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CHEK2

  • Official Full Name

    checkpoint kinase 2

  • Overview

    In response to DNA damage and replication blocks, cell cycle progression is halted through the control of critical cell cycle regulators. The protein encoded by this gene is a cell cycle checkpoint regulator and putative tumor suppressor. It contains a forkhead-associated protein interaction domain essential for activation in response to DNA damage and is rapidly phosphorylated in response to replication blocks and DNA damage. When activated, the encoded protein is known to inhibit CDC25C phosphatase, preventing entry into mitosis, and has been shown to stabilize the tumor suppressor protein p53, leading to cell cycle arrest in G1. In addition, this protein interacts with and phosphorylates BRCA1, allowing BRCA1 to restore survival after DNA damage. Mutations in this gene have been linked with Li-Fraumeni syndrome, a highly penetrant familial cancer phenotype usually associated with inherited mutations in TP53. Also, mutations in this gene are thought to confer a predisposition to sarcomas, breast cancer, and brain tumors. This nuclear protein is a member of the CDS1 subfamily of serine/threonine protein kinases. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Apr 2012]
  • Synonyms

    CHEK2; checkpoint kinase 2; CDS1; CHK2; LFS2; RAD53; hCds1; HuCds1; PP1425; serine/threonine-protein kinase Chk2; cds1 homolog; CHK2 checkpoint homolog; checkpoint-like protein CHK2;

  • Recombinant Proteins
  • Protein Pre-coupled Magnetic Beads
  • Cell & Tissue Lysates
  • Chicken
  • Human
  • Human
  • Mouse
  • Zebrafish
  • E. coli
  • E.coli
  • HEK293
  • HEK293T
  • In Vitro Cell Free System
  • Insect (sf21)
  • Insect Cell
  • Mammalian Cell
  • Mammalian cells
  • S.frugiperda
  • Sf9 Insect Cell
  • Wheat Germ
  • Flag
  • GST
  • GST,His
  • His
  • His (Fc)
  • Avi
  • His|GST
  • Myc
  • DDK
  • Myc|DDK
  • N/A
  • N
  • No tag
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human CHEK2-141H Active Recombinant Human CHEK2, GST-tagged E.coli GST
Human CHEK2-48H Active Recombinant Human CHEK2(I157T)(5-end) Mutation Protein, N-GST,C-His-tagged E. coli GST,His 5-end
Human CHEK2-204HFL Active Recombinant Full Length Human CHEK2 Protein, C-Flag-tagged Mammalian cells Flag
Human CHEK2-49H Active Recombinant Human CHEK2(5-543) Protein, N-GST,C-His-tagged E. coli GST,His 5-543 aa
Human CHEK2-47H Active Recombinant Human CHEK2(R145W)(5-end) Mutation Protein, N-GST,C-His-tagged E. coli GST,His 5-end
Human CHEK2-26713TH Recombinant Human CHEK2 N/A
Human CHEK2-686H Recombinant Human CHEK2, His-tagged S.frugiperda His
Human CHEK2-694H Recombinant Human CHEK2 Mammalian Cell His
Human CHEK2-635H Recombinant Human CHEK2, His-tagged Sf9 Insect Cell His
Human CHEK2-282H Recombinant Human CHEK2, GST-tagged, Active Sf9 Insect Cell GST
Human CHEK2-1223H Recombinant Human CHEK2 Protein, GST-Tagged Wheat Germ GST
Human CHEK2-335H Recombinant Human CHEK2 Protein, GST-tagged Insect Cell GST Met1-Leu543
Human CHEK2-9203HF Active Recombinant Full Length Human CHEK2 Protein, GST-tagged Insect (sf21) GST 1-543
Human CHEK2-335HAF555 Recombinant Human CHEK2 Protein, GST-tagged, Alexa Fluor 555 conjugated Insect Cell GST Met1-Leu543, 777
Human CHEK2-3214H Recombinant Human CHEK2 Protein, MYC/DDK-tagged HEK293 Myc/DDK
Human CHEK2-1188H Recombinant Human CHEK2 Protein (S2-L543), Tag Free Insect Cell No tag S2-L543
Human CHEK2-1395H Recombinant Human CHEK2 Protein (Val300-Ala540), N-His tagged E.coli N-His Val300-Ala540
Human CHEK2-335HF Recombinant Human CHEK2 Protein, GST-tagged, FITC conjugated Insect Cell GST Met1-Leu543, 777
Human CHEK2-335HAF488 Recombinant Human CHEK2 Protein, GST-tagged, Alexa Fluor 488 conjugated Insect Cell GST Met1-Leu543, 777
Human CHEK2-1189H Recombinant Human CHEK2 Protein (S2-L543), GST tagged Insect Cell GST S2-L543
Human CHEK2-335HAF647 Recombinant Human CHEK2 Protein, GST-tagged, Alexa Fluor 647 conjugated Insect Cell GST Met1-Leu543, 777
Human CHEK2-596H Recombinant Human CHEK2 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Human CHEK2-3189HF Recombinant Full Length Human CHEK2 Protein, GST-tagged In Vitro Cell Free System GST 543 amino acids
Human CHEK2-596H-B Recombinant Human CHEK2 Protein Pre-coupled Magnetic Beads HEK293
Human CHEK2-09H Recombinant Active Human CHEK2 Protein, His-tagged Insect Cell His
Mouse Chek2-5172M Recombinant Mouse Chek2, His & GST tagged Insect Cell His/GST
Mouse CHEK2-541MCL Recombinant Mouse CHEK2 cell lysate Insect Cell N/A
Mouse Chek2-5172MAF647 Recombinant Mouse Chek2 Protein, His/GST-tagged, Alexa Fluor 647 conjugated Insect Cell His/GST 783
Mouse Chek2-2141M Recombinant Mouse Chek2 Protein, Myc/DDK-tagged HEK293T Myc/DDK
Mouse Chek2-5172MAF488 Recombinant Mouse Chek2 Protein, His/GST-tagged, Alexa Fluor 488 conjugated Insect Cell His/GST 783
Mouse Chek2-5172MAF555 Recombinant Mouse Chek2 Protein, His/GST-tagged, Alexa Fluor 555 conjugated Insect Cell His/GST 783
Mouse Chek2-5172MF Recombinant Mouse Chek2 Protein, His/GST-tagged, FITC conjugated Insect Cell His/GST 783
Zebrafish CHEK2-10400Z Recombinant Zebrafish CHEK2 Mammalian Cell His
Chicken CHEK2-3604C Recombinant Chicken CHEK2 Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • CHEK2 Related Research Area

