagged Mammalian cells Flag
Human CEBPB-573H-B Recombinant Human CEBPB Protein Pre-coupled Magnetic Beads HEK293
Human CEBPB-573H Recombinant Human CEBPB Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mouse CEBPB-3260M Recombinant Mouse CEBPB Protein Mammalian Cell His
Mouse Cebpb-876M Recombinant Mouse Cebpb Protein, MYC/DDK-tagged HEK293T MYC/DDK
Mouse CEBPB-1560M Recombinant Mouse CEBPB Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mouse Cebpb-736M Recombinant Mouse Cebpb Protein, His-tagged E.coli N-His Glu224-Leu285
Mouse Cebpb-737M Recombinant Mouse Cebpb Protein, His-tagged E.coli N-His Ala25-Lys283
Mouse CEBPB-1560M-B Recombinant Mouse CEBPB Protein Pre-coupled Magnetic Beads HEK293
Rat CEBPB-1325R Recombinant Rat CEBPB Protein Mammalian Cell His
Rat CEBPB-983R Recombinant Rat CEBPB Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rat CEBPB-983R-B Recombinant Rat CEBPB Protein Pre-coupled Magnetic Beads HEK293
Zebrafish CEBPB-9388Z Recombinant Zebrafish CEBPB Mammalian Cell His
Chicken CEBPB-6805C Recombinant Chicken CEBPB Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein

CEBPB involved in several pathways and played different roles in them. We selected most pathways CEBPB participated on our site, such as Adipogenesis, C-MYB transcription factor network, Cellular Senescence, which may be useful for your reference. Also, other proteins which involved in the same pathway with CEBPB were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
AdipogenesisCREB1;MEF2B;CELF1;E2F4;CYP26A1;CEBPD;DLK1;CDKN1A;KCNA3
C-MYB transcription factor networkYEATS4;MYC;GATA1;ADA;TOM1;TRIM28;PIAS3;MYF6;CSF1R
Cellular SenescencePHC1;EED;BMI1B;ACD;PHC2;RBBP4;H3F3B.1;CBX4;TERF2
Cellular responses to stressCBX6A;SUZ12;DYNLL2B;HTATIP;RAD50;ATG7;UVRAG;HMGA1B;EGLN3
Developmental BiologyPAQR3A;RASGRP1;CLTC;FRS2A;BOC;RNF8;MYF6;DOCK1;NADL1.1
Diurnally regulated genes with circadian orthologsEIF4G2;CEBPB;PURA;SF3A3;CBX3;ERC2;G0S2;ITM2B;DAZAP2
EGFR1 Signaling PathwayDNM1;KRT17;RALBB;TNK2;JUND;RALBP1;DOK2;CRKL;ZNF259
FOXA1 transcription factor networkAP1B1;FOXA1;NRIP1;NFIA;TFF1;CEBPB;NFIC;DSCAM;NFIB

CEBPB has several biochemical functions, for example, DNA binding, RNA polymerase II core promoter proximal region sequence-specific DNA binding, RNA polymerase II regulatory region sequence-specific DNA binding. Some of the functions are cooperated with other proteins, some of the functions could acted by CEBPB itself. We selected most functions CEBPB had, and list some proteins which have the same functions with CEBPB. You can find most of the proteins on our site.

Function Related Protein
DNA bindingZFP322A;NKX2.4B;ZNF26;HOPX;FOXD5;ZNF285A;ERCC6L;PALB2;ZNF701
RNA polymerase II core promoter proximal region sequence-specific DNA bindingCTCFL;NACC2;BCL11A;TCF7L2;HOXA7;NKX6;ZNF680;MZF1;ETV4
RNA polymerase II regulatory region sequence-specific DNA bindingPLAGL1;BARX2;FOXF1;HOXD8;HES6;CREB3L3;RORA;ELF5;JARID2
chromatin bindingHMG20A;PHC1;FOXN4;MED12;NCOA3;PHF13;CBX4;GATA6;MBD1
glucocorticoid receptor bindingNRIP1;STAT5B;CEBPB;STAT3;NR4A2;FKBP4;YWHAH;ETS2;EP300
histone acetyltransferase bindingEGR1;CITED2;FOXP3;PCNA;EID1;TRIM68;HIF1A;MTF1;EPAS1
histone deacetylase bindingKLF4;GMNN;TOP2A;HES1;NCOR1;RAD9A;MEF2D;NKX3;BCOR
kinase bindingHAP1;BARD1;PFKFB1;MIDN;CDC37;NTRK1;LDHA;PFKM;CAB39
protein bindingDDX21;C14orf118;C14orf166;CAMLG;KIF2C;TEF;CASP6;GTF3C5;NOC2L
protein heterodimerization activityTAF11;BAXB;RAF1;INHBA;SOX15;Pdgfa&Pdgfb;CEBPE;POLE3;P2RY1
protein homodimerization activityBST2;S100A16;VPS4B;SERPINF2;ACTN1;STOM;SLC11A1;SMAD3;ACCS
transcription factor activity, RNA polymerase II distal enhancer sequence-specific bindingMEIS1;NKX2-5;POU3F3;NR1H4;NKX2;FOXF1;HNF1B;GATA5;TFAP4
transcription factor activity, sequence-specific DNA bindingCNOT8;HOXD3A;ZNF789;E4F1;HIF1AL;POU4F2;ZHX3;HOXB7;TFE3
transcription factor bindingMED6;SP1;NLK;HIF1A;TFDP1A;TRAPPC2;PAX2;HES3;FOXA1
transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific bindingNKX2-8;MYOG;SREBF1;TP73;TRP53;BCL11B;KLF15;FOXK2;E2F4
ubiquitin-like protein ligase bindingDDRGK1;USP13;VCP;CEBPB;CDK5RAP3;TRIP4

CEBPB has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CEBPB here. Most of them are supplied by our site. Hope this information will be useful for your research of CEBPB.

SMAD4; E2; TP53; E2; E2; E2; HMGA1

  • Q&As
  • Reviews

Q&As (5)

Ask a question
Can targeting CEBPB be a potential strategy for managing inflammatory diseases? 06/19/2022

Yes, targeting CEBPB may be a strategy for managing inflammatory diseases, as it regulates the expression of genes involved in the inflammatory response.

What are the potential clinical applications of targeting CEBPB in cancer treatment? 05/29/2020

Targeting CEBPB in cancer treatment may have applications in controlling cell proliferation, promoting apoptosis, and modulating the tumor microenvironment to inhibit cancer progression.

How is CEBPB protein implicated in the clinical context? 12/24/2018

CEBPB protein is implicated in the clinical context due to its involvement in the regulation of genes related to immune function, cell differentiation, and inflammatory responses.

How does CEBPB contribute to immune response regulation, and how can this be applied clinically? 12/13/2017

CEBPB regulates the expression of immune-related genes, making it a potential target for modulating immune responses in clinical settings, such as autoimmune diseases or enhancing immune activity in cancer immunotherapy.

Are there any ongoing clinical trials exploring the therapeutic potential of CEBPB modulation? 08/22/2016

It's advisable to check current clinical trial databases for the latest information, as ongoing trials may be exploring the therapeutic potential of CEBPB modulation in various diseases.

Customer Reviews (3)

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Reviews
06/25/2021

    It can be effectively employed in in vitro and in vivo studies, offering insights into the intricate mechanisms underlying angiogenesis, lipid metabolism, and cardiovascular diseases.

    01/13/2021

      One of the primary advantages of the CEBPB protein is its versatility in various trial applications.

      03/28/2018

        In addition to its scientific advantages, the manufacturer of the CEBPB protein stands out for their exceptional support and assistance.

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