CHRM3
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Official Full Name
cholinergic receptor, muscarinic 3
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Overview
The muscarinic cholinergic receptors belong to a larger family of G protein-coupled receptors. The functional diversity of these receptors is defined by the binding of acetylcholine and includes cellular responses such as adenylate cyclase inhibition, phosphoinositide degeneration, and potassium channel mediation. Muscarinic receptors influence many effects of acetylcholine in the central and peripheral nervous system. The muscarinic cholinergic receptor 3 controls smooth muscle contraction and its stimulation causes secretion of glandular tissue. -
Synonyms
CHRM3; cholinergic receptor muscarinic 3; CHRM 3; HM3; M3 muscarinic receptor; muscarinic 3; Muscarinic M3 Receptor (a.a. 580-589); Muscarinic M3 Receptor; muscarinic acetylcholine receptor M3; OTTHUMP00000037632;
- Recombinant Proteins
- Cell & Tissue Lysates
- Protein Pre-coupled Magnetic Beads
- Assay Kits
- Bos taurus (Bovine)
- Chicken
- Gallus gallus (Chicken)
- Gorilla gorilla gorilla (Western lowland gorilla)
- Human
- Mus musculus (Mouse)
- Pan troglodytes (Chimpanzee)
- Pongo pygmaeus (Bornean orangutan)
- Rat
- Rattus norvegicus (Rat)
- Rhesus Macaque
- Sus scrofa (Pig)
- E.coli
- E.coli expression system
- HEK293
- In Vitro Cell Free System
- Mammalian Cell
- Wheat Germ
- Yeast
- GST
- His
- His (Fc)
- Avi
- Flag
- His|B2M
- N/A
- Involved Pathway
- Protein Function
- Interacting Protein
CHRM3 involved in several pathways and played different roles in them. We selected most pathways CHRM3 participated on our site, such as Acetylcholine regulates insulin secretion, Amine ligand-binding receptors, Calcium Regulation in the Cardiac Cell, which may be useful for your reference. Also, other proteins which involved in the same pathway with CHRM3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Acetylcholine regulates insulin secretion | MARCKSA;CHRM3;MARCKSB |
| Amine ligand-binding receptors | DRD3;HRH3;ADRB2;ADRA2C;CHRM1;CHRM3;DRD2;DRD5;ADRA2A |
| Calcium Regulation in the Cardiac Cell | CHRM4;RGS5B;GJB1;CX27.5;PKIG;PKIB;CX35.4;ADRA1B;CX30.3 |
| Calcium signaling pathway | GRIN2C;PPP3R1B;CALM1B;CAMK2D2;GRM1;PLCD1B;EDNRAA;ERBB4;PPP3CCB |
| Cholinergic synapse | KCNJ14;GNAI1;GNG8;KCNQ5;CREB3;KRAS;CHRNA6;KCNJ3;NRAS |
| Class A/1 (Rhodopsin-like receptors) | APLNR;PROKR2;ZFPM2B;GPR55;GAL;SSTR5;PRLH;AMCF-II;SST1.1 |
| G alpha (q) signalling events | GCGB;NPSR1;TRIO;EDN2;GPRC6A;LPAR1;NMB;CHRM5;KALRNB |
| GPCR downstream signaling | TRIO;OR2AP1;RGS21;OXGR1A.3;RGS20;CXCR6;PROK1;SST;CHRM2 |
CHRM3 has several biochemical functions, for example, G-protein coupled acetylcholine receptor activity, acetylcholine binding, drug binding. Some of the functions are cooperated with other proteins, some of the functions could acted by CHRM3 itself. We selected most functions CHRM3 had, and list some proteins which have the same functions with CHRM3. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| G-protein coupled acetylcholine receptor activity | CHRM1;CHRM4;CHRM3;CHRM2;CHRM5A;CHRM2A;CHRM5B;CHRM5 |
| acetylcholine binding | CHRNB3;CHRNA3;CHRM3;CHRNB2;ACHE;CHRNA4;CHRNB1;CHRFAM7A;CHRNA7 |
| drug binding | FABP1;CHRNB3;TLR8;RARB;ABP1;MT2A;SLC6A4A;ADRB2;GPR30 |
| phosphatidylinositol phospholipase C activity | PLCD1;PLD4;PLCH2;PLCE1;CCL5;PLCD1A;CASR;CCR1;PLCD1B |
| protein binding | MGST1;CECR2;RAB21;RIOK3;CARTPT;VEGFC;ZBTB24;KDM4A;CTRC |
| receptor activity | P2RY1;MED14;GABRA5;TREM2;ICAM1;CD33;MED17;EIF2D;VMN1R47 |
CHRM3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CHRM3 here. Most of them are supplied by our site. Hope this information will be useful for your research of CHRM3.
MDM2; PPP1R9B; NALCN
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