CHEK2
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Official Full Name
checkpoint kinase 2
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Overview
In response to DNA damage and replication blocks, cell cycle progression is halted through the control of critical cell cycle regulators. The protein encoded by this gene is a cell cycle checkpoint regulator and putative tumor suppressor. It contains a forkhead-associated protein interaction domain essential for activation in response to DNA damage and is rapidly phosphorylated in response to replication blocks and DNA damage. When activated, the encoded protein is known to inhibit CDC25C phosphatase, preventing entry into mitosis, and has been shown to stabilize the tumor suppressor protein p53, leading to cell cycle arrest in G1. In addition, this protein interacts with and phosphorylates BRCA1, allowing BRCA1 to restore survival after DNA damage. Mutations in this gene have been linked with Li-Fraumeni syndrome, a highly penetrant familial cancer phenotype usually associated with inherited mutations in TP53. Also, mutations in this gene are thought to confer a predisposition to sarcomas, breast cancer, and brain tumors. This nuclear protein is a member of the CDS1 subfamily of serine/threonine protein kinases. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Apr 2012] -
Synonyms
CHEK2; checkpoint kinase 2; CDS1; CHK2; LFS2; RAD53; hCds1; HuCds1; PP1425; serine/threonine-protein kinase Chk2; cds1 homolog; CHK2 checkpoint homolog; checkpoint-like protein CHK2;
- Recombinant Proteins
- Protein Pre-coupled Magnetic Beads
- Cell & Tissue Lysates
- Chicken
- Human
- Human
- Mouse
- Zebrafish
- E. coli
- E.coli
- HEK293
- HEK293T
- In Vitro Cell Free System
- Insect (sf21)
- Insect Cell
- Mammalian Cell
- Mammalian cells
- S.frugiperda
- Sf9 Insect Cell
- Wheat Germ
- Flag
- GST
- GST,His
- His
- His (Fc)
- Avi
- His|GST
- Myc
- DDK
- Myc|DDK
- N/A
- N
- No tag
- Involved Pathway
- Protein Function
- Interacting Protein
- CHEK2 Related Research Area
CHEK2 involved in several pathways and played different roles in them. We selected most pathways CHEK2 participated on our site, such as Cell Cycle, Cell Cycle Checkpoints, DNA Double Strand Break Response, which may be useful for your reference. Also, other proteins which involved in the same pathway with CHEK2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name | Pathway Related Protein |
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Cell Cycle | MYCB;RANGAP1B;LIN54;NCAPG;NCAPD3;CCNB3;STAG2A;CSNK1E;RBL2 |
Cell Cycle Checkpoints | CDK5RAP2;RAD9B;RAD9A;RAD50;CHEK2;MCM10;FAM175A;RNF168;HTATIP |
DNA Double Strand Break Response | KDM4B;BAZ1B;UBE2V2;BARD1;BABAM1;THRSP;FAM175A;TP53BP1;BRE |
DNA Double-Strand Break Repair | EME1;WRN;RAD17;BRCC3;DNA2;PPP4CA;BRE;PPP4CB;CHEK1 |
DNA Repair | EME2;INO80E;EME1;MGMT;RAD1;POLD3;USP43;BAZ1B;INO80 |
DNA damage response | DDB2;HUS1B;RAD9A;RAD1;GADD45A;GADD45G;RAD17;CDK5;TLK2 |
FOXM1 transcription factor network | FOXM1;AURKB;CHEK2;CENPA;CKS1B;CENPB |
CHEK2 has several biochemical functions, for example, ATP binding, identical protein binding, metal ion binding. Some of the functions are cooperated with other proteins, some of the functions could acted by CHEK2 itself. We selected most functions CHEK2 had, and list some proteins which have the same functions with CHEK2. You can find most of the proteins on our site.
Function | Related Protein |
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ATP binding | LARS2;BBS12;LRRK2;ATP8B1;NSF;RUNX3;TOP2B;XRCC2;MAPK6 |
identical protein binding | AIM2;SH3BP4;PIK3AP1;GOT2A;MUL1A;SNX1;COL1A2;MCM6;REG3B |
metal ion binding | MPPED2;CYP8B3;FTR82;VAV2;ZNF839;KCNIP1B;ZNF559;Itgam&Itgb2;SP1 |
protein binding | SENP7;ELK1;SLC16A3;RGS2;KCNJ5;MAL;BCDIN3D;MAGEB4;ABI2 |
protein homodimerization activity | HM13;CADM3;CEBPA;UPK1A;CPOX;KYNU;DROSHA;NTRK1;CDH13 |
protein kinase binding | ADRA2A;MEF2A;SCN5A;DNAJA3;GYS1;MAVS;STK39;ATP1A1;FAF1 |
protein serine/threonine kinase activity | LIMK1;ARAF;PRKAA2;TSSK2;PIM1;RPS6KB2;CSNK1G3;CAMK2G1;SYK |
ubiquitin protein ligase binding | USP25;CDC34A;UBE2G1B;HSPA8;USP2;HM13;ERLIN2;CUL5;MYOD1 |
CHEK2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CHEK2 here. Most of them are supplied by our site. Hope this information will be useful for your research of CHEK2.
MDM2; TP53; XRCC1
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