CHST11
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Official Full Name
carbohydrate (chondroitin 4) sulfotransferase 11
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Background
The protein encoded by this gene belongs to the sulfotransferase 2 family. It is localized to the golgi membrane, and catalyzes the transfer of sulfate to position 4 of the N-acetylgalactosamine (GalNAc) residue of chondroitin. Chondroitin sulfate constitutes the predominant proteoglycan present in cartilage, and is distributed on the surfaces of many cells and extracellular matrices. A chromosomal translocation involving this gene and IgH, t(12;14)(q23;q32), has been reported in a patient with B-cell chronic lymphocytic leukemia. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. -
Synonyms
CHST11; carbohydrate (chondroitin 4) sulfotransferase 11; carbohydrate sulfotransferase 11; C4ST; C4St 1; C4ST1; HSA269537; C4S-1; C4ST-1; Chondroitin 4 O sulfotransferase 1; Chondroitin 4 sulfotransferase; Chondroitin 4-O-sulfotransferase 1; Chondroitin 4-sulfotransferase 1; CHST 11; CHSTB_HUMAN; IgH/CHST11 fusion; OTTHUMP00000242139; OTTHUMP00000242140;
- Involved Pathway
- Protein Function
- Interacting Protein
CHST11 involved in several pathways and played different roles in them. We selected most pathways CHST11 participated on our site, such as Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate, which may be useful for your reference. Also, other proteins which involved in the same pathway with CHST11 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate | B3GAT3;CHSY3;UST;DSE;CHST14;CHST11;B3GALT6;CSGALNACT1;CHST3 |
CHST11 has several biochemical functions, for example, N-acetylgalactosamine 4-O-sulfotransferase activity, N-acetylgalactosamine 4-sulfate 6-O-sulfotransferase activity, chondroitin 4-sulfotransferase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by CHST11 itself. We selected most functions CHST11 had, and list some proteins which have the same functions with CHST11. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| N-acetylgalactosamine 4-O-sulfotransferase activity | CHST3A;CHST3B;SULT1ST3;CHST11;HS6ST1B;SULT2ST3;HS6ST3B;SULT1ST4;CHST2A |
| N-acetylgalactosamine 4-sulfate 6-O-sulfotransferase activity | CHST15;CHST11 |
| chondroitin 4-sulfotransferase activity | CHST12;CHST11 |
CHST11 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CHST11 here. Most of them are supplied by our site. Hope this information will be useful for your research of CHST11.
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