Cfd
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Official Full Name
complement factor D (adipsin)
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Overview
Complement Factor D (CFD) is a 253 amino acid secreted protein that belongs to the peptidase S1 family. It contains 1 peptidase S1 domain. Complement Factor D cleaves factor B when the latter is complexed with factor C3b, activating the C3bbb complex, which then becomes the C3 convertase of the alternate pathway. Its function is homologous to that of C1s in the classical pathway. Complement Factor D catalyzes the selective cleavage of Arg-|-Lys bond in complement factor B when in complex with complement subcomponent C3b or with cobra venom factor. Defects in CFD are the cause of complement factor D deficiency (CFDD). CFDD is an immunologic disorder characterized by increased susceptibility to bacterial infections, particularly Neisseria infections, due to a defect in the alternative complement pathway. -
Synonyms
ADIPSIN; ADN; DF; PFD; C3 convertase activator; D component of complement (adipsin); complement factor D; complement factor D preproprotein; properdin factor D;
- Recombinant Proteins
- Native Proteins
- Cell & Tissue Lysates
- Protein Pre-coupled Magnetic Beads
- Human
- Mouse
- Rat
- Rhesus macaque
- Rhesus macaque/Cynomolgus
- Zebrafish
- E.coli
- HEK293
- HEK293T
- Human Cell
- Human Serum
- In Vitro Cell Free System
- Insect Cell
- Mammalian Cell
- Mammalian cells
- Wheat Germ
- Yeast
- C
- 10×His
- His
- Fc
- GST
- His (Fc)
- Avi
- Myc
- His|GST
- His|Myc
- human|IgG1|Fc
- DDK
- MYC
- Myc|DDK
- N/A
- N
- Involved Pathway
- Protein Function
- Interacting Protein
- Cfd Related Articles
Cfd involved in several pathways and played different roles in them. We selected most pathways Cfd participated on our site, such as Adipogenesis, Alternative complement activation, Complement and coagulation cascades, which may be useful for your reference. Also, other proteins which involved in the same pathway with Cfd were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Adipogenesis | KLF7A;KLF6;MEF2AA;NR1H3;EBF1;CTNNB1;KLF5;NR2F1;SPOCK1 |
| Alternative complement activation | GZMM;BFB;CFD |
| Complement and coagulation cascades | F13A1;C1R;C2;C5AR1;CFB;MASP1;C4BP;CD46;SERPING1 |
| Complement cascade | CR1;GZMM;MASP2;BFB;FCN2;CRP;CFHL2;CFHL1;IGKV1-5 |
| Hemostasis | ANXA2A;KIF20A;CABLES1;CEACAM6;CFHL1;SLC7A10;ANXA2B;GATA5;ANGPT2A |
| Immune System | PVRL2L;AP1G1;Siglece;OASL;MGC174155;KLRB1F;IL1RN;SIGLEC14;CFHL1 |
| Initial triggering of complement | FCN1;GZMM;CRP;C1rb;MASP2;CFD;FCN3;IgG3;BFB |
| Innate Immune System | SUGT1;MGC174155;TXNIPA;TREX1;CLEC5A;LGALS3;MAP3K8;CLEC4D;RIPK3 |
Cfd has several biochemical functions, for example, serine-type endopeptidase activity, serine-type peptidase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by Cfd itself. We selected most functions Cfd had, and list some proteins which have the same functions with Cfd. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| serine-type endopeptidase activity | PRSS30;ELA2;KLK9;KLK10;PRSS8;HPR;PLG;TPP2;F9 |
| serine-type peptidase activity | KLK4;PRSS16;CFD;PRSS40;KEX2;PRSS8;FAP;MCPT1;PLAUB |
Cfd has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with Cfd here. Most of them are supplied by our site. Hope this information will be useful for your research of Cfd.
yvrG; ALB
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