CETN2
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Official Full Name
centrin, EF-hand protein, 2 -
Overview
Caltractin belongs to a family of calcium-binding proteins and is a structural component of the centrosome.The high level of conservation from algae to humans and its association with the centrosome suggested that caltractin plays a fundamental role in the structure and function of the microtubule-organizing center, possibly required for the proper duplication and segregation of the centrosome. -
Synonyms
CETN2;centrin, EF-hand protein, 2;CALT;centrin-2;CEN2;20kD calcium binding protein;caltractin;Caltractin isoform 1;centrin;centrin, EF hand protein, 2;Centrin2;CETN2_HUMAN;EF hand protein 2;EF-hand protein;OTTHUMP00000026058;caltractin (20kD calcium-binding protein)
Recombinant Proteins
- Human
- Mouse
- Chicken
- Rhesus macaque
- E.coli
- Wheat Germ
- Mammalian Cells
- HEK293
- In Vitro Cell Free System
- His
- GST
- Fc
- Non
- Avi
- SUMO
Involved Pathway
CETN2 involved in several pathways and played different roles in them. We selected most pathways CETN2 participated on our site, such as Anchoring of the basal body to the plasma membrane,Assembly of the primary cilium,Cell Cycle, which may be useful for your reference. Also, other proteins which involved in the same pathway with CETN2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| DNA Repair | USP43A,TIPIN,TDP1,ASCC2,COPS2,PARP1,EYA2,INO80B,COPS8,UBE2L6 |
| Cell Cycle, Mitotic | HAUS2,FGFR1OP,E2F4,NCAPD3,CENPP,GMNN,NUMA1,CKS1B,CNEP1R1,SMC2 |
| DNA Damage Recognition in GG-NER | COPS2,COPS6,NFRKB,YY1A,PARP2,INO80C,ACTR5,COPS8,INO80,DDB1 |
| Cell cycle | MSH5,NDC80,NDEL1A,SKA1,CDC25B,CCNA2,CDK6,ARF1,NCAPD3,DMC1 |
| Formation of Incision Complex in GG-NER | DDB2,USP45,PARP2,RNF111,DDB1,PIAS3,CHD1L |
| Anchoring of the basal body to the plasma membrane | DYNC1I2,SSNA1,RPGRIP1L,HAUS2,PCM1,CEP70,DCTN2,CP110,MKS1,CLASP1 |
| Centrosome maturation | PLK4,TUBGCP2,SDCCAG8,CSNK1D,CEP57,TSGA14,TUBG2,CEP72,MAPRE1,CEP70 |
| Assembly of the primary cilium | NPHP3,TSGA14,B9D1,PKD2,IQCB1,TCTN3,IFT74,NPHP4,NEDD1,RABL5 |
Protein Function
CETN2 has several biochemical functions, for example, G-protein beta/gamma-subunit complex binding,calcium ion binding,heterotrimeric G-protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by CETN2 itself. We selected most functions CETN2 had, and list some proteins which have the same functions with CETN2. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| microtubule binding | EML1,CDK5RAP2,HOOK3,MTUS2,RAE1,BIRC5,ARHGEF2,NUSAP1,RACGAP1,KIF19 |
| heterotrimeric G-protein binding | ADORA1,CETN1,CETN4,ADRA2A |
| calcium ion binding | NUCB2B,PLSCR4,EFEMP2A,BMP1,ACTN3,LDLRB,CETN3,GUCA1D,CAPN3B,AIF1 |
| protein binding | TCF7,ALAS2,CRIPAK,CA1,B9D2,RNF32,COBRA1,PLEKHG2,GRK5,DAZL |
| G-protein beta/gamma-subunit complex binding | GNA14,GNA15,GNA15.4,GNAQ,GNA11B,GNA13A,GNAV1,GNAO1A,GNAS,GNA12A |
Interacting Protein
CETN2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CETN2 here. Most of them are supplied by our site. Hope this information will be useful for your research of CETN2.
SFI1;SGSM1;POC5;PNMA5;CCP110;XPC
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References
- Lutz, W; Lingle, WL; et al. Phosphorylation of centrin during the cell cycle and its role in centriole separation preceding centrosome duplication. JOURNAL OF BIOLOGICAL CHEMISTRY 276:20774-20780(2001).
- Laoukili, J; Perret, E; et al. Differential expression and cellular distribution of centrin isoforms during human ciliated cell differentiation in vitro. JOURNAL OF CELL SCIENCE 113:1355-1364(2000).
