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Official Full Name cholinergic receptor, muscarinic 2
Background The muscarinic cholinergic receptors belong to a larger family of G protein-coupled receptors. The functional diversity of these receptors is defined by the binding of acetylcholine to these receptors and includes cellular responses such as adenylate cyclase inhibition, phosphoinositide degeneration, and potassium channel mediation. Muscarinic receptors influence many effects of acetylcholine in the central and peripheral nervous system. The muscarinic cholinergic receptor 2 is involved in mediation of bradycardia and a decrease in cardiac contractility. Multiple alternatively spliced transcript variants have been described for this gene.
Synonyms CHRM2; cholinergic receptor, muscarinic 2; HM2; FLJ43243; MGC120006; MGC120007; muscarinic acetylcholine receptor M2; 7TM receptor; OTTHUMP00000208393; OTTHUMP00000208394; OTTHUMP00000208395; OTTHUMP00000208396; muscarinic M2 receptor; cholinergic receptor, muscarinic 2, isoform a; Muscarinic receptors; mAChRs
    • Species :
    • Chicken
    • Human
    • Mouse
    • Rat
    • Source :
    • HEK293
    • Mammalian Cell
    • Wheat Germ
    • Tag :
    • GST
    • His
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human CHRM2-1270H Recombinant Human CHRM2 Protein Wheat Germ N/A
    Human CHRM2-1271H Recombinant Human CHRM2 Protein, GST-Tagged Wheat Germ GST
    Human CHRM2-175H Recombinant Human CHRM2 Mammalian Cell His
    Human CHRM2-7520HCL Recombinant Human CHRM2 293 Cell Lysate HEK293 N/A
    Mouse CHRM2-3425M Recombinant Mouse CHRM2 Protein Mammalian Cell His
    Rat CHRM2-1386R Recombinant Rat CHRM2 Protein Mammalian Cell His
    Chicken CHRM2-2464C Recombinant Chicken CHRM2 Mammalian Cell His
    Kit-0875 Continuous AMP Deaminase Assay Kit N/A
    Kit-1057 Lactose Colorimetric/Fluorometric Assay Kit N/A
    Kit-1167 CHRM2 Activated GPCR Internalization Assay Kit N/A
    Kit-1168 CHRM2 CHO-K1 β-Arrestin GPCR Assay Kit N/A
    Kit-1169 cAMP CHRM2 CHO-K1 GPCR Assay Kit N/A

    chrm2 involved in several pathways and played different roles in them. We selected most pathways chrm2 participated on our site, such as Amine ligand-binding receptors, Arf6 trafficking events, Calcium Regulation in the Cardiac Cell, which may be useful for your reference. Also, other proteins which involved in the same pathway with chrm2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Amine ligand-binding receptors TAAR1; HRH3; CHRM3; ADRa1A; ADRA2C; DRD2; CHRM5; DRD4; DRD1; DRD3
    Arf6 trafficking events EXOC6; SCAMP2; CTNND1; EXOC1; SPAG9; ADRB2; JUP; EXOC5; PTBP3; DNM2
    Calcium Regulation in the Cardiac Cell CX35.4; RGS4; RGS5B; RGS10; CASQ1B; RGS20; CHRM2; GJA10; RGS5A; GJB4
    Calcium signaling pathway PHKA2; ORAI1; TRHRB; SLC8A2; TNNC2; GNA11A; PTGER1B; ATP2B2; PTK2B; MYLK2
    Cholinergic synapse GNAI3; CAMK4; GNG3; CAMK2D; ACHE; KCNJ6; PLCB4; GNB1; FOS; PIK3R1
    Class A/1 (Rhodopsin-like receptors) GPR4; CHRM4; ADORA2A; NMU; OPN1LW; MLN; ADRA2C; EDN3; POMCB; LTB4R
    G alpha (i) signalling events AGT; HCAR1-2; CCL35.2; LPAR5A; PENKA; OPN1SW1; DRD3; RGS18; SSTR5; CNR1
    GPCR downstream signaling FPR-RS4; FPR-RS6; OPN1LW2; ARHGEF17; RAMP1; NPSR1; NMS; PRKCHB; PROK2; DGKA

    chrm2 has several biochemical functions, for example, G-protein coupled acetylcholine receptor activity, drug binding. Some of the functions are cooperated with other proteins, some of the functions could acted by chrm2 itself. We selected most functions chrm2 had, and list some proteins which have the same functions with chrm2. You can find most of the proteins on our site.

    Function Related Protein
    G-protein coupled acetylcholine receptor activity CHRM5A; CHRM2; CHRM4; CHRM5B; CHRM2A; CHRM3; CHRM1; CHRM5
    drug binding CHRNA7; P2RX2; CYP4B1; GRIK1; HMGCS1; ABP1; CNR1; MT2A; NAMPT; CHRNA2

    chrm2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with chrm2 here. Most of them are supplied by our site. Hope this information will be useful for your research of chrm2.

    GPRASP1; GPRASP2; af-dx 384; methoctramine; Lamp1; Arrb2

    Riese, H; Munoz, LM; et al. Identifying Genetic Variants for Heart Rate Variability in the Acetylcholine Pathway. PLOS ONE 9:-(2014).
    Srivastava, P; Yadav, RS; et al. Unraveling the mechanism of neuroprotection of curcumin in arsenic induced cholinergic dysfunctions in rats. TOXICOLOGY AND APPLIED PHARMACOLOGY 279:428-440(2014).

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