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CELF1

  • Official Full Name

    CUGBP, Elav-like family member 1

  • Overview

    Members of the CELF/BRUNOL protein family contain two N-terminal RNA recognition motif (RRM) domains, one C-terminal RRM domain, and a divergent segment of 160-230 aa between the second and third RRM domains. Members of this protein family regulate pre-mRNA alternative splicing and may also be involved in mRNA editing, and translation. This gene may play a role in myotonic dystrophy type 1 (DM1) via interactions with the dystrophia myotonica-protein kinase (DMPK) gene. Alternative splicing results in multiple transcript variants encoding different isoforms.
  • Synonyms

    CELF1; CUGBP, Elav-like family member 1; CUG triplet repeat, RNA binding protein 1 , CUG triplet repeat, RNA binding protein 1 , CUGBP1; CUGBP Elav-like family member 1; bruno like 2; BRUNOL2; CUG RNA binding protein; CUG BP; CUGBP; EDEN BP; embryo deadenylation element binding protein; hNab50; NAB50; NAPOR; nuclear polyadenylated RNA binding protein; 50 kD; 50 kDa Nuclear polyadenylated RNA binding protein; Deadenylation factor CUG BP; RNA binding protein BRUNOL 2; 50 kDa nuclear polyadenylated RNA-binding protein; bruno like protein 2; Bruno-like protein 2; BRUNOL 2; CELF 1; CELF-1; CELF1 CUGBP, Elav like family member 1; CELF1_HUMAN; CUG BP and ETR 3 like factor 1; CUG BP1; CUG triplet repeat RNA binding protein 1; CUG triplet repeat RNA-binding protein 1; CUG-BP- and ETR-3-like factor 1; CUG-BP1; CUGBP 1; CUGBP and ETR3 like factor 1; CUGBP Elav like family member 1; CUGBP1; Cytidine Uridine Guanosine Binding Protein 1; Deadenylation factor CUG-BP; Deadenylation factor CUGBP; EDEN BP homolog; EDEN-BP homolog; embryo deadenylation element binding protein homolog; Embryo deadenylation element-binding protein homolog; hNab 50; NAB 50; Nuclear polyadenylated RNA binding protein 50 kD; RNA binding protein BRUNOL2; RNA-binding protein BRUNOL-2; bruno-like 2; CUG RNA-binding protein; CUG; CUG-BP; EDEN-BP;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Chicken
  • Human
  • Mouse
  • Rat
  • Zebrafish
  • E.coli
  • HEK293
  • HEK293T
  • In Vitro Cell Free System
  • Mammalian Cell
  • Mammalian cells
  • Wheat Germ
  • Flag
  • GST
  • His
  • His (Fc)
  • Avi
  • Myc
  • DDK
  • N/A
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human CELF1-2127H Recombinant Human CELF1 Protein, GST-tagged Wheat Germ GST
Human CUGBP1-11699H Recombinant Human CUGBP1, His-tagged E.coli His 107-479a.a.
Human CELF1-7589HCL Recombinant Human CELF1 293 Cell Lysate HEK293 N/A
Human CELF1-7590HCL Recombinant Human CELF1 293 Cell Lysate HEK293 N/A
Human CELF1-705H Recombinant Human CELF1 protein(T173E,S178D,S285D,S288D,S295D,S296D,S298D) E.coli N/A 1-482aa (T173E,S178D,S285D,S288D,S295D,S296D,S298D)
Human CELF1-1244H Recombinant Human CELF1 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Human CELF1-707H Recombinant Human CELF1 protein(T173E,S178D,S285D,S288D,S295D,S296D,S298D) E.coli N/A 1-475aa (T173E,S178D,S285D,S288D,S295D,S296D,S298D)
Human CELF1-2391HF Recombinant Full Length Human CELF1 Protein, GST-tagged In Vitro Cell Free System GST 483 amino acids
Human CELF1-706H Recombinant Human CELF1 protein(T173E,S178D,S285D,S288D,S295D,S296D,S298D,L404A,P405A) E.coli N/A 1-482aa (T173E,S178D,S285D,S288D,S295D,S296D,S298D,L404A,P405A)
Human CELF1-1436HFL Recombinant Full Length Human CELF1 Protein, C-Flag-tagged Mammalian cells Flag
Human CELF1-574H Recombinant Human CELF1 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Human CELF1-574H-B Recombinant Human CELF1 Protein Pre-coupled Magnetic Beads HEK293
Mouse CELF1-3272M Recombinant Mouse CELF1 Protein Mammalian Cell His
Mouse Celf1-2100M Recombinant Mouse Celf1 Protein, Myc/DDK-tagged HEK293T Myc/DDK
Mouse CELF1-1567M-B Recombinant Mouse CELF1 Protein Pre-coupled Magnetic Beads HEK293
Mouse CELF1-1567M Recombinant Mouse CELF1 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rat CELF1-1330R Recombinant Rat CELF1 Protein Mammalian Cell His
Rat CELF1-988R-B Recombinant Rat CELF1 Protein Pre-coupled Magnetic Beads HEK293
Rat CELF1-988R Recombinant Rat CELF1 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Zebrafish CELF1-9152Z Recombinant Zebrafish CELF1 Mammalian Cell His
Chicken CELF1-1896C Recombinant Chicken CELF1 Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • CELF1 Related Articles
  • CELF1 Related Research Area