CHEK2 involved in several pathways and played different roles in them. We selected most pathways CHEK2 participated on our site, such as Cell Cycle, Cell Cycle Checkpoints, DNA Double Strand Break Response, which may be useful for your reference. Also, other proteins which involved in the same pathway with CHEK2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Cell CycleMYCB;RANGAP1B;LIN54;NCAPG;NCAPD3;CCNB3;STAG2A;CSNK1E;RBL2
Cell Cycle CheckpointsCDK5RAP2;RAD9B;RAD9A;RAD50;CHEK2;MCM10;FAM175A;RNF168;HTATIP
DNA Double Strand Break ResponseKDM4B;BAZ1B;UBE2V2;BARD1;BABAM1;THRSP;FAM175A;TP53BP1;BRE
DNA Double-Strand Break RepairEME1;WRN;RAD17;BRCC3;DNA2;PPP4CA;BRE;PPP4CB;CHEK1
DNA RepairEME2;INO80E;EME1;MGMT;RAD1;POLD3;USP43;BAZ1B;INO80
DNA damage responseDDB2;HUS1B;RAD9A;RAD1;GADD45A;GADD45G;RAD17;CDK5;TLK2
FOXM1 transcription factor networkFOXM1;AURKB;CHEK2;CENPA;CKS1B;CENPB

CHEK2 has several biochemical functions, for example, ATP binding, identical protein binding, metal ion binding. Some of the functions are cooperated with other proteins, some of the functions could acted by CHEK2 itself. We selected most functions CHEK2 had, and list some proteins which have the same functions with CHEK2. You can find most of the proteins on our site.

Function Related Protein
ATP bindingLARS2;BBS12;LRRK2;ATP8B1;NSF;RUNX3;TOP2B;XRCC2;MAPK6
identical protein bindingAIM2;SH3BP4;PIK3AP1;GOT2A;MUL1A;SNX1;COL1A2;MCM6;REG3B
metal ion bindingMPPED2;CYP8B3;FTR82;VAV2;ZNF839;KCNIP1B;ZNF559;Itgam&Itgb2;SP1
protein bindingSENP7;ELK1;SLC16A3;RGS2;KCNJ5;MAL;BCDIN3D;MAGEB4;ABI2
protein homodimerization activityHM13;CADM3;CEBPA;UPK1A;CPOX;KYNU;DROSHA;NTRK1;CDH13
protein kinase bindingADRA2A;MEF2A;SCN5A;DNAJA3;GYS1;MAVS;STK39;ATP1A1;FAF1
protein serine/threonine kinase activityLIMK1;ARAF;PRKAA2;TSSK2;PIM1;RPS6KB2;CSNK1G3;CAMK2G1;SYK
ubiquitin protein ligase bindingUSP25;CDC34A;UBE2G1B;HSPA8;USP2;HM13;ERLIN2;CUL5;MYOD1

CHEK2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CHEK2 here. Most of them are supplied by our site. Hope this information will be useful for your research of CHEK2.

MDM2; TP53; XRCC1

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