Recombinant Human CHST11, His-tagged

• Cat.No.: CHST11-11224H
• Product Overview: Recombinant Human CHST11 protein, fused to His-tag, was expressed in E.coli and purified by Ni-sepharose.

Specification

• Species: Human
• Source: E.coli
• Tag: His
• Protein Length: 37-352a.a.
• Description: The protein encoded by this gene belongs to the sulfotransferase 2 family. It is localized to the golgi membrane, and catalyzes the transfer of sulfate to position 4 of the N-acetylgalactosamine (GalNAc) residue of chondroitin. Chondroitin sulfate constitutes the predominant proteoglycan present in cartilage, and is distributed on the surfaces of many cells and extracellular matrices. A chromosomal translocation involving this gene and IgH, t(12;14)(q23;q32), has been reported in a patient with B-cell chronic lymphocytic leukemia. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
• Storage: The protein is stored in PBS buffer at -20℃. Avoid repeated freezing and thawing cycles.
• Storage Buffer: 1M PBS (58mM Na2HPO4,17mM NaH2PO4, 68mM NaCl, pH8. ) added with 300mM Imidazole and 0.7% Sarcosyl, 15%glycerol.

Gene Information

• Gene Name: CHST11 carbohydrate (chondroitin 4) sulfotransferase 11 [ Homo sapiens ]
• Official Symbol: CHST11
• Synonyms: CHST11; carbohydrate (chondroitin 4) sulfotransferase 11; carbohydrate sulfotransferase 11; C4ST; C4St 1; C4ST1; HSA269537; C4S-1; IgH/CHST11 fusion; chondroitin 4-O-sulfotransferase 1; C4ST-1; FLJ41682; DKFZp667A035
• Gene ID: 50515
• mRNA Refseq: NM_001173982
• Protein Refseq: NP_001167453
• MIM: 610128
• UniProt ID: Q9NPF2
• Chromosome Location: 12q23.3
• Pathway: Endochondral Ossification, organism-specific biosystem; Glycosaminoglycan biosynthesis - chondroitin sulfate, organism-specific biosystem; Glycosaminoglycan biosynthesis - chondroitin sulfate, conserved biosystem; Sulfur metabolism, organism-specific biosystem; Sulfur metabolism, conserved biosystem; chondroitin sulfate biosynthesis, organism-specific biosystem; chondroitin sulfate biosynthesis, conserved biosystem
• Function: N-acetylgalactosamine 4-O-sulfotransferase activity; chondroitin 4-sulfotransferase activity; transferase activity