CELF1 involved in several pathways and played different roles in them. We selected most pathways CELF1 participated on our site, such as Adipogenesis, mRNA processing, which may be useful for your reference. Also, other proteins which involved in the same pathway with CELF1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
AdipogenesisBSCL2;NDN;EGR2B;KLF6A;RETN;KLF5;NAMPT;AGT;KCNA3
mRNA processingPTBP1A;HNRNPABA;HNRNPH2;CELF4;PTBP2;SF3B4;SFRS3A;CELF1;QK

CELF1 has several biochemical functions, for example, BRE binding, RNA binding, mRNA binding. Some of the functions are cooperated with other proteins, some of the functions could acted by CELF1 itself. We selected most functions CELF1 had, and list some proteins which have the same functions with CELF1. You can find most of the proteins on our site.

Function Related Protein
BRE bindingCELF4;CELF1
RNA bindingSRP9;RPL26;OASL1;HUG;LIN28B;RBFOX1;ZMAT2;RBM12B2;Akap17b
mRNA bindingCELF4;KHSRP;QKI;RBFOX1L;SLBP;ESRP1;FMR1;SRRM4;MRPL13
nucleotide bindingRAB32A;GRK1A;DNM1B;MYO7A;U2AF2A;MAP4K6;CPEB4;A1CF;SEPT4A
poly(A) RNA bindingKIAA1324;PCBP2;DDX17;HIST1H4K;MYBBP1A;RPL5;C4BPA;HOXB6;RPS14
protein bindingMYOM1;TBC1D5;JAGN1;THBS2;KLHL20;SATB1;RAB1B;CALCOCO1;ANKRD45
translation initiation factor bindingEIF3M;ZFP259;TRIM32;CELF1;LARP1;POLR2G;RPS24;EIF2B4;ZNF259
translation repressor activity, nucleic acid bindingCPEB3;CELF1;PPP1R2P9;CPEB1B;CPEB2;CELF4;CPEB4;CPEB1A;CPEB1

CELF1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CELF1 here. Most of them are supplied by our site. Hope this information will be useful for your research of CELF1.

HNRNPH1; USP10; MBNL1; TOM1L1; PPBP; HNRNPC; FUBP1; RALY; ssrna_cg; PTBP3

Morgan, GT; et al. Localized co-transcriptional recruitment of the multifunctional RNA-binding protein CELF1 by lampbrush chromosome transcription units. CHROMOSOME RESEARCH 15:985-1000(2007).
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